AICDA

Functionⁱ

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).5 Publications

Catalytic activityⁱ

Cytosine in single-stranded DNA + H₂O = uracil in single-stranded DNA + NH₃.1 Publication

Cofactorⁱ

Zn²⁺1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	56	Zinc; catalytic1 Publication	1
Active siteⁱ	58	Proton donorBy similarity	1
Metal bindingⁱ	87	Zinc; catalytic1 Publication	1
Metal bindingⁱ	90	Zinc; catalytic1 Publication	1

GO - Molecular functionⁱ

cytidine deaminase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18722174
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 19412186
RNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 23277564
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

B cell differentiation
Source: UniProtKB
Non-traceable author statementⁱ
- 11007475
cellular response to lipopolysaccharide Source: Ensembl
cytidine to uridine editing
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
defense response to bacterium Source: Ensembl
defense response to virus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA cytosine deamination
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA demethylation
Source: UniProtKB
Inferred from direct assayⁱ
- 21496894
isotype switching Source: Ensembl
mRNA processing Source: UniProtKB-KW
negative regulation of methylation-dependent chromatin silencing
Source: UniProtKB
Inferred from direct assayⁱ
- 21496894
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of transposition
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of nuclear cell cycle DNA replication
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19734146
somatic diversification of immunoglobulins
Source: UniProtKB
Inferred from direct assayⁱ
- 18722174
somatic hypermutation of immunoglobulin genes
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21518874

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	mRNA processing
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

BRENDAⁱ	3.5.4.38 2681
SIGNORⁱ	Q9GZX7

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Single-stranded DNA cytosine deaminase (EC:3.5.4.381 Publication) Alternative name(s): Activation-induced cytidine deaminase Short name: AID Cytidine aminohydrolase
Gene namesⁱ	Name:AICDA Synonyms:AID
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000111732.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13203 AICDA
MIMⁱ	605257 gene
neXtProtⁱ	NX_Q9GZX7

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Immunodeficiency with hyper-IgM 2 (HIGM2)5 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	10	K → A: Little effect on nuclear import; when associated with A-193. No effect on CTNNBL1 binding. 1 Publication	1
Mutagenesisⁱ	18	V → S: Greatly impaired nuclear import; when associated with V-19 and A-193. Reduced interaction with both CTNNBL1 and KPNA1, and abolishes immunoglobulin class switching; when associated with V-19. 1 Publication	1
Mutagenesisⁱ	19	R → V: Greatly impaired nuclear import; when associated with S-18 and A-193. Reduced interaction with both CTNNBL1 and KPNA1, and abolishes immunoglobulin class switching; when associated with S-18. 1 Publication	1
Mutagenesisⁱ	20	W → K: Impaired nuclear import; when associated with A-193. No effect on CTNNBL1 binding. 1 Publication	1
Mutagenesisⁱ	27	T → A: Loss of phosphorylation. No effect on cytidine deaminase activity. Impaired class-switch recombination activity. 2 Publications	1
Mutagenesisⁱ	27	T → E: Phosphomimetic mutant which shows loss of cytidine deaminase activity and impaired class-switch recombination activity. 2 Publications	1
Mutagenesisⁱ	38	S → A: Loss of phosphorylation. Impaired class-switch recombination activity. No effect on interaction with CTNNBL1. 2 Publications	1
Mutagenesisⁱ	38	S → D: No effect on interaction with CTNNBL1. 2 Publications	1
Mutagenesisⁱ	39 – 42	ATSF → GGQV: Greatly reduced interaction with CTNNBL1 but no effect on subcellular location, enzyme activity, ability to oligomerize nor on phosphorylation at Ser-38. Diminished antibody diversification. 1 Publication	4
Mutagenesisⁱ	50	R → G: Some reduced nuclear import; when associated with A-193. 1 Publication	1
Mutagenesisⁱ	112	R → D: Greatly reduced nuclear import; when associated with A-193. 1 Publication	1
Mutagenesisⁱ	193	F → A: Completely abolishes nuclear import; when associated with W-24 or D-112. Little affect on nuclear import; when associated with A-10. Greatly impaired nuclear import; when associated with K-20 or G-50. Almost completely abolishes nuclear import; when associated with S-18 and V-19. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57379
MalaCards human disease database More...MalaCardsⁱ	AICDA
MIMⁱ	605258 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000111732
Orphanetⁱ	101089 Hyper-IgM syndrome type 2
PharmGKBⁱ	PA24644

