Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9GZX6 (IL22_HUMAN)

Entry version 174 (02 Dec 2020)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
Add a publicationFeedback
Protein

Interleukin-22

Gene

IL22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokine that contributes to the inflammatory response in vivo.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9GZX6

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8854691, Interleukin-20 family signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9GZX6

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9GZX6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-22
Short name:
IL-22
Alternative name(s):
Cytokine Zcyto18
IL-10-related T-cell-derived-inducible factor
Short name:
IL-TIF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL22
Synonyms:ILTIF, ZCYTO18
ORF Names:UNQ3099/PRO10096
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000127318.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:14900, IL22

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605330, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9GZX6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		50616

Open Targets

More...OpenTargetsi		ENSG00000127318

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29822

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9GZX6, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3712915

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IL22

Domain mapping of disease mutations (DMDM)

More...DMDMi		17366814

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 331 PublicationAdd BLAST33
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001538334 – 179Interleukin-22Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi40 ↔ 1321 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi54N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi89 ↔ 1781 Publication
Glycosylationi97N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9GZX6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9GZX6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9GZX6

PeptideAtlas

More...PeptideAtlasi		Q9GZX6

PRoteomics IDEntifications database

More...PRIDEi		Q9GZX6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80167

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9GZX6, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9GZX6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9GZX6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000127318, Expressed in urinary bladder and 47 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9GZX6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000127318, Tissue enhanced (lymphoid tissue, urinary bladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119096, 3 interactors

Database of interacting proteins

More...DIPi		DIP-46035N

Protein interaction database and analysis system

More...IntActi		Q9GZX6, 3 interactors

Molecular INTeraction database

More...MINTi		Q9GZX6

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000442424

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9GZX6

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9GZX6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9GZX6

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9GZX6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S5PC, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00510000048550

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_127397_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9GZX6

Identification of Orthologs from Complete Genome Data

More...OMAi		YMQEVVS

Database of Orthologous Groups

More...OrthoDBi		1406348at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9GZX6

TreeFam database of animal gene trees

More...TreeFami		TF333253

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009079, 4_helix_cytokine-like_core
IPR020423, IL-10_CS
IPR020453, IL-22

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14565, IL22, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037726, Interleukin-22, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01936, INTRLEUKIN22

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47266, SSF47266, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00520, INTERLEUKIN_10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GZX6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALQKSVSS FLMGTLATSC LLLLALLVQG GAAAPISSHC RLDKSNFQQP 
        60         70         80         90        100
YITNRTFMLA KEASLADNNT DVRLIGEKLF HGVSMSERCY LMKQVLNFTL 
       110        120        130        140        150
EEVLFPQSDR FQPYMQEVVP FLARLSNRLS TCHIEGDDLH IQRNVQKLKD 
       160        170 
TVKKLGESGE IKAIGELDLL FMSLRNACI
Length:179
Mass (Da):20,011
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C35E64D60CF8767
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013078158S → G1 PublicationCorresponds to variant dbSNP:rs2227507EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ277247 mRNA Translation: CAC06085.1
AJ277248 Genomic DNA Translation: CAC19409.1
AF279437 mRNA Translation: AAG22064.1
AY358890 mRNA Translation: AAQ89249.1
AF387519 Genomic DNA Translation: AAK62468.1
BC066263 mRNA Translation: AAH66263.1
BC067510 mRNA Translation: AAH67510.1
BC069112 mRNA Translation: AAH69112.1
BC069308 mRNA Translation: AAH69308.1
BC070261 mRNA Translation: AAH70261.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8982.1

NCBI Reference Sequences

More...RefSeqi		NP_065386.1, NM_020525.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000328087; ENSP00000329384; ENSG00000127318
ENST00000538666; ENSP00000442424; ENSG00000127318

