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UniProtKB - Q9GZT6 (CC90B_HUMAN)
Protein
Coiled-coil domain-containing protein 90B, mitochondrial
Gene
CCDC90B
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 90B, mitochondrial |
Gene namesi | Name:CCDC90B ORF Names:CUA003, MDS011, MDS025 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28108, CCDC90B |
neXtProti | NX_Q9GZT6 |
VEuPathDBi | HostDB:ENSG00000137500 |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane 1 Publication; Single-pass membrane protein Sequence analysis
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
- mitochondrion Source: LIFEdb
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 231 – 253 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Membrane, MitochondrionPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000137500 |
PharmGKBi | PA162381967 |
Miscellaneous databases
Pharosi | Q9GZT6, Tdark |
Genetic variation databases
BioMutai | CCDC90B |
DMDMi | 294862420 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 42 | MitochondrionSequence analysisAdd BLAST | 42 | |
ChainiPRO_0000295695 | 43 – 254 | Coiled-coil domain-containing protein 90B, mitochondrialAdd BLAST | 212 |
Proteomic databases
EPDi | Q9GZT6 |
jPOSTi | Q9GZT6 |
MassIVEi | Q9GZT6 |
MaxQBi | Q9GZT6 |
PaxDbi | Q9GZT6 |
PeptideAtlasi | Q9GZT6 |
PRIDEi | Q9GZT6 |
ProteomicsDBi | 3524 80133 [Q9GZT6-1] 80134 [Q9GZT6-2] |
TopDownProteomicsi | Q9GZT6-1 [Q9GZT6-1] Q9GZT6-2 [Q9GZT6-2] |
PTM databases
iPTMneti | Q9GZT6 |
PhosphoSitePlusi | Q9GZT6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000137500, Expressed in corpus callosum and 237 other tissues |
ExpressionAtlasi | Q9GZT6, baseline and differential |
Genevisiblei | Q9GZT6, HS |
Organism-specific databases
HPAi | ENSG00000137500, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with MCU (PubMed:27184846).
1 PublicationBinary interactionsi
Q9GZT6
Protein-protein interaction databases
BioGRIDi | 121923, 216 interactors |
IntActi | Q9GZT6, 43 interactors |
MINTi | Q9GZT6 |
STRINGi | 9606.ENSP00000434724 |
Miscellaneous databases
RNActi | Q9GZT6, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q9GZT6 |
SMRi | Q9GZT6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 129 – 164 | Sequence analysisAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the CCDC90 family.Curated
Keywords - Domaini
Coiled coil, Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3156, Eukaryota |
GeneTreei | ENSGT00940000155453 |
HOGENOMi | CLU_063283_1_0_1 |
InParanoidi | Q9GZT6 |
OMAi | QAVAMMK |
OrthoDBi | 1252164at2759 |
PhylomeDBi | Q9GZT6 |
TreeFami | TF331442 |
Family and domain databases
InterProi | View protein in InterPro IPR024461, CCDC90-like |
PANTHERi | PTHR14360, PTHR14360, 1 hit |
Pfami | View protein in Pfam PF07798, DUF1640, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9GZT6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNSRQAWRLF LSQGRGDRWV SRPRGHFSPA LRREFFTTTT KEGYDRRPVD
60 70 80 90 100
ITPLEQRKLT FDTHALVQDL ETHGFDKTQA ETIVSALTAL SNVSLDTIYK
110 120 130 140 150
EMVTQAQQEI TVQQLMAHLD AIRKDMVILE KSEFANLRAE NEKMKIELDQ
160 170 180 190 200
VKQQLMHETS RIRADNKLDI NLERSRVTDM FTDQEKQLME TTTEFTKKDT
210 220 230 240 250
