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UniProtKB - Q9GZY8 (MFF_HUMAN)

Entry version 127 (16 Oct 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Mitochondrial fission factor

Gene

MFF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9GZY8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial fission factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MFF
Synonyms:C2orf33
ORF Names:AD030, AD033, GL004
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24858 MFF

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614785 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9GZY8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 322CytoplasmicSequence analysisAdd BLAST322
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei323 – 340Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST18
Topological domaini341 – 342Mitochondrial intermembraneSequence analysis2

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Mitochondrion, Mitochondrion outer membrane, Peroxisome, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Encephalopathy due to defective mitochondrial and peroxisomal fission 2 (EMPF2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by delayed psychomotor development, severe hypotonia with inability to walk, microcephaly, and abnormal signals in the basal ganglia. More variable features include early-onset seizures, optic atrophy, and peripheral neuropathy.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		56947

MalaCards human disease database

More...MalaCardsi		MFF
MIMi617086 phenotype

Open Targets

More...OpenTargetsi		ENSG00000168958

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		485421 MFF-related encephalopathy due to mitochondrial and peroxisomal fission defect

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162395839

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9GZY8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MFF

Domain mapping of disease mutations (DMDM)

More...DMDMi		74725008

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002891841 – 342Mitochondrial fission factorAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei115PhosphothreonineCombined sources1
Modified residuei155PhosphoserineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei172PhosphoserineBy similarity1
Modified residuei200PhosphothreonineCombined sources1
Modified residuei202PhosphoserineCombined sources1
Modified residuei229PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei295PhosphoserineBy similarity1
Isoform 2 (identifier: Q9GZY8-2)
Modified residuei146PhosphoserineCombined sources1
Modified residuei149PhosphothreonineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Isoform 5 (identifier: Q9GZY8-5)
Modified residuei146PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9GZY8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9GZY8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9GZY8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9GZY8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9GZY8

PeptideAtlas

More...PeptideAtlasi		Q9GZY8

PRoteomics IDEntifications database

More...PRIDEi		Q9GZY8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80176 [Q9GZY8-1]
80177 [Q9GZY8-2]
80178 [Q9GZY8-3]
80179 [Q9GZY8-4]
80180 [Q9GZY8-5]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q9GZY8-2 [Q9GZY8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9GZY8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9GZY8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart, kidney, liver, brain, muscle, and stomach.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168958 Expressed in 229 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9GZY8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9GZY8 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA010968
HPA074625

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with DNM1L (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		121271, 21 interactors

Protein interaction database and analysis system

More...IntActi		Q9GZY8, 108 interactors

Molecular INTeraction database

More...MINTi		Q9GZY8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000302037

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9GZY8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili291 – 322Sequence analysisAdd BLAST32

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Tango11 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410III7 Eukaryota
ENOG410XSQR LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000009776

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000285976

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9GZY8

KEGG Orthology (KO)

More...KOi		K22076

Identification of Orthologs from Complete Genome Data

More...OMAi		TDSMWHR

Database of Orthologous Groups

More...OrthoDBi		1383657at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9GZY8

TreeFam database of animal gene trees

More...TreeFami		TF325506

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039433 Mff-like_dom
IPR008518 Mff/Tango-11

The PANTHER Classification System

More...PANTHERi		PTHR16501 PTHR16501, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05644 Miff, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9GZY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKGTSSDTS LGRVSRAAFP SPTAAEMAEI SRIQYEMEYT EGISQRMRVP 
        60         70         80         90        100
EKLKVAPPNA DLEQGFQEGV PNASVIMQVP ERIVVAGNNE DVSFSRPADL 
       110        120        130        140        150
DLIQSTPFKP LALKTPPRVL TLSERPLDFL DLERPPTTPQ NEEIRAVGRL 
       160        170        180        190        200
KRERSMSENA VRQNGQLVRN DSLWHRSDSA PRNKISRFQA PISAPEYTVT 
       210        220        230        240        250
PSPQQARVCP PHMLPEDGAN LSSARGILSL IQSSTRRAYQ QILDVLDENR 
       260        270        280        290        300
RPVLRGGSAA ATSNPHHDNV RYGISNIDTT IEGTSDDLTV VDAASLRRQI 
       310        320        330        340 
IKLNRRLQLL EEENKERAKR EMVMYSITVA FWLLNSWLWF RR
Length:342
Mass (Da):38,465
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1DBFBBE17DB122A0
GO
Isoform 2 (identifier: Q9GZY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.
     174-198: Missing.

Show »
Length:291
Mass (Da):32,973
Checksum:i1CEA83C57D1E6FE6
GO
Isoform 3 (identifier: Q9GZY8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.
     199-271: Missing.

