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Protein

Polyadenylate-binding protein-interacting protein 1

Gene

PAIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.2 Publications

GO - Molecular functioni

  • RNA binding Source: ProtInc
  • translation activator activity Source: UniProtKB

GO - Biological processi

  • mRNA stabilization Source: UniProtKB
  • regulation of translational initiation Source: GO_Central
  • translational initiation Source: ProtInc

Keywordsi

Biological processTranslation regulation

Enzyme and pathway databases

ReactomeiR-HSA-429947 Deadenylation of mRNA

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein-interacting protein 1
Short name:
PABP-interacting protein 1
Short name:
PAIP-1
Short name:
Poly(A)-binding protein-interacting protein 1
Gene namesi
Name:PAIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000172239.13
HGNCiHGNC:16945 PAIP1
MIMi605184 gene
neXtProtiNX_Q9H074

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172239
PharmGKBiPA134941557

Polymorphism and mutation databases

BioMutaiPAIP1
DMDMi46397025

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000581771 – 479Polyadenylate-binding protein-interacting protein 1Add BLAST479
Isoform 3 (identifier: Q9H074-3)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Omega-N-methylarginineCombined sources1
Isoform 3 (identifier: Q9H074-3)
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiQ9H074
MaxQBiQ9H074
PaxDbiQ9H074
PeptideAtlasiQ9H074
PRIDEiQ9H074
ProteomicsDBi80210
80211 [Q9H074-2]

PTM databases

iPTMnetiQ9H074
PhosphoSitePlusiQ9H074
SwissPalmiQ9H074

Expressioni

Gene expression databases

BgeeiENSG00000172239 Expressed in 211 organ(s), highest expression level in oocyte
CleanExiHS_PAIP1
ExpressionAtlasiQ9H074 baseline and differential
GenevisibleiQ9H074 HS

Organism-specific databases

HPAiHPA073653
HPA076187

Interactioni

Subunit structurei

Interacts with the RRM1-RRM2 and C-terminus regions of PABPC1 in a 1:1 stoichiometry. Interacts with EIF4A.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PABPC1P1194013EBI-81519,EBI-81531

Protein-protein interaction databases

BioGridi115851, 47 interactors
ComplexPortaliCPX-1076 mCRD-poly(A)-bridging complex
CORUMiQ9H074
ELMiQ9H074
IntActiQ9H074, 18 interactors
MINTiQ9H074
STRINGi9606.ENSP00000302768

Structurei

Secondary structure

1479
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H074
SMRiQ9H074
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H074

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini159 – 376MIF4GAdd BLAST218

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni116 – 143PABPC1-interacting motif-2 (PAM2)Add BLAST28
Regioni440 – 479PABPC1-interacting motif-1 (PAM1)Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 36Gly-richAdd BLAST27
Compositional biasi45 – 98Pro-richAdd BLAST54

Domaini

Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation.

Phylogenomic databases

eggNOGiENOG410IPIA Eukaryota
ENOG41109D3 LUCA
GeneTreeiENSGT00630000089897
HOGENOMiHOG000285987
HOVERGENiHBG053492
InParanoidiQ9H074
KOiK14322
OMAiEPTFYTE
OrthoDBiEOG091G05G0
PhylomeDBiQ9H074
TreeFamiTF325625

Family and domain databases

Gene3Di1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR009818 Ataxin-2_C
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
PfamiView protein in Pfam
PF02854 MIF4G, 1 hit
PF07145 PAM2, 1 hit
SMARTiView protein in SMART
SM00543 MIF4G, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H074-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDGFDRAPG AGRGRSRGLG RGGGGPEGGG FPNGAGPAER ARHQPPQPKA
60 70 80 90 100
PGFLQPPPLR QPRTTPPPGA QCEVPASPQR PSRPGALPEQ TRPLRAPPSS
110 120 130 140 150
QDKIPQQNSE SAMAKPQVVV APVLMSKLSV NAPEFYPSGY SSSYTESYED
160 170 180 190 200
GCEDYPTLSE YVQDFLNHLT EQPGSFETEI EQFAETLNGC VTTDDALQEL
210 220 230 240 250
VELIYQQATS IPNFSYMGAR LCNYLSHHLT ISPQSGNFRQ LLLQRCRTEY
260 270 280 290 300
EVKDQAAKGD EVTRKRFHAF VLFLGELYLN LEIKGTNGQV TRADILQVGL
310 320 330 340 350
RELLNALFSN PMDDNLICAV KLLKLTGSVL EDAWKEKGKM DMEEIIQRIE
360 370 380 390 400
NVVLDANCSR DVKQMLLKLV ELRSSNWGRV HATSTYREAT PENDPNYFMN
410 420 430 440 450
EPTFYTSDGV PFTAADPDYQ EKYQELLERE DFFPDYEENG TDLSGAGDPY
460 470
LDDIDDEMDP EIEEAYEKFC LESERKRKQ
Length:479
Mass (Da):53,525
Last modified:March 1, 2001 - v1
Checksum:iA4820607190A3A43
GO
Isoform 2 (identifier: Q9H074-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-88: Missing.

