IL22

Functionⁱ

Cytokine that contributes to the inflammatory response in vivo.

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
interleukin-22 receptor binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10875937

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acute-phase response
Source: UniProtKB
Non-traceable author statementⁱ
- 11481447
cytokine-mediated signaling pathway Source: Reactome
inflammatory response
Source: UniProtKB
Non-traceable author statementⁱ
- 10954742
response to glucocorticoid Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine

Molecular function

Cytokine

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8854691 Interleukin-20 family signaling
SignaLinkⁱ	Q9GZX6
SIGNORⁱ	Q9GZX6

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-22 Short name: IL-22 Alternative name(s): Cytokine Zcyto18 IL-10-related T-cell-derived-inducible factor Short name: IL-TIF
Gene namesⁱ	Name:IL22 Synonyms:ILTIF, ZCYTO18 ORF Names:UNQ3099/PRO10096
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000127318.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14900 IL22
MIMⁱ	605330 gene
neXtProtⁱ	NX_Q9GZX6

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	50616
Open Targets More...OpenTargetsⁱ	ENSG00000127318
PharmGKBⁱ	PA29822

Chemistry databases

ChEMBLⁱ	CHEMBL3712915

ChEMBLⁱ

CHEMBL3712915

Polymorphism and mutation databases

BioMutaⁱ	IL22
DMDMⁱ	17366814

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 33	1 PublicationAdd BLAST		33
ChainⁱPRO_0000015383	34 – 179	Interleukin-22Add BLAST		146

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	40 ↔ 132	1 Publication
Glycosylationⁱ	54	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	68	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	89 ↔ 178	1 Publication
Glycosylationⁱ	97	N-linked (GlcNAc...) asparagine1 Publication	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q9GZX6
PeptideAtlas More...PeptideAtlasⁱ	Q9GZX6
PRIDEⁱ	Q9GZX6
ProteomicsDBⁱ	80167

PTM databases

iPTMnetⁱ	Q9GZX6
PhosphoSitePlusⁱ	Q9GZX6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000127318 Expressed in 27 organ(s), highest expression level in zone of skin
CleanExⁱ	HS_IL22
Genevisibleⁱ	Q9GZX6 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
IL10RB	Q08334	2	EBI-8040250,EBI-11175900
IL22RA1	Q8N6P7	9	EBI-8040250,EBI-3940749

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
interleukin-22 receptor binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10875937

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119096, 3 interactors
Database of interacting proteins More...DIPⁱ	DIP-46035N
IntActⁱ	Q9GZX6, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q9GZX6
STRINGⁱ	9606.ENSP00000329384

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	44 – 47	Combined sources	4
Helixⁱ	50 – 65	Combined sources	16
Beta strandⁱ	74 – 76	Combined sources	3
Helixⁱ	77 – 80	Combined sources	4
Helixⁱ	85 – 87	Combined sources	3
Helixⁱ	88 – 102	Combined sources	15
Turnⁱ	103 – 109	Combined sources	7
Helixⁱ	114 – 129	Combined sources	16
Helixⁱ	141 – 155	Combined sources	15
Helixⁱ	157 – 165	Combined sources	9
Helixⁱ	167 – 178	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9GZX6
SMRⁱ	Q9GZX6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q9GZX6

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the IL-10 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IV9D Eukaryota ENOG4112217 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048550
HOGENOMⁱ	HOG000280686
HOVERGENⁱ	HBG018572
InParanoidⁱ	Q9GZX6
KEGG Orthology (KO) More...KOⁱ	K05445
OMAⁱ	HIQKNVQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MJW
PhylomeDBⁱ	Q9GZX6
TreeFamⁱ	TF333253

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR020423 IL-10_CS IPR020453 IL-22
PANTHERⁱ	PTHR44864 PTHR44864, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14565 IL22, 1 hit
PIRSFⁱ	PIRSF037726 Interleukin-22, 1 hit
PRINTSⁱ	PR01936 INTRLEUKIN22
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00520 INTERLEUKIN_10, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9GZX6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAALQKSVSS FLMGTLATSC LLLLALLVQG GAAAPISSHC RLDKSNFQQP 
        60         70         80         90        100
YITNRTFMLA KEASLADNNT DVRLIGEKLF HGVSMSERCY LMKQVLNFTL 
       110        120        130        140        150
EEVLFPQSDR FQPYMQEVVP FLARLSNRLS TCHIEGDDLH IQRNVQKLKD 
       160        170 
TVKKLGESGE IKAIGELDLL FMSLRNACI

Length:179

Mass (Da):20,011

Last modified:March 1, 2001 - v1

Checksum:ⁱ3C35E64D60CF8767

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_013078	158	S → G1 PublicationCorresponds to variant dbSNP:rs2227507Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ277247 mRNA Translation: CAC06085.1 AJ277248 Genomic DNA Translation: CAC19409.1 AF279437 mRNA Translation: AAG22064.1 AY358890 mRNA Translation: AAQ89249.1 AF387519 Genomic DNA Translation: AAK62468.1 BC066263 mRNA Translation: AAH66263.1 BC067510 mRNA Translation: AAH67510.1 BC069112 mRNA Translation: AAH69112.1 BC069308 mRNA Translation: AAH69308.1 BC070261 mRNA Translation: AAH70261.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8982.1
NCBI Reference Sequences More...RefSeqⁱ	NP_065386.1, NM_020525.4
UniGeneⁱ	Hs.287369

