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Entry version 157 (18 Sep 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Paternally-expressed gene 3 protein

Gene

PEG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri452 – 474C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri563 – 585C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 649C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri969 – 991C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1107 – 1129C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1163 – 1185C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1225 – 1247C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1282 – 1304C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1332 – 1354C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1505 – 1527C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1564 – 1586C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Paternally-expressed gene 3 protein
Alternative name(s):
Zinc finger and SCAN domain-containing protein 24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PEG3
Synonyms:KIAA0287, ZSCAN24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8826 PEG3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601483 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9GZU2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5178

Open Targets

More...
OpenTargetsi
ENSG00000198300

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33171

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PEG3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762724

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002492281 – 1588Paternally-expressed gene 3 proteinAdd BLAST1588

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9GZU2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9GZU2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9GZU2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9GZU2

PeptideAtlas

More...
PeptideAtlasi
Q9GZU2

PRoteomics IDEntifications database

More...
PRIDEi
Q9GZU2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1789
80145 [Q9GZU2-1]
80146 [Q9GZU2-2]
80147 [Q9GZU2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9GZU2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9GZU2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198300 Expressed in 234 organ(s), highest expression level in endothelial cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9GZU2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9GZU2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA026070

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with SIAH1A and SIAH2.

Interacts with TRAF2 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111204, 9 interactors

Database of interacting proteins

More...
DIPi
DIP-38426N

Protein interaction database and analysis system

More...
IntActi
Q9GZU2, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000326581

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11588
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9GZU2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 128SCAN boxPROSITE-ProRule annotationAdd BLAST83
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1397 – 14032-17
Repeati1404 – 14102-27
Repeati1411 – 14172-37
Repeati1418 – 14221-15
Repeati1425 – 14291-25
Repeati1432 – 14361-35
Repeati1439 – 14431-45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1397 – 14173 X 7 AA repeat of P-E-V-E-A-A-EAdd BLAST21
Regioni1418 – 14434 X 5 AA repeat of P-X-G-E-AAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1352 – 1512Glu-richAdd BLAST161

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SCAN domain enables PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri452 – 474C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri563 – 585C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri627 – 649C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri969 – 991C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1107 – 1129C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1163 – 1185C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1225 – 1247C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1282 – 1304C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1332 – 1354C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1505 – 1527C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1564 – 1586C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162525

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000001564

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9GZU2

KEGG Orthology (KO)