QTKSIISETS NKIDAEIASL KTLMESNKLE TIRYLAASVF TCLAIALGFY
RFWK
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PKQ5 | E9PKQ5_HUMAN | Coiled-coil domain-containing prote... | CCDC90B | 208 | Annotation score: | ||
J3KN19 | J3KN19_HUMAN | Coiled-coil domain-containing prote... | CCDC90B MDS025, hCG_27349 | 162 | Annotation score: | ||
H0YF06 | H0YF06_HUMAN | Coiled-coil domain-containing prote... | CCDC90B | 133 | Annotation score: | ||
E9PRC2 | E9PRC2_HUMAN | Coiled-coil domain-containing prote... | CCDC90B | 97 | Annotation score: | ||
H0YD95 | H0YD95_HUMAN | Coiled-coil domain-containing prote... | CCDC90B | 95 | Annotation score: | ||
E9PPJ7 | E9PPJ7_HUMAN | Coiled-coil domain-containing prote... | CCDC90B | 117 | Annotation score: | ||
E9PMQ7 | E9PMQ7_HUMAN | Coiled-coil domain-containing prote... | CCDC90B | 57 | Annotation score: | ||
E9PSG6 | E9PSG6_HUMAN | Coiled-coil domain-containing prote... | CCDC90B | 43 | Annotation score: | ||
E9PNI8 | E9PNI8_HUMAN | Coiled-coil domain-containing prote... | CCDC90B | 38 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033322 | 10 | F → L2 PublicationsCorresponds to variant dbSNP:rs494791Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055663 | 1 – 101 | Missing in isoform 3. 1 PublicationAdd BLAST | 101 | |
Alternative sequenceiVSP_027003 | 1 – 33 | MNSRQ…PALRR → MLANCGSVCEETQFRGTTVA PALG in isoform 2. 2 PublicationsAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136791 mRNA Translation: CAB66725.1 AF182412 mRNA Translation: AAG14948.1 AF182424 mRNA Translation: AAG14960.1 AF271782 mRNA Translation: AAG44793.1 AK055972 mRNA Translation: BAG51599.1 AK292349 mRNA Translation: BAF85038.1 AK304769 mRNA Translation: BAG65524.1 AP000873 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW75089.1 CH471076 Genomic DNA Translation: EAW75091.1 BC014573 mRNA Translation: AAH14573.1 BC020783 mRNA Translation: AAH20783.1 BC107755 mRNA Translation: AAI07756.1 |
CCDSi | CCDS66190.1 [Q9GZT6-3] CCDS66191.1 [Q9GZT6-3] CCDS8266.1 [Q9GZT6-1] |
RefSeqi | NP_001273045.1, NM_001286116.1 [Q9GZT6-2] NP_001273046.1, NM_001286117.1 [Q9GZT6-3] NP_001273047.1, NM_001286118.1 NP_001273048.1, NM_001286119.1 NP_001273049.1, NM_001286120.1 NP_068597.2, NM_021825.4 [Q9GZT6-1] XP_005274216.1, XM_005274159.3 [Q9GZT6-3] XP_016873593.1, XM_017018104.1 [Q9GZT6-3] |
Genome annotation databases
Ensembli | ENST00000455220.6; ENSP00000390990.2; ENSG00000137500.10 [Q9GZT6-2] ENST00000525503.5; ENSP00000431424.1; ENSG00000137500.10 [Q9GZT6-3] ENST00000529611.5; ENSP00000431345.1; ENSG00000137500.10 [Q9GZT6-3] ENST00000529689.6; ENSP00000434724.1; ENSG00000137500.10 |
GeneIDi | 60492 |
KEGGi | hsa:60492 |
MANE-Selecti | ENST00000529689.6; ENSP00000434724.1; NM_021825.5; NP_068597.2 |
UCSCi | uc001pac.5, human [Q9GZT6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136791 mRNA Translation: CAB66725.1 AF182412 mRNA Translation: AAG14948.1 AF182424 mRNA Translation: AAG14960.1 AF271782 mRNA Translation: AAG44793.1 AK055972 mRNA Translation: BAG51599.1 AK292349 mRNA Translation: BAF85038.1 AK304769 mRNA Translation: BAG65524.1 AP000873 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW75089.1 CH471076 Genomic DNA Translation: EAW75091.1 BC014573 mRNA Translation: AAH14573.1 BC020783 mRNA Translation: AAH20783.1 BC107755 mRNA Translation: AAI07756.1 |
