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Entry version 164 (12 Aug 2020)
Sequence version 3 (30 Nov 2010)
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Protein

Zinc finger protein 350

Gene

ZNF350

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri206 – 228C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9GZX5

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway
R-HSA-3899300, SUMOylation of transcription cofactors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 350
Alternative name(s):
KRAB zinc finger protein ZFQR
Zinc finger and BRCA1-interacting protein with a KRAB domain 1
Zinc finger protein ZBRK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF350
Synonyms:ZBRK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000256683.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16656, ZNF350

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605422, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9GZX5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
59348

Open Targets

More...
OpenTargetsi
ENSG00000256683

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134972827

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9GZX5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF350

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104255

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475461 – 532Zinc finger protein 350Add BLAST532

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9GZX5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9GZX5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9GZX5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9GZX5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9GZX5

PeptideAtlas

More...
PeptideAtlasi
Q9GZX5

PRoteomics IDEntifications database

More...
PRIDEi
Q9GZX5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80166

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9GZX5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9GZX5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000256683, Expressed in prostate gland and 204 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9GZX5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9GZX5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000256683, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BRCA1.

Interacts with RNF11.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121889, 12 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9GZX5

Protein interaction database and analysis system

More...
IntActi
Q9GZX5, 8 interactors

Molecular INTeraction database

More...
MINTi
Q9GZX5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000243644

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9GZX5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9GZX5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 228C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162449

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9GZX5

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
LTDHQII

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9GZX5

TreeFam database of animal gene trees

More...
TreeFami
TF340593

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9GZX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIQAQESITL EDVAVDFTWE EWQLLGAAQK DLYRDVMLEN YSNLVAVGYQ
60 70 80 90 100
ASKPDALFKL EQGEQLWTIE DGIHSGACSD IWKVDHVLER LQSESLVNRR
110 120 130 140 150
KPCHEHDAFE NIVHCSKSQF LLGQNHDIFD LRGKSLKSNL TLVNQSKGYE
160 170 180 190 200
IKNSVEFTGN GDSFLHANHE RLHTAIKFPA SQKLISTKSQ FISPKHQKTR
210 220 230 240 250
KLEKHHVCSE CGKAFIKKSW LTDHQVMHTG EKPHRCSLCE KAFSRKFMLT
260 270 280 290 300
EHQRTHTGEK PYECPECGKA FLKKSRLNIH QKTHTGEKPY ICSECGKGFI
310 320 330 340 350
QKGNLIVHQR IHTGEKPYIC NECGKGFIQK TCLIAHQRFH TGKTPFVCSE
360 370 380 390 400
CGKSCSQKSG LIKHQRIHTG EKPFECSECG KAFSTKQKLI VHQRTHTGER
410 420 430 440 450
PYGCNECGKA FAYMSCLVKH KRIHTREKQE AAKVENPPAE RHSSLHTSDV
460 470 480 490 500
MQEKNSANGA TTQVPSVAPQ TSLNISGLLA NRNVVLVGQP VVRCAASGDN
510 520 530
RGFAQDRNLV NAVNVVVPSV INYVLFYVTE NP
Length:532
Mass (Da):60,011
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFEF12A92F95BAC8A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R017M0R017_HUMAN
Zinc finger protein 350
ZNF350
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYT6M0QYT6_HUMAN
Zinc finger protein 350
ZNF350
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1T8M0R1T8_HUMAN
Zinc finger protein 350
ZNF350
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY52M0QY52_HUMAN
Zinc finger protein 350
ZNF350
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04671837M → I. Corresponds to variant dbSNP:rs4987241Ensembl.1
Natural variantiVAR_01990266L → P3 PublicationsCorresponds to variant dbSNP:rs2278420Ensembl.1
Natural variantiVAR_04671969I → T. Corresponds to variant dbSNP:rs4987042Ensembl.1
Natural variantiVAR_046720132R → C. Corresponds to variant dbSNP:rs28997584Ensembl.1
Natural variantiVAR_046721406E → K. Corresponds to variant dbSNP:rs3764539Ensembl.1
Natural variantiVAR_019903472S → P1 PublicationCorresponds to variant dbSNP:rs4986771Ensembl.1
Natural variantiVAR_019904501R → S3 PublicationsCorresponds to variant dbSNP:rs2278415Ensembl.1
Natural variantiVAR_019905524V → I2 PublicationsCorresponds to variant dbSNP:rs4988337Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF295096 mRNA Translation: AAG17439.1
AF309561 mRNA Translation: AAG25714.1
AK023467 mRNA Translation: BAB14583.1
AC011460 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72056.1
BC009921 mRNA Translation: AAH09921.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12845.1