Show »
Length:243
Mass (Da):27,964
Checksum:i2D2B8A36FEA1C038
GO
Isoform 4 (identifier: Q9GZY8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.
     174-271: Missing.

Show »
Length:218
Mass (Da):25,067
Checksum:i07B22DF970A4995F
GO
Isoform 5 (identifier: Q9GZY8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.
     174-251: Missing.

Show »
Length:238
Mass (Da):27,105
Checksum:i3F647B952DAE2A05
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MS29A0A0A0MS29_HUMAN
Mitochondrial fission factor
MFF
221Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JHF5C9JHF5_HUMAN
Mitochondrial fission factor
MFF
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPW6E9PPW6_HUMAN
Mitochondrial fission factor
MFF
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C433H7C433_HUMAN
Mitochondrial fission factor
MFF
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JAF1C9JAF1_HUMAN
Mitochondrial fission factor
MFF
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK16E9PK16_HUMAN
Mitochondrial fission factor
MFF
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKS0E9PKS0_HUMAN
Mitochondrial fission factor
MFF
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQX8E9PQX8_HUMAN
Mitochondrial fission factor
MFF
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J846C9J846_HUMAN
Mitochondrial fission factor
MFF
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JI76C9JI76_HUMAN
Mitochondrial fission factor
MFF
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti212H → Y in CAH56328 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0539157S → C. Corresponds to variant dbSNP:rs3211097EnsemblClinVar.1
Natural variantiVAR_0539167S → I. Corresponds to variant dbSNP:rs3211098EnsemblClinVar.1
Natural variantiVAR_03602829E → K in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0259541 – 26Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST26
Alternative sequenceiVSP_025955174 – 271Missing in isoform 4. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_025956174 – 251Missing in isoform 5. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_025957174 – 198Missing in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_025958199 – 271Missing in isoform 3. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK026137 mRNA Translation: BAB15373.1
AF246239 mRNA Translation: AAG44486.1
AF226049 mRNA Translation: AAF86949.1
AF258660 mRNA Translation: AAG44658.1
AC097662 Genomic DNA Translation: AAY24252.1
BC000797 mRNA Translation: AAH00797.1
BC093024 mRNA Translation: AAH93024.1
AL833032 mRNA Translation: CAH56328.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2465.1 [Q9GZY8-1]
CCDS63139.1 [Q9GZY8-3]
CCDS63140.1 [Q9GZY8-2]
CCDS63141.1 [Q9GZY8-5]
CCDS63142.1 [Q9GZY8-4]

NCBI Reference Sequences

More...RefSeqi		NP_001263990.1, NM_001277061.1 [Q9GZY8-1]
NP_001263991.1, NM_001277062.1 [Q9GZY8-2]
NP_001263992.1, NM_001277063.1 [Q9GZY8-3]
NP_001263993.1, NM_001277064.1 [Q9GZY8-5]
NP_001263994.1, NM_001277065.1 [Q9GZY8-4]
NP_001263995.1, NM_001277066.1 [Q9GZY8-4]
NP_001263996.1, NM_001277067.1
NP_001263997.1, NM_001277068.1
NP_064579.3, NM_020194.5 [Q9GZY8-1]
XP_006712701.1, XM_006712638.1 [Q9GZY8-2]
XP_006712702.1, XM_006712639.2 [Q9GZY8-5]
XP_011509802.1, XM_011511500.1 [Q9GZY8-1]
XP_016860004.1, XM_017004515.1 [Q9GZY8-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000304593; ENSP00000304898; ENSG00000168958 [Q9GZY8-2]
ENST00000337110; ENSP00000338412; ENSG00000168958 [Q9GZY8-3]
ENST00000349901; ENSP00000304134; ENSG00000168958 [Q9GZY8-5]
ENST00000353339; ENSP00000302037; ENSG00000168958 [Q9GZY8-1]
ENST00000354503; ENSP00000346498; ENSG00000168958 [Q9GZY8-4]
ENST00000409565; ENSP00000386964; ENSG00000168958 [Q9GZY8-4]
ENST00000409616; ENSP00000386641; ENSG00000168958 [Q9GZY8-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56947

