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UniProtKB - Q9H078 (CLPB_HUMAN)

Entry version 175 (23 Feb 2022)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
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Protein

Caseinolytic peptidase B protein homolog

Gene

CLPB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a regulatory ATPase and be related to secretion/protein trafficking process. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and proinflammatory cytokine IL6 (PubMed:31522117).

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi381 – 388ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H078

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9H078

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caseinolytic peptidase B protein homolog (EC:3.6.1.-1 Publication)
Alternative name(s):
Suppressor of potassium transport defect 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLPB
Synonyms:HSP78, SKD3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30664, CLPB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616254, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H078

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000162129

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

3-methylglutaconic aciduria 7 (MGCA7)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive inborn error of metabolism with a highly variable phenotype. Primary disease symptoms are increased levels of 3-methylglutaconic acid, neurologic deterioration and neutropenia. Other common features include progressive encephalopathy, movement abnormalities, delayed psychomotor development, cataracts, seizures, and recurrent infections.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073397268T → M in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs200032855Ensembl.1
Natural variantiVAR_073398272Y → C in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs777313457Ensembl.1
Natural variantiVAR_073399408R → G in MGCA7; reduced ATPase activity in vitro. 1 PublicationCorresponds to variant dbSNP:rs144078282Ensembl.1
Natural variantiVAR_073400411M → I in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs786205137Ensembl.1
Natural variantiVAR_073401435 – 436EG → DP in MGCA7. 1 Publication2
Natural variantiVAR_073402486C → R in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs886041118Ensembl.1
Natural variantiVAR_073403501E → K in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs748915609Ensembl.1
Natural variantiVAR_073404567Y → C in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs150857620Ensembl.1
Natural variantiVAR_073405591A → V in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs748010262Ensembl.1
Natural variantiVAR_073406617Y → C in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs786205138Ensembl.1
Natural variantiVAR_073407646G → V in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs759500860Ensembl.1
Natural variantiVAR_073408682I → N in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs886041120Ensembl.1

Keywords - Diseasei

Cataract, Disease variant, Epilepsy

Organism-specific databases

DisGeNET

More...DisGeNETi		81570

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		CLPB

MalaCards human disease database

More...MalaCardsi		CLPB
MIMi616271, phenotype

Open Targets

More...OpenTargetsi		ENSG00000162129

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		445038, 3-methylglutaconic aciduria type 7

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672092

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H078, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CLPB

Domain mapping of disease mutations (DMDM)

More...DMDMi		25009267

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 36MitochondrionSequence analysisAdd BLAST36
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000019123937 – 707Caseinolytic peptidase B protein homologAdd BLAST671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei589N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H078

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H078

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H078

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H078

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H078

PeptideAtlas

More...PeptideAtlasi		Q9H078

PRoteomics IDEntifications database

More...PRIDEi		Q9H078

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		18882
29984
5473
80212 [Q9H078-1]
80213 [Q9H078-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9H078, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H078

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9H078

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H078

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9H078

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed (at protein level) (PubMed:25597511). Expressed in fetal, as well as in adult tissues, with highest levels in adult brain, including thalamus, hippocampus, occipital cortex and parietal cortex. Low expression in granulocytes (PubMed:25597510).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000162129, Expressed in right testis and 183 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H078, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H078, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000162129, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PHB and PHB2 (PubMed:31522117).

Interacts with MAVS; the interaction is enhanced by Sendai virus infection (PubMed:31522117).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123531, 172 interactors

Protein interaction database and analysis system

More...IntActi		Q9H078, 74 interactors

Molecular INTeraction database

More...MINTi		Q9H078

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000294053

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H078, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H078

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati133 – 162ANK 1Add BLAST30
Repeati166 – 195ANK 2Add BLAST30
Repeati265 – 295ANK 3Add BLAST31
Repeati298 – 327ANK 4Add BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ClpA/ClpB family.Curated

Keywords - Domaini

ANK repeat, Repeat, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1051, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012961

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005070_9_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H078

