UniProtKB - Q9GZV9 (FGF23_HUMAN)
Protein
Fibroblast growth factor 23
Gene
FGF23
Organism
Homo sapiens (Human)
Status
Functioni
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.By similarity5 Publications
GO - Molecular functioni
- fibroblast growth factor receptor binding Source: GO_Central
- growth factor activity Source: GO_Central
- type 1 fibroblast growth factor receptor binding Source: GO_Central
GO - Biological processi
- animal organ morphogenesis Source: GO_Central
- cell differentiation Source: GO_Central
- cellular phosphate ion homeostasis Source: Ensembl
- cellular protein metabolic process Source: Reactome
- cellular response to interleukin-6 Source: Ensembl
- cellular response to leptin stimulus Source: Ensembl
- cellular response to parathyroid hormone stimulus Source: Ensembl
- cellular response to vitamin D Source: Ensembl
- fibroblast growth factor receptor signaling pathway Source: GO_Central
- MAPK cascade Source: Reactome
- negative regulation of bone mineralization Source: UniProtKB
- negative regulation of hormone secretion Source: UniProtKB
- negative regulation of osteoblast differentiation Source: UniProtKB
- phosphate-containing compound metabolic process Source: Ensembl
- phosphate ion homeostasis Source: UniProtKB
- positive regulation of cell population proliferation Source: GO_Central
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of gene expression Source: GO_Central
- positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: Ensembl
- positive regulation of protein kinase B signaling Source: Reactome
- positive regulation of protein phosphorylation Source: GO_Central
- positive regulation of transcription, DNA-templated Source: Ensembl
- positive regulation of vitamin D 24-hydroxylase activity Source: UniProtKB
- post-translational protein modification Source: Reactome
- regulation of cell migration Source: GO_Central
- regulation of phosphate transport Source: UniProtKB
- response to magnesium ion Source: Ensembl
- response to sodium phosphate Source: Ensembl
- vitamin D catabolic process Source: UniProtKB
Keywordsi
Molecular function | Growth factor |
Biological process | Differentiation |
Enzyme and pathway databases
PathwayCommonsi | Q9GZV9 |
Reactomei | R-HSA-109704, PI3K Cascade R-HSA-1257604, PIP3 activates AKT signaling R-HSA-1839122, Signaling by activated point mutants of FGFR1 R-HSA-1839130, Signaling by activated point mutants of FGFR3 R-HSA-190322, FGFR4 ligand binding and activation R-HSA-190372, FGFR3c ligand binding and activation R-HSA-190373, FGFR1c ligand binding and activation R-HSA-190374, FGFR1c and Klotho ligand binding and activation R-HSA-190375, FGFR2c ligand binding and activation R-HSA-2033514, FGFR3 mutant receptor activation R-HSA-2033519, Activated point mutants of FGFR2 R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5654219, Phospholipase C-mediated cascade: FGFR1 R-HSA-5654221, Phospholipase C-mediated cascade, FGFR2 R-HSA-5654227, Phospholipase C-mediated cascade, FGFR3 R-HSA-5654228, Phospholipase C-mediated cascade, FGFR4 R-HSA-5654687, Downstream signaling of activated FGFR1 R-HSA-5654688, SHC-mediated cascade:FGFR1 R-HSA-5654689, PI-3K cascade:FGFR1 R-HSA-5654693, FRS-mediated FGFR1 signaling R-HSA-5654695, PI-3K cascade:FGFR2 R-HSA-5654699, SHC-mediated cascade:FGFR2 R-HSA-5654700, FRS-mediated FGFR2 signaling R-HSA-5654704, SHC-mediated cascade:FGFR3 R-HSA-5654706, FRS-mediated FGFR3 signaling R-HSA-5654710, PI-3K cascade:FGFR3 R-HSA-5654712, FRS-mediated FGFR4 signaling R-HSA-5654719, SHC-mediated cascade:FGFR4 R-HSA-5654720, PI-3K cascade:FGFR4 R-HSA-5654726, Negative regulation of FGFR1 signaling R-HSA-5654727, Negative regulation of FGFR2 signaling R-HSA-5654732, Negative regulation of FGFR3 signaling R-HSA-5654733, Negative regulation of FGFR4 signaling R-HSA-5655253, Signaling by FGFR2 in disease R-HSA-5655302, Signaling by FGFR1 in disease R-HSA-5658623, FGFRL1 modulation of FGFR1 signaling R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8853338, Signaling by FGFR3 point mutants in cancer R-HSA-8957275, Post-translational protein phosphorylation |
SIGNORi | Q9GZV9 |
Protein family/group databases
TCDBi | 1.A.108.1.2, the fibroblast growth factor 2 (fgf2) family |
Names & Taxonomyi
Protein namesi | Recommended name: Fibroblast growth factor 23Short name: FGF-23 Alternative name(s): Phosphatonin Tumor-derived hypophosphatemia-inducing factor Cleaved into the following 2 chains: |
Gene namesi | Name:FGF23 Synonyms:HYPF ORF Names:UNQ3027/PRO9828 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3680, FGF23 |
MIMi | 605380, gene |
neXtProti | NX_Q9GZV9 |
VEuPathDBi | HostDB:ENSG00000118972.1 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Note: Secretion is dependent on O-glycosylation.
