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Entry version 163 (16 Oct 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Caseinolytic peptidase B protein homolog

Gene

CLPB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a regulatory ATPase and be related to secretion/protein trafficking process.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi381 – 388ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cellular response to heat Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caseinolytic peptidase B protein homolog (EC:3.6.1.31 Publication)
Alternative name(s):
Suppressor of potassium transport defect 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLPB
Synonyms:HSP78, SKD3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30664 CLPB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616254 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H078

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

3-methylglutaconic aciduria with cataracts, neurologic involvement and neutropenia (MEGCANN)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive inborn error of metabolism with a highly variable phenotype. Primary disease symptoms are increased levels of 3-methylglutaconic acid, neurologic deterioration and neutropenia. Other common features include progressive encephalopathy, movement abnormalities, delayed psychomotor development, cataracts, seizures, and recurrent infections.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073397268T → M in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs200032855Ensembl.1
Natural variantiVAR_073398272Y → C in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs777313457Ensembl.1
Natural variantiVAR_073399408R → G in MEGCANN; reduced ATPase activity in vitro. 1 PublicationCorresponds to variant dbSNP:rs144078282Ensembl.1
Natural variantiVAR_073400411M → I in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs786205137Ensembl.1
Natural variantiVAR_073401435 – 436EG → DP in MEGCANN. 1 Publication2
Natural variantiVAR_073402486C → R in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs886041118Ensembl.1
Natural variantiVAR_073403501E → K in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs748915609Ensembl.1
Natural variantiVAR_073404567Y → C in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs150857620Ensembl.1
Natural variantiVAR_073405591A → V in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs748010262Ensembl.1
Natural variantiVAR_073406617Y → C in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs786205138Ensembl.1
Natural variantiVAR_073407646G → V in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs759500860Ensembl.1
Natural variantiVAR_073408682I → N in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs886041120Ensembl.1

Keywords - Diseasei

Cataract, Disease mutation, Epilepsy

Organism-specific databases

DisGeNET

More...
DisGeNETi
81570

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
CLPB

MalaCards human disease database

More...
MalaCardsi
CLPB
MIMi616271 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000162129

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
445038 3-methylglutaconic aciduria type 7

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672092

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H078

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CLPB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
25009267

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 36MitochondrionSequence analysisAdd BLAST36
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000019123937 – 707Caseinolytic peptidase B protein homologAdd BLAST671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei589N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H078

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H078

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H078

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H078

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H078

PeptideAtlas

More...
PeptideAtlasi
Q9H078

PRoteomics IDEntifications database

More...
PRIDEi
Q9H078

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
18882
29984
5473
80212 [Q9H078-1]
80213 [Q9H078-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H078

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H078

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9H078

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed (at protein level) (PubMed:25597511). Expressed in fetal, as well as in adult tissues, with highest levels in adult brain, including thalamus, hippocampus, occipital cortex and parietal cortex. Low expression in granulocytes (PubMed:25597510).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162129 Expressed in 166 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H078 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H078 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039005
HPA039006
HPA064571

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q8NHQ13EBI-2107221,EBI-739624

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123531, 65 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H078, 63 interactors

Molecular INTeraction database

More...
MINTi
Q9H078

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000294053

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati133 – 162ANK 1Add BLAST30
Repeati166 – 195ANK 2Add BLAST30
Repeati265 – 295ANK 3Add BLAST31
Repeati298 – 327ANK 4Add BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ClpA/ClpB family.Curated

Keywords - Domaini

ANK repeat, Repeat, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1051 Eukaryota
COG0542 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012961

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006543

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H078

KEGG Orthology (KO)

More...
KOi
K03695

Database of Orthologous Groups

More...
OrthoDBi
611758at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H078