More...
KOi
K09230

Identification of Orthologs from Complete Genome Data

More...
OMAi
NCEKLVT

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9GZU2

TreeFam database of animal gene trees

More...
TreeFami
TF337075

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07936 SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9GZU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPPKHLSAT KPKKSWAPNL YELDSDLTKE PDVIIGEGPT DSEFFHQRFR
60 70 80 90 100
NLIYVEFVGP RKTLIKLRNL CLDWLQPETR TKEEIIELLV LEQYLTIIPE
110 120 130 140 150
KLKPWVRAKK PENCEKLVTL LENYKEMYQP EDDNNSDVTS DDDMTRNRRE
160 170 180 190 200
SSPPHSVHSF SDRDWDRRGR SRDMEPRDRW SHTRNPRSRM PPRDLSLPVV
210 220 230 240 250
AKTSFEMDRE DDRDSRAYES RSQDAESYQN VVDLAEDRKP HNTIQDNMEN
260 270 280 290 300
YRKLLSLVQL AEDDGHSHMT QGHSSRSKRS AYPSTSRGLK TMPEAKKSTH
310 320 330 340 350
RRGICEDESS HGVIMEKFIK DVSRSSKSGR ARESSDRSQR FPRMSDDNWK
360 370 380 390 400
DISLNKRESV IQQRVYEGNA FRGGFRFNST LVSRKRVLER KRRYHFDTDG
410 420 430 440 450
KGSIHDQKGC PRKKPFECGS EMRKAMSVSS LSSLSSPSFT ESQPIDFGAM
460 470 480 490 500
PYVCDECGRS FSVISEFVEH QIMHTRENLY EYGESFIHSV AVSEVQKSQV
510 520 530 540 550
GGKRFECKDC GETFNKSAAL AEHRKIHARG YLVECKNQEC EEAFMPSPTF
560 570 580 590 600
SELQKIYGKD KFYECRVCKE TFLHSSALIE HQKIHFGDDK DNEREHERER
610 620 630 640 650
ERERGETFRP SPALNEFQKM YGKEKMYECK VCGETFLHSS SLKEHQKIHT
660 670 680 690 700
RGNPFENKGK VCEETFIPGQ SLKRRQKTYN KEKLCDFTDG RDAFMQSSEL
710 720 730 740 750
SEHQKIHSRK NLFEGRGYEK SVIHSGPFTE SQKSHTITRP LESDEDEKAF
760 770 780 790 800
TISSNPYENQ KIPTKENVYE AKSYERSVIH SLASVEAQKS HSVAGPSKPK
810 820 830 840 850
VMAESTIQSF DAINHQRVRA GGNTSEGREY SRSVIHSLVA SKPPRSHNGN
860 870 880 890 900
ELVESNEKGE SSIYISDLND KRQKIPAREN PCEGGSKNRN YEDSVIQSVF
910 920 930 940 950
RAKPQKSVPG EGSGEFKKDG EFSVPSSNVR EYQKARAKKK YIEHRSNETS
960 970 980 990 1000
VIHSLPFGEQ TFRPRGMLYE CQECGECFAH SSDLTEHQKI HDREKPSGSR
1010 1020 1030 1040 1050
NYEWSVIRSL APTDPQTSYA QEQYAKEQAR NKCKDFRQFF ATSEDLNTNQ
1060 1070 1080 1090 1100
KIYDQEKSHG EESQGENTDG EETHSEETHG QETIEDPVIQ GSDMEDPQKD
1110 1120 1130 1140 1150
DPDDKIYECE DCGLGFVDLT DLTDHQKVHS RKCLVDSREY THSVIHTHSI
1160 1170 1180 1190 1200
SEYQRDYTGE QLYECPKCGE SFIHSSFLFE HQRIHEQDQL YSMKGCDDGF
1210 1220 1230 1240 1250
IALLPMKPRR NRAAERNPAL AGSAIRCLLC GQGFIHSSAL NEHMRLHRED
1260 1270 1280 1290 1300
DLLEQSQMAE EAIIPGLALT EFQRSQTEER LFECAVCGES FVNPAELADH
1310 1320 1330 1340 1350
VTVHKNEPYE YGSSYTHTSF LTEPLKGAIP FYECKDCGKS FIHSTVLTKH
1360 1370 1380 1390 1400
KELHLEEEEE DEAAAAAAAA AQEVEANVHV PQVVLRIQGL NVEAAEPEVE
1410 1420 1430 1440 1450
AAEPEVEAAE PEVEAAEPNG EAEGPDGEAA EPIGEAGQPN GEAEQPNGDA
1460 1470 1480 1490 1500
DEPDGAGIED PEERAEEPEG KAEEPEGDAD EPDGVGIEDP EEGEDQEIQV
1510 1520 1530 1540 1550
EEPYYDCHEC TETFTSSTAF SEHLKTHASM IIFEPANAFG ECSGYIERAS
1560 1570 1580
TSTGGANQAD EKYFKCDVCG QLFNDRLSLA RHQNTHTG
Length:1,588
Mass (Da):180,827
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E4F34A01F189F3E
GO
Isoform 2 (identifier: Q9GZU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Show »
Length:1,462
Mass (Da):165,957
Checksum:i29F1A63C6CC02BFF
GO
Isoform 3 (identifier: Q9GZU2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-287: Missing.
     547-550: SPTF → NPCL
     551-1588: Missing.

Show »
Length:520
Mass (Da):60,547
Checksum:iAA43A03C9CE8D178
GO
Isoform 4 (identifier: Q9GZU2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.
     161-161: S → SG
     257-257: L → LG

