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Protein

SprT-like domain-containing protein Spartan

Gene

SPRTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri453 – 476UBZ-typeAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-110320 Translesion Synthesis by POLH

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SprT-like domain-containing protein Spartan
Alternative name(s):
DNA damage protein targeting VCP
Short name:
DVC1
Protein with SprT-like domain at the N terminus
Short name:
Spartan
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPRTN
Synonyms:C1orf124, DVC1
ORF Names:UNQ1880/PRO4323
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000010072.15

Human Gene Nomenclature Database

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HGNCi
HGNC:25356 SPRTN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616086 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H040

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ruijs-Aalfs syndrome (RJALS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by genomic instability, progeroid features, and susceptibility toward early onset hepatocellular carcinoma.
See also OMIM:616200
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_072708117Y → C in RJALS; cells ectopically expressing the mutant are completely unable to restore DNA replication fork progression. 1 PublicationCorresponds to variant dbSNP:rs527236213EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi253F → A: Abolishes binding to VCP/p97; when associated with A-260. 1 Publication1
Mutagenesisi260L → A: Abolishes binding to VCP/p97; when associated with A-253. 1 Publication1
Mutagenesisi325 – 332QNVLSNYF → ANVASNAA: Abolishes binding to PCNA. 1 Publication8
Mutagenesisi331 – 332YF → AA: Abolishes binding to PCNA. 2 Publications2
Mutagenesisi456 – 459CPVC → APVA: Abolishes binding to ubiquitin. 3 Publications4
Mutagenesisi473D → A: Abolishes binding to ubiquitin. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
83932

MalaCards human disease database

More...
MalaCardsi
SPRTN
MIMi616200 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000010072

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
435953 Progeroid features-hepatocellular carcinoma predisposition syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA142672442

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPRTN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
162416221

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003127481 – 489SprT-like domain-containing protein SpartanAdd BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei268PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki303Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki341Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki361Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki376Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki423Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki424Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki484Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9H040

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9H040

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H040

PeptideAtlas

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PeptideAtlasi
Q9H040

PRoteomics IDEntifications database

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PRIDEi
Q9H040

ProteomicsDB human proteome resource

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ProteomicsDBi
80202
80203 [Q9H040-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9H040

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9H040

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Predominantly expressed during S- and G2-phases and early M-phase. It then drops, and is probably degraded by the APC/C complex.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000010072 Expressed in 177 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

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CleanExi
HS_C1orf124

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H040 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H040 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA025073

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PCNA (when ubiquitinated). Interacts with RAD18. Interacts (via its SHP-box) with VCP/p97. Interacts with KCTD13 and POLD3.6 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123817, 97 interactors

Protein interaction database and analysis system

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IntActi
Q9H040, 4 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000295050

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1489
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9H040

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H040

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 212SprT-likeAdd BLAST168

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi253 – 261SHP-box9
Motifi325 – 332PIP-box8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi444 – 451Poly-Ser8

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PIP-box mediates the interaction with PCNA, while the UBZ-type zinc finger mediates binding to 'Lys-48'- and 'Lys-63'-linked polyubiquitin (PubMed:22894931, PubMed:22681887, PubMed:23042607, PubMed:23042605 and PubMed:22987070).3 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Spartan family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri453 – 476UBZ-typeAdd BLAST24

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3931 Eukaryota
ENOG410XPXU LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000003585

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000031496

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG101206

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H040

Identification of Orthologs from Complete Genome Data

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OMAi
NEHLDWC

Database of Orthologous Groups

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OrthoDBi
EOG091G02ZI

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H040

TreeFam database of animal gene trees

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TreeFami
TF314762

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006640 SprT-like_domain
IPR006642 Znf_Rad18_put

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10263 SprT-like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00731 SprT, 1 hit
SM00734 ZnF_Rad18, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H040-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDDLMLALR LQEEWNLQEA ERDHAQESLS LVDASWELVD PTPDLQALFV
60 70 80 90 100
QFNDQFFWGQ LEAVEVKWSV RMTLCAGICS YEGKGGMCSI RLSEPLLKLR
110 120 130 140 150
PRKDLVETLL HEMIHAYLFV TNNDKDREGH GPEFCKHMHR INSLTGANIT
160 170 180 190 200
VYHTFHDEVD EYRRHWWRCN GPCQHRPPYY GYVKRATNRE PSAHDYWWAE
210 220 230 240 250
HQKTCGGTYI KIKEPENYSK KGKGKAKLGK EPVLAAENKD KPNRGEAQLV
260 270 280 290 300
IPFSGKGYVL GETSNLPSPG KLITSHAINK TQDLLNQNHS ANAVRPNSKI
310 320 330 340 350
KVKFEQNGSS KNSHLVSPAV SNSHQNVLSN YFPRVSFANQ KAFRGVNGSP
360 370 380 390 400
RISVTVGNIP KNSVSSSSQR RVSSSKISLR NSSKVTESAS VMPSQDVSGS
410 420 430 440 450
EDTFPNKRPR LEDKTVFDNF FIKKEQIKSS GNDPKYSTTT AQNSSSSSSQ
460 470 480
SKMVNCPVCQ NEVLESQINE HLDWCLEGDS IKVKSEESL
Length:489
Mass (Da):55,134
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CF437C057B2BA2B
GO
Isoform 2 (identifier: Q9H040-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     240-250: DKPNRGEAQLV → GTFVYILLIFM
     251-489: Missing.

Note: No experimental confirmation available.
Show »
Length:250
Mass (Da):29,191
Checksum:iF06A426627CF2473
GO
Isoform 3 (identifier: Q9H040-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-150: Missing.
     240-250: DKPNRGEAQLV → GTFVYILLIFM
     251-489: Missing.

