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Protein

Extracellular glycoprotein lacritin

Gene

LACRT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates secretion by lacrimal acinar cells.

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • fibronectin binding Source: UniProtKB
  • growth factor activity Source: UniProtKB
  • laminin-1 binding Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB

GO - Biological processi

  • calcineurin-NFAT signaling cascade Source: UniProtKB
  • calcium-mediated signaling Source: UniProtKB
  • defense response to bacterium Source: FlyBase
  • epithelial structure maintenance Source: FlyBase
  • negative regulation of apoptotic process Source: FlyBase
  • negative regulation of lipopolysaccharide-mediated signaling pathway Source: FlyBase
  • positive regulation of calcineurin-NFAT signaling cascade Source: UniProtKB
  • positive regulation of calcium-mediated signaling Source: FlyBase
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of epithelial cell proliferation Source: UniProtKB
  • positive regulation of epithelial cell proliferation involved in wound healing Source: FlyBase
  • positive regulation of macroautophagy Source: FlyBase
  • positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  • positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  • positive regulation of secretion Source: UniProtKB
  • protein acetylation Source: FlyBase
  • protein localization to Golgi apparatus Source: UniProtKB
  • tear secretion Source: FlyBase

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular glycoprotein lacritin
Gene namesi
Name:LACRT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000135413.8
HGNCiHGNC:16430 LACRT
MIMi607360 gene
neXtProtiNX_Q9GZZ8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi90070
OpenTargetsiENSG00000135413
PharmGKBiPA30261

Polymorphism and mutation databases

BioMutaiLACRT
DMDMi33301325

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000002157420 – 138Extracellular glycoprotein lacritinAdd BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi119N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9GZZ8
PaxDbiQ9GZZ8
PeptideAtlasiQ9GZZ8
PRIDEiQ9GZZ8
ProteomicsDBi80188

PTM databases

iPTMnetiQ9GZZ8
PhosphoSitePlusiQ9GZZ8

Expressioni

Tissue specificityi

Expressed in secretory granules of many acinar cells in lacrimal gland and in scattered acinar cells of salivary glands.

Gene expression databases

BgeeiENSG00000135413
CleanExiHS_LACRT
ExpressionAtlasiQ9GZZ8 baseline and differential
GenevisibleiQ9GZZ8 HS

Interactioni

GO - Molecular functioni

  • fibronectin binding Source: UniProtKB
  • growth factor activity Source: UniProtKB
  • laminin-1 binding Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124659, 47 interactors
IntActiQ9GZZ8, 4 interactors
STRINGi9606.ENSP00000257867

Structurei

3D structure databases

ProteinModelPortaliQ9GZZ8
SMRiQ9GZZ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KH2Q Eukaryota
ENOG4110RQ2 LUCA
GeneTreeiENSGT00390000008599
HOGENOMiHOG000113273
HOVERGENiHBG052295
InParanoidiQ9GZZ8
OMAiGGKQFIE
OrthoDBiEOG091G13ZK
PhylomeDBiQ9GZZ8
TreeFamiTF340896

Family and domain databases

InterProiView protein in InterPro
IPR033530 Lacritin
PANTHERiPTHR40711:SF2 PTHR40711:SF2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GZZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFTTLLFLA AVAGALVYAE DASSDSTGAD PAQEAGTSKP NEEISGPAEP
60 70 80 90 100
ASPPETTTTA QETSAAAVQG TAKVTSSRQE LNPLKSIVEK SILLTEQALA
110 120 130
KAGKGMHGGV PGGKQFIENG SEFAQKLLKK FSLLKPWA
Length:138
Mass (Da):14,246
Last modified:March 1, 2001 - v1
Checksum:i09910581E650F6FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY005150 Genomic DNA Translation: AAG32949.1
AF238867 mRNA Translation: AAG44392.1
BC062217 mRNA Translation: AAH62217.1
BC069317 mRNA Translation: AAH69317.1
CCDSiCCDS8883.1
RefSeqiNP_150593.1, NM_033277.1
UniGeneiHs.307096

Genome annotation databases

EnsembliENST00000257867; ENSP00000257867; ENSG00000135413
GeneIDi90070
KEGGihsa:90070
UCSCiuc001sgi.2 human

Similar proteinsi

Entry informationi

Entry nameiLACRT_HUMAN
AccessioniPrimary (citable) accession number: Q9GZZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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