NCBI Reference Sequences

More...
RefSeqi
NP_067645.3, NM_021632.3
XP_016882587.1, XM_017027098.1
XP_016882588.1, XM_017027099.1
XP_016882589.1, XM_017027100.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000243644; ENSP00000243644; ENSG00000256683

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
59348

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:59348

UCSC genome browser

More...
UCSCi
uc002pyd.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295096 mRNA Translation: AAG17439.1
AF309561 mRNA Translation: AAG25714.1
AK023467 mRNA Translation: BAB14583.1
AC011460 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72056.1
BC009921 mRNA Translation: AAH09921.1
CCDSiCCDS12845.1
RefSeqiNP_067645.3, NM_021632.3
XP_016882587.1, XM_017027098.1
XP_016882588.1, XM_017027099.1
XP_016882589.1, XM_017027100.1

3D structure databases

SMRiQ9GZX5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121889, 12 interactors
CORUMiQ9GZX5
IntActiQ9GZX5, 8 interactors
MINTiQ9GZX5
STRINGi9606.ENSP00000243644

PTM databases

iPTMnetiQ9GZX5
PhosphoSitePlusiQ9GZX5

Polymorphism and mutation databases

BioMutaiZNF350
DMDMi313104255

Proteomic databases

EPDiQ9GZX5
jPOSTiQ9GZX5
MassIVEiQ9GZX5
MaxQBiQ9GZX5
PaxDbiQ9GZX5
PeptideAtlasiQ9GZX5
PRIDEiQ9GZX5
ProteomicsDBi80166

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
49600, 200 antibodies

The DNASU plasmid repository

More...
DNASUi
59348

Genome annotation databases

EnsembliENST00000243644; ENSP00000243644; ENSG00000256683
GeneIDi59348
KEGGihsa:59348
UCSCiuc002pyd.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
59348
DisGeNETi59348
EuPathDBiHostDB:ENSG00000256683.6

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF350
HGNCiHGNC:16656, ZNF350
HPAiENSG00000256683, Low tissue specificity
MIMi605422, gene
neXtProtiNX_Q9GZX5
OpenTargetsiENSG00000256683
PharmGKBiPA134972827

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000162449
HOGENOMiCLU_002678_0_2_1
InParanoidiQ9GZX5
KOiK09228
OMAiLTDHQII
OrthoDBi1318335at2759
PhylomeDBiQ9GZX5
TreeFamiTF340593

Enzyme and pathway databases

PathwayCommonsiQ9GZX5
ReactomeiR-HSA-212436, Generic Transcription Pathway
R-HSA-3899300, SUMOylation of transcription cofactors

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
59348, 4 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF350, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZNF350

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
59348
PharosiQ9GZX5, Tbio

Protein Ontology

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PROi
PR:Q9GZX5
RNActiQ9GZX5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000256683, Expressed in prostate gland and 204 other tissues
ExpressionAtlasiQ9GZX5, baseline and differential
GenevisibleiQ9GZX5, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 8 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN350_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZX5
Secondary accession number(s): Q96G73, Q9HAQ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 30, 2010
Last modified: August 12, 2020
This is version 164 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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