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Protein

KATNB1-like protein 1

Gene

KATNBL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro.1 Publication

GO - Biological processi

  • positive regulation of cytoskeleton organization Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
KATNB1-like protein 1
Alternative name(s):
Katanin p80 subunit B-like 11 Publication
Gene namesi
Name:KATNBL11 Publication
Synonyms:C15orf29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000134152.10
HGNCiHGNC:26199 KATNBL1
MIMi616235 gene
neXtProtiNX_Q9H079

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi9K → A: Complete redistribution from the nucleus to the cytoplasm; when associated with A-10; A-11; A-26; A-27; A-28; A-71; A-72; A-73 and A-74. 1 Publication1
Mutagenesisi10K → A: Complete redistribution from the nucleus to the cytoplasm; when associated with A-9; A-11; A-26; A-27; A-28; A-71; A-72; A-73 and A-74. 1 Publication1
Mutagenesisi11R → A: Complete redistribution from the nucleus to the cytoplasm; when associated with A-9; A-10; A-26; A-27; A-28; A-71; A-72; A-73 and A-74. 1 Publication1
Mutagenesisi26R → A: Complete redistribution from the nucleus to the cytoplasm; when associated with A-9; A-10; A-11; A-27; A-28; A-71; A-72; A-73 and A-74. 1 Publication1
Mutagenesisi27K → A: Complete redistribution from the nucleus to the cytoplasm; when associated with A-9; A-10; A-11; A-26; A-28; A-71; A-72; A-73 and A-74. 1 Publication1
Mutagenesisi28K → A: Complete redistribution from the nucleus to the cytoplasm; when associated with A-9; A-10; A-11; A-26; A-27; A-71; A-72; A-73 and A-74. 1 Publication1
Mutagenesisi71R → A: Redistributes from the nucleus to both nucleus and cytoplasm; when associated with A-72; A-73 and A-74. Complete redistribution from the nucleus to the cytoplasm; when associated with A-9; A-10; A-11; A-26; A-27; A-28; A-72; A-73 and A-74. 1 Publication1
Mutagenesisi72R → A: Redistributes from the nucleus to both nucleus and cytoplasm; when associated with A-71; A-73 and A-74. Complete redistribution from the nucleus to the cytoplasm; when associated with A-9; A-10; A-11; A-26; A-27; A-28; A-71; A-73 and A-74. 1 Publication1
Mutagenesisi73K → A: Redistributes from the nucleus to both nucleus and cytoplasm; when associated with A-71; A-72 and A-74. Complete redistribution from the nucleus to the cytoplasm; when associated with A-9; A-10; A-11; A-26; A-27; A-28; A-71; A-72 and A-74. 1 Publication1
Mutagenesisi74K → A: Redistributes from the nucleus to both nucleus and cytoplasm; when associated with A-71; A-72 and A-73. Complete redistribution from the nucleus to the cytoplasm; when associated with A-9; A-10; A-11; A-26; A-27; A-28; A-71; A-72 and A-73. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000134152
PharmGKBiPA134985944

Polymorphism and mutation databases

BioMutaiKATNBL1
DMDMi73917822

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899811 – 304KATNB1-like protein 1Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H079
MaxQBiQ9H079
PaxDbiQ9H079
PeptideAtlasiQ9H079
PRIDEiQ9H079
ProteomicsDBi80214

PTM databases

iPTMnetiQ9H079
PhosphoSitePlusiQ9H079

Expressioni

Gene expression databases

BgeeiENSG00000134152 Expressed in 216 organ(s), highest expression level in placenta
CleanExiHS_C15orf29
ExpressionAtlasiQ9H079 baseline and differential
GenevisibleiQ9H079 HS

Organism-specific databases

HPAiHPA062573

Interactioni

Subunit structurei

Interacts with KATNA1 and KATNAL1; these interactions are competed by KATNB1 which has a higher affinity for them.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi122873, 11 interactors
IntActiQ9H079, 56 interactors
MINTiQ9H079
STRINGi9606.ENSP00000256544

Structurei

3D structure databases

ProteinModelPortaliQ9H079
SMRiQ9H079
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi26 – 33Nuclear localization signal 1PROSITE-ProRule annotation8
Motifi72 – 79Nuclear localization signal 2PROSITE-ProRule annotation8

Phylogenomic databases

eggNOGiENOG410IIPM Eukaryota
ENOG4111ZSI LUCA
GeneTreeiENSGT00390000012351
HOGENOMiHOG000231426
HOVERGENiHBG055310
InParanoidiQ9H079
OMAiMASEAHN
OrthoDBiEOG091G14WC
PhylomeDBiQ9H079
TreeFamiTF332359

Family and domain databases

InterProiView protein in InterPro
IPR028021 Katanin_C-terminal
PfamiView protein in Pfam
PF13925 Katanin_con80, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q9H079-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASETHNVKK RNFCNKIEDH FIDLPRKKIS NFTNKNMKEV KKSPKQLAAY
60 70 80 90 100
INRTVGQTVK SPDKLRKVIY RRKKVHHPFP NPCYRKKQSP GSGGCDMANK
110 120 130 140 150
ENELACAGHL PEKLHHDSRT YLVNSSDSGS SQTESPSSKY SGFFSEVSQD
160 170 180 190 200
HETMAQVLFS RNMRLNVALT FWRKRSISEL VAYLLRIEDL GVVVDCLPVL
210 220 230 240 250
TNCLQEEKQY ISLGCCVDLL PLVKSLLKSK FEEYVIVGLN WLQAVIKRWW
260 270 280 290 300
SELSSKTEII NDGNIQILKQ QLSGLWEQEN HLTLVPGYTG NIAKDVDAYL

