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Protein

WW domain-containing transcription regulator protein 1

Gene

WWTR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2028269 Signaling by Hippo
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-5578768 Physiological factors
R-HSA-8940973 RUNX2 regulates osteoblast differentiation
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q9GZV5

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9GZV5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WW domain-containing transcription regulator protein 1
Alternative name(s):
Transcriptional coactivator with PDZ-binding motif
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WWTR1
Synonyms:TAZ
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000018408.14

Human Gene Nomenclature Database

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HGNCi
HGNC:24042 WWTR1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607392 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9GZV5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi51S → A or D: Loss of interaction with TEAD4. 1 Publication1
Mutagenesisi89S → A: Significant resistance to inhibition by STK3/MST2 and LATS2. 1 Publication1
Mutagenesisi311S → A: Partial resistance to inhibition by MST2 and LATS2. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

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DisGeNETi
25937

MalaCards human disease database

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MalaCardsi
WWTR1

Open Targets

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OpenTargetsi
ENSG00000018408

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
157791 Epithelioid hemangioendothelioma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134899667

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
WWTR1

Domain mapping of disease mutations (DMDM)

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DMDMi
67462080

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000760691 – 400WW domain-containing transcription regulator protein 1Add BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei62PhosphoserineCombined sources1
Modified residuei89Phosphoserine; by LATS21 Publication1
Modified residuei105PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei311Phosphoserine; by LATS21 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by LATS2 and STK3/MST2. Phosphorylation by LATS2 results in creation of 14-3-3 binding sites, retention in the cytoplasm, and functional inactivation. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9GZV5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9GZV5

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9GZV5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9GZV5

PeptideAtlas

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PeptideAtlasi
Q9GZV5

PRoteomics IDEntifications database

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PRIDEi
Q9GZV5

ProteomicsDB human proteome resource

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ProteomicsDBi
80157

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9GZV5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9GZV5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000018408 Expressed in 238 organ(s), highest expression level in pigmented layer of retina

CleanEx database of gene expression profiles

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CleanExi
HS_TAZ
HS_WWTR1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9GZV5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9GZV5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017483
CAB068248
HPA007415

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP (By similarity). Interacts (via coiled-coil domain) with SMAD2 (via MH1 domain), SMAD3 and SMAD4. Interacts with MED15, PAX8 and NKX2-1. Interacts with TEAD1, TEAD2, TEAD3 and TEAD4.By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117434, 27 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9GZV5

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9GZV5

Protein interaction database and analysis system

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IntActi
Q9GZV5, 41 interactors

Molecular INTeraction database

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MINTi
Q9GZV5

STRING: functional protein association networks

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STRINGi
9606.ENSP00000353847

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5N5RX-ray1.80P87-95[»]
5N5TX-ray1.80P87-94[»]
5N5WX-ray1.37P86-95[»]
5N75X-ray1.80P86-95[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9GZV5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9GZV5

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini124 – 157WWPROSITE-ProRule annotationAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili225 – 259Sequence analysisAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi394 – 400PDZ-binding7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi194 – 241Gln-richAdd BLAST48

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes (By similarity).By similarity
Binds to transcription factors via its WW domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410INUC Eukaryota
ENOG4111U1C LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00510000046760

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007854

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG002748

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9GZV5

KEGG Orthology (KO)

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KOi
K16820

Identification of Orthologs from Complete Genome Data

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OMAi
AMSQPNL

Database of Orthologous Groups

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OrthoDBi
1006566at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9GZV5

TreeFam database of animal gene trees

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TreeFami
TF326941

Family and domain databases

Conserved Domains Database

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CDDi
cd00201 WW, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001202 WW_dom
IPR036020 WW_dom_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00397 WW, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00456 WW, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF51045 SSF51045, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9GZV5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPASAPPPL PPPGQQVIHV TQDLDTDLEA LFNSVMNPKP SSWRKKILPE
60 70 80 90 100
SFFKEPDSGS HSRQSSTDSS GGHPGPRLAG GAQHVRSHSS PASLQLGTGA
110 120 130 140 150
GAAGSPAQQH AHLRQQSYDV TDELPLPPGW EMTFTATGQR YFLNHIEKIT
160 170 180 190 200
TWQDPRKAMN QPLNHMNLHP AVSSTPVPQR SMAVSQPNLV MNHQHQQQMA
210 220 230 240 250
PSTLSQQNHP TQNPPAGLMS MPNALTTQQQ QQQKLRLQRI QMERERIRMR
260 270 280 290 300
QEELMRQEAA LCRQLPMEAE TLAPVQAAVN PPTMTPDMRS ITNNSSDPFL
310 320 330 340 350
NGGPYHSREQ STDSGLGLGC YSVPTTPEDF LSNVDEMDTG ENAGQTPMNI
360 370 380 390 400
NPQQTRFPDF LDCLPGTNVD LGTLESEDLI PLFNDVESAL NKSEPFLTWL
Length:400
Mass (Da):44,101
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i630B50F46FB74C60
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J038C9J038_HUMAN
WW domain-containing transcription ...
WWTR1
189Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J337C9J337_HUMAN
WW domain-containing transcription ...
WWTR1
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JR84C9JR84_HUMAN
WW domain-containing transcription ...
WWTR1
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQS8C9JQS8_HUMAN
WW domain-containing transcription ...
WWTR1
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4Z7H7C4Z7_HUMAN
WW domain-containing transcription ...
WWTR1
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J588C9J588_HUMAN
WW domain-containing transcription ...
WWTR1
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4Q0H7C4Q0_HUMAN
WW domain-containing transcription ...
WWTR1
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ299431 mRNA Translation: CAC17722.1
AK022036 mRNA Translation: BAB13957.1
CH471052 Genomic DNA Translation: EAW78868.1
CH471052 Genomic DNA Translation: EAW78869.1
BC014052 mRNA Translation: AAH14052.1
AL050107 mRNA Translation: CAB43275.1
AL833852 mRNA Translation: CAD38711.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3144.1

