Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-22

Gene

IL22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that contributes to the inflammatory response in vivo.

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • interleukin-22 receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-8854691 Interleukin-20 family signaling
SignaLinkiQ9GZX6
SIGNORiQ9GZX6

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-22
Short name:
IL-22
Alternative name(s):
Cytokine Zcyto18
IL-10-related T-cell-derived-inducible factor
Short name:
IL-TIF
Gene namesi
Name:IL22
Synonyms:ILTIF, ZCYTO18
ORF Names:UNQ3099/PRO10096
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000127318.10
HGNCiHGNC:14900 IL22
MIMi605330 gene
neXtProtiNX_Q9GZX6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi50616
OpenTargetsiENSG00000127318
PharmGKBiPA29822

Chemistry databases

ChEMBLiCHEMBL3712915

Polymorphism and mutation databases

BioMutaiIL22
DMDMi17366814

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 331 PublicationAdd BLAST33
ChainiPRO_000001538334 – 179Interleukin-22Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 1321 Publication
Glycosylationi54N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi89 ↔ 1781 Publication
Glycosylationi97N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZX6
PeptideAtlasiQ9GZX6
PRIDEiQ9GZX6
ProteomicsDBi80167

PTM databases

iPTMnetiQ9GZX6
PhosphoSitePlusiQ9GZX6

Expressioni

Gene expression databases

BgeeiENSG00000127318 Expressed in 27 organ(s), highest expression level in zone of skin
CleanExiHS_IL22
GenevisibleiQ9GZX6 HS

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119096, 3 interactors
DIPiDIP-46035N
IntActiQ9GZX6, 3 interactors
MINTiQ9GZX6
STRINGi9606.ENSP00000329384

Structurei

Secondary structure

1179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9GZX6
SMRiQ9GZX6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9GZX6

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IV9D Eukaryota
ENOG4112217 LUCA
GeneTreeiENSGT00510000048550
HOGENOMiHOG000280686
HOVERGENiHBG018572
InParanoidiQ9GZX6
KOiK05445
OMAiHIQKNVQ
OrthoDBiEOG091G0MJW
PhylomeDBiQ9GZX6
TreeFamiTF333253

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020423 IL-10_CS
IPR020453 IL-22
PANTHERiPTHR44864 PTHR44864, 1 hit
PfamiView protein in Pfam
PF14565 IL22, 1 hit
PIRSFiPIRSF037726 Interleukin-22, 1 hit
PRINTSiPR01936 INTRLEUKIN22
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00520 INTERLEUKIN_10, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GZX6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALQKSVSS FLMGTLATSC LLLLALLVQG GAAAPISSHC RLDKSNFQQP
60 70 80 90 100
YITNRTFMLA KEASLADNNT DVRLIGEKLF HGVSMSERCY LMKQVLNFTL
110 120 130 140 150
EEVLFPQSDR FQPYMQEVVP FLARLSNRLS TCHIEGDDLH IQRNVQKLKD
160 170
TVKKLGESGE IKAIGELDLL FMSLRNACI
Length:179
Mass (Da):20,011
Last modified:March 1, 2001 - v1
Checksum:i3C35E64D60CF8767
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013078158S → G1 PublicationCorresponds to variant dbSNP:rs2227507Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277247 mRNA Translation: CAC06085.1
AJ277248 Genomic DNA Translation: CAC19409.1
AF279437 mRNA Translation: AAG22064.1
AY358890 mRNA Translation: AAQ89249.1
AF387519 Genomic DNA Translation: AAK62468.1
BC066263 mRNA Translation: AAH66263.1
BC067510 mRNA Translation: AAH67510.1
BC069112 mRNA Translation: AAH69112.1
BC069308 mRNA Translation: AAH69308.1
BC070261 mRNA Translation: AAH70261.1
CCDSiCCDS8982.1
RefSeqiNP_065386.1, NM_020525.4
UniGeneiHs.287369

Genome annotation databases

EnsembliENST00000328087; ENSP00000329384; ENSG00000127318
ENST00000538666; ENSP00000442424; ENSG00000127318
GeneIDi50616
KEGGihsa:50616
UCSCiuc001sty.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277247 mRNA Translation: CAC06085.1
AJ277248 Genomic DNA Translation: CAC19409.1
AF279437 mRNA Translation: AAG22064.1
AY358890 mRNA Translation: AAQ89249.1
AF387519 Genomic DNA Translation: AAK62468.1
BC066263 mRNA Translation: AAH66263.1
BC067510 mRNA Translation: AAH67510.1
BC069112 mRNA Translation: AAH69112.1
BC069308 mRNA Translation: AAH69308.1
BC070261 mRNA Translation: AAH70261.1
CCDSiCCDS8982.1
RefSeqiNP_065386.1, NM_020525.4
UniGeneiHs.287369

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M4RX-ray2.00A/B29-179[»]
1YKBX-ray2.60A/B/C/D/E/F38-179[»]
3DGCX-ray2.50L/M39-179[»]
3DLQX-ray1.90I29-179[»]
3G9VX-ray2.76B/D29-179[»]
3Q1SX-ray2.15I29-179[»]
ProteinModelPortaliQ9GZX6
SMRiQ9GZX6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119096, 3 interactors
DIPiDIP-46035N
IntActiQ9GZX6, 3 interactors
MINTiQ9GZX6
STRINGi9606.ENSP00000329384

Chemistry databases

ChEMBLiCHEMBL3712915

PTM databases

iPTMnetiQ9GZX6
PhosphoSitePlusiQ9GZX6

Polymorphism and mutation databases

BioMutaiIL22
DMDMi17366814

Proteomic databases

PaxDbiQ9GZX6
PeptideAtlasiQ9GZX6
PRIDEiQ9GZX6
ProteomicsDBi80167

Protocols and materials databases

DNASUi50616
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328087; ENSP00000329384; ENSG00000127318
ENST00000538666; ENSP00000442424; ENSG00000127318
GeneIDi50616
KEGGihsa:50616
UCSCiuc001sty.2 human

Organism-specific databases

CTDi50616
DisGeNETi50616
EuPathDBiHostDB:ENSG00000127318.10
GeneCardsiIL22
HGNCiHGNC:14900 IL22
MIMi605330 gene
neXtProtiNX_Q9GZX6
OpenTargetsiENSG00000127318
PharmGKBiPA29822
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IV9D Eukaryota
ENOG4112217 LUCA
GeneTreeiENSGT00510000048550
HOGENOMiHOG000280686
HOVERGENiHBG018572
InParanoidiQ9GZX6
KOiK05445
OMAiHIQKNVQ
OrthoDBiEOG091G0MJW
PhylomeDBiQ9GZX6
TreeFamiTF333253

Enzyme and pathway databases

ReactomeiR-HSA-8854691 Interleukin-20 family signaling
SignaLinkiQ9GZX6
SIGNORiQ9GZX6

Miscellaneous databases

EvolutionaryTraceiQ9GZX6
GeneWikiiInterleukin_22
GenomeRNAii50616
PROiPR:Q9GZX6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127318 Expressed in 27 organ(s), highest expression level in zone of skin
CleanExiHS_IL22
GenevisibleiQ9GZX6 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020423 IL-10_CS
IPR020453 IL-22
PANTHERiPTHR44864 PTHR44864, 1 hit
PfamiView protein in Pfam
PF14565 IL22, 1 hit
PIRSFiPIRSF037726 Interleukin-22, 1 hit
PRINTSiPR01936 INTRLEUKIN22
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00520 INTERLEUKIN_10, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL22_HUMAN
AccessioniPrimary (citable) accession number: Q9GZX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again