Note: No experimental confirmation available.
Show »
Length:207
Mass (Da):24,247
Checksum:i18733A05FD49D4B1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AKT1B1AKT1_HUMAN
SprT-like domain-containing protein...
SPRTN
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB55037 differs from that shown. Reason: Frameshift at position 224.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_072708117Y → C in RJALS; cells ectopically expressing the mutant are completely unable to restore DNA replication fork progression. 1 PublicationCorresponds to variant dbSNP:rs527236213EnsemblClinVar.1
Natural variantiVAR_037556296P → L3 PublicationsCorresponds to variant dbSNP:rs2437150Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_046925108 – 150Missing in isoform 3. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_029891240 – 250DKPNRGEAQLV → GTFVYILLIFM in isoform 2 and isoform 3. 3 PublicationsAdd BLAST11
Alternative sequenceiVSP_029892251 – 489Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST239

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358611 mRNA Translation: AAQ88974.1
AK027613 mRNA Translation: BAB55232.1
AK027317 mRNA Translation: BAB55037.1 Frameshift.
AL512744 mRNA Translation: CAC21670.1
AL117352 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69956.1
BC015740 mRNA Translation: AAH15740.1
BC068478 mRNA Translation: AAH68478.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1594.1 [Q9H040-1]
CCDS31054.1 [Q9H040-2]
CCDS58066.1 [Q9H040-3]

NCBI Reference Sequences

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RefSeqi
NP_001010984.1, NM_001010984.3 [Q9H040-2]
NP_001248391.1, NM_001261462.2 [Q9H040-3]
NP_114407.3, NM_032018.6 [Q9H040-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.554892

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000008440; ENSP00000008440; ENSG00000010072 [Q9H040-3]
ENST00000295050; ENSP00000295050; ENSG00000010072 [Q9H040-1]
ENST00000391858; ENSP00000375731; ENSG00000010072 [Q9H040-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
83932

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:83932

UCSC genome browser

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UCSCi
uc001hur.5 human [Q9H040-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358611 mRNA Translation: AAQ88974.1
AK027613 mRNA Translation: BAB55232.1
AK027317 mRNA Translation: BAB55037.1 Frameshift.
AL512744 mRNA Translation: CAC21670.1
AL117352 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69956.1
BC015740 mRNA Translation: AAH15740.1
BC068478 mRNA Translation: AAH68478.1
CCDSiCCDS1594.1 [Q9H040-1]
CCDS31054.1 [Q9H040-2]
CCDS58066.1 [Q9H040-3]
RefSeqiNP_001010984.1, NM_001010984.3 [Q9H040-2]
NP_001248391.1, NM_001261462.2 [Q9H040-3]
NP_114407.3, NM_032018.6 [Q9H040-1]
UniGeneiHs.554892

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IY4X-ray2.94B/D/F321-336[»]
ProteinModelPortaliQ9H040
SMRiQ9H040
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123817, 97 interactors
IntActiQ9H040, 4 interactors
STRINGi9606.ENSP00000295050

PTM databases

iPTMnetiQ9H040
PhosphoSitePlusiQ9H040

Polymorphism and mutation databases

BioMutaiSPRTN
DMDMi162416221

Proteomic databases

EPDiQ9H040
MaxQBiQ9H040
PaxDbiQ9H040
PeptideAtlasiQ9H040
PRIDEiQ9H040
ProteomicsDBi80202
80203 [Q9H040-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
83932
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000008440; ENSP00000008440; ENSG00000010072 [Q9H040-3]
ENST00000295050; ENSP00000295050; ENSG00000010072 [Q9H040-1]
ENST00000391858; ENSP00000375731; ENSG00000010072 [Q9H040-2]
GeneIDi83932
KEGGihsa:83932
UCSCiuc001hur.5 human [Q9H040-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
83932
DisGeNETi83932
EuPathDBiHostDB:ENSG00000010072.15

GeneCards: human genes, protein and diseases

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GeneCardsi
SPRTN

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0001695
HGNCiHGNC:25356 SPRTN
HPAiHPA025073
MalaCardsiSPRTN
MIMi616086 gene
616200 phenotype
neXtProtiNX_Q9H040
OpenTargetsiENSG00000010072
Orphaneti435953 Progeroid features-hepatocellular carcinoma predisposition syndrome
PharmGKBiPA142672442

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3931 Eukaryota
ENOG410XPXU LUCA
GeneTreeiENSGT00390000003585
HOGENOMiHOG000031496
HOVERGENiHBG101206
InParanoidiQ9H040
OMAiNEHLDWC
OrthoDBiEOG091G02ZI
PhylomeDBiQ9H040
TreeFamiTF314762

Enzyme and pathway databases

ReactomeiR-HSA-110320 Translesion Synthesis by POLH

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
C1orf124

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
83932

Protein Ontology

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PROi
PR:Q9H040

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000010072 Expressed in 177 organ(s), highest expression level in testis
CleanExiHS_C1orf124
ExpressionAtlasiQ9H040 baseline and differential
GenevisibleiQ9H040 HS

Family and domain databases

InterProiView protein in InterPro
IPR006640 SprT-like_domain
IPR006642 Znf_Rad18_put
PfamiView protein in Pfam
PF10263 SprT-like, 1 hit
SMARTiView protein in SMART
SM00731 SprT, 1 hit
SM00734 ZnF_Rad18, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPRTN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H040
Secondary accession number(s): B1AKT0
, B5MEF7, Q5TE78, Q6UWW6, Q96BC5, Q96KA0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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