Polymorphism and mutation databases

BioMutaⁱ	AICDA
DMDMⁱ	23813666

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000171687	1 – 198	Single-stranded DNA cytosine deaminaseAdd BLAST		198

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	27	Phosphothreonine; by PKA1 Publication		1
Modified residueⁱ	38	Phosphoserine; by PKA2 Publications		1

Post-translational modificationⁱ

Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity.2 Publications

Probably monoubiquitinated on several residues by RNF126.1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9GZX7
PaxDbⁱ	Q9GZX7
PeptideAtlas More...PeptideAtlasⁱ	Q9GZX7
PRIDEⁱ	Q9GZX7
ProteomicsDBⁱ	80168

PTM databases

iPTMnetⁱ	Q9GZX7
PhosphoSitePlusⁱ	Q9GZX7

Expressionⁱ

Tissue specificityⁱ

Strongly expressed in lymph nodes and tonsils.1 Publication

Inductionⁱ

Negatively regulated by microRNA-155 (miR-155).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000111732 Expressed in 68 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_AICDA
ExpressionAtlasⁱ	Q9GZX7 baseline and differential
Genevisibleⁱ	Q9GZX7 HS

Interactionⁱ

Subunit structureⁱ

Interacts with CTNNBL1; the interaction is important for the immunoglobulin switch activity of AICDA. Interacts (via its NLS) with KPNA1. Interacts with PKA/PRKACA and PRKAR1A/PKR1. Interacts with TRIM28 and NCL (By similarity). Interacts with SUPT6H. Interacts with RNF126.By similarity5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-3834328,EBI-3834328
C	Q784Z8	2	EBI-3834328,EBI-11666471	From Hepatitis B virus.
DNAJA1	P31689	6	EBI-3834328,EBI-347834
DNAJA2	O60884	3	EBI-3834328,EBI-352957
GADD45A	P24522	5	EBI-3834328,EBI-448167
HSPA8	P11142	2	EBI-3834328,EBI-351896
KPNA1	P52294	2	EBI-3834328,EBI-358383
KPNA3	O00505	2	EBI-3834328,EBI-358297
KPNA5	O15131	2	EBI-3834328,EBI-540602
PRKACA	P17612	3	EBI-3834328,EBI-476586
PRKAR1A	P10644	5	EBI-3834328,EBI-476431
TDG	Q13569	5	EBI-3834328,EBI-348333

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 19412186
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 23277564

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121497, 54 interactors
Database of interacting proteins More...DIPⁱ	DIP-48519N
ELMⁱ	Q9GZX7
IntActⁱ	Q9GZX7, 30 interactors
Molecular INTeraction database More...MINTⁱ	Q9GZX7
STRINGⁱ	9606.ENSP00000229335

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	8 – 15	Combined sources	8
Beta strandⁱ	18 – 20	Combined sources	3
Beta strandⁱ	28 – 34	Combined sources	7
Beta strandⁱ	36 – 40	Combined sources	5
Beta strandⁱ	43 – 50	Combined sources	8
Helixⁱ	57 – 66	Combined sources	10
Beta strandⁱ	72 – 74	Combined sources	3
Beta strandⁱ	76 – 84	Combined sources	9
Helixⁱ	88 – 100	Combined sources	13
Beta strandⁱ	104 – 112	Combined sources	9
Turnⁱ	117 – 119	Combined sources	3
Helixⁱ	122 – 132	Combined sources	11
Beta strandⁱ	135 – 138	Combined sources	4
Helixⁱ	141 – 148	Combined sources	8
Helixⁱ	165 – 179	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9GZX7
SMRⁱ	Q9GZX7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	23 – 129	CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST		107

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	2 – 26	Interaction with SUPT6H1 PublicationAdd BLAST	25
Regionⁱ	39 – 42	Important for interaction with CTNNBL11 Publication	4
Regionⁱ	88 – 116	Required for interaction with RNF1261 PublicationAdd BLAST	29

