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UniProtKB - Q9GZV8 (PRD14_HUMAN)

Entry version 183 (07 Apr 2021)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
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Protein

PR domain zinc finger protein 14

Gene

PRDM14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri400 – 424C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri432 – 455C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri461 – 483C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 540C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri546 – 568C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9GZV8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-452723, Transcriptional regulation of pluripotent stem cells

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9GZV8

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9GZV8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PR domain zinc finger protein 14 (EC:2.1.1.-)
Alternative name(s):
PR domain-containing protein 14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRDM14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14001, PRDM14

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611781, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9GZV8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000147596.3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		63978

Open Targets

More...OpenTargetsi		ENSG00000147596

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33712

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9GZV8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRDM14

Domain mapping of disease mutations (DMDM)

More...DMDMi		17368925

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000477711 – 571PR domain zinc finger protein 14Add BLAST571

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei79PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9GZV8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9GZV8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9GZV8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9GZV8

PeptideAtlas

More...PeptideAtlasi		Q9GZV8

PRoteomics IDEntifications database

More...PRIDEi		Q9GZV8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80159

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9GZV8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9GZV8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000147596, Expressed in buccal mucosa cell and 19 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9GZV8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9GZV8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000147596, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CBFA2T2.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9GZV8
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-3957793,EBI-11096309
AKAP9 - isoform 2 [Q99996-2]3EBI-3957793,EBI-9641546
AQP1 [P29972]3EBI-3957793,EBI-745213
ATPAF2 [Q8N5M1]10EBI-3957793,EBI-1166928
BAHD1 [Q8TBE0]3EBI-3957793,EBI-742750
BEX2 [Q9BXY8]3EBI-3957793,EBI-745073
CARD10 [Q9BWT7]3EBI-3957793,EBI-3866279
CBFA2T2 [O43439]10EBI-3957793,EBI-748628
CBFA2T2 - isoform 4 [O43439-4]6EBI-3957793,EBI-11954144
CDCA7L [Q96GN5]6EBI-3957793,EBI-5278764
CREB5 - isoform 3 [Q02930-3]3EBI-3957793,EBI-10192698
DMRT3 [Q9NQL9]3EBI-3957793,EBI-9679045
EIF4E2 [O60573]3EBI-3957793,EBI-398610
ENKD1 [Q9H0I2]3EBI-3957793,EBI-744099
FAM83A [Q86UY5]3EBI-3957793,EBI-1384254
GAS8 [O95995]3EBI-3957793,EBI-1052570
GEM [P55040]3EBI-3957793,EBI-744104
GLYCTK [Q8IVS8]3EBI-3957793,EBI-748515
GPATCH2L [Q9NWQ4]3EBI-3957793,EBI-5666657
GPATCH2L - isoform 2 [Q9NWQ4-1]3EBI-3957793,EBI-11959863
HEXIM2 [Q96MH2]4EBI-3957793,EBI-5460660
HOXB5 [P09067]3EBI-3957793,EBI-3893317
HOXC8 [P31273]3EBI-3957793,EBI-1752118
HSPB7 [Q9UBY9]3EBI-3957793,EBI-739361
KANK2 [Q63ZY3]3EBI-3957793,EBI-2556193
LNX1 [Q8TBB1]5EBI-3957793,EBI-739832
MIA3 - isoform 2 [Q5JRA6-2]3EBI-3957793,EBI-10244342
MRPL32 [Q9BYC8]3EBI-3957793,EBI-7825220
MYPOP [Q86VE0]3EBI-3957793,EBI-2858213
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-3957793,EBI-11022007
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-3957793,EBI-12000762
PRKAB2 [O43741]4EBI-3957793,EBI-1053424
PRPF31 [Q8WWY3]3EBI-3957793,EBI-1567797
PSMA1 [P25786]3EBI-3957793,EBI-359352
RAD51D [O75771]3EBI-3957793,EBI-1055693
RBM10 [P98175]6EBI-3957793,EBI-721525
RCOR3 [Q9P2K3]3EBI-3957793,EBI-743428
RUNX1T1 - isoform MTG8A [Q06455-2]6EBI-3957793,EBI-11984663
RUNX1T1 - isoform 4 [Q06455-4]3EBI-3957793,EBI-10224192
RUSC1 [Q9BVN2]3EBI-3957793,EBI-6257312
SCNM1 [Q9BWG6]5EBI-3957793,EBI-748391
SNRPC [P09234]3EBI-3957793,EBI-766589
TCAF1 - isoform 2 [Q9Y4C2-2]3EBI-3957793,EBI-11974855
TEAD4 [Q15561]3EBI-3957793,EBI-747736
TEKT4 [Q8WW24]6EBI-3957793,EBI-750487
TLE5 - isoform 2 [Q08117-2]5EBI-3957793,EBI-11741437
TRIM41 [Q8WV44]3EBI-3957793,EBI-725997
TSGA10 [Q9BZW7]3EBI-3957793,EBI-744794
TTC32 [Q5I0X7]3EBI-3957793,EBI-8636434
TXK [P42681]3EBI-3957793,EBI-7877438
USP2 [O75604]3EBI-3957793,EBI-743272
WDR25 - isoform 2 [Q64LD2-2]3EBI-3957793,EBI-12032042
ZNF250 - isoform 3 [P15622-3]3EBI-3957793,EBI-10177272
ZNF587 [Q96SQ5]3EBI-3957793,EBI-6427977
ZNF835 [Q9Y2P0]3EBI-3957793,EBI-5667516
Hoxa1 [P09022] from Mus musculus.3EBI-3957793,EBI-3957603

