UniProtKB - Q9H013 (ADA19_HUMAN)
Disintegrin and metalloproteinase domain-containing protein 19
ADAM19
Functioni
Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).
By similarityCofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 132 | Zinc; in inhibited formBy similarity | 1 | |
Metal bindingi | 345 | Zinc; catalyticBy similarity | 1 | |
Active sitei | 346 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 349 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 355 | Zinc; catalyticBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- metalloendopeptidase activity Source: UniProtKB
- metalloendopeptidase activity involved in amyloid precursor protein catabolic process Source: ARUK-UCL
- SH3 domain binding Source: UniProtKB-KW
GO - Biological processi
- amyloid precursor protein catabolic process Source: ARUK-UCL
- membrane protein ectodomain proteolysis Source: GO_Central
- placenta development Source: UniProtKB
- positive regulation of cell-cell adhesion mediated by cadherin Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- protein processing Source: ARUK-UCL
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9H013 |
Reactomei | R-HSA-8941237, Invadopodia formation |
SABIO-RKi | Q9H013 |
SignaLinki | Q9H013 |
SIGNORi | Q9H013 |
Protein family/group databases
MEROPSi | M12.214 |
Names & Taxonomyi
Protein namesi | Recommended name: Disintegrin and metalloproteinase domain-containing protein 19 (EC:3.4.24.-)Short name: ADAM 19 Alternative name(s): Meltrin-beta Metalloprotease and disintegrin dendritic antigen marker Short name: MADDAM |
Gene namesi | Name:ADAM19 Synonyms:MLTNB ORF Names:FKSG34 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:197, ADAM19 |
MIMi | 603640, gene |
neXtProti | NX_Q9H013 |
VEuPathDBi | HostDB:ENSG00000135074 |
Subcellular locationi
Other locations
Golgi apparatus
- Golgi apparatus Source: InterPro
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 203 – 699 | ExtracellularSequence analysisAdd BLAST | 497 | |
Transmembranei | 700 – 720 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 721 – 955 | CytoplasmicSequence analysisAdd BLAST | 235 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 8728 |
OpenTargetsi | ENSG00000135074 |
PharmGKBi | PA24514 |
Miscellaneous databases
Pharosi | Q9H013, Tbio |
Genetic variation databases
BioMutai | ADAM19 |
DMDMi | 302393821 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
PropeptideiPRO_0000029102 | 26 – 202 | By similarityAdd BLAST | 177 | |
ChainiPRO_0000029103 | 203 – 955 | Disintegrin and metalloproteinase domain-containing protein 19Add BLAST | 753 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 144 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 320 ↔ 403 | By similarity | ||
Disulfide bondi | 360 ↔ 387 | By similarity | ||
Disulfide bondi | 361 ↔ 370 | By similarity | ||
Glycosylationi | 444 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 447 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 474 ↔ 494 | By similarity | ||
Glycosylationi | 645 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 654 ↔ 664 | By similarity | ||
Disulfide bondi | 658 ↔ 670 | By similarity | ||
Disulfide bondi | 672 ↔ 681 | By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenProteomic databases
jPOSTi | Q9H013 |
MassIVEi | Q9H013 |
MaxQBi | Q9H013 |
PaxDbi | Q9H013 |
PeptideAtlasi | Q9H013 |
PRIDEi | Q9H013 |
ProteomicsDBi | 80195 [Q9H013-1] 80196 [Q9H013-2] |
PTM databases
GlyGeni | Q9H013, 4 sites |
iPTMneti | Q9H013 |
PhosphoSitePlusi | Q9H013 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000135074, Expressed in blood and 221 other tissues |
ExpressionAtlasi | Q9H013, baseline and differential |
Genevisiblei | Q9H013, HS |
Organism-specific databases
HPAi | ENSG00000135074, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with SH3PXD2A.