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	1 – 30	Bipartite nuclear localization signal1 PublicationAdd BLAST		30
Motifⁱ	183 – 198	Nuclear export signal1 PublicationAdd BLAST		16

Sequence similaritiesⁱ

Belongs to the cytidine and deoxycytidylate deaminase family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IFHW Eukaryota ENOG4111HYQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062933
HOGENOMⁱ	HOG000033754
HOVERGENⁱ	HBG050434
InParanoidⁱ	Q9GZX7
KEGG Orthology (KO) More...KOⁱ	K10989
OMAⁱ	GYPNLSL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0J2L
PhylomeDBⁱ	Q9GZX7
TreeFamⁱ	TF331356

Family and domain databases

InterProⁱ	View protein in InterPro IPR016192 APOBEC/CMP_deaminase_Zn-bd IPR013158 APOBEC_N IPR002125 CMP_dCMP_dom IPR016193 Cytidine_deaminase-like
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08210 APOBEC_N, 1 hit
SUPFAMⁱ	SSF53927 SSF53927, 1 hit
PROSITEⁱ	View protein in PROSITE PS00903 CYT_DCMP_DEAMINASES_1, 1 hit PS51747 CYT_DCMP_DEAMINASES_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9GZX7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSLLMNRRK FLYQFKNVRW AKGRRETYLC YVVKRRDSAT SFSLDFGYLR 
        60         70         80         90        100
NKNGCHVELL FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG 
       110        120        130        140        150
NPNLSLRIFT ARLYFCEDRK AEPEGLRRLH RAGVQIAIMT FKDYFYCWNT 
       160        170        180        190 
FVENHERTFK AWEGLHENSV RLSRQLRRIL LPLYEVDDLR DAFRTLGL

Length:198

Mass (Da):23,954

Last modified:March 1, 2001 - v1

Checksum:ⁱ3C27BB143DB184A9

GO

Isoform 2 (identifier: Q9GZX7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
143-152: Missing.

« Hide

        10         20         30         40         50
MDSLLMNRRK FLYQFKNVRW AKGRRETYLC YVVKRRDSAT SFSLDFGYLR 
        60         70         80         90        100
NKNGCHVELL FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG 
       110        120        130        140        150
NPNLSLRIFT ARLYFCEDRK AEPEGLRRLH RAGVQIAIMT FKENHERTFK 
       160        170        180 
AWEGLHENSV RLSRQLRRIL LPLYEVDDLR DAFRTLGL

Show »

Length:188

Mass (Da):22,614

Checksum:ⁱ02C20DFDA47793E3

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YGF6	H0YGF6_HUMAN	Single-stranded DNA cytosine deamin... Single-stranded DNA cytosine deaminase	AICDA	197	Annotation score:
H0YFL3	H0YFL3_HUMAN	Single-stranded DNA cytosine deamin... Single-stranded DNA cytosine deaminase	AICDA	144	Annotation score:
H0YFP1	H0YFP1_HUMAN	Single-stranded DNA cytosine deamin... Single-stranded DNA cytosine deaminase	AICDA	68	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	119	R → H in AAM95406 (PubMed:12202747).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_077563	15	F → L in HIGM2. 1 Publication	1
Natural variantⁱVAR_013774	24	R → W in HIGM2; completely abolishes nuclear import and interaction with CTNNBL1, diminishes interaction with KPNA1 and abolishes immunoglobulin class switching. 3 PublicationsCorresponds to variant dbSNP:rs104894324EnsemblClinVar.	1
Natural variantⁱVAR_014091	25	R → C1 PublicationCorresponds to variant dbSNP:rs1404944797Ensembl.	1
Natural variantⁱVAR_077564	31	Y → H in HIGM2. 1 Publication	1
Natural variantⁱVAR_077565	56	H → Y in HIGM2; unknown pathological significance; loss of mutagenic activity. 2 Publications	1
Natural variantⁱVAR_013775	80	W → R in HIGM2. 2 PublicationsCorresponds to variant dbSNP:rs104894320EnsemblClinVar.	1
Natural variantⁱVAR_077566	87	C → R in HIGM2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs762590894Ensembl.	1
Natural variantⁱVAR_013776	106	L → P in HIGM2. 2 PublicationsCorresponds to variant dbSNP:rs104894321EnsemblClinVar.	1
Natural variantⁱVAR_077567	130	H → P in HIGM2; slightly decreased mutagenic activity. 2 Publications	1
Natural variantⁱVAR_013777	139	M → V in HIGM2. 2 PublicationsCorresponds to variant dbSNP:rs104894322EnsemblClinVar.	1
Natural variantⁱVAR_013778	151	F → S in HIGM2. 2 PublicationsCorresponds to variant dbSNP:rs104894327EnsemblClinVar.	1
Natural variantⁱVAR_077568	174	R → S in HIGM2; unknown pathological significance. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047803	143 – 152	Missing in isoform 2. 1 Publication		10