Protein sequence database of the Protein Information Resource

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PIRi
T08755

NCBI Reference Sequences

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RefSeqi
NP_001161750.1, NM_001168278.2
NP_001161752.1, NM_001168280.2
NP_001335291.1, NM_001348362.1
NP_056287.1, NM_015472.5
XP_016861611.1, XM_017006122.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.477921

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000360632; ENSP00000353847; ENSG00000018408
ENST00000465804; ENSP00000419465; ENSG00000018408
ENST00000467467; ENSP00000419234; ENSG00000018408

Database of genes from NCBI RefSeq genomes

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GeneIDi
25937

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:25937

UCSC genome browser

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UCSCi
uc003exf.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ299431 mRNA Translation: CAC17722.1
AK022036 mRNA Translation: BAB13957.1
CH471052 Genomic DNA Translation: EAW78868.1
CH471052 Genomic DNA Translation: EAW78869.1
BC014052 mRNA Translation: AAH14052.1
AL050107 mRNA Translation: CAB43275.1
AL833852 mRNA Translation: CAD38711.1
CCDSiCCDS3144.1
PIRiT08755
RefSeqiNP_001161750.1, NM_001168278.2
NP_001161752.1, NM_001168280.2
NP_001335291.1, NM_001348362.1
NP_056287.1, NM_015472.5
XP_016861611.1, XM_017006122.1
UniGeneiHs.477921

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5N5RX-ray1.80P87-95[»]
5N5TX-ray1.80P87-94[»]
5N5WX-ray1.37P86-95[»]
5N75X-ray1.80P86-95[»]
ProteinModelPortaliQ9GZV5
SMRiQ9GZV5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117434, 27 interactors
CORUMiQ9GZV5
ELMiQ9GZV5
IntActiQ9GZV5, 41 interactors
MINTiQ9GZV5
STRINGi9606.ENSP00000353847

PTM databases

iPTMnetiQ9GZV5
PhosphoSitePlusiQ9GZV5

Polymorphism and mutation databases

BioMutaiWWTR1
DMDMi67462080

Proteomic databases

EPDiQ9GZV5
jPOSTiQ9GZV5
MaxQBiQ9GZV5
PaxDbiQ9GZV5
PeptideAtlasiQ9GZV5
PRIDEiQ9GZV5
ProteomicsDBi80157

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
25937
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360632; ENSP00000353847; ENSG00000018408
ENST00000465804; ENSP00000419465; ENSG00000018408
ENST00000467467; ENSP00000419234; ENSG00000018408
GeneIDi25937
KEGGihsa:25937
UCSCiuc003exf.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
25937
DisGeNETi25937
EuPathDBiHostDB:ENSG00000018408.14

GeneCards: human genes, protein and diseases

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GeneCardsi
WWTR1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0024313
HGNCiHGNC:24042 WWTR1
HPAiCAB017483
CAB068248
HPA007415
MalaCardsiWWTR1
MIMi607392 gene
neXtProtiNX_Q9GZV5
OpenTargetsiENSG00000018408
Orphaneti157791 Epithelioid hemangioendothelioma
PharmGKBiPA134899667

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410INUC Eukaryota
ENOG4111U1C LUCA
GeneTreeiENSGT00510000046760
HOGENOMiHOG000007854
HOVERGENiHBG002748
InParanoidiQ9GZV5
KOiK16820
OMAiAMSQPNL
OrthoDBi1006566at2759
PhylomeDBiQ9GZV5
TreeFamiTF326941

Enzyme and pathway databases

ReactomeiR-HSA-2028269 Signaling by Hippo
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-5578768 Physiological factors
R-HSA-8940973 RUNX2 regulates osteoblast differentiation
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription
SignaLinkiQ9GZV5
SIGNORiQ9GZV5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
WWTR1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
WWTR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25937

Protein Ontology

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PROi
PR:Q9GZV5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000018408 Expressed in 238 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_TAZ
HS_WWTR1
ExpressionAtlasiQ9GZV5 baseline and differential
GenevisibleiQ9GZV5 HS

Family and domain databases

CDDicd00201 WW, 1 hit
InterProiView protein in InterPro
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWWTR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZV5
Secondary accession number(s): D3DNH7, Q8N3P2, Q9Y3W6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2001
Last modified: January 16, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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