Database of genes from NCBI RefSeq genomes

More...GeneIDi		50616

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:50616

UCSC genome browser

More...UCSCi		uc001sty.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277247 mRNA Translation: CAC06085.1
AJ277248 Genomic DNA Translation: CAC19409.1
AF279437 mRNA Translation: AAG22064.1
AY358890 mRNA Translation: AAQ89249.1
AF387519 Genomic DNA Translation: AAK62468.1
BC066263 mRNA Translation: AAH66263.1
BC067510 mRNA Translation: AAH67510.1
BC069112 mRNA Translation: AAH69112.1
BC069308 mRNA Translation: AAH69308.1
BC070261 mRNA Translation: AAH70261.1
CCDSiCCDS8982.1
RefSeqiNP_065386.1, NM_020525.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M4RX-ray2.00A/B29-179[»]
1YKBX-ray2.60A/B/C/D/E/F38-179[»]
3DGCX-ray2.50L/M39-179[»]
3DLQX-ray1.90I29-179[»]
3G9VX-ray2.76B/D29-179[»]
3Q1SX-ray2.15I29-179[»]
SMRiQ9GZX6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119096, 3 interactors
DIPiDIP-46035N
IntActiQ9GZX6, 3 interactors
MINTiQ9GZX6
STRINGi9606.ENSP00000442424

Chemistry databases

BindingDBiQ9GZX6
ChEMBLiCHEMBL3712915

PTM databases

GlyGeniQ9GZX6, 3 sites
iPTMnetiQ9GZX6
PhosphoSitePlusiQ9GZX6

Polymorphism and mutation databases

BioMutaiIL22
DMDMi17366814

Proteomic databases

jPOSTiQ9GZX6
MassIVEiQ9GZX6
PaxDbiQ9GZX6
PeptideAtlasiQ9GZX6
PRIDEiQ9GZX6
ProteomicsDBi80167

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9GZX6, 35 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16687, 942 antibodies

The DNASU plasmid repository

More...DNASUi		50616

Genome annotation databases

EnsembliENST00000328087; ENSP00000329384; ENSG00000127318
ENST00000538666; ENSP00000442424; ENSG00000127318
GeneIDi50616
KEGGihsa:50616
UCSCiuc001sty.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		50616
DisGeNETi50616
EuPathDBiHostDB:ENSG00000127318.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		IL22
HGNCiHGNC:14900, IL22
HPAiENSG00000127318, Tissue enhanced (lymphoid tissue, urinary bladder)
MIMi605330, gene
neXtProtiNX_Q9GZX6
OpenTargetsiENSG00000127318
PharmGKBiPA29822

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S5PC, Eukaryota
GeneTreeiENSGT00510000048550
HOGENOMiCLU_127397_0_0_1
InParanoidiQ9GZX6
OMAiYMQEVVS
OrthoDBi1406348at2759
PhylomeDBiQ9GZX6
TreeFamiTF333253

Enzyme and pathway databases

PathwayCommonsiQ9GZX6
ReactomeiR-HSA-8854691, Interleukin-20 family signaling
SignaLinkiQ9GZX6
SIGNORiQ9GZX6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		50616, 3 hits in 836 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IL22, human
EvolutionaryTraceiQ9GZX6

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Interleukin_22

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		50616
PharosiQ9GZX6, Tbio

Protein Ontology

More...PROi		PR:Q9GZX6
RNActiQ9GZX6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000127318, Expressed in urinary bladder and 47 other tissues
GenevisibleiQ9GZX6, HS

Family and domain databases

InterProiView protein in InterPro
IPR009079, 4_helix_cytokine-like_core
IPR020423, IL-10_CS
IPR020453, IL-22
PfamiView protein in Pfam
PF14565, IL22, 1 hit
PIRSFiPIRSF037726, Interleukin-22, 1 hit
PRINTSiPR01936, INTRLEUKIN22
SUPFAMiSSF47266, SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00520, INTERLEUKIN_10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL22_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZX6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: December 2, 2020
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again