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB040431 mRNA Translation: BAB12721.1 AB040430 Genomic DNA Translation: BAB12720.1 AF529819 mRNA Translation: AAM95406.1 AY536516 mRNA Translation: AAS92920.1 BT007402 mRNA Translation: AAP36066.1 AC092184 Genomic DNA No translation available. BC006296 mRNA Translation: AAH06296.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41747.1 [Q9GZX7-1] CCDS81662.1 [Q9GZX7-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001317272.1, NM_001330343.1 [Q9GZX7-2] NP_065712.1, NM_020661.3 [Q9GZX7-1]
UniGeneⁱ	Hs.149342

Genome annotation databases

Ensemblⁱ	ENST00000229335; ENSP00000229335; ENSG00000111732 [Q9GZX7-1] ENST00000537228; ENSP00000445691; ENSG00000111732 [Q9GZX7-2]
GeneIDⁱ	57379
KEGGⁱ	hsa:57379
UCSC genome browser More...UCSCⁱ	uc001qur.3 human [Q9GZX7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9GZX7	AID (Fragment)		HUMAN		198	UniRef100_Q9GZX7
Uncharacterized protein		PANPA		198
AID (Fragment)		MOUSE		198
Q9GZX7-2	Activation induced cytidine deaminase		GORGO		188	UniRef100_G3QLD2

Protein	Similar proteins		Species	Score	Length	Source
Q9GZX7	Single-stranded DNA cytosine deaminase		BOVIN		199	UniRef90_Q9GZX7
Single-stranded DNA cytosine deaminase		MOUSE		198
AID (Fragment)		HUMAN		198
Uncharacterized protein		PANPA		198
single-stranded DNA cytosine deaminase		Florida manatee		244
+111
Q9GZX7-2	Single-stranded DNA cytosine deaminase		CANLF		198	UniRef90_Q75W64
Activation induced cytidine deaminase		FELCA		232
Activation-induced cytidine deaminase (Fragment)		RABIT		191
Truncated AID		HUMAN		189
AICDA isoform 4		PONAB		188
+11

Protein	Similar proteins		Species	Score	Length	Source
Q9GZX7	Single-stranded DNA cytosine deaminase		BOVIN		199	UniRef50_Q9GZX7
Single-stranded DNA cytosine deaminase		MOUSE		198
AID (Fragment)		HUMAN		198
Uncharacterized protein		PANPA		198
single-stranded DNA cytosine deaminase		Florida manatee		244
+206
Q9GZX7-2	Single-stranded DNA cytosine deaminase		CANLF		198	UniRef50_Q75W64
Activation induced cytidine deaminase		FELCA		232
Activation-induced cytidine deaminase (Fragment)		RABIT		191
Truncated AID		HUMAN		189
AICDA isoform 4		PONAB		188
+93

Cross-referencesⁱ

Web resourcesⁱ

AICDAbase

AICDA mutation db

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB040431 mRNA Translation: BAB12721.1 AB040430 Genomic DNA Translation: BAB12720.1 AF529819 mRNA Translation: AAM95406.1 AY536516 mRNA Translation: AAS92920.1 BT007402 mRNA Translation: AAP36066.1 AC092184 Genomic DNA No translation available. BC006296 mRNA Translation: AAH06296.1
CCDSⁱ	CCDS41747.1 [Q9GZX7-1] CCDS81662.1 [Q9GZX7-2]
RefSeqⁱ	NP_001317272.1, NM_001330343.1 [Q9GZX7-2] NP_065712.1, NM_020661.3 [Q9GZX7-1]
UniGeneⁱ	Hs.149342

