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Protein

PSME3-interacting protein

Gene

FAM192A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus.1 Publication

GO - Biological processi

  • negative regulation of proteasomal protein catabolic process Source: UniProtKB
  • negative regulation of protein binding Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
PSME3-interacting proteinCurated
Alternative name(s):
NEFA-interacting nuclear protein NIP30By similarity
PA28G-interacting protein1 Publication
Gene namesi
Name:FAM192AImported
Synonyms:C16orf94Imported, NIP30By similarity, PIP301 Publication
ORF Names:CDA018, CDA10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000172775.16
HGNCiHGNC:29856 FAM192A
MIMi617766 gene
neXtProtiNX_Q9GZU8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi222S → A: Reduces phosphorylation by CK2 and interaction with PSME3; when associated with A-228. 1 Publication1
Mutagenesisi223 – 225DSE → KSK: Abolishes phosphorylation by CK2, strongly reduces interaction with PSME3 and abolishes effect on proteasome activity. 1 Publication3
Mutagenesisi228S → A: Reduces phosphorylation by CK2 and interaction with PSME3; when associated with A-222. 1 Publication1
Mutagenesisi229 – 231DSE → KSK: Strongly reduces phosphorylation by CK2 and interaction with PSME3. 1 Publication3

Organism-specific databases

OpenTargetsiENSG00000172775
PharmGKBiPA165450001

Polymorphism and mutation databases

BioMutaiFAM192A
DMDMi46577123

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000968471 – 254PSME3-interacting proteinAdd BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei139N6-acetyllysineCombined sources1
Modified residuei222Phosphoserine; by CK21 Publication1
Modified residuei228Phosphoserine; by CK21 Publication1

Post-translational modificationi

Phosphorylation by CK2 stabilizes the interaction with PSME3.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9GZU8
MaxQBiQ9GZU8
PaxDbiQ9GZU8
PeptideAtlasiQ9GZU8
PRIDEiQ9GZU8
ProteomicsDBi80152

PTM databases

iPTMnetiQ9GZU8
PhosphoSitePlusiQ9GZU8

Expressioni

Gene expression databases

BgeeiENSG00000172775 Expressed in 213 organ(s), highest expression level in testis
ExpressionAtlasiQ9GZU8 baseline and differential
GenevisibleiQ9GZU8 HS

Organism-specific databases

HPAiHPA054382
HPA059652

Interactioni

Subunit structurei

Interacts (via C-terminus) with both free and 20S proteasome-bound forms of the proteasome activator complex subunit PSME3; the interaction is direct.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF2Q129333EBI-2371956,EBI-355744

Protein-protein interaction databases

BioGridi123067, 57 interactors
IntActiQ9GZU8, 24 interactors
MINTiQ9GZU8
STRINGi9606.ENSP00000335808

Structurei

3D structure databases

ProteinModelPortaliQ9GZU8
SMRiQ9GZU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni201 – 254Interaction with PSME31 PublicationAdd BLAST54

Phylogenomic databases

eggNOGiKOG4036 Eukaryota
ENOG4111INN LUCA
GeneTreeiENSGT00500000044916
HOGENOMiHOG000045055
HOVERGENiHBG052624
InParanoidiQ9GZU8
OMAiWERVRQP
OrthoDBiEOG091G0RWI
PhylomeDBiQ9GZU8
TreeFamiTF314540

Family and domain databases

InterProiView protein in InterPro
IPR039845 FAM192A
IPR019331 FAM192A/Fyv6_N
PANTHERiPTHR13495 PTHR13495, 1 hit
PfamiView protein in Pfam
PF10187 Nefa_Nip30_N, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All

Q9GZU8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGGDDGNLI IKKRFVSEAE LDERRKRRQE EWEKVRKPED PEECPEEVYD
60 70 80 90 100
PRSLYERLQE QKDRKQQEYE EQFKFKNMVR GLDEDETNFL DEVSRQQELI
110 120 130 140 150
EKQRREEELK ELKEYRNNLK KVGISQENKK EVEKKLTVKP IETKNKFSQA
160 170 180 190 200
KLLAGAVKHK SSESGNSVKR LKPDPEPDDK NQEPSSCKSL GNTSLSGPSI
210 220 230 240 250
HCPSAAVCIG ILPGLGAYSG SSDSESSSDS EGTINATGKI VSSIFRTNTF

LEAP
Length:254
Mass (Da):28,912
Last modified:March 1, 2001 - v1
Checksum:i725D2AD4AB3AD5DA
GO

Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P4H7Q6P4H7_HUMAN
NIP30 protein
FAM192A NIP30
81Annotation score:
H3BUL4H3BUL4_HUMAN
PSME3-interacting protein
FAM192A
160Annotation score:
H3BSF0H3BSF0_HUMAN
PSME3-interacting protein
FAM192A
88Annotation score:
H3BSY6H3BSY6_HUMAN
PSME3-interacting protein
FAM192A
140Annotation score:
H3BU93H3BU93_HUMAN
PSME3-interacting protein
FAM192A
177Annotation score:
H3BP64H3BP64_HUMAN
PSME3-interacting protein
FAM192A
148Annotation score:
H3BTP8H3BTP8_HUMAN
PSME3-interacting protein
FAM192A
130Annotation score:
H3BQQ6H3BQQ6_HUMAN
PSME3-interacting protein
FAM192A
96Annotation score:
H3BTI2H3BTI2_HUMAN
PSME3-interacting protein
FAM192A
106Annotation score:
H3BMX9H3BMX9_HUMAN
PSME3-interacting protein
FAM192A
165Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356585 mRNA Translation: AAK43697.1
AF212249 mRNA Translation: AAK14932.1
AF271785 mRNA Translation: AAG44796.1
AK023291 mRNA Translation: BAB14512.1
AK025452 mRNA Translation: BAB15136.1
AL834421 mRNA Translation: CAD39082.1
BC020536 mRNA Translation: AAH20536.1
BC071952 mRNA Translation: AAH71952.1
CCDSiCCDS42168.1
RefSeqiNP_079222.1, NM_024946.2
XP_005256217.1, XM_005256160.2
XP_005256220.1, XM_005256163.2
XP_005256221.1, XM_005256164.3
XP_005256222.1, XM_005256165.2
XP_011521645.1, XM_011523343.2
XP_016879171.1, XM_017023682.1
XP_016879172.1, XM_017023683.1
XP_016879173.1, XM_017023684.1
XP_016879174.1, XM_017023685.1
XP_016879175.1, XM_017023686.1
XP_016879176.1, XM_017023687.1
XP_016879177.1, XM_017023688.1
XP_016879178.1, XM_017023689.1
XP_016879179.1, XM_017023690.1
XP_016879180.1, XM_017023691.1
XP_016879181.1, XM_017023692.1
XP_016879182.1, XM_017023693.1
XP_016879183.1, XM_017023694.1
XP_016879184.1, XM_017023695.1
XP_016879185.1, XM_017023696.1
XP_016879186.1, XM_017023697.1
XP_016879187.1, XM_017023698.1
XP_016879188.1, XM_017023699.1
XP_016879189.1, XM_017023700.1
XP_016879190.1, XM_017023701.1
XP_016879191.1, XM_017023702.1
XP_016879192.1, XM_017023703.1
XP_016879193.1, XM_017023704.1
UniGeneiHs.396740