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Golgi apparatus
- Golgi lumen Source: Reactome
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Hypophosphatemic rickets, autosomal dominant (ADHR)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disease characterized by isolated renal phosphate wasting, hypophosphatemia, and inappropriately normal 1,25-dihydroxyvitamin D3 (calcitriol) levels. Patients frequently present with bone pain, rickets, and tooth abscesses.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_010717 | 176 | R → Q in ADHR; partially resistant to cleavage by furin. 2 PublicationsCorresponds to variant dbSNP:rs104894347EnsemblClinVar. | 1 | |
Natural variantiVAR_010719 | 179 | R → Q in ADHR; C-terminal processing is abolished; reduced proteolysis by PHEX; resistant to cleavage by furin. 3 PublicationsCorresponds to variant dbSNP:rs193922702EnsemblClinVar. | 1 | |
Natural variantiVAR_010718 | 179 | R → W in ADHR; C-terminal processing is abolished. 1 PublicationCorresponds to variant dbSNP:rs28937882EnsemblClinVar. | 1 |
Tumoral calcinosis, hyperphosphatemic, familial, 2 (HFTC2)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of hyperphosphatemic tumoral calcinosis, a rare autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Some patients have recurrent, transient, painful swellings of the long bones associated with the radiographic findings of periosteal reaction and cortical hyperostosis and absence of skin involvement.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023831 | 71 | S → G in HFTC2; only the C-terminal fragment is secreted, whereas the intact protein is retained in the Golgi complex. 1 PublicationCorresponds to variant dbSNP:rs104894342EnsemblClinVar. | 1 | |
Natural variantiVAR_071711 | 96 | M → T in HFTC2. 1 PublicationCorresponds to variant dbSNP:rs104894343EnsemblClinVar. | 1 | |
Natural variantiVAR_071712 | 129 | S → F in HFTC2; full-length and N-terminal fragments are barely detectable, whereas a C-terminal fragment with the same molecular weight as that from wild-type can be detected. 1 PublicationCorresponds to variant dbSNP:rs104894344EnsemblClinVar. | 1 | |
Natural variantiVAR_071713 | 157 | F → L in HFTC2. 1 PublicationCorresponds to variant dbSNP:rs772964687Ensembl. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 8074 |
GeneReviewsi | FGF23 |
MalaCardsi | FGF23 |
MIMi | 193100, phenotype 617993, phenotype |
OpenTargetsi | ENSG00000118972 |
Orphaneti | 89937, Autosomal dominant hypophosphatemic rickets 306661, Familial hyperphosphatemic tumoral calcinosis/Hyperphosphatemic hyperostosis syndrome |
PharmGKBi | PA28119 |
Miscellaneous databases
Pharosi | Q9GZV9, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3713913 |
DrugCentrali | Q9GZV9 |
Genetic variation databases
BioMutai | FGF23 |
DMDMi | 13626688 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | 1 PublicationAdd BLAST | 24 | |
ChainiPRO_0000008998 | 25 – 251 | Fibroblast growth factor 23Add BLAST | 227 | |
ChainiPRO_0000352875 | 25 – 179 | Fibroblast growth factor 23 N-terminal peptideAdd BLAST | 155 | |
ChainiPRO_0000352876 | 180 – 251 | Fibroblast growth factor 23 C-terminal peptideAdd BLAST | 72 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 95 ↔ 113 | |||
Glycosylationi | 178 | O-linked (GalNAc) threonine1 Publication | 1 |
Post-translational modificationi
Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases.
