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Protein

Nascent polypeptide-associated complex subunit alpha-2

Gene

NACA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).By similarity

Miscellaneous

NACAL arose from a recent (40-63 million-year-old), anthropoid primate-specific retroduplication of NACA.

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nascent polypeptide-associated complex subunit alpha-2
Alternative name(s):
Alpha-NAC-like
Hom s 2.01
Nascent polypeptide-associated complex subunit alpha-like
Short name:
NAC-alpha-like
Gene namesi
Name:NACA2
Synonyms:NACAL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000253506.2
HGNCiHGNC:23290 NACA2
MIMi609274 gene
neXtProtiNX_Q9H009

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000253506
PharmGKBiPA162396699

Protein family/group databases

Allergomei412 Hom s 2

Polymorphism and mutation databases

BioMutaiNACA2
DMDMi74733511

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002807461 – 215Nascent polypeptide-associated complex subunit alpha-2Add BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineBy similarity1
Modified residuei132PhosphoserineBy similarity1
Modified residuei142N6-acetyllysine; alternateBy similarity1
Cross-linki142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei161PhosphothreonineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei186PhosphoserineBy similarity1
Modified residuei191PhosphoserineBy similarity1
Modified residuei203PhosphoserineBy similarity1
Modified residuei214PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9H009
MaxQBiQ9H009
PaxDbiQ9H009
PeptideAtlasiQ9H009
PRIDEiQ9H009
ProteomicsDBi80194

PTM databases

iPTMnetiQ9H009
PhosphoSitePlusiQ9H009

Expressioni

Tissue specificityi

Expressed specifically in testis and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000253506
CleanExiHS_NACA2
GenevisibleiQ9H009 HS

Organism-specific databases

HPAiHPA073152
HPA073648

Interactioni

Subunit structurei

Part of the nascent polypeptide-associated complex (NAC), consisting of NACA and BTF3. NAC associates with ribosomes through the BTF3 subunit. Both subunits can contact nascent polypeptide chains (By similarity).By similarity

Protein-protein interaction databases

BioGridi131183, 21 interactors
STRINGi9606.ENSP00000427802

Structurei

3D structure databases

ProteinModelPortaliQ9H009
SMRiQ9H009
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 135NAC-A/BPROSITE-ProRule annotationAdd BLAST66
Domaini176 – 213UBAAdd BLAST38

Sequence similaritiesi

Belongs to the NAC-alpha family.Curated

Phylogenomic databases

eggNOGiKOG2239 Eukaryota
COG1308 LUCA
GeneTreeiENSGT00440000033468
HOGENOMiHOG000239674
HOVERGENiHBG082004
InParanoidiQ9H009
OMAiSDAYIVF
OrthoDBiEOG091G0292
PhylomeDBiQ9H009
TreeFamiTF313348

Family and domain databases

Gene3Di2.20.70.30, 1 hit
InterProiView protein in InterPro
IPR016641 EGD2/NACA
IPR038187 NAC_A/B_dom_sf
IPR002715 Nas_poly-pep-assoc_cplx_dom
PANTHERiPTHR21713 PTHR21713, 1 hit
PfamiView protein in Pfam
PF01849 NAC, 1 hit
PIRSFiPIRSF015901 NAC_alpha, 1 hit
SMARTiView protein in SMART
SM01407 NAC, 1 hit
PROSITEiView protein in PROSITE
PS51151 NAC_AB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGEATETVP ATEQELPQSQ AETGSGTASD SGESVPGIEE QDSTQTTTQK
60 70 80 90 100
AWLVAAAEID EEPVGKAKQS RSEKRARKAM SKLGLLQVTG VTRVTIWKSK
110 120 130 140 150
NILFVITKLD VYKSPASDAY IVFGEAKIQD LSQQAQLAAA EKFRVQGEAV
160 170 180 190 200
GNIQENTQTP TVQEESEEEE VDETGVEVKD VKLVMSQANV SRAKAVRALK
210
NNSNDIVNAI MELTV
Length:215
Mass (Da):23,223
Last modified:March 1, 2001 - v1
Checksum:iC6B96A8370E9B24E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05021864V → I. Corresponds to variant dbSNP:rs17531723Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278883 Genomic DNA Translation: CAC06614.1
BC062710 mRNA Translation: AAH62710.1
DQ120612 Genomic DNA Translation: ABB92399.1
CCDSiCCDS11630.1
RefSeqiNP_954984.1, NM_199290.3
UniGeneiHs.591178

Genome annotation databases

EnsembliENST00000521764; ENSP00000427802; ENSG00000253506
GeneIDi342538
KEGGihsa:342538
UCSCiuc002izj.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNACA2_HUMAN
AccessioniPrimary (citable) accession number: Q9H009
Secondary accession number(s): Q2VIR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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