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56947

UCSC genome browser

More...UCSCi		uc002vos.5 human [Q9GZY8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026137 mRNA Translation: BAB15373.1
AF246239 mRNA Translation: AAG44486.1
AF226049 mRNA Translation: AAF86949.1
AF258660 mRNA Translation: AAG44658.1
AC097662 Genomic DNA Translation: AAY24252.1
BC000797 mRNA Translation: AAH00797.1
BC093024 mRNA Translation: AAH93024.1
AL833032 mRNA Translation: CAH56328.1
CCDSiCCDS2465.1 [Q9GZY8-1]
CCDS63139.1 [Q9GZY8-3]
CCDS63140.1 [Q9GZY8-2]
CCDS63141.1 [Q9GZY8-5]
CCDS63142.1 [Q9GZY8-4]
RefSeqiNP_001263990.1, NM_001277061.1 [Q9GZY8-1]
NP_001263991.1, NM_001277062.1 [Q9GZY8-2]
NP_001263992.1, NM_001277063.1 [Q9GZY8-3]
NP_001263993.1, NM_001277064.1 [Q9GZY8-5]
NP_001263994.1, NM_001277065.1 [Q9GZY8-4]
NP_001263995.1, NM_001277066.1 [Q9GZY8-4]
NP_001263996.1, NM_001277067.1
NP_001263997.1, NM_001277068.1
NP_064579.3, NM_020194.5 [Q9GZY8-1]
XP_006712701.1, XM_006712638.1 [Q9GZY8-2]
XP_006712702.1, XM_006712639.2 [Q9GZY8-5]
XP_011509802.1, XM_011511500.1 [Q9GZY8-1]
XP_016860004.1, XM_017004515.1 [Q9GZY8-3]

3D structure databases

SMRiQ9GZY8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121271, 21 interactors
IntActiQ9GZY8, 108 interactors
MINTiQ9GZY8
STRINGi9606.ENSP00000302037

PTM databases

iPTMnetiQ9GZY8
PhosphoSitePlusiQ9GZY8

Polymorphism and mutation databases

BioMutaiMFF
DMDMi74725008

Proteomic databases

EPDiQ9GZY8
jPOSTiQ9GZY8
MassIVEiQ9GZY8
MaxQBiQ9GZY8
PaxDbiQ9GZY8
PeptideAtlasiQ9GZY8
PRIDEiQ9GZY8
ProteomicsDBi80176 [Q9GZY8-1]
80177 [Q9GZY8-2]
80178 [Q9GZY8-3]
80179 [Q9GZY8-4]
80180 [Q9GZY8-5]
TopDownProteomicsiQ9GZY8-2 [Q9GZY8-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		56947

Genome annotation databases

EnsembliENST00000304593; ENSP00000304898; ENSG00000168958 [Q9GZY8-2]
ENST00000337110; ENSP00000338412; ENSG00000168958 [Q9GZY8-3]
ENST00000349901; ENSP00000304134; ENSG00000168958 [Q9GZY8-5]
ENST00000353339; ENSP00000302037; ENSG00000168958 [Q9GZY8-1]
ENST00000354503; ENSP00000346498; ENSG00000168958 [Q9GZY8-4]
ENST00000409565; ENSP00000386964; ENSG00000168958 [Q9GZY8-4]
ENST00000409616; ENSP00000386641; ENSG00000168958 [Q9GZY8-5]
GeneIDi56947
KEGGihsa:56947
UCSCiuc002vos.5 human [Q9GZY8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56947
DisGeNETi56947

GeneCards: human genes, protein and diseases

More...GeneCardsi		MFF
HGNCiHGNC:24858 MFF
HPAiHPA010968
HPA074625
MalaCardsiMFF
MIMi614785 gene
617086 phenotype
neXtProtiNX_Q9GZY8
OpenTargetsiENSG00000168958
Orphaneti485421 MFF-related encephalopathy due to mitochondrial and peroxisomal fission defect
PharmGKBiPA162395839

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410III7 Eukaryota
ENOG410XSQR LUCA
GeneTreeiENSGT00390000009776
HOGENOMiHOG000285976
InParanoidiQ9GZY8
KOiK22076
OMAiTDSMWHR
OrthoDBi1383657at2759
PhylomeDBiQ9GZY8
TreeFamiTF325506

Enzyme and pathway databases

SIGNORiQ9GZY8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MFF human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Mitochondrial_fission_factor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56947
PharosiQ9GZY8

Protein Ontology

More...PROi		PR:Q9GZY8

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168958 Expressed in 229 organ(s), highest expression level in sperm
ExpressionAtlasiQ9GZY8 baseline and differential
GenevisibleiQ9GZY8 HS

Family and domain databases

InterProiView protein in InterPro
IPR039433 Mff-like_dom
IPR008518 Mff/Tango-11
PANTHERiPTHR16501 PTHR16501, 1 hit
PfamiView protein in Pfam
PF05644 Miff, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMFF_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZY8
Secondary accession number(s): Q567U1
, Q658R6, Q9BVZ1, Q9H690, Q9NRG8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2001
Last modified: October 16, 2019
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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