TreeFam database of animal gene trees

More...
TreeFami
TF328654

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR003959 ATPase_AAA_core
IPR019489 Clp_ATPase_C
IPR001270 ClpA/B
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07724 AAA_2, 1 hit
PF12796 Ank_2, 2 hits
PF10431 ClpB_D2-small, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00300 CLPPROTEASEA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 1 hit
SM00248 ANK, 3 hits
SM01086 ClpB_D2-small, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H078-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGSLVLRRK ALAPRLLLRL LRSPTLRGHG GASGRNVTTG SLGEPQWLRV
60 70 80 90 100
ATGGRPGTSP ALFSGRGAAT GGRQGGRFDT KCLAAATWGR LPGPEETLPG
110 120 130 140 150
QDSWNGVPSR AGLGMCALAA ALVVHCYSKS PSNKDAALLE AARANNMQEV
160 170 180 190 200
SRLLSEGADV NAKHRLGWTA LMVAAINRNN SVVQVLLAAG ADPNLGDDFS
210 220 230 240 250
SVYKTAKEQG IHSLEDGGQD GASRHITNQW TSALEFRRWL GLPAGVLITR
260 270 280 290 300
EDDFNNRLNN RASFKGCTAL HYAVLADDYR TVKELLDGGA NPLQRNEMGH
310 320 330 340 350
TPLDYAREGE VMKLLRTSEA KYQEKQRKRE AEERRRFPLE QRLKEHIIGQ
360 370 380 390 400
ESAIATVGAA IRRKENGWYD EEHPLVFLFL GSSGIGKTEL AKQTAKYMHK
410 420 430 440 450
DAKKGFIRLD MSEFQERHEV AKFIGSPPGY VGHEEGGQLT KKLKQCPNAV
460 470 480 490 500
VLFDEVDKAH PDVLTIMLQL FDEGRLTDGK GKTIDCKDAI FIMTSNVASD
510 520 530 540 550
EIAQHALQLR QEALEMSRNR IAENLGDVQI SDKITISKNF KENVIRPILK
560 570 580 590 600
AHFRRDEFLG RINEIVYFLP FCHSELIQLV NKELNFWAKR AKQRHNITLL
610 620 630 640 650
WDREVADVLV DGYNVHYGAR SIKHEVERRV VNQLAAAYEQ DLLPGGCTLR
660 670 680 690 700
ITVEDSDKQL LKSPELPSPQ AEKRLPKLRL EIIDKDSKTR RLDIRAPLHP

EKVCNTI
Length:707
Mass (Da):78,729
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E0F2A244CA20635
GO
Isoform 2 (identifier: Q9H078-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-245: Missing.

Note: No experimental confirmation available.
Show »
Length:677
Mass (Da):75,449
Checksum:iC03F18C94337B9E4
GO
Isoform 3 (identifier: Q9H078-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-180: Missing.
     216-245: Missing.

Note: No experimental confirmation available.
Show »
Length:648
Mass (Da):72,276
Checksum:i586F3100E877B4D4
GO
Isoform 4 (identifier: Q9H078-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: MLGSLVLRRK...ARANNMQEVS → MPRGCHLGTP...TKISSSEWPL

Note: No experimental confirmation available.
Show »
Length:662
Mass (Da):74,543
Checksum:iF9DE15704672A495
GO
Isoform 5 (identifier: Q9H078-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.
     216-245: Missing.

Note: No experimental confirmation available.
Show »
Length:506
Mass (Da):57,664
Checksum:i55E4A602D8B4F44A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YGM0H0YGM0_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
712Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y602A0A2R8Y602_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
382Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2U3TZY2A0A2U3TZY2_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
692Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDH5A0A2R8YDH5_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H392F5H392_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7A5F5H7A5_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6R5A0A2R8Y6R5_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
327Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GX99F5GX99_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SS08F6SS08_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YG50H0YG50_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti413E → K in BAG63459 (PubMed:14702039).Curated1
Sequence conflicti563N → S in BAG63409 (PubMed:14702039).Curated1
Sequence conflicti650R → C in BAG63459 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073397268T → M in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs200032855Ensembl.1
Natural variantiVAR_073398272Y → C in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs777313457Ensembl.1
Natural variantiVAR_048740295R → T. Corresponds to variant dbSNP:rs7938203Ensembl.1
Natural variantiVAR_073399408R → G in MEGCANN; reduced ATPase activity in vitro. 1 PublicationCorresponds to variant dbSNP:rs144078282Ensembl.1
Natural variantiVAR_073400411M → I in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs786205137Ensembl.1
Natural variantiVAR_073401435 – 436EG → DP in MEGCANN. 1 Publication2
Natural variantiVAR_073402486C → R in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs886041118Ensembl.1
Natural variantiVAR_073403501E → K in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs748915609Ensembl.1
Natural variantiVAR_073404567Y → C in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs150857620Ensembl.1
Natural variantiVAR_073405591A → V in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs748010262Ensembl.1
Natural variantiVAR_073406617Y → C in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs786205138Ensembl.1
Natural variantiVAR_073407646G → V in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs759500860Ensembl.1
Natural variantiVAR_073408682I → N in MEGCANN. 1 PublicationCorresponds to variant dbSNP:rs886041120Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0573971 – 171Missing in isoform 5. 1 PublicationAdd BLAST171
Alternative sequenceiVSP_0447251 – 151MLGSL…MQEVS → MPRGCHLGTPSWSRRNTPRT GQLERGPQQGRTGHVRPGRS AGGSLLQQESVQQGCSPVGS CPCQQYARSQQPQETAKNDA QSRSWAGLNAGVSLKNTKIS SSEWPL in isoform 4. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_044726152 – 180Missing in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_001106216 – 245Missing in isoform 2, isoform 3 and isoform 5. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136909 mRNA Translation: CAB66843.1
AL834484 mRNA Translation: CAD39142.1
AK023214 mRNA Translation: BAB14467.1
AK302006 mRNA Translation: BAG63409.1
AK302069 mRNA Translation: BAG63459.1
AK302158 mRNA Translation: BAG63526.1
AP000593 Genomic DNA No translation available.
AP002892 Genomic DNA No translation available.
AP003785 Genomic DNA No translation available.
BC006404 mRNA Translation: AAH06404.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58152.1 [Q9H078-4]
CCDS58153.1 [Q9H078-3]
CCDS58154.1 [Q9H078-2]
CCDS8215.1 [Q9H078-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001245321.1, NM_001258392.2 [Q9H078-2]
NP_001245322.1, NM_001258393.2 [Q9H078-3]
NP_001245323.1, NM_001258394.2 [Q9H078-4]
NP_110440.1, NM_030813.5 [Q9H078-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000294053; ENSP00000294053; ENSG00000162129 [Q9H078-1]
ENST00000340729; ENSP00000340385; ENSG00000162129 [Q9H078-3]
ENST00000437826; ENSP00000407296; ENSG00000162129 [Q9H078-4]
ENST00000538039; ENSP00000441518; ENSG00000162129 [Q9H078-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
81570

