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Protein

Eukaryotic translation initiation factor 5A-2

Gene

EIF5A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionElongation factor, RNA-binding
Biological processmRNA transport, Protein biosynthesis, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204626 Hypusine synthesis from eIF5A-lysine

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 5A-2
Short name:
eIF-5A-2
Short name:
eIF-5A2
Alternative name(s):
Eukaryotic initiation factor 5A isoform 2
Gene namesi
Name:EIF5A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163577.7
HGNCiHGNC:3301 EIF5A2
MIMi605782 gene
neXtProtiNX_Q9GZV4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56648
OpenTargetsiENSG00000163577
PharmGKBiPA27727

Polymorphism and mutation databases

BioMutaiEIF5A2
DMDMi74762725

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002297642 – 153Eukaryotic translation initiation factor 5A-2Add BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei50Hypusine1 Publication1

Post-translational modificationi

eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).

Keywords - PTMi

Acetylation, Hypusine

Proteomic databases

EPDiQ9GZV4
MaxQBiQ9GZV4
PaxDbiQ9GZV4
PeptideAtlasiQ9GZV4
PRIDEiQ9GZV4
ProteomicsDBi80156

PTM databases

iPTMnetiQ9GZV4
PhosphoSitePlusiQ9GZV4
SwissPalmiQ9GZV4

Expressioni

Tissue specificityi

Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells.2 Publications

Gene expression databases

BgeeiENSG00000163577 Expressed in 167 organ(s), highest expression level in right testis
CleanExiHS_EIF5A2
ExpressionAtlasiQ9GZV4 baseline and differential
GenevisibleiQ9GZV4 HS

Organism-specific databases

HPAiHPA029090

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi121162, 29 interactors
IntActiQ9GZV4, 12 interactors
STRINGi9606.ENSP00000295822

Structurei

3D structure databases

ProteinModelPortaliQ9GZV4
SMRiQ9GZV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-5A family.Curated

Phylogenomic databases

eggNOGiKOG3271 Eukaryota
COG0231 LUCA
GeneTreeiENSGT00390000003738
HOGENOMiHOG000106270
HOVERGENiHBG001104
InParanoidiQ9GZV4
KOiK03263
OMAiMIRGRPC
OrthoDBiEOG091G0P2P
PhylomeDBiQ9GZV4
TreeFamiTF101534

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR001884 IF5A-like
IPR012340 NA-bd_OB-fold
IPR014722 Rib_L2_dom2
IPR019769 Trans_elong_IF5A_hypusine_site
IPR020189 Transl_elong_IF5A_C
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11673 PTHR11673, 1 hit
PfamiView protein in Pfam
PF01287 eIF-5a, 1 hit
PIRSFiPIRSF003025 eIF5A, 1 hit
SMARTiView protein in SMART
SM01376 eIF-5a, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00037 eIF_5A, 1 hit
PROSITEiView protein in PROSITE
PS00302 IF5A_HYPUSINE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9GZV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADEIDFTTG DAGASSTYPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK
60 70 80 90 100
HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKRNDYQ LICIQDGYLS
110 120 130 140 150
LLTETGEVRE DLKLPEGELG KEIEGKYNAG EDVQVSVMCA MSEEYAVAIK

PCK
Length:153
Mass (Da):16,793
Last modified:January 23, 2007 - v3
Checksum:i632BFE7F6DB073BD
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J4W5C9J4W5_HUMAN
Eukaryotic translation initiation f...
EIF5A2
115Annotation score:
F8WCJ1F8WCJ1_HUMAN
Eukaryotic translation initiation f...
EIF5A2
105Annotation score:
C9J7B5C9J7B5_HUMAN
Eukaryotic translation initiation f...
EIF5A2
109Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02794342E → D1 PublicationCorresponds to variant dbSNP:rs776545602Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF262027 mRNA Translation: AAF98810.1
AF293387, AF293386 Genomic DNA Translation: AAG23176.1
AY205258 mRNA Translation: AAO18676.1
AY205259 mRNA Translation: AAO18677.1
AY205260 mRNA Translation: AAO18678.1
AY205261 mRNA Translation: AAO18679.1
AK311962 mRNA Translation: BAG34902.1
CH471052 Genomic DNA Translation: EAW78501.1
BC036072 mRNA Translation: AAH36072.1
CCDSiCCDS3214.1
RefSeqiNP_065123.1, NM_020390.5
UniGeneiHs.164144