1 PublicationBinary interactionsi
Q9H013
With | #Exp. | IntAct |
---|---|---|
EPS8L1 [Q8TE68] | 2 | EBI-8567699,EBI-7487998 |
TSPOAP1 [O95153] | 2 | EBI-8567699,EBI-5915931 |
GO - Molecular functioni
- SH3 domain binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 114267, 30 interactors |
IntActi | Q9H013, 17 interactors |
MINTi | Q9H013 |
STRINGi | 9606.ENSP00000257527 |
Miscellaneous databases
RNActi | Q9H013, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 210 – 408 | Peptidase M12BPROSITE-ProRule annotationAdd BLAST | 199 | |
Domaini | 416 – 502 | DisintegrinPROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 650 – 682 | EGF-likePROSITE-ProRule annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 753 – 917 | DisorderedSequence analysisAdd BLAST | 165 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 130 – 137 | Cysteine switchBy similarity | 8 | |
Motifi | 833 – 844 | SH3-bindingSequence analysisAdd BLAST | 12 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 753 – 775 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 784 – 802 | Pro residuesSequence analysisAdd BLAST | 19 |
Domaini
Keywords - Domaini
EGF-like domain, SH3-binding, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3607, Eukaryota |
GeneTreei | ENSGT00940000159624 |
HOGENOMi | CLU_012714_7_0_1 |
InParanoidi | Q9H013 |
OMAi | GKYRSCK |
OrthoDBi | 162519at2759 |
PhylomeDBi | Q9H013 |
TreeFami | TF314733 |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR033596, ADAM19 IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
PANTHERi | PTHR11905:SF19, PTHR11905:SF19, 1 hit |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS00142, ZINC_PROTEASE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPGGAGAARL CLLAFALQPL RPRAAREPGW TRGSEEGSPK LQHELIIPQW
60 70 80 90 100
KTSESPVREK HPLKAELRVM AEGRELILDL EKNEQLFAPS YTETHYTSSG
110 120 130 140 150
NPQTTTRKLE DHCFYHGTVR ETELSSVTLS TCRGIRGLIT VSSNLSYVIE
160 170 180 190 200
PLPDSKGQHL IYRSEHLKPP PGNCGFEHSK PTTRDWALQF TQQTKKRPRR
210 220 230 240 250
MKREDLNSMK YVELYLVADY LEFQKNRRDQ DATKHKLIEI ANYVDKFYRS
260 270 280 290 300
LNIRIALVGL EVWTHGNMCE VSENPYSTLW SFLSWRRKLL AQKYHDNAQL
310 320 330 340 350
ITGMSFHGTT IGLAPLMAMC SVYQSGGVNM DHSENAIGVA ATMAHEMGHN
360 370 380 390 400
FGMTHDSADC CSASAADGGC IMAAATGHPF PKVFNGCNRR ELDRYLQSGG
410 420 430 440 450
GMCLSNMPDT RMLYGGRRCG NGYLEDGEEC DCGEEEECNN PCCNASNCTL
460 470 480 490 500
RPGAECAHGS CCHQCKLLAP GTLCREQARQ CDLPEFCTGK SPHCPTNFYQ
510 520 530 540 550
MDGTPCEGGQ AYCYNGMCLT YQEQCQQLWG PGARPAPDLC FEKVNVAGDT
560 570 580 590 600
FGNCGKDMNG EHRKCNMRDA KCGKIQCQSS EARPLESNAV PIDTTIIMNG
610 620 630 640 650
RQIQCRGTHV YRGPEEEGDM LDPGLVMTGT KCGYNHICFE GQCRNTSFFE
660 670 680 690 700
TEGCGKKCNG HGVCNNNQNC HCLPGWAPPF CNTPGHGGSI DSGPMPPESV
710 720 730 740 750
GPVVAGVLVA ILVLAVLMLM YYCCRQNNKL GQLKPSALPS KLRQQFSCPF
760 770 780 790 800
RVSQNSGTGH ANPTFKLQTP QGKRKVINTP EILRKPSQPP PRPPPDYLRG
810 820 830 840 850
GSPPAPLPAH LSRAARNSPG PGSQIERTES SRRPPPSRPI PPAPNCIVSQ
860 870 880 890 900
DFSRPRPPQK ALPANPVPGR RSLPRPGGAS PLRPPGAGPQ QSRPLAALAP
910 920 930 940 950
KVSPREALKV KAGTRGLQGG RCRVEKTKQF MLLVVWTELP EQKPRAKHSC
FLVPA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YC66 | H0YC66_HUMAN | Disintegrin and metalloproteinase d... | ADAM19 | 489 | Annotation score: | ||
E5RIS2 | E5RIS2_HUMAN | Disintegrin and metalloproteinase d... | ADAM19 | 272 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 32 | R → SK in AAG50282 (Ref. 1) Curated | 1 | |
Sequence conflicti | 557 | D → V in AAG50282 (Ref. 1) Curated | 1 | |
Sequence conflicti | 557 | D → V in AAF22162 (Ref. 5) Curated | 1 | |
Sequence conflicti | 622 | D → N in AAG50282 (Ref. 1) Curated | 1 | |
Sequence conflicti | 622 | D → N in AAF22162 (Ref. 5) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057066 | 4 | G → S1 PublicationCorresponds to variant dbSNP:rs11465228Ensembl. | 1 | |
Natural variantiVAR_036146 | 133 | R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs200894535Ensembl. | 1 | |
Natural variantiVAR_036147 | 298 | A → T in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1178207005Ensembl. | 1 | |
