UniProtKB - Q9GZX6 (IL22_HUMAN)
Protein
Interleukin-22
Gene
IL22
Organism
Homo sapiens (Human)
Status
Functioni
Cytokine that contributes to the inflammatory response in vivo.
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- interleukin-22 receptor binding Source: UniProtKB
GO - Biological processi
- acute-phase response Source: UniProtKB
- cytokine-mediated signaling pathway Source: Reactome
- inflammatory response Source: UniProtKB
- response to glucocorticoid Source: Ensembl
Keywordsi
Molecular function | Cytokine |
Enzyme and pathway databases
PathwayCommonsi | Q9GZX6 |
Reactomei | R-HSA-8854691, Interleukin-20 family signaling |
SignaLinki | Q9GZX6 |
SIGNORi | Q9GZX6 |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-22Short name: IL-22 Alternative name(s): Cytokine Zcyto18 IL-10-related T-cell-derived-inducible factor Short name: IL-TIF |
Gene namesi | Name:IL22 Synonyms:ILTIF, ZCYTO18 ORF Names:UNQ3099/PRO10096 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000127318.10 |
HGNCi | HGNC:14900, IL22 |
MIMi | 605330, gene |
neXtProti | NX_Q9GZX6 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 50616 |
OpenTargetsi | ENSG00000127318 |
PharmGKBi | PA29822 |
Miscellaneous databases
Pharosi | Q9GZX6, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3712915 |
Polymorphism and mutation databases
BioMutai | IL22 |
DMDMi | 17366814 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | 1 PublicationAdd BLAST | 33 | |
ChainiPRO_0000015383 | 34 – 179 | Interleukin-22Add BLAST | 146 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 40 ↔ 132 | 1 Publication | ||
Glycosylationi | 54 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 68 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 89 ↔ 178 | 1 Publication | ||
Glycosylationi | 97 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q9GZX6 |
MassIVEi | Q9GZX6 |
PaxDbi | Q9GZX6 |
PeptideAtlasi | Q9GZX6 |
PRIDEi | Q9GZX6 |
ProteomicsDBi | 80167 |
PTM databases
GlyGeni | Q9GZX6, 3 sites |
iPTMneti | Q9GZX6 |
PhosphoSitePlusi | Q9GZX6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000127318, Expressed in urinary bladder and 47 other tissues |
Genevisiblei | Q9GZX6, HS |
Organism-specific databases
HPAi | ENSG00000127318, Tissue enhanced (lymphoid tissue, urinary bladder) |
Interactioni
Binary interactionsi
Hide detailsQ9GZX6
With | #Exp. | IntAct |
---|---|---|
IL10RB [Q08334] | 2 | EBI-8040250,EBI-11175900 |
IL22RA1 [Q8N6P7] | 9 | EBI-8040250,EBI-3940749 |
Interleukin-22 (PRO_0000015383)
With | #Exp. | IntAct |
---|---|---|
IL22RA1 [Q8N6P7] | 5 | EBI-11315863,EBI-3940749 |
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- interleukin-22 receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119096, 3 interactors |
DIPi | DIP-46035N |
IntActi | Q9GZX6, 3 interactors |
MINTi | Q9GZX6 |
STRINGi | 9606.ENSP00000442424 |
Chemistry databases
BindingDBi | Q9GZX6 |
Miscellaneous databases
RNActi | Q9GZX6, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9GZX6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9GZX6 |
Family & Domainsi
Sequence similaritiesi
Belongs to the IL-10 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S5PC, Eukaryota |
GeneTreei | ENSGT00510000048550 |
HOGENOMi | CLU_127397_0_0_1 |
InParanoidi | Q9GZX6 |
OMAi | YMQEVVS |
OrthoDBi | 1406348at2759 |
PhylomeDBi | Q9GZX6 |
TreeFami | TF333253 |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR020423, IL-10_CS IPR020453, IL-22 |
Pfami | View protein in Pfam PF14565, IL22, 1 hit |
PIRSFi | PIRSF037726, Interleukin-22, 1 hit |
PRINTSi | PR01936, INTRLEUKIN22 |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00520, INTERLEUKIN_10, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9GZX6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAALQKSVSS FLMGTLATSC LLLLALLVQG GAAAPISSHC RLDKSNFQQP
60 70 80 90 100
YITNRTFMLA KEASLADNNT DVRLIGEKLF HGVSMSERCY LMKQVLNFTL
110 120 130 140 150
EEVLFPQSDR FQPYMQEVVP FLARLSNRLS TCHIEGDDLH IQRNVQKLKD
160 170
TVKKLGESGE IKAIGELDLL FMSLRNACI