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122025, 79 interactors

Database of interacting proteins

More...DIPi		DIP-58143N

Protein interaction database and analysis system

More...IntActi		Q9GZV8, 79 interactors

Molecular INTeraction database

More...MINTi		Q9GZV8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000276594

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9GZV8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9GZV8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini251 – 367SETPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni194 – 384Interaction with CBFA2T2By similarityAdd BLAST191

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The first 5 zinc fingers, but not the last one, are required for DNA-binding and transcriptional activity.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri400 – 424C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri432 – 455C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri461 – 483C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri517 – 540C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri546 – 568C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159454

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_034551_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9GZV8

Identification of Orthologs from Complete Genome Data

More...OMAi		WYPIPHL

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9GZV8

TreeFam database of animal gene trees

More...TreeFami		TF106412

Family and domain databases

Conserved Domains Database

More...CDDi		cd19198, PR-SET_PRDM14, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR044408, PRDM14_PR-SET
IPR001214, SET_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00317, SET, 1 hit
SM00355, ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50280, SET, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9GZV8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPRPSEAV PQDKVCYPPE SSPQNLAAYY TPFPSYGHYR NSLATVEEDF 
        60         70         80         90        100
QPFRQLEAAA SAAPAMPPFP FRMAPPLLSP GLGLQREPLY DLPWYSKLPP 
       110        120        130        140        150
WYPIPHVPRE VPPFLSSSHE YAGASSEDLG HQIIGGDNES GPCCGPDTLI 
       160        170        180        190        200
PPPPADASLL PEGLRTSQLL PCSPSKQSED GPKPSNQEGK SPARFQFTEE 
       210        220        230        240        250
DLHFVLYGVT PSLEHPASLH HAISGLLVPP DSSGSDSLPQ TLDKDSLQLP 
       260        270        280        290        300
EGLCLMQTVF GEVPHFGVFC SSFIAKGVRF GPFQGKVVNA SEVKTYGDNS 
       310        320        330        340        350
VMWEIFEDGH LSHFIDGKGG TGNWMSYVNC ARFPKEQNLV AVQCQGHIFY 
       360        370        380        390        400
ESCKEIHQNQ ELLVWYGDCY EKFLDIPVSL QVTEPGKQPS GPSEESAEGY 
       410        420        430        440        450
RCERCGKVFT YKYYRDKHLK YTPCVDKGDR KFPCSLCKRS FEKRDRLRIH 
       460        470        480        490        500
ILHVHEKHRP HKCSTCGKCF SQSSSLNKHM RVHSGDRPYQ CVYCTKRFTA 
       510        520        530        540        550
SSILRTHIRQ HSGEKPFKCK YCGKSFASHA AHDSHVRRSH KEDDGCSCSI 
       560        570 
CGKIFSDQET FYSHMKFHED Y
Length:571
Mass (Da):64,062
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60D5ACC96DADE500
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JMM8C9JMM8_HUMAN
PR domain zinc finger protein 14
PRDM14
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021895244K → E1 PublicationCorresponds to variant dbSNP:rs3750228Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF319458 mRNA Translation: AAG39635.1
AK022595 mRNA Translation: BAB14120.1
BC052311 mRNA Translation: AAH52311.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6206.1

