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Entry version 185 (10 Apr 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Nuclear RNA export factor 2

Gene

NXF2

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the export of mRNA from the nucleus to the cytoplasm.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear RNA export factor 2
Alternative name(s):
Cancer/testis antigen 39
Short name:
CT39
TAP-like protein 2
Short name:
TAPL-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NXF2
Synonyms:TAPL2
AND
Name:NXF2B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000269405.6
HostDB:ENSG00000269437.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8072 NXF2
HGNC:23984 NXF2B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300315 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9GZY0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi598E → A: Has no effect on FG-nucleoporin binding. 1 Publication1
Mutagenesisi599W → A: Suppresses FG-nucleoporin binding. 1 Publication1
Mutagenesisi600N → A: Has no effect on FG-nucleoporin binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
56001

Open Targets

More...
OpenTargetsi
ENSG00000269405
ENSG00000269437

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162398310

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NXF2B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20978536

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002205331 – 626Nuclear RNA export factor 2Add BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei34PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9GZY0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9GZY0

PeptideAtlas

More...
PeptideAtlasi
Q9GZY0

PRoteomics IDEntifications database

More...
PRIDEi
Q9GZY0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80171

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9GZY0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9GZY0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed almost exclusively in testis. Also expressed in several cancers.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000269405 Expressed in 26 organ(s), highest expression level in right testis

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9GZY0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA002079

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NXT1, NXT2, E1B-AP5, the REF proteins and with nucleoporins, Nup62, Nup153 and Nup214. Interacts with LUZP4.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121026, 65 interactors
608771, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9GZY0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000485586

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9GZY0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9GZY0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini124 – 203RRMAdd BLAST80
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati271 – 296LRR 1Add BLAST26
Repeati297 – 320LRR 2Add BLAST24
Repeati321 – 348LRR 3Add BLAST28
Repeati349 – 376LRR 4Add BLAST28
Domaini391 – 541NTF2PROSITE-ProRule annotationAdd BLAST151
Domaini570 – 625TAP-CPROSITE-ProRule annotationAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi528 – 531Poly-Ser4
Compositional biasi561 – 564Poly-Ser4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1 heterodimers is required for NXF2-mediated nuclear mRNA export.
The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus.
The C-terminal fragment, containing the TAP domain (also called UBA-like domain) and part of the NTF2-like domain, named the NPC-binding domain, mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF2 to the nuclear rim.
The RNA-binding domain is a non-canonical RNP-type domain.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NXF family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3763 Eukaryota
ENOG410XR55 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007539

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236269

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG013199

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9GZY0

KEGG Orthology (KO)

More...
KOi
K14284

Identification of Orthologs from Complete Genome Data

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OMAi
DMWFHTE

Database of Orthologous Groups

More...
OrthoDBi
1051093at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9GZY0

TreeFam database of animal gene trees

More...
TreeFami
TF314566

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00780 NTF2, 1 hit
cd14342 UBA_TAP-C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR030218 NXF5
IPR030217 NXF_fam
IPR035979 RBD_domain_sf
IPR005637 TAP_C_dom
IPR015245 Tap_RNA-bd
IPR009060 UBA-like_sf

The PANTHER Classification System

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PANTHERi
PTHR10662 PTHR10662, 1 hit
PTHR10662:SF15 PTHR10662:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02136 NTF2, 1 hit
PF09162 Tap-RNA_bind, 1 hit
PF03943 TAP_C, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD043466 Tap_RNA_bd, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00804 TAP_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934 SSF46934, 1 hit
SSF54427 SSF54427, 1 hit
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 3 hits
PS50177 NTF2_DOMAIN, 1 hit
PS51281 TAP_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9GZY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCSTLKKCGT YRTEVAECHD HGSTFQGRKK GGSSFRDNFD KRSCHYEHGG
60 70 80 90 100
YERPPSHCQE NDGSVEMRDV HKDQQLRHTP YSIRCERRMK WHSEDEIRIT
110 120 130 140 150
TWRNRKPPER KMSQNTQDGY TRNWFKVTIP YGIKYDKAWL MNSIQSHCSD
160 170 180 190 200
RFTPVDFHYV RNRACFFVQD ASAASALKDV SYKIYDDENQ KICIFVNHST
210 220 230 240 250
APYSVKNKLK PGQMEMLKLT MNKRYNVSQQ ALDLQNLRFD PDLMGRDIDI
260 270 280 290 300
ILNRRNCMAA TLKIIERNFP ELLSLNLCNN KLYQLDGLSD ITEKAPKVKT
310 320 330 340 350
LNLSKNKLES AWELGKVKGL KLEELWLEGN PLCSTFSDQS AYVSAIRDCF
360 370 380 390 400
PKLLRLDGRE LSAPVIVDID SSETMKPCKE NFTGSETLKH LVLQFLQQYY
410 420 430 440 450
SIYDSGDRQG LLGAYHDEAC FSLAIPFDPK DSAPSSLCKY FEDSRNMKTL
460 470 480 490 500
KDPYLKGELL RRTKRDIVDS LSALPKTQHD LSSILVDVWC QTERMLCFSV
510 520 530 540 550
NGVFKEVEGQ SQGSVLAFTR TFIATPGSSS SLCIVNDELF VRDASPQETQ
560 570 580 590 600
SAFSIPVSTL SSSSEPSLSQ EQQEMVQAFS AQSGMKLEWS QKCLQDNEWN
610 620
YTRAGQAFTM LQTEGKIPAE AFKQIS
Length:626
Mass (Da):71,627
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i319CFEDF3E67A163
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK31975 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91154 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB75659 differs from that shown. The sequence differs from that shown due to either intron retention or a splicing event.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ277526 mRNA Translation: CAC16588.1
AJ277659 mRNA Translation: CAC20433.1
AL157436 mRNA Translation: CAB75659.1 Sequence problems.
Z81367 Genomic DNA Translation: CAI42026.1
AL590069 Genomic DNA Translation: CAD13494.1
BC015020 mRNA Translation: AAH15020.1
AF285596 mRNA Translation: AAK31975.1 Different initiation.
AK000423 mRNA Translation: BAA91154.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14497.1
CCDS43979.1

