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Protein

Membrane-spanning 4-domains subfamily A member 7

Gene

MS4A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in signal transduction as a component of a multimeric receptor complex.

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 7
Alternative name(s):
CD20 antigen-like 4
CD20/FC-epsilon-RI-beta family member 4
Four-span transmembrane protein 2
Gene namesi
Name:MS4A7
Synonyms:4SPAN2, CD20L4, CFFM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166927.12
HGNCiHGNC:13378 MS4A7
MIMi606502 gene
neXtProtiNX_Q9GZW8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47CytoplasmicSequence analysisAdd BLAST47
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 83ExtracellularSequence analysisAdd BLAST15
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 121CytoplasmicSequence analysisAdd BLAST17
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 178ExtracellularSequence analysisAdd BLAST36
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 240CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi58475
OpenTargetsiENSG00000166927
PharmGKBiPA31124

Polymorphism and mutation databases

BioMutaiMS4A7
DMDMi29611829

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586431 – 240Membrane-spanning 4-domains subfamily A member 7Add BLAST240

Proteomic databases

PaxDbiQ9GZW8
PRIDEiQ9GZW8
ProteomicsDBi80163
80164 [Q9GZW8-2]

PTM databases

iPTMnetiQ9GZW8
PhosphoSitePlusiQ9GZW8

Expressioni

Tissue specificityi

Ubiquitous expression in normal tissues. Expression is more elevated in adult liver, lung, spleen, and heart than in their fetal counterparts, and is higher in normal tissues than in the cancerous tissue or cell lines. Low levels of expression were detected in the promonocytic stage, whereas high levels of expression were detected in mature monocytes.

Gene expression databases

BgeeiENSG00000166927 Expressed in 151 organ(s), highest expression level in spleen
CleanExiHS_MS4A7
ExpressionAtlasiQ9GZW8 baseline and differential
GenevisibleiQ9GZW8 HS

Organism-specific databases

HPAiCAB026387
HPA017418

Interactioni

Protein-protein interaction databases

BioGridi121808, 3 interactors
IntActiQ9GZW8, 10 interactors
STRINGi9606.ENSP00000300184

Structurei

3D structure databases

ProteinModelPortaliQ9GZW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKSY Eukaryota
ENOG4111578 LUCA
GeneTreeiENSGT00510000047037
HOGENOMiHOG000293396
HOVERGENiHBG052387
InParanoidiQ9GZW8
KOiK22191
OMAiQILCCLM
OrthoDBiEOG091G0IBB
PhylomeDBiQ9GZW8
TreeFamiTF335157

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030423 MS4A7
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF8 PTHR23320:SF8, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9GZW8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLQSQTMGV SHSFTPKGIT IPQREKPGHM YQNEDYLQNG LPTETTVLGT
60 70 80 90 100
VQILCCLLIS SLGAILVFAP YPSHFNPAIS TTLMSGYPFL GALCFGITGS
110 120 130 140 150
LSIISGKQST KPFDLSSLTS NAVSSVTAGA GLFLLADSMV ALRTASQHCG
160 170 180 190 200
SEMDYLSSLP YSEYYYPIYE IKDCLLTSVS LTGVLVVMLI FTVLELLLAA
210 220 230 240
YSSVFWWKQL YSNNPGSSFS STQSQDHIQQ VKKSSSRSWI
Length:240
Mass (Da):26,131
Last modified:March 1, 2001 - v1
Checksum:i512BC9C126C76DC0
GO
Isoform 2 (identifier: Q9GZW8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     50-94: Missing.

Note: No experimental confirmation available.
Show »
Length:195
Mass (Da):21,404
Checksum:i4AF51AD87DF2A74B
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PN40E9PN40_HUMAN
Membrane-spanning 4-domains subfami...
MS4A7
161Annotation score:
E9PM26E9PM26_HUMAN
Membrane-spanning 4-domains subfami...
MS4A7
98Annotation score:
E9PIV6E9PIV6_HUMAN
Membrane-spanning 4-domains subfami...
MS4A7
169Annotation score:
E9PL98E9PL98_HUMAN
Membrane-spanning 4-domains subfami...
MS4A7
39Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05352034E → K. Corresponds to variant dbSNP:rs2233241Ensembl.1
Natural variantiVAR_053521112P → H. Corresponds to variant dbSNP:rs2233249Ensembl.1
Natural variantiVAR_053522157S → F. Corresponds to variant dbSNP:rs2233251Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04200950 – 94Missing in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026043 mRNA Translation: BAB18755.1
AF309653 mRNA Translation: AAG30930.1
AF237916 mRNA Translation: AAK37599.1
AF350501 mRNA Translation: AAL56221.1
AF201951 mRNA Translation: AAF17243.1
AK075106 mRNA Translation: BAC11405.1
AK297027 mRNA Translation: BAG59556.1
CR457187 mRNA Translation: CAG33468.1
AP003127 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73878.1
CH471076 Genomic DNA Translation: EAW73879.1
BC020673 mRNA Translation: AAH20673.1
CCDSiCCDS7985.1 [Q9GZW8-1]
CCDS7986.1 [Q9GZW8-2]
RefSeqiNP_067024.1, NM_021201.4 [Q9GZW8-1]
NP_996821.1, NM_206938.1 [Q9GZW8-2]
NP_996822.1, NM_206939.1 [Q9GZW8-1]
NP_996823.1, NM_206940.1 [Q9GZW8-2]
UniGeneiHs.530735

Genome annotation databases

EnsembliENST00000300184; ENSP00000300184; ENSG00000166927 [Q9GZW8-1]
ENST00000358246; ENSP00000350983; ENSG00000166927 [Q9GZW8-2]
ENST00000534016; ENSP00000434637; ENSG00000166927 [Q9GZW8-2]
GeneIDi58475
KEGGihsa:58475
UCSCiuc001npf.4 human [Q9GZW8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026043 mRNA Translation: BAB18755.1
AF309653 mRNA Translation: AAG30930.1
AF237916 mRNA Translation: AAK37599.1
AF350501 mRNA Translation: AAL56221.1
AF201951 mRNA Translation: AAF17243.1
AK075106 mRNA Translation: BAC11405.1
AK297027 mRNA Translation: BAG59556.1
CR457187 mRNA Translation: CAG33468.1
AP003127 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73878.1
CH471076 Genomic DNA Translation: EAW73879.1
BC020673 mRNA Translation: AAH20673.1
CCDSiCCDS7985.1 [Q9GZW8-1]
CCDS7986.1 [Q9GZW8-2]
RefSeqiNP_067024.1, NM_021201.4 [Q9GZW8-1]
NP_996821.1, NM_206938.1 [Q9GZW8-2]
NP_996822.1, NM_206939.1 [Q9GZW8-1]
NP_996823.1, NM_206940.1 [Q9GZW8-2]
UniGeneiHs.530735

3D structure databases

ProteinModelPortaliQ9GZW8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121808, 3 interactors
IntActiQ9GZW8, 10 interactors
STRINGi9606.ENSP00000300184

PTM databases

iPTMnetiQ9GZW8
PhosphoSitePlusiQ9GZW8

Polymorphism and mutation databases

BioMutaiMS4A7
DMDMi29611829

Proteomic databases

PaxDbiQ9GZW8
PRIDEiQ9GZW8
ProteomicsDBi80163
80164 [Q9GZW8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300184; ENSP00000300184; ENSG00000166927 [Q9GZW8-1]
ENST00000358246; ENSP00000350983; ENSG00000166927 [Q9GZW8-2]
ENST00000534016; ENSP00000434637; ENSG00000166927 [Q9GZW8-2]
GeneIDi58475
KEGGihsa:58475
UCSCiuc001npf.4 human [Q9GZW8-1]

Organism-specific databases

CTDi58475
DisGeNETi58475
EuPathDBiHostDB:ENSG00000166927.12
GeneCardsiMS4A7
HGNCiHGNC:13378 MS4A7
HPAiCAB026387
HPA017418
MIMi606502 gene
neXtProtiNX_Q9GZW8
OpenTargetsiENSG00000166927
PharmGKBiPA31124
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKSY Eukaryota
ENOG4111578 LUCA
GeneTreeiENSGT00510000047037
HOGENOMiHOG000293396
HOVERGENiHBG052387
InParanoidiQ9GZW8
KOiK22191
OMAiQILCCLM
OrthoDBiEOG091G0IBB
PhylomeDBiQ9GZW8
TreeFamiTF335157

Miscellaneous databases

ChiTaRSiMS4A7 human
GeneWikiiMS4A7
GenomeRNAii58475
PROiPR:Q9GZW8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166927 Expressed in 151 organ(s), highest expression level in spleen
CleanExiHS_MS4A7
ExpressionAtlasiQ9GZW8 baseline and differential
GenevisibleiQ9GZW8 HS

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030423 MS4A7
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF8 PTHR23320:SF8, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMS4A7_HUMAN
AccessioniPrimary (citable) accession number: Q9GZW8
Secondary accession number(s): A6NP53, Q6IAG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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