NCBI Reference Sequences

More...RefSeqi		NP_078780.1, NM_024504.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000276594; ENSP00000276594; ENSG00000147596

Database of genes from NCBI RefSeq genomes

More...GeneIDi		63978

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:63978

UCSC genome browser

More...UCSCi		uc003xym.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319458 mRNA Translation: AAG39635.1
AK022595 mRNA Translation: BAB14120.1
BC052311 mRNA Translation: AAH52311.1
CCDSiCCDS6206.1
RefSeqiNP_078780.1, NM_024504.3

3D structure databases

SMRiQ9GZV8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122025, 79 interactors
DIPiDIP-58143N
IntActiQ9GZV8, 79 interactors
MINTiQ9GZV8
STRINGi9606.ENSP00000276594

PTM databases

iPTMnetiQ9GZV8
PhosphoSitePlusiQ9GZV8

Genetic variation databases

BioMutaiPRDM14
DMDMi17368925

Proteomic databases

EPDiQ9GZV8
jPOSTiQ9GZV8
MassIVEiQ9GZV8
PaxDbiQ9GZV8
PeptideAtlasiQ9GZV8
PRIDEiQ9GZV8
ProteomicsDBi80159

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12206, 410 antibodies

The DNASU plasmid repository

More...DNASUi		63978

Genome annotation databases

EnsembliENST00000276594; ENSP00000276594; ENSG00000147596
GeneIDi63978
KEGGihsa:63978
UCSCiuc003xym.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		63978
DisGeNETi63978

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRDM14
HGNCiHGNC:14001, PRDM14
HPAiENSG00000147596, Tissue enhanced (testis)
MIMi611781, gene
neXtProtiNX_Q9GZV8
OpenTargetsiENSG00000147596
PharmGKBiPA33712
VEuPathDBiHostDB:ENSG00000147596.3

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000159454
HOGENOMiCLU_034551_1_0_1
InParanoidiQ9GZV8
OMAiWYPIPHL
OrthoDBi1318335at2759
PhylomeDBiQ9GZV8
TreeFamiTF106412

Enzyme and pathway databases

PathwayCommonsiQ9GZV8
ReactomeiR-HSA-452723, Transcriptional regulation of pluripotent stem cells
SignaLinkiQ9GZV8
SIGNORiQ9GZV8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		63978, 8 hits in 1005 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		63978
PharosiQ9GZV8, Tbio

Protein Ontology

More...PROi		PR:Q9GZV8
RNActiQ9GZV8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000147596, Expressed in buccal mucosa cell and 19 other tissues
ExpressionAtlasiQ9GZV8, baseline and differential
GenevisibleiQ9GZV8, HS

Family and domain databases

CDDicd19198, PR-SET_PRDM14, 1 hit
InterProiView protein in InterPro
IPR044408, PRDM14_PR-SET
IPR001214, SET_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00317, SET, 1 hit
SM00355, ZnF_C2H2, 6 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50280, SET, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRD14_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZV8
Secondary accession number(s): Q86UX9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: April 7, 2021
This is version 183 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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