O-glycosylated by GALT3. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 179 – 180 | Cleavage; by proprotein convertases | 2 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9GZV9 |
PeptideAtlasi | Q9GZV9 |
PRIDEi | Q9GZV9 |
ProteomicsDBi | 80160 |
PTM databases
GlyGeni | Q9GZV9, 1 site |
iPTMneti | Q9GZV9 |
PhosphoSitePlusi | Q9GZV9 |
Expressioni
Tissue specificityi
Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts).1 Publication
Gene expression databases
Bgeei | ENSG00000118972, Expressed in sural nerve and 35 other tissues |
Genevisiblei | Q9GZV9, HS |
Organism-specific databases
HPAi | ENSG00000118972, Tissue enhanced (blood, heart muscle, liver, urinary bladder) |
Interactioni
Subunit structurei
Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).
By similarityBinary interactionsi
Hide detailsQ9GZV9
With | #Exp. | IntAct |
---|---|---|
FGFR1 [P11362] | 2 | EBI-6594125,EBI-1028277 |
Kl [O35082] from Mus musculus. | 5 | EBI-6594125,EBI-1570828 |
GO - Molecular functioni
- fibroblast growth factor receptor binding Source: GO_Central
- growth factor activity Source: GO_Central
- type 1 fibroblast growth factor receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 113748, 3 interactors |
CORUMi | Q9GZV9 |
DIPi | DIP-58507N |
IntActi | Q9GZV9, 6 interactors |
STRINGi | 9606.ENSP00000237837 |
Miscellaneous databases
RNActi | Q9GZV9, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9GZV9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9GZV9 |
Family & Domainsi
Sequence similaritiesi
Belongs to the heparin-binding growth factors family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3885, Eukaryota |
GeneTreei | ENSGT00940000160821 |
HOGENOMi | CLU_094251_0_0_1 |
InParanoidi | Q9GZV9 |
OMAi | DDCLFNH |
OrthoDBi | 1345259at2759 |
PhylomeDBi | Q9GZV9 |
TreeFami | TF335872 |
Family and domain databases
CDDi | cd00058, FGF, 1 hit |
InterProi | View protein in InterPro IPR028304, FGF23 IPR002209, Fibroblast_GF_fam IPR008996, IL1/FGF |
PANTHERi | PTHR11486, PTHR11486, 1 hit PTHR11486:SF69, PTHR11486:SF69, 1 hit |
Pfami | View protein in Pfam PF00167, FGF, 1 hit |
SMARTi | View protein in SMART SM00442, FGF, 1 hit |
SUPFAMi | SSF50353, SSF50353, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9GZV9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGARLRLWV CALCSVCSMS VLRAYPNASP LLGSSWGGLI HLYTATARNS
60 70 80 90 100
YHLQIHKNGH VDGAPHQTIY SALMIRSEDA GFVVITGVMS RRYLCMDFRG
110 120 130 140 150
NIFGSHYFDP ENCRFQHQTL ENGYDVYHSP QYHFLVSLGR AKRAFLPGMN
160 170 180 190 200
PPPYSQFLSR RNEIPLIHFN TPIPRRHTRS AEDDSERDPL NVLKPRARMT
210 220 230 240 250
PAPASCSQEL PSAEDNSPMA SDPLGVVRGG RVNTHAGGTG PEGCRPFAKF
I
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023831 | 71 | S → G in HFTC2; only the C-terminal fragment is secreted, whereas the intact protein is retained in the Golgi complex. 1 PublicationCorresponds to variant dbSNP:rs104894342EnsemblClinVar. | 1 | |
Natural variantiVAR_071711 | 96 | M → T in HFTC2. 1 PublicationCorresponds to variant dbSNP:rs104894343EnsemblClinVar. | 1 | |
Natural variantiVAR_071712 | 129 | S → F in HFTC2; full-length and N-terminal fragments are barely detectable, whereas a C-terminal fragment with the same molecular weight as that from wild-type can be detected. 1 PublicationCorresponds to variant dbSNP:rs104894344EnsemblClinVar. | 1 | |