Show »
Length:1,464
Mass (Da):166,071
Checksum:iB57A789363951AE6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZD4M0QZD4_HUMAN
Paternally-expressed gene 3 protein
PEG3
519Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISL2A0A3B3ISL2_HUMAN
Paternally-expressed gene 3 protein
PEG3
1,227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRU6A0A3B3IRU6_HUMAN
Paternally-expressed gene 3 protein
PEG3
1,433Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITJ6A0A3B3ITJ6_HUMAN
Paternally-expressed gene 3 protein
PEG3
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXG1M0QXG1_HUMAN
Paternally-expressed gene 3 protein
PEG3
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB85588 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence CAI45975 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti310 – 311SH → PP in BAB85588 (PubMed:11260267).Curated2
Sequence conflicti439F → L in BAG58536 (PubMed:14702039).Curated1
Sequence conflicti677K → I in BAB85588 (PubMed:11260267).Curated1
Sequence conflicti690G → A in BAB85588 (PubMed:11260267).Curated1
Sequence conflicti750F → V in BAB85588 (PubMed:11260267).Curated1
Sequence conflicti755N → Y in BAB85588 (PubMed:11260267).Curated1
Sequence conflicti1117V → M in BAB85588 (PubMed:11260267).Curated1
Sequence conflicti1145I → V in BAB85588 (PubMed:11260267).Curated1
Sequence conflicti1587T → M in BAB85588 (PubMed:11260267).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027397235A → T. Corresponds to variant dbSNP:rs2191432Ensembl.1
Natural variantiVAR_035562594R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs754473044Ensembl.1
Natural variantiVAR_052725624E → G. Corresponds to variant dbSNP:rs36016896Ensembl.1
Natural variantiVAR_027398839V → L. Corresponds to variant dbSNP:rs7251798Ensembl.1
Natural variantiVAR_052726947N → S1 PublicationCorresponds to variant dbSNP:rs35851866Ensembl.1
Natural variantiVAR_027399983D → G. Corresponds to variant dbSNP:rs10412932Ensembl.1
Natural variantiVAR_0527271456A → V. Corresponds to variant dbSNP:rs34831553Ensembl.1
Natural variantiVAR_0527281576R → H. Corresponds to variant dbSNP:rs34051133Ensembl.1
Natural variantiVAR_0274001576R → L1 PublicationCorresponds to variant dbSNP:rs34051133Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0203711 – 126Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST126
Alternative sequenceiVSP_045527161S → SG in isoform 4. 2 Publications1
Alternative sequenceiVSP_045528257L → LG in isoform 4. 2 Publications1
Alternative sequenceiVSP_020372258 – 287Missing in isoform 3. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_020373547 – 550SPTF → NPCL in isoform 3. 1 Publication4
Alternative sequenceiVSP_020374551 – 1588Missing in isoform 3. 1 PublicationAdd BLAST1038

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF208980
, AF208974, AF208975, AF208976, AF208977, AF208978, AF208979 Genomic DNA Translation: AAG42324.1
AF208980
, AF208974, AF208975, AF208976, AF208977, AF208978, AF208979 Genomic DNA Translation: AAG42325.1
AF208967 mRNA Translation: AAG35739.1
AF208968 mRNA Translation: AAG35740.1
AF208969 mRNA Translation: AAG35741.1
AF208970 mRNA Translation: AAG35742.1
AK295679 mRNA Translation: BAG58536.1
CH471135 Genomic DNA Translation: EAW72474.1
BC052616 mRNA Translation: AAH52616.1
BC150272 mRNA Translation: AAI50273.1
AB003039 mRNA Translation: BAB85588.1 Frameshift.
CR933682 mRNA Translation: CAI45975.1 Different initiation.
U90336 mRNA Translation: AAB50011.1
AC006115 Genomic DNA Translation: AAC83176.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12948.1 [Q9GZU2-1]
CCDS58684.1 [Q9GZU2-4]
CCDS58685.1 [Q9GZU2-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001139656.1, NM_001146184.1 [Q9GZU2-1]
NP_001139657.1, NM_001146185.1 [Q9GZU2-2]
NP_001139658.1, NM_001146186.1
NP_001139659.1, NM_001146187.1 [Q9GZU2-4]
NP_006201.1, NM_006210.2 [Q9GZU2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000326441; ENSP00000326581; ENSG00000198300 [Q9GZU2-1]
ENST00000593695; ENSP00000472402; ENSG00000198300 [Q9GZU2-2]
ENST00000598410; ENSP00000473190; ENSG00000198300 [Q9GZU2-4]
ENST00000599534; ENSP00000472395; ENSG00000198300 [Q9GZU2-1]
ENST00000599577; ENSP00000469486; ENSG00000198300 [Q9GZU2-1]
ENST00000648694; ENSP00000496914; ENSG00000198300 [Q9GZU2-4]
ENST00000649233; ENSP00000498047; ENSG00000198300 [Q9GZU2-4]
ENST00000649428; ENSP00000498138; ENSG00000198300 [Q9GZU2-4]
ENST00000649680; ENSP00000497512; ENSG00000198300 [Q9GZU2-4]
ENST00000649876; ENSP00000496867; ENSG00000198300 [Q9GZU2-4]
ENST00000650102; ENSP00000497466; ENSG00000198300 [Q9GZU2-4]
ENST00000650632; ENSP00000497971; ENSG00000198300 [Q9GZU2-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5178

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5178

UCSC genome browser

More...
UCSCi
uc002qnv.3 human [Q9GZU2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208980
, AF208974, AF208975, AF208976, AF208977, AF208978, AF208979 Genomic DNA Translation: AAG42324.1
AF208980
, AF208974, AF208975, AF208976, AF208977, AF208978, AF208979 Genomic DNA Translation: AAG42325.1
AF208967 mRNA Translation: AAG35739.1
AF208968 mRNA Translation: AAG35740.1
AF208969 mRNA Translation: AAG35741.1
AF208970 mRNA Translation: AAG35742.1
AK295679 mRNA Translation: BAG58536.1
CH471135 Genomic DNA Translation: EAW72474.1
BC052616 mRNA Translation: AAH52616.1
BC150272 mRNA Translation: AAI50273.1
AB003039 mRNA Translation: BAB85588.1 Frameshift.
CR933682 mRNA Translation: CAI45975.1 Different initiation.
U90336 mRNA Translation: AAB50011.1
AC006115 Genomic DNA Translation: AAC83176.1
CCDSiCCDS12948.1 [Q9GZU2-1]
CCDS58684.1 [Q9GZU2-4]
CCDS58685.1 [Q9GZU2-2]
RefSeqiNP_001139656.1, NM_001146184.1 [Q9GZU2-1]
NP_001139657.1, NM_001146185.1 [Q9GZU2-2]
NP_001139658.1, NM_001146186.1
NP_001139659.1, NM_001146187.1 [Q9GZU2-4]
NP_006201.1, NM_006210.2 [Q9GZU2-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BHXX-ray1.95A/B40-130[»]
SMRiQ9GZU2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111204, 9 interactors
DIPiDIP-38426N
IntActiQ9GZU2, 5 interactors
STRINGi9606.ENSP00000326581

PTM databases

iPTMnetiQ9GZU2
PhosphoSitePlusiQ9GZU2

Polymorphism and mutation databases

BioMutaiPEG3
DMDMi74762724

Proteomic databases

jPOSTiQ9GZU2
MassIVEiQ9GZU2
MaxQBiQ9GZU2
PaxDbiQ9GZU2
PeptideAtlasiQ9GZU2
PRIDEiQ9GZU2
ProteomicsDBi1789
80145 [Q9GZU2-1]
80146 [Q9GZU2-2]
80147 [Q9GZU2-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326441; ENSP00000326581; ENSG00000198300 [Q9GZU2-1]
ENST00000593695; ENSP00000472402; ENSG00000198300 [Q9GZU2-2]
ENST00000598410; ENSP00000473190; ENSG00000198300 [Q9GZU2-4]
ENST00000599534; ENSP00000472395; ENSG00000198300 [Q9GZU2-1]
ENST00000599577; ENSP00000469486; ENSG00000198300 [Q9GZU2-1]
ENST00000648694; ENSP00000496914; ENSG00000198300 [Q9GZU2-4]
ENST00000649233; ENSP00000498047; ENSG00000198300 [Q9GZU2-4]
ENST00000649428; ENSP00000498138; ENSG00000198300 [Q9GZU2-4]
ENST00000649680; ENSP00000497512; ENSG00000198300 [Q9GZU2-4]
ENST00000649876; ENSP00000496867; ENSG00000198300 [Q9GZU2-4]
ENST00000650102; ENSP00000497466; ENSG00000198300 [Q9GZU2-4]
ENST00000650632; ENSP00000497971; ENSG00000198300 [Q9GZU2-4]
GeneIDi5178
KEGGihsa:5178
UCSCiuc002qnv.3 human [Q9GZU2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5178
DisGeNETi5178

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PEG3
HGNCiHGNC:8826 PEG3
HPAiHPA026070
MIMi601483 gene
neXtProtiNX_Q9GZU2
OpenTargetsiENSG00000198300
PharmGKBiPA33171

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162525
HOGENOMiHOG000001564
InParanoidiQ9GZU2
KOiK09230
OMAiNCEKLVT
OrthoDBi1318335at2759
PhylomeDBiQ9GZU2
TreeFamiTF337075

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PEG3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5178

Pharos

More...
Pharosi
Q9GZU2

Protein Ontology

More...
PROi
PR:Q9GZU2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198300 Expressed in 234 organ(s), highest expression level in endothelial cell
ExpressionAtlasiQ9GZU2 baseline and differential
GenevisibleiQ9GZU2 HS

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPEG3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZU2
Secondary accession number(s): A7E2B8
, B4DIM4, C9JP50, P78418, Q5H9P9, Q7Z7H7, Q8TF75, Q9GZY2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2001
Last modified: September 18, 2019
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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