NCBI Reference Sequences

More...
RefSeqi
NP_001093156.1, NM_001099686.2
NP_071336.1, NM_022053.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.530358
Hs.648337
Hs.689668
Hs.737538

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000602195; ENSP00000472530; ENSG00000269437
ENST00000604395; ENSP00000474659; ENSG00000269437
ENST00000604790; ENSP00000474598; ENSG00000269405
ENST00000625106; ENSP00000485586; ENSG00000269405

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56001
728343

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56001
hsa:728343

UCSC genome browser

More...
UCSCi
uc004eix.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277526 mRNA Translation: CAC16588.1
AJ277659 mRNA Translation: CAC20433.1
AL157436 mRNA Translation: CAB75659.1 Sequence problems.
Z81367 Genomic DNA Translation: CAI42026.1
AL590069 Genomic DNA Translation: CAD13494.1
BC015020 mRNA Translation: AAH15020.1
AF285596 mRNA Translation: AAK31975.1 Different initiation.
AK000423 mRNA Translation: BAA91154.1 Different initiation.
CCDSiCCDS14497.1
CCDS43979.1
RefSeqiNP_001093156.1, NM_001099686.2
NP_071336.1, NM_022053.3
UniGeneiHs.530358
Hs.648337
Hs.689668
Hs.737538

3D structure databases

ProteinModelPortaliQ9GZY0
SMRiQ9GZY0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121026, 65 interactors
608771, 3 interactors
IntActiQ9GZY0, 2 interactors
STRINGi9606.ENSP00000485586

PTM databases

iPTMnetiQ9GZY0
PhosphoSitePlusiQ9GZY0

Polymorphism and mutation databases

BioMutaiNXF2B
DMDMi20978536

Proteomic databases

EPDiQ9GZY0
PaxDbiQ9GZY0
PeptideAtlasiQ9GZY0
PRIDEiQ9GZY0
ProteomicsDBi80171

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
56001
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000602195; ENSP00000472530; ENSG00000269437
ENST00000604395; ENSP00000474659; ENSG00000269437
ENST00000604790; ENSP00000474598; ENSG00000269405
ENST00000625106; ENSP00000485586; ENSG00000269405
GeneIDi56001
728343
KEGGihsa:56001
hsa:728343
UCSCiuc004eix.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56001
728343
DisGeNETi56001
EuPathDBiHostDB:ENSG00000269405.6
HostDB:ENSG00000269437.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ENSG00000284800
NXF2
NXF2B
HGNCiHGNC:8072 NXF2
HGNC:23984 NXF2B
HPAiHPA002079
MIMi300315 gene
neXtProtiNX_Q9GZY0
OpenTargetsiENSG00000269405
ENSG00000269437
PharmGKBiPA162398310

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3763 Eukaryota
ENOG410XR55 LUCA
GeneTreeiENSGT00390000007539
HOGENOMiHOG000236269
HOVERGENiHBG013199
InParanoidiQ9GZY0
KOiK14284
OMAiDMWFHTE
OrthoDBi1051093at2759
PhylomeDBiQ9GZY0
TreeFamiTF314566

Enzyme and pathway databases

ReactomeiR-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NXF2B human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NXF2

Protein Ontology

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PROi
PR:Q9GZY0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000269405 Expressed in 26 organ(s), highest expression level in right testis
GenevisibleiQ9GZY0 HS

Family and domain databases

CDDicd00780 NTF2, 1 hit
cd14342 UBA_TAP-C, 1 hit
Gene3Di3.30.70.330, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR030218 NXF5
IPR030217 NXF_fam
IPR035979 RBD_domain_sf
IPR005637 TAP_C_dom
IPR015245 Tap_RNA-bd
IPR009060 UBA-like_sf
PANTHERiPTHR10662 PTHR10662, 1 hit
PTHR10662:SF15 PTHR10662:SF15, 1 hit
PfamiView protein in Pfam
PF02136 NTF2, 1 hit
PF09162 Tap-RNA_bind, 1 hit
PF03943 TAP_C, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD043466 Tap_RNA_bd, 1 hit
SMARTiView protein in SMART
SM00804 TAP_C, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF54427 SSF54427, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 3 hits
PS50177 NTF2_DOMAIN, 1 hit
PS51281 TAP_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNXF2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZY0
Secondary accession number(s): Q9BXU4, Q9NSS1, Q9NX66
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: March 1, 2001
Last modified: April 10, 2019
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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