Genome annotation databases

Ensemblⁱ	ENST00000328087; ENSP00000329384; ENSG00000127318 ENST00000538666; ENSP00000442424; ENSG00000127318
GeneIDⁱ	50616
KEGGⁱ	hsa:50616
UCSC genome browser More...UCSCⁱ	uc001sty.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9GZX6	Interleukin 22		GORGO		179	UniRef100_Q9GZX6
UPI00001B13F9		HUMAN		151
UPI000055D2DB		HUMAN		142

Protein	Similar proteins		Species	Score	Length	Source
Q9GZX6	Interleukin 22		GORGO		179	UniRef90_Q9GZX6
Uncharacterized protein		RHIRO		179
Uncharacterized protein		NOMLE		179
IL22 isoform 1		PONAB		179
Interleukin-22		MACMU		179
+10

Protein	Similar proteins		Species	Score	Length	Source
Q9GZX6	Interleukin-22		MOUSE		179	UniRef50_Q9GZX6
Interleukin 22		GORGO		179
Uncharacterized protein		RHIRO		179
Interleukin-22		MACMU		179
Interleukin-22		MACFA		179
+135

Cross-referencesⁱ

Web resourcesⁱ

SeattleSNPs

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ277247 mRNA Translation: CAC06085.1 AJ277248 Genomic DNA Translation: CAC19409.1 AF279437 mRNA Translation: AAG22064.1 AY358890 mRNA Translation: AAQ89249.1 AF387519 Genomic DNA Translation: AAK62468.1 BC066263 mRNA Translation: AAH66263.1 BC067510 mRNA Translation: AAH67510.1 BC069112 mRNA Translation: AAH69112.1 BC069308 mRNA Translation: AAH69308.1 BC070261 mRNA Translation: AAH70261.1
CCDSⁱ	CCDS8982.1
RefSeqⁱ	NP_065386.1, NM_020525.4
UniGeneⁱ	Hs.287369

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1M4R	X-ray	2.00	A/B	29-179	[»]
	1YKB	X-ray	2.60	A/B/C/D/E/F	38-179	[»]
	3DGC	X-ray	2.50	L/M	39-179	[»]
	3DLQ	X-ray	1.90	I	29-179	[»]
	3G9V	X-ray	2.76	B/D	29-179	[»]
	3Q1S	X-ray	2.15	I	29-179	[»]
ProteinModelPortalⁱ	Q9GZX6
SMRⁱ	Q9GZX6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119096, 3 interactors
DIPⁱ	DIP-46035N
IntActⁱ	Q9GZX6, 3 interactors
MINTⁱ	Q9GZX6
STRINGⁱ	9606.ENSP00000329384

Chemistry databases

ChEMBLⁱ	CHEMBL3712915

ChEMBLⁱ

CHEMBL3712915

PTM databases

iPTMnetⁱ	Q9GZX6
PhosphoSitePlusⁱ	Q9GZX6

Polymorphism and mutation databases

BioMutaⁱ	IL22
DMDMⁱ	17366814

Proteomic databases

PaxDbⁱ	Q9GZX6
PeptideAtlasⁱ	Q9GZX6
PRIDEⁱ	Q9GZX6
ProteomicsDBⁱ	80167

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	50616
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000328087; ENSP00000329384; ENSG00000127318 ENST00000538666; ENSP00000442424; ENSG00000127318
GeneIDⁱ	50616
KEGGⁱ	hsa:50616
UCSCⁱ	uc001sty.2 human

Organism-specific databases

CTDⁱ	50616
DisGeNETⁱ	50616
EuPathDBⁱ	HostDB:ENSG00000127318.10
GeneCardsⁱ	IL22
HGNCⁱ	HGNC:14900 IL22
MIMⁱ	605330 gene
neXtProtⁱ	NX_Q9GZX6
OpenTargetsⁱ	ENSG00000127318
PharmGKBⁱ	PA29822
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IV9D Eukaryota ENOG4112217 LUCA
GeneTreeⁱ	ENSGT00510000048550
HOGENOMⁱ	HOG000280686
HOVERGENⁱ	HBG018572
InParanoidⁱ	Q9GZX6
KOⁱ	K05445
OMAⁱ	HIQKNVQ
OrthoDBⁱ	EOG091G0MJW
PhylomeDBⁱ	Q9GZX6
TreeFamⁱ	TF333253

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8854691 Interleukin-20 family signaling
SignaLinkⁱ	Q9GZX6
SIGNORⁱ	Q9GZX6

Miscellaneous databases

EvolutionaryTraceⁱ	Q9GZX6
GeneWikiⁱ	Interleukin_22
GenomeRNAiⁱ	50616
Protein Ontology More...PROⁱ	PR:Q9GZX6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000127318 Expressed in 27 organ(s), highest expression level in zone of skin
CleanExⁱ	HS_IL22
Genevisibleⁱ	Q9GZX6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR020423 IL-10_CS IPR020453 IL-22
PANTHERⁱ	PTHR44864 PTHR44864, 1 hit
Pfamⁱ	View protein in Pfam PF14565 IL22, 1 hit
PIRSFⁱ	PIRSF037726 Interleukin-22, 1 hit
PRINTSⁱ	PR01936 INTRLEUKIN22
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00520 INTERLEUKIN_10, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IL22_HUMAN
Accessionⁱ	Q9GZX6Primary (citable) accession number: Q9GZX6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9GZX6 (IL22_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Interleukin-22

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