Genome annotation databases

EnsembliENST00000309137; ENSP00000335808; ENSG00000172775
ENST00000389447; ENSP00000374098; ENSG00000172775
ENST00000564108; ENSP00000456211; ENSG00000172775
ENST00000567439; ENSP00000457850; ENSG00000172775
ENST00000569266; ENSP00000457740; ENSG00000172775
GeneIDi80011
KEGGihsa:80011
UCSCiuc021tiy.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356585 mRNA Translation: AAK43697.1
AF212249 mRNA Translation: AAK14932.1
AF271785 mRNA Translation: AAG44796.1
AK023291 mRNA Translation: BAB14512.1
AK025452 mRNA Translation: BAB15136.1
AL834421 mRNA Translation: CAD39082.1
BC020536 mRNA Translation: AAH20536.1
BC071952 mRNA Translation: AAH71952.1
CCDSiCCDS42168.1
RefSeqiNP_079222.1, NM_024946.2
XP_005256217.1, XM_005256160.2
XP_005256220.1, XM_005256163.2
XP_005256221.1, XM_005256164.3
XP_005256222.1, XM_005256165.2
XP_011521645.1, XM_011523343.2
XP_016879171.1, XM_017023682.1
XP_016879172.1, XM_017023683.1
XP_016879173.1, XM_017023684.1
XP_016879174.1, XM_017023685.1
XP_016879175.1, XM_017023686.1
XP_016879176.1, XM_017023687.1
XP_016879177.1, XM_017023688.1
XP_016879178.1, XM_017023689.1
XP_016879179.1, XM_017023690.1
XP_016879180.1, XM_017023691.1
XP_016879181.1, XM_017023692.1
XP_016879182.1, XM_017023693.1
XP_016879183.1, XM_017023694.1
XP_016879184.1, XM_017023695.1
XP_016879185.1, XM_017023696.1
XP_016879186.1, XM_017023697.1
XP_016879187.1, XM_017023698.1
XP_016879188.1, XM_017023699.1
XP_016879189.1, XM_017023700.1
XP_016879190.1, XM_017023701.1
XP_016879191.1, XM_017023702.1
XP_016879192.1, XM_017023703.1
XP_016879193.1, XM_017023704.1
UniGeneiHs.396740

3D structure databases

ProteinModelPortaliQ9GZU8
SMRiQ9GZU8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123067, 57 interactors
IntActiQ9GZU8, 24 interactors
MINTiQ9GZU8
STRINGi9606.ENSP00000335808

PTM databases

iPTMnetiQ9GZU8
PhosphoSitePlusiQ9GZU8

Polymorphism and mutation databases

BioMutaiFAM192A
DMDMi46577123

Proteomic databases

EPDiQ9GZU8
MaxQBiQ9GZU8
PaxDbiQ9GZU8
PeptideAtlasiQ9GZU8
PRIDEiQ9GZU8
ProteomicsDBi80152

Protocols and materials databases

DNASUi80011
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309137; ENSP00000335808; ENSG00000172775
ENST00000389447; ENSP00000374098; ENSG00000172775
ENST00000564108; ENSP00000456211; ENSG00000172775
ENST00000567439; ENSP00000457850; ENSG00000172775
ENST00000569266; ENSP00000457740; ENSG00000172775
GeneIDi80011
KEGGihsa:80011
UCSCiuc021tiy.1 human

Organism-specific databases

CTDi80011
EuPathDBiHostDB:ENSG00000172775.16
GeneCardsiFAM192A
HGNCiHGNC:29856 FAM192A
HPAiHPA054382
HPA059652
MIMi617766 gene
neXtProtiNX_Q9GZU8
OpenTargetsiENSG00000172775
PharmGKBiPA165450001
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4036 Eukaryota
ENOG4111INN LUCA
GeneTreeiENSGT00500000044916
HOGENOMiHOG000045055
HOVERGENiHBG052624
InParanoidiQ9GZU8
OMAiWERVRQP
OrthoDBiEOG091G0RWI
PhylomeDBiQ9GZU8
TreeFamiTF314540

Miscellaneous databases

ChiTaRSiFAM192A human
GeneWikiiNIP30
GenomeRNAii80011
PROiPR:Q9GZU8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172775 Expressed in 213 organ(s), highest expression level in testis
ExpressionAtlasiQ9GZU8 baseline and differential
GenevisibleiQ9GZU8 HS

Family and domain databases

InterProiView protein in InterPro
IPR039845 FAM192A
IPR019331 FAM192A/Fyv6_N
PANTHERiPTHR13495 PTHR13495, 1 hit
PfamiView protein in Pfam
PF10187 Nefa_Nip30_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPIP30_HUMAN
AccessioniPrimary (citable) accession number: Q9GZU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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