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Protein

Cytochrome c oxidase assembly factor 1 homolog

Gene

COA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV.1 Publication

GO - Biological processi

  • mitochondrial respiratory chain complex I assembly Source: UniProtKB
  • mitochondrial respiratory chain complex IV assembly Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly factor 1 homolog
Alternative name(s):
Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa
Gene namesi
Name:COA1
Synonyms:C7orf44, MITRAC15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106603.17
HGNCiHGNC:21868 COA1
MIMi614769 gene
neXtProtiNX_Q9GZY4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14Mitochondrial matrixSequence analysisAdd BLAST14
Transmembranei15 – 37HelicalSequence analysisAdd BLAST23
Topological domaini38 – 146Mitochondrial intermembraneSequence analysisAdd BLAST109

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55744
OpenTargetsiENSG00000106603
PharmGKBiPA162380473

Polymorphism and mutation databases

BioMutaiCOA1
DMDMi74733508

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794071 – 146Cytochrome c oxidase assembly factor 1 homologAdd BLAST146

Proteomic databases

EPDiQ9GZY4
MaxQBiQ9GZY4
PaxDbiQ9GZY4
PeptideAtlasiQ9GZY4
PRIDEiQ9GZY4
ProteomicsDBi80173
TopDownProteomicsiQ9GZY4

PTM databases

iPTMnetiQ9GZY4
PhosphoSitePlusiQ9GZY4

Expressioni

Gene expression databases

BgeeiENSG00000106603 Expressed in 218 organ(s), highest expression level in secondary oocyte
CleanExiHS_C7orf44
ExpressionAtlasiQ9GZY4 baseline and differential
GenevisibleiQ9GZY4 HS

Organism-specific databases

HPAiHPA011944

Interactioni

Subunit structurei

Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, the core components of this complex being COA3/MITRAC12 and COX14. Interacts with COX17 and COA6.2 Publications

Protein-protein interaction databases

BioGridi120862, 17 interactors
CORUMiQ9GZY4
IntActiQ9GZY4, 6 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9GZY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COA1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0CE Eukaryota
ENOG410XVWT LUCA
GeneTreeiENSGT00440000033985
HOGENOMiHOG000039974
HOVERGENiHBG081128
InParanoidiQ9GZY4
KOiK18173
OMAiAPFQRWH
OrthoDBiEOG091G0UR8
PhylomeDBiQ9GZY4
TreeFamiTF324468

Family and domain databases

InterProiView protein in InterPro
IPR014807 Cyt_oxidase_assembly-1
PfamiView protein in Pfam
PF08695 Coa1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9GZY4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMWQKYAGSR RSMPLGARIL FHGVFYAGGF AIVYYLIQKF HSRALYYKLA
60 70 80 90 100
VEQLQSHPEA QEALGPPLNI HYLKLIDREN FVDIVDAKLK IPVSGSKSEG
110 120 130 140
LLYVHSSRGG PFQRWHLDEV FLELKDGQQI PVFKLSGENG DEVKKE
Length:146
Mass (Da):16,694
Last modified:March 1, 2001 - v1
Checksum:i24582046A282291C
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JA07C9JA07_HUMAN
Cytochrome c oxidase assembly facto...
COA1
113Annotation score:
C9J6J1C9J6J1_HUMAN
Cytochrome c oxidase assembly facto...
COA1
88Annotation score:
F2Z2J3F2Z2J3_HUMAN
Cytochrome c oxidase assembly facto...
COA1
63Annotation score:
F8WBS2F8WBS2_HUMAN
Cytochrome c oxidase assembly facto...
COA1
41Annotation score:
F2Z2D1F2Z2D1_HUMAN
Cytochrome c oxidase assembly facto...
COA1
34Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2M → T in BAB13932 (PubMed:14702039).Curated1
Sequence conflicti17A → V in BAA91821 (PubMed:14702039).Curated1
Sequence conflicti116H → R in BAB13932 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001665 mRNA Translation: BAA91821.1
AK021905 mRNA Translation: BAB13932.1
AK023007 mRNA Translation: BAB14356.1
AK023053 mRNA Translation: BAB14379.1
AK293043 mRNA Translation: BAF85732.1
AC005189 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW94165.1
BC056884 mRNA Translation: AAH56884.1
CCDSiCCDS5471.1
RefSeqiNP_001308126.1, NM_001321197.1
NP_001308127.1, NM_001321198.1
NP_001308128.1, NM_001321199.1
NP_001308129.1, NM_001321200.1
NP_060694.2, NM_018224.3
XP_005249864.1, XM_005249807.4
XP_006715815.1, XM_006715752.2
XP_016867903.1, XM_017012414.1
XP_016867904.1, XM_017012415.1
XP_016867905.1, XM_017012416.1
XP_016867906.1, XM_017012417.1
XP_016867907.1, XM_017012418.1
XP_016867908.1, XM_017012419.1
XP_016867910.1, XM_017012421.1
XP_016867911.1, XM_017012422.1
XP_016867912.1, XM_017012423.1
XP_016867913.1, XM_017012424.1
XP_016867914.1, XM_017012425.1
XP_016867915.1, XM_017012426.1
XP_016867916.1, XM_017012427.1
XP_016867917.1, XM_017012428.1
XP_016867918.1, XM_017012429.1
XP_016867919.1, XM_017012430.1
XP_016867920.1, XM_017012431.1
XP_016867921.1, XM_017012432.1
UniGeneiHs.268887
Hs.654779
Hs.655165