Identification of Orthologs from Complete Genome Data

More...OMAi		CKNAIFI

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H078

TreeFam database of animal gene trees

More...TreeFami		TF328654

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 2 hits
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR003959, ATPase_AAA_core
IPR019489, Clp_ATPase_C
IPR001270, ClpA/B
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07724, AAA_2, 1 hit
PF12796, Ank_2, 1 hit
PF13857, Ank_5, 1 hit
PF10431, ClpB_D2-small, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00300, CLPPROTEASEA

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 1 hit
SM00248, ANK, 3 hits
SM01086, ClpB_D2-small, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H078-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGSLVLRRK ALAPRLLLRL LRSPTLRGHG GASGRNVTTG SLGEPQWLRV 
        60         70         80         90        100
ATGGRPGTSP ALFSGRGAAT GGRQGGRFDT KCLAAATWGR LPGPEETLPG 
       110        120        130        140        150
QDSWNGVPSR AGLGMCALAA ALVVHCYSKS PSNKDAALLE AARANNMQEV 
       160        170        180        190        200
SRLLSEGADV NAKHRLGWTA LMVAAINRNN SVVQVLLAAG ADPNLGDDFS 
       210        220        230        240        250
SVYKTAKEQG IHSLEDGGQD GASRHITNQW TSALEFRRWL GLPAGVLITR 
       260        270        280        290        300
EDDFNNRLNN RASFKGCTAL HYAVLADDYR TVKELLDGGA NPLQRNEMGH 
       310        320        330        340        350
TPLDYAREGE VMKLLRTSEA KYQEKQRKRE AEERRRFPLE QRLKEHIIGQ 
       360        370        380        390        400
ESAIATVGAA IRRKENGWYD EEHPLVFLFL GSSGIGKTEL AKQTAKYMHK 
       410        420        430        440        450
DAKKGFIRLD MSEFQERHEV AKFIGSPPGY VGHEEGGQLT KKLKQCPNAV 
       460        470        480        490        500
VLFDEVDKAH PDVLTIMLQL FDEGRLTDGK GKTIDCKDAI FIMTSNVASD 
       510        520        530        540        550
EIAQHALQLR QEALEMSRNR IAENLGDVQI SDKITISKNF KENVIRPILK 
       560        570        580        590        600
AHFRRDEFLG RINEIVYFLP FCHSELIQLV NKELNFWAKR AKQRHNITLL 
       610        620        630        640        650
WDREVADVLV DGYNVHYGAR SIKHEVERRV VNQLAAAYEQ DLLPGGCTLR 
       660        670        680        690        700
ITVEDSDKQL LKSPELPSPQ AEKRLPKLRL EIIDKDSKTR RLDIRAPLHP 

EKVCNTI
Length:707
Mass (Da):78,729
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E0F2A244CA20635
GO
Isoform 2 (identifier: Q9H078-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-245: Missing.

Show »
Length:677
Mass (Da):75,449
Checksum:iC03F18C94337B9E4
GO
Isoform 3 (identifier: Q9H078-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-180: Missing.
     216-245: Missing.

Show »
Length:648
Mass (Da):72,276
Checksum:i586F3100E877B4D4
GO
Isoform 4 (identifier: Q9H078-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: MLGSLVLRRK...ARANNMQEVS → MPRGCHLGTP...TKISSSEWPL

Show »
Length:662
Mass (Da):74,543
Checksum:iF9DE15704672A495
GO
Isoform 5 (identifier: Q9H078-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.
     216-245: Missing.