Natural variantiVAR_071713 | 157 | F → L in HFTC2. 1 PublicationCorresponds to variant dbSNP:rs772964687Ensembl. | 1 | |
Natural variantiVAR_010717 | 176 | R → Q in ADHR; partially resistant to cleavage by furin. 2 PublicationsCorresponds to variant dbSNP:rs104894347EnsemblClinVar. | 1 | |
Natural variantiVAR_010719 | 179 | R → Q in ADHR; C-terminal processing is abolished; reduced proteolysis by PHEX; resistant to cleavage by furin. 3 PublicationsCorresponds to variant dbSNP:rs193922702EnsemblClinVar. | 1 | |
Natural variantiVAR_010718 | 179 | R → W in ADHR; C-terminal processing is abolished. 1 PublicationCorresponds to variant dbSNP:rs28937882EnsemblClinVar. | 1 | |
Natural variantiVAR_018887 | 195 | P → S1 PublicationCorresponds to variant dbSNP:rs13312793EnsemblClinVar. | 1 | |
Natural variantiVAR_010720 | 239 | T → M2 PublicationsCorresponds to variant dbSNP:rs7955866EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037973 mRNA Translation: BAB13477.1 AF263537 mRNA Translation: AAG09917.1 AB047858 mRNA Translation: BAB55889.1 AY358323 mRNA Translation: AAQ88689.1 AY566236 Genomic DNA Translation: AAS59157.1 BC069333 mRNA Translation: AAH69333.1 BC096713 mRNA Translation: AAH96713.1 BC098147 mRNA Translation: AAH98147.1 BC098252 mRNA Translation: AAH98252.1 |
CCDSi | CCDS8526.1 |
RefSeqi | NP_065689.1, NM_020638.2 |
Genome annotation databases
Ensembli | ENST00000237837; ENSP00000237837; ENSG00000118972 |
GeneIDi | 8074 |
KEGGi | hsa:8074 |
UCSCi | uc001qmq.1, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037973 mRNA Translation: BAB13477.1 AF263537 mRNA Translation: AAG09917.1 AB047858 mRNA Translation: BAB55889.1 AY358323 mRNA Translation: AAQ88689.1 AY566236 Genomic DNA Translation: AAS59157.1 BC069333 mRNA Translation: AAH69333.1 BC096713 mRNA Translation: AAH96713.1 BC098147 mRNA Translation: AAH98147.1 BC098252 mRNA Translation: AAH98252.1 |
CCDSi | CCDS8526.1 |
RefSeqi | NP_065689.1, NM_020638.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2P39 | X-ray | 1.50 | A | 25-179 | [»] | |
5W21 | X-ray | 3.00 | B | 25-204 | [»] | |
6S22 | X-ray | 1.96 | F | 170-181 | [»] | |
SMRi | Q9GZV9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113748, 3 interactors |
CORUMi | Q9GZV9 |
DIPi | DIP-58507N |
IntActi | Q9GZV9, 6 interactors |
STRINGi | 9606.ENSP00000237837 |
Chemistry databases
ChEMBLi | CHEMBL3713913 |
DrugCentrali | Q9GZV9 |
Protein family/group databases
TCDBi | 1.A.108.1.2, the fibroblast growth factor 2 (fgf2) family |
PTM databases
GlyGeni | Q9GZV9, 1 site |
iPTMneti | Q9GZV9 |
PhosphoSitePlusi | Q9GZV9 |
Genetic variation databases
BioMutai | FGF23 |
DMDMi | 13626688 |
Proteomic databases
PaxDbi | Q9GZV9 |
PeptideAtlasi | Q9GZV9 |
PRIDEi | Q9GZV9 |
ProteomicsDBi | 80160 |
Protocols and materials databases
ABCDi | Q9GZV9, 1 sequenced antibody |
Antibodypediai | 22263, 487 antibodies |
Genome annotation databases
Ensembli | ENST00000237837; ENSP00000237837; ENSG00000118972 |
GeneIDi | 8074 |
KEGGi | hsa:8074 |
UCSCi | uc001qmq.1, human |
Organism-specific databases
CTDi | 8074 |
DisGeNETi | 8074 |
GeneCardsi | FGF23 |
GeneReviewsi | FGF23 |
HGNCi | HGNC:3680, FGF23 |
HPAi | ENSG00000118972, Tissue enhanced (blood, heart muscle, liver, urinary bladder) |
MalaCardsi | FGF23 |
MIMi | 193100, phenotype 605380, gene 617993, phenotype |
neXtProti | NX_Q9GZV9 |
OpenTargetsi | ENSG00000118972 |