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5JJ4	X-ray	2.81	A/B/C	23-183	[»]
	5W0R	X-ray	2.40	A/B	13-181	[»]
	5W0U	X-ray	2.90	A/B	13-181	[»]
	5W0Z	X-ray	3.61	A/B	13-181	[»]
	5W1C	X-ray	3.18	A/B	5-181	[»]
ProteinModelPortalⁱ	Q9GZX7
SMRⁱ	Q9GZX7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121497, 54 interactors
DIPⁱ	DIP-48519N
ELMⁱ	Q9GZX7
IntActⁱ	Q9GZX7, 30 interactors
MINTⁱ	Q9GZX7
STRINGⁱ	9606.ENSP00000229335

PTM databases

iPTMnetⁱ	Q9GZX7
PhosphoSitePlusⁱ	Q9GZX7

Polymorphism and mutation databases

BioMutaⁱ	AICDA
DMDMⁱ	23813666

Proteomic databases

MaxQBⁱ	Q9GZX7
PaxDbⁱ	Q9GZX7
PeptideAtlasⁱ	Q9GZX7
PRIDEⁱ	Q9GZX7
ProteomicsDBⁱ	80168

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	57379
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000229335; ENSP00000229335; ENSG00000111732 [Q9GZX7-1] ENST00000537228; ENSP00000445691; ENSG00000111732 [Q9GZX7-2]
GeneIDⁱ	57379
KEGGⁱ	hsa:57379
UCSCⁱ	uc001qur.3 human [Q9GZX7-1]

Organism-specific databases

CTDⁱ	57379
DisGeNETⁱ	57379
EuPathDBⁱ	HostDB:ENSG00000111732.10
GeneCardsⁱ	AICDA
HGNCⁱ	HGNC:13203 AICDA
MalaCardsⁱ	AICDA
MIMⁱ	605257 gene 605258 phenotype
neXtProtⁱ	NX_Q9GZX7
OpenTargetsⁱ	ENSG00000111732
Orphanetⁱ	101089 Hyper-IgM syndrome type 2
PharmGKBⁱ	PA24644
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFHW Eukaryota ENOG4111HYQ LUCA
GeneTreeⁱ	ENSGT00530000062933
HOGENOMⁱ	HOG000033754
HOVERGENⁱ	HBG050434
InParanoidⁱ	Q9GZX7
KOⁱ	K10989
OMAⁱ	GYPNLSL
OrthoDBⁱ	EOG091G0J2L
PhylomeDBⁱ	Q9GZX7
TreeFamⁱ	TF331356

Enzyme and pathway databases

BRENDAⁱ	3.5.4.38 2681
SIGNORⁱ	Q9GZX7

Miscellaneous databases

GeneWikiⁱ	AICDA
GenomeRNAiⁱ	57379
Protein Ontology More...PROⁱ	PR:Q9GZX7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000111732 Expressed in 68 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_AICDA
ExpressionAtlasⁱ	Q9GZX7 baseline and differential
Genevisibleⁱ	Q9GZX7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR016192 APOBEC/CMP_deaminase_Zn-bd IPR013158 APOBEC_N IPR002125 CMP_dCMP_dom IPR016193 Cytidine_deaminase-like
Pfamⁱ	View protein in Pfam PF08210 APOBEC_N, 1 hit
SUPFAMⁱ	SSF53927 SSF53927, 1 hit
PROSITEⁱ	View protein in PROSITE PS00903 CYT_DCMP_DEAMINASES_1, 1 hit PS51747 CYT_DCMP_DEAMINASES_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AICDA_HUMAN
Accessionⁱ	Q9GZX7Primary (citable) accession number: Q9GZX7 Secondary accession number(s): Q6QJ81, Q8NFC1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - Q9GZX7 (AICDA_HUMAN)

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Single-stranded DNA cytosine deaminase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