Show »
Length:506
Mass (Da):57,664
Checksum:i55E4A602D8B4F44A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YGM0H0YGM0_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
712Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y602A0A2R8Y602_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
382Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2U3TZY2A0A2U3TZY2_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
692Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDH5A0A2R8YDH5_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SS08F6SS08_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H392F5H392_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7A5F5H7A5_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6R5A0A2R8Y6R5_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
327Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GX99F5GX99_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YG50H0YG50_HUMAN
Caseinolytic peptidase B protein ho...
CLPB
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti413E → K in BAG63459 (PubMed:14702039).Curated1
Sequence conflicti563N → S in BAG63409 (PubMed:14702039).Curated1
Sequence conflicti650R → C in BAG63459 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073397268T → M in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs200032855Ensembl.1
Natural variantiVAR_073398272Y → C in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs777313457Ensembl.1
Natural variantiVAR_048740295R → T. Corresponds to variant dbSNP:rs7938203Ensembl.1
Natural variantiVAR_073399408R → G in MGCA7; reduced ATPase activity in vitro. 1 PublicationCorresponds to variant dbSNP:rs144078282Ensembl.1
Natural variantiVAR_073400411M → I in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs786205137Ensembl.1
Natural variantiVAR_073401435 – 436EG → DP in MGCA7. 1 Publication2
Natural variantiVAR_073402486C → R in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs886041118Ensembl.1
Natural variantiVAR_073403501E → K in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs748915609Ensembl.1
Natural variantiVAR_073404567Y → C in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs150857620Ensembl.1
Natural variantiVAR_073405591A → V in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs748010262Ensembl.1
Natural variantiVAR_073406617Y → C in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs786205138Ensembl.1
Natural variantiVAR_073407646G → V in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs759500860Ensembl.1
Natural variantiVAR_073408682I → N in MGCA7. 1 PublicationCorresponds to variant dbSNP:rs886041120Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0573971 – 171Missing in isoform 5. 1 PublicationAdd BLAST171
Alternative sequenceiVSP_0447251 – 151MLGSL…MQEVS → MPRGCHLGTPSWSRRNTPRT GQLERGPQQGRTGHVRPGRS AGGSLLQQESVQQGCSPVGS CPCQQYARSQQPQETAKNDA QSRSWAGLNAGVSLKNTKIS SSEWPL in isoform 4. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_044726152 – 180Missing in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_001106216 – 245Missing in isoform 2, isoform 3 and isoform 5. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL136909 mRNA Translation: CAB66843.1
AL834484 mRNA Translation: CAD39142.1
AK023214 mRNA Translation: BAB14467.1
AK302006 mRNA Translation: BAG63409.1
AK302069 mRNA Translation: BAG63459.1
AK302158 mRNA Translation: BAG63526.1
AP000593 Genomic DNA No translation available.
AP002892 Genomic DNA No translation available.
AP003785 Genomic DNA No translation available.
BC006404 mRNA Translation: AAH06404.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS58152.1 [Q9H078-4]
CCDS58153.1 [Q9H078-3]
CCDS58154.1 [Q9H078-2]
CCDS8215.1 [Q9H078-1]

NCBI Reference Sequences

More...RefSeqi		NP_001245321.1, NM_001258392.2 [Q9H078-2]
NP_001245322.1, NM_001258393.2 [Q9H078-3]
NP_001245323.1, NM_001258394.2 [Q9H078-4]
NP_110440.1, NM_030813.5 [Q9H078-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000294053; ENSP00000294053; ENSG00000162129
ENST00000340729; ENSP00000340385; ENSG00000162129 [Q9H078-3]
ENST00000437826; ENSP00000407296; ENSG00000162129 [Q9H078-4]
ENST00000538039; ENSP00000441518; ENSG00000162129 [Q9H078-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		81570

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:81570

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000538039.6; ENSP00000441518.1; NM_001258392.3; NP_001245321.1 [Q9H078-2]

UCSC genome browser

More...UCSCi		uc001osj.5, human [Q9H078-1]
uc010rqz.3, human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136909 mRNA Translation: CAB66843.1
AL834484 mRNA Translation: CAD39142.1
AK023214 mRNA Translation: BAB14467.1
AK302006 mRNA Translation: BAG63409.1
AK302069 mRNA Translation: BAG63459.1
AK302158 mRNA Translation: BAG63526.1
AP000593 Genomic DNA No translation available.
AP002892 Genomic DNA No translation available.
AP003785 Genomic DNA No translation available.
BC006404 mRNA Translation: AAH06404.1
CCDSiCCDS58152.1 [Q9H078-4]
CCDS58153.1 [Q9H078-3]
CCDS58154.1 [Q9H078-2]
CCDS8215.1 [Q9H078-1]
RefSeqiNP_001245321.1, NM_001258392.2 [Q9H078-2]
NP_001245322.1, NM_001258393.2 [Q9H078-3]
NP_001245323.1, NM_001258394.2 [Q9H078-4]
NP_110440.1, NM_030813.5 [Q9H078-1]