LQLH
Length:304
Mass (Da):34,767
Last modified:March 1, 2001 - v1
Checksum:i5F7515A3A95FEBBB
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YLX9H0YLX9_HUMAN
KATNB1-like protein 1
KATNBL1
111Annotation score:
H0YL62H0YL62_HUMAN
KATNB1-like protein 1
KATNBL1
168Annotation score:
H0YMR8H0YMR8_HUMAN
KATNB1-like protein 1
KATNBL1
152Annotation score:
H0YNH1H0YNH1_HUMAN
KATNB1-like protein 1
KATNBL1
81Annotation score:
H0YNW3H0YNW3_HUMAN
KATNB1-like protein 1
KATNBL1
126Annotation score:
H0YNG2H0YNG2_HUMAN
KATNB1-like protein 1
KATNBL1
177Annotation score:
H0YKW3H0YKW3_HUMAN
KATNB1-like protein 1
KATNBL1
178Annotation score:
H0YNF7H0YNF7_HUMAN
KATNB1-like protein 1
KATNBL1
74Annotation score:
H0YLP4H0YLP4_HUMAN
KATNB1-like protein 1
KATNBL1
39Annotation score:

Sequence cautioni

The sequence BAB15394 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136908 mRNA Translation: CAB66842.1
AK026210 mRNA Translation: BAB15394.1 Different initiation.
AK293021 mRNA Translation: BAF85710.1
CH471125 Genomic DNA Translation: EAW92288.1
BC026234 mRNA Translation: AAH26234.1
BC111000 mRNA Translation: AAI11001.1
CCDSiCCDS10034.1
RefSeqiNP_078989.1, NM_024713.2
XP_016878060.1, XM_017022571.1
XP_016878061.1, XM_017022572.1
XP_016878062.1, XM_017022573.1
XP_016878063.1, XM_017022574.1
UniGeneiHs.633566

Genome annotation databases

EnsembliENST00000256544; ENSP00000256544; ENSG00000134152
GeneIDi79768
KEGGihsa:79768
UCSCiuc001zhp.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136908 mRNA Translation: CAB66842.1
AK026210 mRNA Translation: BAB15394.1 Different initiation.
AK293021 mRNA Translation: BAF85710.1
CH471125 Genomic DNA Translation: EAW92288.1
BC026234 mRNA Translation: AAH26234.1
BC111000 mRNA Translation: AAI11001.1
CCDSiCCDS10034.1
RefSeqiNP_078989.1, NM_024713.2
XP_016878060.1, XM_017022571.1
XP_016878061.1, XM_017022572.1
XP_016878062.1, XM_017022573.1
XP_016878063.1, XM_017022574.1
UniGeneiHs.633566

3D structure databases

ProteinModelPortaliQ9H079
SMRiQ9H079
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122873, 11 interactors
IntActiQ9H079, 56 interactors
MINTiQ9H079
STRINGi9606.ENSP00000256544

PTM databases

iPTMnetiQ9H079
PhosphoSitePlusiQ9H079

Polymorphism and mutation databases

BioMutaiKATNBL1
DMDMi73917822

Proteomic databases

EPDiQ9H079
MaxQBiQ9H079
PaxDbiQ9H079
PeptideAtlasiQ9H079
PRIDEiQ9H079
ProteomicsDBi80214

Protocols and materials databases

DNASUi79768
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256544; ENSP00000256544; ENSG00000134152
GeneIDi79768
KEGGihsa:79768
UCSCiuc001zhp.4 human

Organism-specific databases

CTDi79768
EuPathDBiHostDB:ENSG00000134152.10
GeneCardsiKATNBL1
HGNCiHGNC:26199 KATNBL1
HPAiHPA062573
MIMi616235 gene
neXtProtiNX_Q9H079
OpenTargetsiENSG00000134152
PharmGKBiPA134985944
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIPM Eukaryota
ENOG4111ZSI LUCA
GeneTreeiENSGT00390000012351
HOGENOMiHOG000231426
HOVERGENiHBG055310
InParanoidiQ9H079
OMAiMASEAHN
OrthoDBiEOG091G14WC
PhylomeDBiQ9H079
TreeFamiTF332359

Miscellaneous databases

ChiTaRSiKATNBL1 human
GeneWikiiC15orf29
GenomeRNAii79768
PROiPR:Q9H079
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134152 Expressed in 216 organ(s), highest expression level in placenta
CleanExiHS_C15orf29
ExpressionAtlasiQ9H079 baseline and differential
GenevisibleiQ9H079 HS

Family and domain databases

InterProiView protein in InterPro
IPR028021 Katanin_C-terminal
PfamiView protein in Pfam
PF13925 Katanin_con80, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKTBL1_HUMAN
AccessioniPrimary (citable) accession number: Q9H079
Secondary accession number(s): A8KAF6, Q2TAC0, Q9H670
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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