Orphaneti | 89937, Autosomal dominant hypophosphatemic rickets 306661, Familial hyperphosphatemic tumoral calcinosis/Hyperphosphatemic hyperostosis syndrome |
PharmGKBi | PA28119 |
VEuPathDBi | HostDB:ENSG00000118972.1 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3885, Eukaryota |
GeneTreei | ENSGT00940000160821 |
HOGENOMi | CLU_094251_0_0_1 |
InParanoidi | Q9GZV9 |
OMAi | DDCLFNH |
OrthoDBi | 1345259at2759 |
PhylomeDBi | Q9GZV9 |
TreeFami | TF335872 |
Enzyme and pathway databases
PathwayCommonsi | Q9GZV9 |
Reactomei | R-HSA-109704, PI3K Cascade R-HSA-1257604, PIP3 activates AKT signaling R-HSA-1839122, Signaling by activated point mutants of FGFR1 R-HSA-1839130, Signaling by activated point mutants of FGFR3 R-HSA-190322, FGFR4 ligand binding and activation R-HSA-190372, FGFR3c ligand binding and activation R-HSA-190373, FGFR1c ligand binding and activation R-HSA-190374, FGFR1c and Klotho ligand binding and activation R-HSA-190375, FGFR2c ligand binding and activation R-HSA-2033514, FGFR3 mutant receptor activation R-HSA-2033519, Activated point mutants of FGFR2 R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5654219, Phospholipase C-mediated cascade: FGFR1 R-HSA-5654221, Phospholipase C-mediated cascade, FGFR2 R-HSA-5654227, Phospholipase C-mediated cascade, FGFR3 R-HSA-5654228, Phospholipase C-mediated cascade, FGFR4 R-HSA-5654687, Downstream signaling of activated FGFR1 R-HSA-5654688, SHC-mediated cascade:FGFR1 R-HSA-5654689, PI-3K cascade:FGFR1 R-HSA-5654693, FRS-mediated FGFR1 signaling R-HSA-5654695, PI-3K cascade:FGFR2 R-HSA-5654699, SHC-mediated cascade:FGFR2 R-HSA-5654700, FRS-mediated FGFR2 signaling R-HSA-5654704, SHC-mediated cascade:FGFR3 R-HSA-5654706, FRS-mediated FGFR3 signaling R-HSA-5654710, PI-3K cascade:FGFR3 R-HSA-5654712, FRS-mediated FGFR4 signaling R-HSA-5654719, SHC-mediated cascade:FGFR4 R-HSA-5654720, PI-3K cascade:FGFR4 R-HSA-5654726, Negative regulation of FGFR1 signaling R-HSA-5654727, Negative regulation of FGFR2 signaling R-HSA-5654732, Negative regulation of FGFR3 signaling R-HSA-5654733, Negative regulation of FGFR4 signaling R-HSA-5655253, Signaling by FGFR2 in disease R-HSA-5655302, Signaling by FGFR1 in disease R-HSA-5658623, FGFRL1 modulation of FGFR1 signaling R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8853338, Signaling by FGFR3 point mutants in cancer R-HSA-8957275, Post-translational protein phosphorylation |
SIGNORi | Q9GZV9 |
Miscellaneous databases
BioGRID-ORCSi | 8074, 1 hit in 988 CRISPR screens |
EvolutionaryTracei | Q9GZV9 |
GeneWikii | Fibroblast_growth_factor_23 |
GenomeRNAii | 8074 |
Pharosi | Q9GZV9, Tbio |
PROi | PR:Q9GZV9 |
RNActi | Q9GZV9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000118972, Expressed in sural nerve and 35 other tissues |
Genevisiblei | Q9GZV9, HS |
Family and domain databases
CDDi | cd00058, FGF, 1 hit |
InterProi | View protein in InterPro IPR028304, FGF23 IPR002209, Fibroblast_GF_fam IPR008996, IL1/FGF |
PANTHERi | PTHR11486, PTHR11486, 1 hit PTHR11486:SF69, PTHR11486:SF69, 1 hit |
Pfami | View protein in Pfam PF00167, FGF, 1 hit |
SMARTi | View protein in SMART SM00442, FGF, 1 hit |
SUPFAMi | SSF50353, SSF50353, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FGF23_HUMAN | |
Accessioni | Q9GZV9Primary (citable) accession number: Q9GZV9 Secondary accession number(s): Q4V758 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 202 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families