Natural variantiVAR_062670 | 609 | H → Q in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005481 | 902 – 955 | VSPRE…FLVPA → FPEYRSQRAGGMISSKI in isoform B. 2 PublicationsAdd BLAST | 54 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF326918 mRNA Translation: AAG50282.1 Y13786 mRNA Translation: CAC20585.1 AF311317 mRNA Translation: AAK07852.1 AC008676 Genomic DNA No translation available. AC008694 Genomic DNA No translation available. AC106801 Genomic DNA No translation available. AF134707 mRNA Translation: AAF22162.1 |
CCDSi | CCDS4338.1 [Q9H013-2] |
RefSeqi | NP_150377.1, NM_033274.4 [Q9H013-2] XP_005266060.1, XM_005266003.2 |
Genome annotation databases
Ensembli | ENST00000257527; ENSP00000257527; ENSG00000135074 [Q9H013-2] ENST00000517905; ENSP00000428654; ENSG00000135074 |
GeneIDi | 8728 |
KEGGi | hsa:8728 |
MANE-Selecti | ENST00000257527.9; ENSP00000257527.5; NM_033274.5; NP_150377.1 [Q9H013-2] |
UCSCi | uc003lwz.5, human [Q9H013-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF326918 mRNA Translation: AAG50282.1 Y13786 mRNA Translation: CAC20585.1 AF311317 mRNA Translation: AAK07852.1 AC008676 Genomic DNA No translation available. AC008694 Genomic DNA No translation available. AC106801 Genomic DNA No translation available. AF134707 mRNA Translation: AAF22162.1 |
CCDSi | CCDS4338.1 [Q9H013-2] |
RefSeqi | NP_150377.1, NM_033274.4 [Q9H013-2] XP_005266060.1, XM_005266003.2 |
3D structure databases
SMRi | Q9H013 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114267, 30 interactors |
IntActi | Q9H013, 17 interactors |
MINTi | Q9H013 |
STRINGi | 9606.ENSP00000257527 |
Protein family/group databases
MEROPSi | M12.214 |
PTM databases
GlyGeni | Q9H013, 4 sites |
iPTMneti | Q9H013 |
PhosphoSitePlusi | Q9H013 |
Genetic variation databases
BioMutai | ADAM19 |
DMDMi | 302393821 |
Proteomic databases
jPOSTi | Q9H013 |
MassIVEi | Q9H013 |
MaxQBi | Q9H013 |
PaxDbi | Q9H013 |
PeptideAtlasi | Q9H013 |
PRIDEi | Q9H013 |
ProteomicsDBi | 80195 [Q9H013-1] 80196 [Q9H013-2] |
Protocols and materials databases
Antibodypediai | 16547, 255 antibodies from 36 providers |
DNASUi | 8728 |
Genome annotation databases
Ensembli | ENST00000257527; ENSP00000257527; ENSG00000135074 [Q9H013-2] ENST00000517905; ENSP00000428654; ENSG00000135074 |
GeneIDi | 8728 |
KEGGi | hsa:8728 |
MANE-Selecti | ENST00000257527.9; ENSP00000257527.5; NM_033274.5; NP_150377.1 [Q9H013-2] |
UCSCi | uc003lwz.5, human [Q9H013-1] |
Organism-specific databases
CTDi | 8728 |
DisGeNETi | 8728 |
GeneCardsi | ADAM19 |
HGNCi | HGNC:197, ADAM19 |
HPAi | ENSG00000135074, Low tissue specificity |
MIMi | 603640, gene |
neXtProti | NX_Q9H013 |
OpenTargetsi | ENSG00000135074 |
PharmGKBi | PA24514 |
VEuPathDBi | HostDB:ENSG00000135074 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3607, Eukaryota |
GeneTreei | ENSGT00940000159624 |
HOGENOMi | CLU_012714_7_0_1 |
InParanoidi | Q9H013 |
OMAi | GKYRSCK |
OrthoDBi | 162519at2759 |
PhylomeDBi | Q9H013 |
TreeFami | TF314733 |
Enzyme and pathway databases
PathwayCommonsi | Q9H013 |
Reactomei | R-HSA-8941237, Invadopodia formation |
SABIO-RKi | Q9H013 |
SignaLinki | Q9H013 |
SIGNORi | Q9H013 |
Miscellaneous databases
BioGRID-ORCSi | 8728, 3 hits in 1034 CRISPR screens |
ChiTaRSi | ADAM19, human |
GeneWikii | ADAM19 |
GenomeRNAii | 8728 |
Pharosi | Q9H013, Tbio |
PROi | PR:Q9H013 |
RNActi | Q9H013, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135074, Expressed in blood and 221 other tissues |
ExpressionAtlasi | Q9H013, baseline and differential |
Genevisiblei | Q9H013, HS |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR033596, ADAM19 IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
PANTHERi | PTHR11905:SF19, PTHR11905:SF19, 1 hit |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS00142, ZINC_PROTEASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ADA19_HUMAN | |
Accessioni | Q9H013Primary (citable) accession number: Q9H013 Secondary accession number(s): Q9BZL5, Q9UHP2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 31, 2002 |
Last sequence update: | August 10, 2010 | |
Last modified: | February 23, 2022 | |
This is version 192 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot