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Protein

Carbohydrate sulfotransferase 6

Gene

CHST6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N-acetyllactosamine structures.2 Publications

Caution

PubMed:12824236 reported a Gly-204 variant, however according to their results reported in figure 1, it is a Gln-204 variant.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 55PAPSBy similarity7
Nucleotide bindingi202 – 210PAPSBy similarity9

GO - Molecular functioni

  • N-acetylglucosamine 6-O-sulfotransferase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

ReactomeiR-HSA-2022854 Keratan sulfate biosynthesis
R-HSA-3656225 Defective CHST6 causes MCDC1

Names & Taxonomyi

Protein namesi
Recommended name:
Carbohydrate sulfotransferase 6 (EC:2.8.2.-)
Alternative name(s):
Corneal N-acetylglucosamine-6-O-sulfotransferase
Short name:
C-GlcNAc6ST
Short name:
hCGn6ST
Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta
Short name:
GST4-beta
N-acetylglucosamine 6-O-sulfotransferase 5
Short name:
GlcNAc6ST-5
Short name:
Gn6st-5
Gene namesi
Name:CHST6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000183196.8
HGNCiHGNC:6938 CHST6
MIMi605294 gene
neXtProtiNX_Q9GZX3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5CytoplasmicSequence analysis5
Transmembranei6 – 26Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini27 – 395LumenalSequence analysisAdd BLAST369

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Macular dystrophy, corneal (MCD)17 Publications
The disease is caused by mutations affecting the gene represented in this entry. CHST6 homozygous missense mutations have been observed in patients with macular corneal dystrophy type I, while type II patients show a large deletion and replacement in the upstream region of CHST6. The only missense mutation for type II is Cys-50, which is heterozygous with a replacement in the upstream region on the other allele of CHST6.
Disease descriptionAn ocular disease characterized by bilateral, progressive corneal opacification, and reduced corneal sensitivity. Onset occurs in the first decade, usually between ages 5 and 9. Painful attacks with photophobia, foreign body sensations, and recurrent erosions occur in most patients. The disease is due to deposition of an unsulfated keratan sulfate both within the intracellular space (within the keratocytes and endothelial cells) and in the extracellular corneal stroma. Macular corneal dystrophy is divided into the clinically indistinguishable types I, IA, and II based on analysis of the normally sulfated, or antigenic, keratan sulfate levels in serum and immunohistochemical evaluation of the cornea. Patients with types I and IA macular corneal dystrophy have undetectable serum levels of antigenic keratan sulfate, whereas those with type II macular corneal dystrophy have normal or low levels, depending on the population examined.
See also OMIM:217800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02141715L → P in MCD. 1 Publication1
Natural variantiVAR_02141822L → R in MCD. 1 PublicationCorresponds to variant dbSNP:rs68043642Ensembl.1
Natural variantiVAR_02141931P → S in MCD. 1 PublicationCorresponds to variant dbSNP:rs72547549Ensembl.1
Natural variantiVAR_02142042H → Y in MCD. 1 Publication1
Natural variantiVAR_02142150R → C in MCD; abolishes ability to sulfate keratan. 2 PublicationsCorresponds to variant dbSNP:rs28937877EnsemblClinVar.1
Natural variantiVAR_02142251S → L in MCD. 2 PublicationsCorresponds to variant dbSNP:rs370335460Ensembl.1
Natural variantiVAR_02142352G → D in MCD. 1 Publication1
Natural variantiVAR_02142453S → L in MCD. 2 Publications1
Natural variantiVAR_02142559L → P in MCD. 1 Publication1
Natural variantiVAR_02142661N → T in MCD. 1 PublicationCorresponds to variant dbSNP:rs72547548Ensembl.1
Natural variantiVAR_02142766V → L in MCD. 1 PublicationCorresponds to variant dbSNP:rs72547547Ensembl.1
Natural variantiVAR_02142868Y → H in MCD. 1 PublicationCorresponds to variant dbSNP:rs775742450Ensembl.1
Natural variantiVAR_02142970M → L in MCD. 1 Publication1
Natural variantiVAR_02143072P → S in MCD. 2 PublicationsCorresponds to variant dbSNP:rs377617168Ensembl.1
Natural variantiVAR_02143176V → M in MCD. 1 Publication1
Natural variantiVAR_02143293R → H in MCD. 1 Publication1
Natural variantiVAR_02143397R → P in MCD. 1 PublicationCorresponds to variant dbSNP:rs72547546Ensembl.1
Natural variantiVAR_02143498S → W in MCD. 1 Publication1
Natural variantiVAR_021435102C → G in MCD. 3 PublicationsCorresponds to variant dbSNP:rs121917822EnsemblClinVar.1
Natural variantiVAR_021436102C → Y in MCD. 1 Publication1
Natural variantiVAR_021437104M → V in MCD. 1 Publication1
Natural variantiVAR_021438107F → S in MCD. 2 PublicationsCorresponds to variant dbSNP:rs72547545Ensembl.1
Natural variantiVAR_021439110Y → C in MCD. 1 PublicationCorresponds to variant dbSNP:rs72547544EnsemblClinVar.1
Natural variantiVAR_075522118S → F in MCD; unknown pathological significance. 1 Publication1
Natural variantiVAR_021440121F → L in MCD. 1 PublicationCorresponds to variant dbSNP:rs1265310255Ensembl.1
Natural variantiVAR_021441122Q → P in MCD. 1 PublicationCorresponds to variant dbSNP:rs758105699Ensembl.1
Natural variantiVAR_021442127R → C in MCD. 1 Publication1
Natural variantiVAR_021443128A → V in MCD. 1 PublicationCorresponds to variant dbSNP:rs72547543Ensembl.1
Natural variantiVAR_021444131S → P in MCD. 1 Publication1
Natural variantiVAR_021445152L → P in MCD. 1 PublicationCorresponds to variant dbSNP:rs142954809Ensembl.1
Natural variantiVAR_021446162R → G in MCD. 1 PublicationCorresponds to variant dbSNP:rs117435647EnsemblClinVar.1
Natural variantiVAR_021447166R → P in MCD. 2 PublicationsCorresponds to variant dbSNP:rs72547542Ensembl.1
Natural variantiVAR_021448174K → R in MCD; abolishes ability to sulfate keratan. 3 PublicationsCorresponds to variant dbSNP:rs28937877EnsemblClinVar.1
Natural variantiVAR_075523177R → G in MCD. 1 Publication1
Natural variantiVAR_021449177R → H in MCD. 1 Publication1
Natural variantiVAR_075524186P → R in MCD. 2 PublicationsCorresponds to variant dbSNP:rs376162109Ensembl.1
Natural variantiVAR_021450198V → E in MCD. 1 Publication1
Natural variantiVAR_021451200L → R in MCD. 5 PublicationsCorresponds to variant dbSNP:rs28937879EnsemblClinVar.1
Natural variantiVAR_021452202R → S in MCD. 1 Publication1
Natural variantiVAR_021453203D → E in MCD; abolishes ability to sulfate keratan. 2 PublicationsCorresponds to variant dbSNP:rs28937878EnsemblClinVar.1
Natural variantiVAR_021454204P → Q in MCD. 3 PublicationsCorresponds to variant dbSNP:rs759870075Ensembl.1
Natural variantiVAR_021455205R → L in MCD. 1 Publication1
Natural variantiVAR_021456205R → Q in MCD. 1 PublicationCorresponds to variant dbSNP:rs377706989Ensembl.1
Natural variantiVAR_075525205R → W in MCD. 2 PublicationsCorresponds to variant dbSNP:rs750219546Ensembl.1
Natural variantiVAR_021457206A → T in MCD. 1 PublicationCorresponds to variant dbSNP:rs374493344Ensembl.1
Natural variantiVAR_021458206A → V in MCD. 1 Publication1
Natural variantiVAR_021459210S → F in MCD. 1 PublicationCorresponds to variant dbSNP:rs745571211Ensembl.1
Natural variantiVAR_021460211R → Q in MCD. 3 PublicationsCorresponds to variant dbSNP:rs771397083Ensembl.1
Natural variantiVAR_021461211R → W in MCD; abolishes ability to sulfate keratan. 3 PublicationsCorresponds to variant dbSNP:rs202175444Ensembl.1
Natural variantiVAR_021462217A → T in MCD; abolishes ability to sulfate keratan. 2 PublicationsCorresponds to variant dbSNP:rs752785520Ensembl.1
Natural variantiVAR_021463221D → E in MCD. 1 Publication1
Natural variantiVAR_021464221D → Y in MCD. 1 Publication1
Natural variantiVAR_021465249H → P in MCD. 1 PublicationCorresponds to variant dbSNP:rs72547540Ensembl.1
Natural variantiVAR_021466268Y → C in MCD. 1 PublicationCorresponds to variant dbSNP:rs72547539Ensembl.1
Natural variantiVAR_021467274E → K in MCD; abolishes ability to sulfate keratan. 4 PublicationsCorresponds to variant dbSNP:rs72547538Ensembl.1
Natural variantiVAR_021468276L → P in MCD. 2 PublicationsCorresponds to variant dbSNP:rs121917824EnsemblClinVar.1
Natural variantiVAR_075526308H → Y in MCD; unknown pathological significance. 1 Publication1
Natural variantiVAR_021469358Y → D in MCD. 1 Publication1
Natural variantiVAR_075527358Y → H in MCD. 2 PublicationsCorresponds to variant dbSNP:rs1384294258Ensembl.1

Keywords - Diseasei

Corneal dystrophy, Disease mutation

Organism-specific databases

DisGeNETi4166
MalaCardsiCHST6
MIMi217800 phenotype
OpenTargetsiENSG00000183196
Orphaneti98969 Macular corneal dystrophy
PharmGKBiPA26506

Polymorphism and mutation databases

BioMutaiCHST6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000851971 – 395Carbohydrate sulfotransferase 6Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9GZX3
PaxDbiQ9GZX3
PeptideAtlasiQ9GZX3
PRIDEiQ9GZX3
ProteomicsDBi80165

PTM databases

iPTMnetiQ9GZX3
PhosphoSitePlusiQ9GZX3

Expressioni

Tissue specificityi

Expressed in cornea. Mainly expressed in brain. Also expressed in spinal cord and trachea.3 Publications

Gene expression databases

BgeeiENSG00000183196 Expressed in 111 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_CHST6
GenevisibleiQ9GZX3 HS

Interactioni

Protein-protein interaction databases

BioGridi110334, 14 interactors
STRINGi9606.ENSP00000328983

Structurei

3D structure databases

ProteinModelPortaliQ9GZX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJXD Eukaryota
ENOG4110V0B LUCA
GeneTreeiENSGT00530000062902
HOGENOMiHOG000261614
HOVERGENiHBG050949
InParanoidiQ9GZX3
KOiK09671
OMAiKPLCARQ
OrthoDBiEOG091G0V3Y
PhylomeDBiQ9GZX3
TreeFamiTF342871

Family and domain databases

InterProiView protein in InterPro
IPR016469 Carbohydrate_sulfotransferase
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom
PfamiView protein in Pfam
PF00685 Sulfotransfer_1, 1 hit
PIRSFiPIRSF005883 Carbohydrate_sulfotransferase, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q9GZX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLPRVSSTA VTALLLAQTF LLLFLVSRPG PSSPAGGEAR VHVLVLSSWR
60 70 80 90 100
SGSSFVGQLF NQHPDVFYLM EPAWHVWTTL SQGSAATLHM AVRDLVRSVF
110 120 130 140 150
LCDMDVFDAY LPWRRNLSDL FQWAVSRALC SPPACSAFPR GAISSEAVCK
160 170 180 190 200
PLCARQSFTL AREACRSYSH VVLKEVRFFN LQVLYPLLSD PALNLRIVHL
210 220 230 240 250
VRDPRAVLRS REQTAKALAR DNGIVLGTNG TWVEADPGLR VVREVCRSHV
260 270 280 290 300
RIAEAATLKP PPFLRGRYRL VRFEDLAREP LAEIRALYAF TGLSLTPQLE
310 320 330 340 350
AWIHNITHGS GPGARREAFK TSSRNALNVS QAWRHALPFA KIRRVQELCA
360 370 380 390
GALQLLGYRP VYSEDEQRNL ALDLVLPRGL NGFTWASSTA SHPRN
Length:395
Mass (Da):44,099
Last modified:March 1, 2001 - v1
Checksum:i433CA60248A48F67
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02141715L → P in MCD. 1 Publication1
Natural variantiVAR_02141822L → R in MCD. 1 PublicationCorresponds to variant dbSNP:rs68043642Ensembl.1
Natural variantiVAR_02141931P → S in MCD. 1 PublicationCorresponds to variant dbSNP:rs72547549Ensembl.1
Natural variantiVAR_02142042H → Y in MCD. 1 Publication1
Natural variantiVAR_02142150R → C in MCD; abolishes ability to sulfate keratan. 2 PublicationsCorresponds to variant dbSNP:rs28937877EnsemblClinVar.1
Natural variantiVAR_02142251S → L in MCD. 2 PublicationsCorresponds to variant dbSNP:rs370335460Ensembl.1
Natural variantiVAR_02142352G → D in MCD. 1 Publication1
Natural variantiVAR_02142453S → L in MCD. 2 Publications1
Natural variantiVAR_02142559L → P in MCD. 1 Publication1
Natural variantiVAR_02142661N → T in MCD. 1 PublicationCorresponds to variant dbSNP:rs72547548Ensembl.1
Natural variantiVAR_02142766V → L in MCD. 1 PublicationCorresponds to variant dbSNP:rs72547547Ensembl.1
Natural variantiVAR_02142868Y → H in MCD. 1 PublicationCorresponds to variant dbSNP:rs775742450Ensembl.1
Natural variantiVAR_02142970M → L in MCD. 1 Publication1
Natural variantiVAR_02143072P → S in MCD. 2 PublicationsCorresponds to variant dbSNP:rs377617168Ensembl.1
Natural variantiVAR_02143176V → M in MCD. 1 Publication1
Natural variantiVAR_02143293R → H in MCD. 1 Publication1
Natural variantiVAR_02143397R → P in MCD. 1 PublicationCorresponds to variant dbSNP:rs72547546Ensembl.1
Natural variantiVAR_02143498S → W in MCD. 1 Publication1
Natural variantiVAR_021435102C → G in MCD. 3 PublicationsCorresponds to variant dbSNP:rs121917822EnsemblClinVar.1
Natural variantiVAR_021436102C → Y in MCD. 1 Publication1
Natural variantiVAR_021437104M → V in MCD. 1 Publication1
Natural variantiVAR_021438107F → S in MCD. 2 PublicationsCorresponds to variant dbSNP:rs72547545Ensembl.1
Natural variantiVAR_021439110Y → C in MCD. 1 PublicationCorresponds to variant dbSNP:rs72547544EnsemblClinVar.1
Natural variantiVAR_075522118S → F in MCD; unknown pathological significance. 1 Publication1
Natural variantiVAR_021440121F → L in MCD. 1 PublicationCorresponds to variant dbSNP:rs1265310255Ensembl.1
Natural variantiVAR_021441122Q → P in MCD. 1 PublicationCorresponds to variant dbSNP:rs758105699Ensembl.1
Natural variantiVAR_021442127R → C in MCD. 1 Publication1
Natural variantiVAR_021443128A → V in MCD. 1 PublicationCorresponds to variant dbSNP:rs72547543Ensembl.1
Natural variantiVAR_021444131S → P in MCD. 1 Publication1
Natural variantiVAR_021445152L → P in MCD. 1 PublicationCorresponds to variant dbSNP:rs142954809Ensembl.1
Natural variantiVAR_021446162R → G in MCD. 1 PublicationCorresponds to variant dbSNP:rs117435647EnsemblClinVar.1
Natural variantiVAR_021447166R → P in MCD. 2 PublicationsCorresponds to variant dbSNP:rs72547542Ensembl.1
Natural variantiVAR_021448174K → R in MCD; abolishes ability to sulfate keratan. 3 PublicationsCorresponds to variant dbSNP:rs28937877EnsemblClinVar.1
Natural variantiVAR_075523177R → G in MCD. 1 Publication1
Natural variantiVAR_021449177R → H in MCD. 1 Publication1
Natural variantiVAR_075524186P → R in MCD. 2 PublicationsCorresponds to variant dbSNP:rs376162109Ensembl.1
Natural variantiVAR_021450198V → E in MCD. 1 Publication1
Natural variantiVAR_021451200L → R in MCD. 5 PublicationsCorresponds to variant dbSNP:rs28937879EnsemblClinVar.1
Natural variantiVAR_021452202R → S in MCD. 1 Publication1
Natural variantiVAR_021453203D → E in MCD; abolishes ability to sulfate keratan. 2 PublicationsCorresponds to variant dbSNP:rs28937878EnsemblClinVar.1
Natural variantiVAR_021454204P → Q in MCD. 3 PublicationsCorresponds to variant dbSNP:rs759870075Ensembl.1
Natural variantiVAR_021455205R → L in MCD. 1 Publication1
Natural variantiVAR_021456205R → Q in MCD. 1 PublicationCorresponds to variant dbSNP:rs377706989Ensembl.1
Natural variantiVAR_075525205R → W in MCD. 2 PublicationsCorresponds to variant dbSNP:rs750219546Ensembl.1
Natural variantiVAR_021457206A → T in MCD. 1 PublicationCorresponds to variant dbSNP:rs374493344Ensembl.1
Natural variantiVAR_021458206A → V in MCD. 1 Publication1
Natural variantiVAR_021459210S → F in MCD. 1 PublicationCorresponds to variant dbSNP:rs745571211Ensembl.1
Natural variantiVAR_021460211R → Q in MCD. 3 PublicationsCorresponds to variant dbSNP:rs771397083Ensembl.1
Natural variantiVAR_021461211R → W in MCD; abolishes ability to sulfate keratan. 3 PublicationsCorresponds to variant dbSNP:rs202175444Ensembl.1
Natural variantiVAR_021462217A → T in MCD; abolishes ability to sulfate keratan. 2 PublicationsCorresponds to variant dbSNP:rs752785520Ensembl.1
Natural variantiVAR_021463221D → E in MCD. 1 Publication1
Natural variantiVAR_021464221D → Y in MCD. 1 Publication1
Natural variantiVAR_021465249H → P in MCD. 1 PublicationCorresponds to variant dbSNP:rs72547540Ensembl.1
Natural variantiVAR_021466268Y → C in MCD. 1 PublicationCorresponds to variant dbSNP:rs72547539Ensembl.1
Natural variantiVAR_021467274E → K in MCD; abolishes ability to sulfate keratan. 4 PublicationsCorresponds to variant dbSNP:rs72547538Ensembl.1
Natural variantiVAR_021468276L → P in MCD. 2 PublicationsCorresponds to variant dbSNP:rs121917824EnsemblClinVar.1
Natural variantiVAR_075526308H → Y in MCD; unknown pathological significance. 1 Publication1
Natural variantiVAR_021469358Y → D in MCD. 1 Publication1
Natural variantiVAR_075527358Y → H in MCD. 2 PublicationsCorresponds to variant dbSNP:rs1384294258Ensembl.1
Natural variantiVAR_033735369N → D. Corresponds to variant dbSNP:rs35036798Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF219990 mRNA Translation: AAG26325.1
AF219991 Genomic DNA Translation: AAG26327.1
AF280086 mRNA Translation: AAG48244.1
CH471114 Genomic DNA Translation: EAW95640.1
CH471114 Genomic DNA Translation: EAW95641.1
BC074883 mRNA Translation: AAH74883.1
BC074834 mRNA Translation: AAH74834.1
CCDSiCCDS10918.1
RefSeqiNP_067628.1, NM_021615.4
XP_005256012.1, XM_005255955.4
XP_011521387.1, XM_011523085.2
UniGeneiHs.655622
Hs.678406

Genome annotation databases

EnsembliENST00000332272; ENSP00000328983; ENSG00000183196
ENST00000390664; ENSP00000375079; ENSG00000183196
GeneIDi4166
KEGGihsa:4166
UCSCiuc002fef.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF219990 mRNA Translation: AAG26325.1
AF219991 Genomic DNA Translation: AAG26327.1
AF280086 mRNA Translation: AAG48244.1
CH471114 Genomic DNA Translation: EAW95640.1
CH471114 Genomic DNA Translation: EAW95641.1
BC074883 mRNA Translation: AAH74883.1
BC074834 mRNA Translation: AAH74834.1
CCDSiCCDS10918.1
RefSeqiNP_067628.1, NM_021615.4
XP_005256012.1, XM_005255955.4
XP_011521387.1, XM_011523085.2
UniGeneiHs.655622
Hs.678406

3D structure databases

ProteinModelPortaliQ9GZX3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110334, 14 interactors
STRINGi9606.ENSP00000328983

PTM databases

iPTMnetiQ9GZX3
PhosphoSitePlusiQ9GZX3

Polymorphism and mutation databases

BioMutaiCHST6

Proteomic databases

EPDiQ9GZX3
PaxDbiQ9GZX3
PeptideAtlasiQ9GZX3
PRIDEiQ9GZX3
ProteomicsDBi80165

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332272; ENSP00000328983; ENSG00000183196
ENST00000390664; ENSP00000375079; ENSG00000183196
GeneIDi4166
KEGGihsa:4166
UCSCiuc002fef.4 human

Organism-specific databases

CTDi4166
DisGeNETi4166
EuPathDBiHostDB:ENSG00000183196.8
GeneCardsiCHST6
HGNCiHGNC:6938 CHST6
MalaCardsiCHST6
MIMi217800 phenotype
605294 gene
neXtProtiNX_Q9GZX3
OpenTargetsiENSG00000183196
Orphaneti98969 Macular corneal dystrophy
PharmGKBiPA26506
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJXD Eukaryota
ENOG4110V0B LUCA
GeneTreeiENSGT00530000062902
HOGENOMiHOG000261614
HOVERGENiHBG050949
InParanoidiQ9GZX3
KOiK09671
OMAiKPLCARQ
OrthoDBiEOG091G0V3Y
PhylomeDBiQ9GZX3
TreeFamiTF342871

Enzyme and pathway databases

ReactomeiR-HSA-2022854 Keratan sulfate biosynthesis
R-HSA-3656225 Defective CHST6 causes MCDC1

Miscellaneous databases

ChiTaRSiCHST6 human
GeneWikiiCHST6
GenomeRNAii4166
PROiPR:Q9GZX3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183196 Expressed in 111 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_CHST6
GenevisibleiQ9GZX3 HS

Family and domain databases

InterProiView protein in InterPro
IPR016469 Carbohydrate_sulfotransferase
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom
PfamiView protein in Pfam
PF00685 Sulfotransfer_1, 1 hit
PIRSFiPIRSF005883 Carbohydrate_sulfotransferase, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCHST6_HUMAN
AccessioniPrimary (citable) accession number: Q9GZX3
Secondary accession number(s): D3DUK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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