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013078 | 158 | S → G1 PublicationCorresponds to variant dbSNP:rs2227507EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ277247 mRNA Translation: CAC06085.1 AJ277248 Genomic DNA Translation: CAC19409.1 AF279437 mRNA Translation: AAG22064.1 AY358890 mRNA Translation: AAQ89249.1 AF387519 Genomic DNA Translation: AAK62468.1 BC066263 mRNA Translation: AAH66263.1 BC067510 mRNA Translation: AAH67510.1 BC069112 mRNA Translation: AAH69112.1 BC069308 mRNA Translation: AAH69308.1 BC070261 mRNA Translation: AAH70261.1 |
CCDSi | CCDS8982.1 |
RefSeqi | NP_065386.1, NM_020525.4 |
Genome annotation databases
Ensembli | ENST00000328087; ENSP00000329384; ENSG00000127318 ENST00000538666; ENSP00000442424; ENSG00000127318 |
GeneIDi | 50616 |
KEGGi | hsa:50616 |
UCSCi | uc001sty.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ277247 mRNA Translation: CAC06085.1 AJ277248 Genomic DNA Translation: CAC19409.1 AF279437 mRNA Translation: AAG22064.1 AY358890 mRNA Translation: AAQ89249.1 AF387519 Genomic DNA Translation: AAK62468.1 BC066263 mRNA Translation: AAH66263.1 BC067510 mRNA Translation: AAH67510.1 BC069112 mRNA Translation: AAH69112.1 BC069308 mRNA Translation: AAH69308.1 BC070261 mRNA Translation: AAH70261.1 |
CCDSi | CCDS8982.1 |
RefSeqi | NP_065386.1, NM_020525.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1M4R | X-ray | 2.00 | A/B | 29-179 | [»] | |
1YKB | X-ray | 2.60 | A/B/C/D/E/F | 38-179 | [»] | |
3DGC | X-ray | 2.50 | L/M | 39-179 | [»] | |
3DLQ | X-ray | 1.90 | I | 29-179 | [»] | |
3G9V | X-ray | 2.76 | B/D | 29-179 | [»] | |
3Q1S | X-ray | 2.15 | I | 29-179 | [»] | |
SMRi | Q9GZX6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119096, 3 interactors |
DIPi | DIP-46035N |
IntActi | Q9GZX6, 3 interactors |
MINTi | Q9GZX6 |
STRINGi | 9606.ENSP00000442424 |
Chemistry databases
BindingDBi | Q9GZX6 |
ChEMBLi | CHEMBL3712915 |
PTM databases
GlyGeni | Q9GZX6, 3 sites |
iPTMneti | Q9GZX6 |
PhosphoSitePlusi | Q9GZX6 |
Polymorphism and mutation databases
BioMutai | IL22 |
DMDMi | 17366814 |
Proteomic databases
jPOSTi | Q9GZX6 |
MassIVEi | Q9GZX6 |
PaxDbi | Q9GZX6 |
PeptideAtlasi | Q9GZX6 |
PRIDEi | Q9GZX6 |
ProteomicsDBi | 80167 |
Protocols and materials databases
ABCDi | Q9GZX6, 35 sequenced antibodies |
Antibodypediai | 16687, 942 antibodies |
DNASUi | 50616 |
Genome annotation databases
Ensembli | ENST00000328087; ENSP00000329384; ENSG00000127318 ENST00000538666; ENSP00000442424; ENSG00000127318 |
GeneIDi | 50616 |
KEGGi | hsa:50616 |
UCSCi | uc001sty.2, human |
Organism-specific databases
CTDi | 50616 |
DisGeNETi | 50616 |
EuPathDBi | HostDB:ENSG00000127318.10 |
GeneCardsi | IL22 |
HGNCi | HGNC:14900, IL22 |
HPAi | ENSG00000127318, Tissue enhanced (lymphoid tissue, urinary bladder) |
MIMi | 605330, gene |
neXtProti | NX_Q9GZX6 |
OpenTargetsi | ENSG00000127318 |
PharmGKBi | PA29822 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S5PC, Eukaryota |
GeneTreei | ENSGT00510000048550 |
HOGENOMi | CLU_127397_0_0_1 |
InParanoidi | Q9GZX6 |
OMAi | YMQEVVS |
OrthoDBi | 1406348at2759 |
PhylomeDBi | Q9GZX6 |
TreeFami | TF333253 |
Enzyme and pathway databases
PathwayCommonsi | Q9GZX6 |
Reactomei | R-HSA-8854691, Interleukin-20 family signaling |
SignaLinki | Q9GZX6 |
SIGNORi | Q9GZX6 |
Miscellaneous databases
BioGRID-ORCSi | 50616, 3 hits in 836 CRISPR screens |
ChiTaRSi | IL22, human |
EvolutionaryTracei | Q9GZX6 |
GeneWikii | Interleukin_22 |
GenomeRNAii | 50616 |
Pharosi | Q9GZX6, Tbio |
PROi | PR:Q9GZX6 |
RNActi | Q9GZX6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000127318, Expressed in urinary bladder and 47 other tissues |
Genevisiblei | Q9GZX6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR020423, IL-10_CS IPR020453, IL-22 |
Pfami | View protein in Pfam PF14565, IL22, 1 hit |
PIRSFi | PIRSF037726, Interleukin-22, 1 hit |
PRINTSi | PR01936, INTRLEUKIN22 |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00520, INTERLEUKIN_10, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL22_HUMAN | |
Accessioni | Q9GZX6Primary (citable) accession number: Q9GZX6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations