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Entry version 148 (18 Sep 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Linker for activation of T-cells family member 2

Gene

LAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • SH2 domain binding Source: HGNC

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Immunity, Mast cell degranulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9GZY6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Linker for activation of T-cells family member 2
Alternative name(s):
Linker for activation of B-cells
Membrane-associated adapter molecule
Non-T-cell activation linker
Williams-Beuren syndrome chromosomal region 15 protein
Williams-Beuren syndrome chromosomal region 5 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAT2
Synonyms:LAB, NTAL, WBS15, WBSCR15, WBSCR5
ORF Names:HSPC046
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12749 LAT2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605719 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9GZY6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 5ExtracellularSequence analysis5
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini27 – 243CytoplasmicSequence analysisAdd BLAST217

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi58Y → F: No change in phosphorylation upon BCR activation. 1 Publication1
Mutagenesisi84Y → F: No change in phosphorylation upon BCR activation. 1 Publication1
Mutagenesisi95Y → F: Slightly reduces phosphorylation upon BCR activation. 1 Publication1
Mutagenesisi110Y → F: No change in phosphorylation upon BCR activation. 1 Publication1
Mutagenesisi118Y → F: No change in phosphorylation upon BCR activation. 1 Publication1
Mutagenesisi136Y → F: Slightly reduces phosphorylation upon BCR activation. 1 Publication1
Mutagenesisi193Y → F: Reduces phosphorylation upon BCR activation. 1 Publication1
Mutagenesisi233Y → F: Strongly reduces phosphorylation upon BCR activation. 1 Publication1

Keywords - Diseasei

Williams-Beuren syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
7462

Open Targets

More...
OpenTargetsi
ENSG00000086730

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37356

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LAT2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000833341 – 243Linker for activation of T-cells family member 2Add BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi25S-palmitoyl cysteine1 Publication1
Lipidationi28S-palmitoyl cysteine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei44PhosphoserineCombined sources1
Modified residuei58PhosphotyrosineBy similarity1
Modified residuei59PhosphoserineBy similarity1
Modified residuei92PhosphoserineBy similarity1
Modified residuei136Phosphotyrosine2 Publications1
Modified residuei193Phosphotyrosine2 Publications1
Modified residuei233Phosphotyrosine2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.3 Publications
May be polyubiquitinated.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-972

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9GZY6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9GZY6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9GZY6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9GZY6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9GZY6

PeptideAtlas

More...
PeptideAtlasi
Q9GZY6

PRoteomics IDEntifications database

More...
PRIDEi
Q9GZY6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80174 [Q9GZY6-1]
80175 [Q9GZY6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9GZY6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9GZY6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9GZY6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000086730 Expressed in 190 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9GZY6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9GZY6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003462

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL.

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113301, 5 interactors

Protein interaction database and analysis system

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IntActi
Q9GZY6, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000420494

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9GZY6

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9GZY6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IZVX Eukaryota
ENOG4111816 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006821

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9GZY6

Identification of Orthologs from Complete Genome Data

More...
OMAi
EDQQSFT

Database of Orthologous Groups

More...
OrthoDBi
1271896at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9GZY6

TreeFam database of animal gene trees

More...
TreeFami
TF336203

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031428 LAT2

The PANTHER Classification System

More...
PANTHERi
PTHR15646 PTHR15646, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15703 LAT2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9GZY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSGTELLWP GAALLVLLGV AASLCVRCSR PGAKRSEKIY QQRSLREDQQ
60 70 80 90 100
SFTGSRTYSL VGQAWPGPLA DMAPTRKDKL LQFYPSLEDP ASSRYQNFSK
110 120 130 140 150
GSRHGSEEAY IDPIAMEYYN WGRFSKPPED DDANSYENVL ICKQKTTETG
160 170 180 190 200
AQQEGIGGLC RGDLSLSLAL KTGPTSGLCP SASPEEDEES EDYQNSASIH
210 220 230 240
QWRESRKVMG QLQREASPGP VGSPDEEDGE PDYVNGEVAA TEA
Length:243
Mass (Da):26,550
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i222D2CCF3C71C503
GO
Isoform 2 (identifier: Q9GZY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-243: Missing.

Note: No experimental confirmation available.
Show »
Length:111
Mass (Da):12,255
Checksum:i09540AE67B44F485
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JXP0C9JXP0_HUMAN
Linker for activation of T-cells fa...
LAT2
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDY7C9JDY7_HUMAN
Linker for activation of T-cells fa...
LAT2
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JA24C9JA24_HUMAN
Linker for activation of T-cells fa...
LAT2
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W947F8W947_HUMAN
Linker for activation of T-cells fa...
LAT2
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF29018 differs from that shown. Reason: Frameshift at positions 82, 86, 130 and 221.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39I → M in BAF82763 (PubMed:14702039).Curated1
Sequence conflicti82Q → A in AAF29018 (PubMed:11042152).Curated1
Sequence conflicti101G → R in AAF29018 (PubMed:11042152).Curated1
Sequence conflicti221V → M in AAF29018 (PubMed:11042152).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016643112 – 243Missing in isoform 2. 1 PublicationAdd BLAST132

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF257135 mRNA Translation: AAF91352.1
AF045555 Genomic DNA Translation: AAF74978.1
AY190023 mRNA Translation: AAO63155.1
AF252611 mRNA Translation: AAK37429.1
AF252612 mRNA Translation: AAK37430.1
AF252613 mRNA Translation: AAK37633.1
AF252614 mRNA Translation: AAK37431.1
AF161531 mRNA Translation: AAF29018.1 Frameshift.
AK002099 mRNA Translation: BAA92084.1
AK092904 mRNA Translation: BAG52627.1
AK290074 mRNA Translation: BAF82763.1
AK290916 mRNA Translation: BAF83605.1
AC005081 Genomic DNA Translation: AAS07404.1
AC005081 Genomic DNA Translation: AAS07405.1
CH471200 Genomic DNA Translation: EAW69610.1
CH471200 Genomic DNA Translation: EAW69611.1
CH471200 Genomic DNA Translation: EAW69612.1
CH471200 Genomic DNA Translation: EAW69613.1
BC001609 mRNA Translation: AAH01609.1
BC009204 mRNA Translation: AAH09204.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5566.2 [Q9GZY6-1]