Genome annotation databases

EnsembliENST00000223336; ENSP00000223336; ENSG00000106603
ENST00000310564; ENSP00000312100; ENSG00000106603
ENST00000395879; ENSP00000379218; ENSG00000106603
ENST00000415076; ENSP00000400759; ENSG00000106603
ENST00000438444; ENSP00000395586; ENSG00000106603
ENST00000446330; ENSP00000416406; ENSG00000106603
ENST00000446564; ENSP00000413777; ENSG00000106603
GeneIDi55744
KEGGihsa:55744
UCSCiuc003tin.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001665 mRNA Translation: BAA91821.1
AK021905 mRNA Translation: BAB13932.1
AK023007 mRNA Translation: BAB14356.1
AK023053 mRNA Translation: BAB14379.1
AK293043 mRNA Translation: BAF85732.1
AC005189 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW94165.1
BC056884 mRNA Translation: AAH56884.1
CCDSiCCDS5471.1
RefSeqiNP_001308126.1, NM_001321197.1
NP_001308127.1, NM_001321198.1
NP_001308128.1, NM_001321199.1
NP_001308129.1, NM_001321200.1
NP_060694.2, NM_018224.3
XP_005249864.1, XM_005249807.4
XP_006715815.1, XM_006715752.2
XP_016867903.1, XM_017012414.1
XP_016867904.1, XM_017012415.1
XP_016867905.1, XM_017012416.1
XP_016867906.1, XM_017012417.1
XP_016867907.1, XM_017012418.1
XP_016867908.1, XM_017012419.1
XP_016867910.1, XM_017012421.1
XP_016867911.1, XM_017012422.1
XP_016867912.1, XM_017012423.1
XP_016867913.1, XM_017012424.1
XP_016867914.1, XM_017012425.1
XP_016867915.1, XM_017012426.1
XP_016867916.1, XM_017012427.1
XP_016867917.1, XM_017012428.1
XP_016867918.1, XM_017012429.1
XP_016867919.1, XM_017012430.1
XP_016867920.1, XM_017012431.1
XP_016867921.1, XM_017012432.1
UniGeneiHs.268887
Hs.654779
Hs.655165

3D structure databases

ProteinModelPortaliQ9GZY4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120862, 17 interactors
CORUMiQ9GZY4
IntActiQ9GZY4, 6 interactors

PTM databases

iPTMnetiQ9GZY4
PhosphoSitePlusiQ9GZY4

Polymorphism and mutation databases

BioMutaiCOA1
DMDMi74733508

Proteomic databases

EPDiQ9GZY4
MaxQBiQ9GZY4
PaxDbiQ9GZY4
PeptideAtlasiQ9GZY4
PRIDEiQ9GZY4
ProteomicsDBi80173
TopDownProteomicsiQ9GZY4

Protocols and materials databases

DNASUi55744
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223336; ENSP00000223336; ENSG00000106603
ENST00000310564; ENSP00000312100; ENSG00000106603
ENST00000395879; ENSP00000379218; ENSG00000106603
ENST00000415076; ENSP00000400759; ENSG00000106603
ENST00000438444; ENSP00000395586; ENSG00000106603
ENST00000446330; ENSP00000416406; ENSG00000106603
ENST00000446564; ENSP00000413777; ENSG00000106603
GeneIDi55744
KEGGihsa:55744
UCSCiuc003tin.2 human

Organism-specific databases

CTDi55744
DisGeNETi55744
EuPathDBiHostDB:ENSG00000106603.17
GeneCardsiCOA1
H-InvDBiHIX0006632
HIX0017741
HGNCiHGNC:21868 COA1
HPAiHPA011944
MIMi614769 gene
neXtProtiNX_Q9GZY4
OpenTargetsiENSG00000106603
PharmGKBiPA162380473
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0CE Eukaryota
ENOG410XVWT LUCA
GeneTreeiENSGT00440000033985
HOGENOMiHOG000039974
HOVERGENiHBG081128
InParanoidiQ9GZY4
KOiK18173
OMAiAPFQRWH
OrthoDBiEOG091G0UR8
PhylomeDBiQ9GZY4
TreeFamiTF324468

Miscellaneous databases

ChiTaRSiCOA1 human
GenomeRNAii55744
PROiPR:Q9GZY4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106603 Expressed in 218 organ(s), highest expression level in secondary oocyte
CleanExiHS_C7orf44
ExpressionAtlasiQ9GZY4 baseline and differential
GenevisibleiQ9GZY4 HS

Family and domain databases

InterProiView protein in InterPro
IPR014807 Cyt_oxidase_assembly-1
PfamiView protein in Pfam
PF08695 Coa1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOA1_HUMAN
AccessioniPrimary (citable) accession number: Q9GZY4
Secondary accession number(s): A6NJU8
, A8KAH8, Q9HAB7, Q9NVD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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