3D structure databases

SMRiQ9H078
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123531, 172 interactors
IntActiQ9H078, 74 interactors
MINTiQ9H078
STRINGi9606.ENSP00000294053

PTM databases

GlyGeniQ9H078, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9H078
MetOSiteiQ9H078
PhosphoSitePlusiQ9H078
SwissPalmiQ9H078

Genetic variation databases

BioMutaiCLPB
DMDMi25009267

Proteomic databases

EPDiQ9H078
jPOSTiQ9H078
MassIVEiQ9H078
MaxQBiQ9H078
PaxDbiQ9H078
PeptideAtlasiQ9H078
PRIDEiQ9H078
ProteomicsDBi18882
29984
5473
80212 [Q9H078-1]
80213 [Q9H078-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30838, 196 antibodies from 27 providers

The DNASU plasmid repository

More...DNASUi		81570

Genome annotation databases

EnsembliENST00000294053; ENSP00000294053; ENSG00000162129
ENST00000340729; ENSP00000340385; ENSG00000162129 [Q9H078-3]
ENST00000437826; ENSP00000407296; ENSG00000162129 [Q9H078-4]
ENST00000538039; ENSP00000441518; ENSG00000162129 [Q9H078-2]
GeneIDi81570
KEGGihsa:81570
MANE-SelectiENST00000538039.6; ENSP00000441518.1; NM_001258392.3; NP_001245321.1 [Q9H078-2]
UCSCiuc001osj.5, human [Q9H078-1]
uc010rqz.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		81570
DisGeNETi81570

GeneCards: human genes, protein and diseases

More...GeneCardsi		CLPB
GeneReviewsiCLPB
HGNCiHGNC:30664, CLPB
HPAiENSG00000162129, Tissue enriched (testis)
MalaCardsiCLPB
MIMi616254, gene
616271, phenotype
neXtProtiNX_Q9H078
OpenTargetsiENSG00000162129
Orphaneti445038, 3-methylglutaconic aciduria type 7
PharmGKBiPA142672092
VEuPathDBiHostDB:ENSG00000162129

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1051, Eukaryota
GeneTreeiENSGT00390000012961
HOGENOMiCLU_005070_9_3_1
InParanoidiQ9H078
OMAiCKNAIFI
PhylomeDBiQ9H078
TreeFamiTF328654

Enzyme and pathway databases

PathwayCommonsiQ9H078
SignaLinkiQ9H078

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		81570, 95 hits in 1045 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CLPB, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CLPB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		81570
PharosiQ9H078, Tbio

Protein Ontology

More...PROi		PR:Q9H078
RNActiQ9H078, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000162129, Expressed in right testis and 183 other tissues
ExpressionAtlasiQ9H078, baseline and differential
GenevisibleiQ9H078, HS

Family and domain databases

Gene3Di1.25.40.20, 2 hits
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR003959, ATPase_AAA_core
IPR019489, Clp_ATPase_C
IPR001270, ClpA/B
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF07724, AAA_2, 1 hit
PF12796, Ank_2, 1 hit
PF13857, Ank_5, 1 hit
PF10431, ClpB_D2-small, 1 hit
PRINTSiPR00300, CLPPROTEASEA
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SM00248, ANK, 3 hits
SM01086, ClpB_D2-small, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLPB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H078
Secondary accession number(s): B4DXJ7
, B4DXP7, B4DXW4, E7EWN6, F8W7P6, Q8ND11, Q9H8Y0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2001
Last modified: February 23, 2022
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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