CCDSi | CCDS66190.1 [Q9GZT6-3] CCDS66191.1 [Q9GZT6-3] CCDS8266.1 [Q9GZT6-1] |
RefSeqi | NP_001273045.1, NM_001286116.1 [Q9GZT6-2] NP_001273046.1, NM_001286117.1 [Q9GZT6-3] NP_001273047.1, NM_001286118.1 NP_001273048.1, NM_001286119.1 NP_001273049.1, NM_001286120.1 NP_068597.2, NM_021825.4 [Q9GZT6-1] XP_005274216.1, XM_005274159.3 [Q9GZT6-3] XP_016873593.1, XM_017018104.1 [Q9GZT6-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6H9M | X-ray | 2.10 | A/B/C | 43-126 | [»] | |
AlphaFoldDBi | Q9GZT6 | |||||
SMRi | Q9GZT6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121923, 216 interactors |
IntActi | Q9GZT6, 43 interactors |
MINTi | Q9GZT6 |
STRINGi | 9606.ENSP00000434724 |
PTM databases
iPTMneti | Q9GZT6 |
PhosphoSitePlusi | Q9GZT6 |
Genetic variation databases
BioMutai | CCDC90B |
DMDMi | 294862420 |
Proteomic databases
EPDi | Q9GZT6 |
jPOSTi | Q9GZT6 |
MassIVEi | Q9GZT6 |
MaxQBi | Q9GZT6 |
PaxDbi | Q9GZT6 |
PeptideAtlasi | Q9GZT6 |
PRIDEi | Q9GZT6 |
ProteomicsDBi | 3524 80133 [Q9GZT6-1] 80134 [Q9GZT6-2] |
TopDownProteomicsi | Q9GZT6-1 [Q9GZT6-1] Q9GZT6-2 [Q9GZT6-2] |
Protocols and materials databases
Antibodypediai | 2471, 129 antibodies from 21 providers |
DNASUi | 60492 |
Genome annotation databases
Ensembli | ENST00000455220.6; ENSP00000390990.2; ENSG00000137500.10 [Q9GZT6-2] ENST00000525503.5; ENSP00000431424.1; ENSG00000137500.10 [Q9GZT6-3] ENST00000529611.5; ENSP00000431345.1; ENSG00000137500.10 [Q9GZT6-3] ENST00000529689.6; ENSP00000434724.1; ENSG00000137500.10 |
GeneIDi | 60492 |
KEGGi | hsa:60492 |
MANE-Selecti | ENST00000529689.6; ENSP00000434724.1; NM_021825.5; NP_068597.2 |
UCSCi | uc001pac.5, human [Q9GZT6-1] |
Organism-specific databases
CTDi | 60492 |
GeneCardsi | CCDC90B |
HGNCi | HGNC:28108, CCDC90B |
HPAi | ENSG00000137500, Low tissue specificity |
neXtProti | NX_Q9GZT6 |
OpenTargetsi | ENSG00000137500 |
PharmGKBi | PA162381967 |
VEuPathDBi | HostDB:ENSG00000137500 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3156, Eukaryota |
GeneTreei | ENSGT00940000155453 |
HOGENOMi | CLU_063283_1_0_1 |
InParanoidi | Q9GZT6 |
OMAi | QAVAMMK |
OrthoDBi | 1252164at2759 |
PhylomeDBi | Q9GZT6 |
TreeFami | TF331442 |
Enzyme and pathway databases
PathwayCommonsi | Q9GZT6 |
SignaLinki | Q9GZT6 |
Miscellaneous databases
BioGRID-ORCSi | 60492, 41 hits in 1081 CRISPR screens |
ChiTaRSi | CCDC90B, human |
GeneWikii | CCDC90B |
GenomeRNAii | 60492 |
Pharosi | Q9GZT6, Tdark |
PROi | PR:Q9GZT6 |
RNActi | Q9GZT6, protein |
Gene expression databases
Bgeei | ENSG00000137500, Expressed in corpus callosum and 237 other tissues |
ExpressionAtlasi | Q9GZT6, baseline and differential |
Genevisiblei | Q9GZT6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR024461, CCDC90-like |
PANTHERi | PTHR14360, PTHR14360, 1 hit |
Pfami | View protein in Pfam PF07798, DUF1640, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CC90B_HUMAN | |
Accessioni | Q9GZT6Primary (citable) accession number: Q9GZT6 Secondary accession number(s): A8K8I4 Q9GZU6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 136 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families