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:81570

UCSC genome browser

More...
UCSCi
uc001osj.5 human [Q9H078-1]
uc010rqz.3 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136909 mRNA Translation: CAB66843.1
AL834484 mRNA Translation: CAD39142.1
AK023214 mRNA Translation: BAB14467.1
AK302006 mRNA Translation: BAG63409.1
AK302069 mRNA Translation: BAG63459.1
AK302158 mRNA Translation: BAG63526.1
AP000593 Genomic DNA No translation available.
AP002892 Genomic DNA No translation available.
AP003785 Genomic DNA No translation available.
BC006404 mRNA Translation: AAH06404.1
CCDSiCCDS58152.1 [Q9H078-4]
CCDS58153.1 [Q9H078-3]
CCDS58154.1 [Q9H078-2]
CCDS8215.1 [Q9H078-1]
RefSeqiNP_001245321.1, NM_001258392.2 [Q9H078-2]
NP_001245322.1, NM_001258393.2 [Q9H078-3]
NP_001245323.1, NM_001258394.2 [Q9H078-4]
NP_110440.1, NM_030813.5 [Q9H078-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123531, 65 interactors
IntActiQ9H078, 63 interactors
MINTiQ9H078
STRINGi9606.ENSP00000294053

PTM databases

iPTMnetiQ9H078
PhosphoSitePlusiQ9H078
SwissPalmiQ9H078

Polymorphism and mutation databases

BioMutaiCLPB
DMDMi25009267

Proteomic databases

EPDiQ9H078
jPOSTiQ9H078
MassIVEiQ9H078
MaxQBiQ9H078
PaxDbiQ9H078
PeptideAtlasiQ9H078
PRIDEiQ9H078
ProteomicsDBi18882
29984
5473
80212 [Q9H078-1]
80213 [Q9H078-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
81570

Genome annotation databases

EnsembliENST00000294053; ENSP00000294053; ENSG00000162129 [Q9H078-1]
ENST00000340729; ENSP00000340385; ENSG00000162129 [Q9H078-3]
ENST00000437826; ENSP00000407296; ENSG00000162129 [Q9H078-4]
ENST00000538039; ENSP00000441518; ENSG00000162129 [Q9H078-2]
GeneIDi81570
KEGGihsa:81570
UCSCiuc001osj.5 human [Q9H078-1]
uc010rqz.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
81570
DisGeNETi81570

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CLPB
GeneReviewsiCLPB
HGNCiHGNC:30664 CLPB
HPAiHPA039005
HPA039006
HPA064571
MalaCardsiCLPB
MIMi616254 gene
616271 phenotype
neXtProtiNX_Q9H078
OpenTargetsiENSG00000162129
Orphaneti445038 3-methylglutaconic aciduria type 7
PharmGKBiPA142672092

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1051 Eukaryota
COG0542 LUCA
GeneTreeiENSGT00390000012961
HOGENOMiHOG000006543
InParanoidiQ9H078
KOiK03695
OrthoDBi611758at2759
PhylomeDBiQ9H078
TreeFamiTF328654

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CLPB human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CLPB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
81570
PharosiQ9H078

Protein Ontology

More...
PROi
PR:Q9H078

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162129 Expressed in 166 organ(s), highest expression level in right testis
ExpressionAtlasiQ9H078 baseline and differential
GenevisibleiQ9H078 HS

Family and domain databases

Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR003959 ATPase_AAA_core
IPR019489 Clp_ATPase_C
IPR001270 ClpA/B
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF07724 AAA_2, 1 hit
PF12796 Ank_2, 2 hits
PF10431 ClpB_D2-small, 1 hit
PRINTSiPR00300 CLPPROTEASEA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00248 ANK, 3 hits
SM01086 ClpB_D2-small, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLPB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H078
Secondary accession number(s): B4DXJ7
, B4DXP7, B4DXW4, E7EWN6, F8W7P6, Q8ND11, Q9H8Y0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2001
Last modified: October 16, 2019
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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