Genome annotation databases

EnsembliENST00000295822; ENSP00000295822; ENSG00000163577
GeneIDi56648
KEGGihsa:56648
UCSCiuc003fhd.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF262027 mRNA Translation: AAF98810.1
AF293387, AF293386 Genomic DNA Translation: AAG23176.1
AY205258 mRNA Translation: AAO18676.1
AY205259 mRNA Translation: AAO18677.1
AY205260 mRNA Translation: AAO18678.1
AY205261 mRNA Translation: AAO18679.1
AK311962 mRNA Translation: BAG34902.1
CH471052 Genomic DNA Translation: EAW78501.1
BC036072 mRNA Translation: AAH36072.1
CCDSiCCDS3214.1
RefSeqiNP_065123.1, NM_020390.5
UniGeneiHs.164144

3D structure databases

ProteinModelPortaliQ9GZV4
SMRiQ9GZV4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121162, 29 interactors
IntActiQ9GZV4, 12 interactors
STRINGi9606.ENSP00000295822

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiQ9GZV4
PhosphoSitePlusiQ9GZV4
SwissPalmiQ9GZV4

Polymorphism and mutation databases

BioMutaiEIF5A2
DMDMi74762725

Proteomic databases

EPDiQ9GZV4
MaxQBiQ9GZV4
PaxDbiQ9GZV4
PeptideAtlasiQ9GZV4
PRIDEiQ9GZV4
ProteomicsDBi80156

Protocols and materials databases

DNASUi56648
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295822; ENSP00000295822; ENSG00000163577
GeneIDi56648
KEGGihsa:56648
UCSCiuc003fhd.4 human

Organism-specific databases

CTDi56648
DisGeNETi56648
EuPathDBiHostDB:ENSG00000163577.7
GeneCardsiEIF5A2
HGNCiHGNC:3301 EIF5A2
HPAiHPA029090
MIMi605782 gene
neXtProtiNX_Q9GZV4
OpenTargetsiENSG00000163577
PharmGKBiPA27727
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3271 Eukaryota
COG0231 LUCA
GeneTreeiENSGT00390000003738
HOGENOMiHOG000106270
HOVERGENiHBG001104
InParanoidiQ9GZV4
KOiK03263
OMAiMIRGRPC
OrthoDBiEOG091G0P2P
PhylomeDBiQ9GZV4
TreeFamiTF101534

Enzyme and pathway databases

ReactomeiR-HSA-204626 Hypusine synthesis from eIF5A-lysine

Miscellaneous databases

ChiTaRSiEIF5A2 human
GeneWikiiEIF5A2
GenomeRNAii56648
PROiPR:Q9GZV4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163577 Expressed in 167 organ(s), highest expression level in right testis
CleanExiHS_EIF5A2
ExpressionAtlasiQ9GZV4 baseline and differential
GenevisibleiQ9GZV4 HS

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR001884 IF5A-like
IPR012340 NA-bd_OB-fold
IPR014722 Rib_L2_dom2
IPR019769 Trans_elong_IF5A_hypusine_site
IPR020189 Transl_elong_IF5A_C
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11673 PTHR11673, 1 hit
PfamiView protein in Pfam
PF01287 eIF-5a, 1 hit
PIRSFiPIRSF003025 eIF5A, 1 hit
SMARTiView protein in SMART
SM01376 eIF-5a, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00037 eIF_5A, 1 hit
PROSITEiView protein in PROSITE
PS00302 IF5A_HYPUSINE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIF5A2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZV4
Secondary accession number(s): B2R4V5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Translation initiation factors
    List of translation initiation factor entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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