Show »
Length:400
Mass (Da):45,631
Checksum:i9743587A6F54BA25
GO
Isoform 3 (identifier: Q9H074-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:367
Mass (Da):42,007
Checksum:iF03BA773A062FA9B
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJF2D6RJF2_HUMAN
Polyadenylate-binding protein-inter...
PAIP1
200Annotation score:
D6R9H8D6R9H8_HUMAN
Polyadenylate-binding protein-inter...
PAIP1
266Annotation score:
D6REB4D6REB4_HUMAN
Polyadenylate-binding protein-inter...
PAIP1
351Annotation score:
D6RJ02D6RJ02_HUMAN
Polyadenylate-binding protein-inter...
PAIP1
168Annotation score:
D6RD97D6RD97_HUMAN
Polyadenylate-binding protein-inter...
PAIP1
95Annotation score:
H0YA44H0YA44_HUMAN
Polyadenylate-binding protein-inter...
PAIP1
49Annotation score:
A0A1D5RMS4A0A1D5RMS4_HUMAN
Polyadenylate-binding protein-inter...
PAIP1
9Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239R → C in AAH15937 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0475031 – 112Missing in isoform 3. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_01000510 – 88Missing in isoform 2. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013758 mRNA Translation: AAC39697.2
AL136920 mRNA Translation: CAB66854.1
AC114956 Genomic DNA No translation available.
BC005295 mRNA Translation: AAH05295.1
BC015937 mRNA Translation: AAH15937.1
DB089732 mRNA No translation available.
CCDSiCCDS3947.1 [Q9H074-1]
CCDS3948.1 [Q9H074-3]
CCDS47204.1 [Q9H074-2]
RefSeqiNP_006442.2, NM_006451.4 [Q9H074-1]
NP_877590.1, NM_182789.3 [Q9H074-2]
NP_899152.1, NM_183323.2 [Q9H074-3]
XP_005248287.1, XM_005248230.3 [Q9H074-3]
XP_016864445.1, XM_017008956.1 [Q9H074-3]
UniGeneiHs.482038

Genome annotation databases

EnsembliENST00000306846; ENSP00000302768; ENSG00000172239 [Q9H074-1]
ENST00000338972; ENSP00000339622; ENSG00000172239 [Q9H074-3]
ENST00000436644; ENSP00000387729; ENSG00000172239 [Q9H074-2]
GeneIDi10605
KEGGihsa:10605
UCSCiuc003joa.4 human [Q9H074-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013758 mRNA Translation: AAC39697.2
AL136920 mRNA Translation: CAB66854.1
AC114956 Genomic DNA No translation available.
BC005295 mRNA Translation: AAH05295.1
BC015937 mRNA Translation: AAH15937.1
DB089732 mRNA No translation available.
CCDSiCCDS3947.1 [Q9H074-1]
CCDS3948.1 [Q9H074-3]
CCDS47204.1 [Q9H074-2]
RefSeqiNP_006442.2, NM_006451.4 [Q9H074-1]
NP_877590.1, NM_182789.3 [Q9H074-2]
NP_899152.1, NM_183323.2 [Q9H074-3]
XP_005248287.1, XM_005248230.3 [Q9H074-3]
XP_016864445.1, XM_017008956.1 [Q9H074-3]
UniGeneiHs.482038

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JH4NMR-B123-144[»]
3NTWX-ray2.60B/D123-144[»]
3RK6X-ray2.00A/B157-373[»]
ProteinModelPortaliQ9H074
SMRiQ9H074
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115851, 47 interactors
ComplexPortaliCPX-1076 mCRD-poly(A)-bridging complex
CORUMiQ9H074
ELMiQ9H074
IntActiQ9H074, 18 interactors
MINTiQ9H074
STRINGi9606.ENSP00000302768

PTM databases

iPTMnetiQ9H074
PhosphoSitePlusiQ9H074
SwissPalmiQ9H074

Polymorphism and mutation databases

BioMutaiPAIP1
DMDMi46397025

Proteomic databases

EPDiQ9H074
MaxQBiQ9H074
PaxDbiQ9H074
PeptideAtlasiQ9H074
PRIDEiQ9H074
ProteomicsDBi80210
80211 [Q9H074-2]

Protocols and materials databases

DNASUi10605
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306846; ENSP00000302768; ENSG00000172239 [Q9H074-1]
ENST00000338972; ENSP00000339622; ENSG00000172239 [Q9H074-3]
ENST00000436644; ENSP00000387729; ENSG00000172239 [Q9H074-2]
GeneIDi10605
KEGGihsa:10605
UCSCiuc003joa.4 human [Q9H074-1]

Organism-specific databases

CTDi10605
EuPathDBiHostDB:ENSG00000172239.13
GeneCardsiPAIP1
HGNCiHGNC:16945 PAIP1
HPAiHPA073653
HPA076187
MIMi605184 gene
neXtProtiNX_Q9H074
OpenTargetsiENSG00000172239
PharmGKBiPA134941557
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPIA Eukaryota
ENOG41109D3 LUCA
GeneTreeiENSGT00630000089897
HOGENOMiHOG000285987
HOVERGENiHBG053492
InParanoidiQ9H074
KOiK14322
OMAiEPTFYTE
OrthoDBiEOG091G05G0
PhylomeDBiQ9H074
TreeFamiTF325625

Enzyme and pathway databases

ReactomeiR-HSA-429947 Deadenylation of mRNA

Miscellaneous databases

ChiTaRSiPAIP1 human
EvolutionaryTraceiQ9H074
GeneWikiiPAIP1
GenomeRNAii10605
PROiPR:Q9H074
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172239 Expressed in 211 organ(s), highest expression level in oocyte
CleanExiHS_PAIP1
ExpressionAtlasiQ9H074 baseline and differential
GenevisibleiQ9H074 HS

Family and domain databases

Gene3Di1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR009818 Ataxin-2_C
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
PfamiView protein in Pfam
PF02854 MIF4G, 1 hit
PF07145 PAM2, 1 hit
SMARTiView protein in SMART
SM00543 MIF4G, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAIP1_HUMAN
AccessioniPrimary (citable) accession number: Q9H074
Secondary accession number(s): A6NKV8
, O60455, Q96B61, Q9BS63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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