NCBI Reference Sequences

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RefSeqi
NP_054865.2, NM_014146.3 [Q9GZY6-1]
NP_115852.1, NM_032463.2 [Q9GZY6-1]
NP_115853.2, NM_032464.2 [Q9GZY6-1]
XP_011514860.1, XM_011516558.2 [Q9GZY6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000275635; ENSP00000275635; ENSG00000086730 [Q9GZY6-1]
ENST00000344995; ENSP00000344881; ENSG00000086730 [Q9GZY6-1]
ENST00000398475; ENSP00000381492; ENSG00000086730 [Q9GZY6-1]
ENST00000460943; ENSP00000420494; ENSG00000086730 [Q9GZY6-1]
ENST00000488266; ENSP00000433807; ENSG00000086730 [Q9GZY6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7462

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7462

UCSC genome browser

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UCSCi
uc003uag.4 human [Q9GZY6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257135 mRNA Translation: AAF91352.1
AF045555 Genomic DNA Translation: AAF74978.1
AY190023 mRNA Translation: AAO63155.1
AF252611 mRNA Translation: AAK37429.1
AF252612 mRNA Translation: AAK37430.1
AF252613 mRNA Translation: AAK37633.1
AF252614 mRNA Translation: AAK37431.1
AF161531 mRNA Translation: AAF29018.1 Frameshift.
AK002099 mRNA Translation: BAA92084.1
AK092904 mRNA Translation: BAG52627.1
AK290074 mRNA Translation: BAF82763.1
AK290916 mRNA Translation: BAF83605.1
AC005081 Genomic DNA Translation: AAS07404.1
AC005081 Genomic DNA Translation: AAS07405.1
CH471200 Genomic DNA Translation: EAW69610.1
CH471200 Genomic DNA Translation: EAW69611.1
CH471200 Genomic DNA Translation: EAW69612.1
CH471200 Genomic DNA Translation: EAW69613.1
BC001609 mRNA Translation: AAH01609.1
BC009204 mRNA Translation: AAH09204.1
CCDSiCCDS5566.2 [Q9GZY6-1]
RefSeqiNP_054865.2, NM_014146.3 [Q9GZY6-1]
NP_115852.1, NM_032463.2 [Q9GZY6-1]
NP_115853.2, NM_032464.2 [Q9GZY6-1]
XP_011514860.1, XM_011516558.2 [Q9GZY6-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MAZX-ray1.90B133-141[»]
SMRiQ9GZY6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi113301, 5 interactors
IntActiQ9GZY6, 1 interactor
STRINGi9606.ENSP00000420494

PTM databases

iPTMnetiQ9GZY6
PhosphoSitePlusiQ9GZY6
SwissPalmiQ9GZY6

Polymorphism and mutation databases

BioMutaiLAT2

Proteomic databases

CPTACiCPTAC-972
EPDiQ9GZY6
jPOSTiQ9GZY6
MassIVEiQ9GZY6
MaxQBiQ9GZY6
PaxDbiQ9GZY6
PeptideAtlasiQ9GZY6
PRIDEiQ9GZY6
ProteomicsDBi80174 [Q9GZY6-1]
80175 [Q9GZY6-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7462
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275635; ENSP00000275635; ENSG00000086730 [Q9GZY6-1]
ENST00000344995; ENSP00000344881; ENSG00000086730 [Q9GZY6-1]
ENST00000398475; ENSP00000381492; ENSG00000086730 [Q9GZY6-1]
ENST00000460943; ENSP00000420494; ENSG00000086730 [Q9GZY6-1]
ENST00000488266; ENSP00000433807; ENSG00000086730 [Q9GZY6-2]
GeneIDi7462
KEGGihsa:7462
UCSCiuc003uag.4 human [Q9GZY6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7462
DisGeNETi7462

GeneCards: human genes, protein and diseases

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GeneCardsi
LAT2
HGNCiHGNC:12749 LAT2
HPAiHPA003462
MIMi605719 gene
neXtProtiNX_Q9GZY6
OpenTargetsiENSG00000086730
PharmGKBiPA37356

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IZVX Eukaryota
ENOG4111816 LUCA
GeneTreeiENSGT00390000006821
InParanoidiQ9GZY6
OMAiEDQQSFT
OrthoDBi1271896at2759
PhylomeDBiQ9GZY6
TreeFamiTF336203

Enzyme and pathway databases

ReactomeiR-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
SignaLinkiQ9GZY6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LAT2 human
EvolutionaryTraceiQ9GZY6

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LAT2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7462

Pharos

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Pharosi
Q9GZY6

Protein Ontology

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PROi
PR:Q9GZY6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000086730 Expressed in 190 organ(s), highest expression level in blood
ExpressionAtlasiQ9GZY6 baseline and differential
GenevisibleiQ9GZY6 HS

Family and domain databases

InterProiView protein in InterPro
IPR031428 LAT2
PANTHERiPTHR15646 PTHR15646, 1 hit
PfamiView protein in Pfam
PF15703 LAT2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNTAL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZY6
Secondary accession number(s): A6NFK6
, A8K209, A8K4F1, D3DXF9, Q9BXX8, Q9NZY9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2001
Last modified: September 18, 2019
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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