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Entry version 162 (25 May 2022)
Sequence version 1 (01 Mar 2001)
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Protein

Serine racemase

Gene

SRR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=6.5 mM for L-serine1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei51ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei56Proton acceptorBy similarity1
Active sitei84Proton acceptorBy similarity1
Binding sitei121ATPBy similarity1
Binding sitei135SubstrateCurated1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi210Magnesium1
Metal bindingi214Magnesium; via carbonyl oxygen1
Metal bindingi216Magnesium1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAllosteric enzyme, Isomerase, Lyase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Pyridoxal phosphate

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
5.1.1.18, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9GZT4

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-977347, Serine biosynthesis

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9GZT4

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9GZT4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine racemase1 Publication (EC:5.1.1.181 Publication)
Alternative name(s):
D-serine ammonia-lyase
D-serine dehydratase (EC:4.3.1.18By similarity)
L-serine ammonia-lyase
L-serine dehydratase (EC:4.3.1.17By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SRR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14398, SRR

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606477, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9GZT4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000167720

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
63826

Open Targets

More...
OpenTargetsi
ENSG00000167720

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37877

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9GZT4, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4460

Drug and drug target database

More...
DrugBanki
DB00114, Pyridoxal phosphate
DB00133, Serine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SRR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20139924

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001856501 – 340Serine racemaseAdd BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei56N6-(pyridoxal phosphate)lysine1
Modified residuei113S-nitrosocysteineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

S-nitrosylated, leading to decrease the enzyme activity.By similarity

Keywords - PTMi

S-nitrosylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9GZT4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9GZT4

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9GZT4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9GZT4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9GZT4

PeptideAtlas

More...
PeptideAtlasi
Q9GZT4

PRoteomics IDEntifications database

More...
PRIDEi
Q9GZT4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80131

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9GZT4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9GZT4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167720, Expressed in subventricular zone (inner) (primate) and 209 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9GZT4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9GZT4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000167720, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121963, 28 interactors

Protein interaction database and analysis system

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IntActi
Q9GZT4, 8 interactors

Molecular INTeraction database

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MINTi
Q9GZT4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000339435

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9GZT4

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9GZT4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1340
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

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AlphaFoldDBi
Q9GZT4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9GZT4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9GZT4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni238 – 239Substrate bindingBy similarity2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1251, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000075026

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_021152_4_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9GZT4

Identification of Orthologs from Complete Genome Data

More...
OMAi
LIHPFDH

Database of Orthologous Groups

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OrthoDBi
943371at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9GZT4

TreeFam database of animal gene trees

More...
TreeFami
TF313346

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1100, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001926, PLP-dep
IPR000634, Ser/Thr_deHydtase_PyrdxlP-BS
IPR036052, Trypto_synt_PLP_dependent

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00291, PALP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53686, SSF53686, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00165, DEHYDRATASE_SER_THR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q9GZT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCAQYCISFA DVEKAHINIR DSIHLTPVLT SSILNQLTGR NLFFKCELFQ
60 70 80 90 100
KTGSFKIRGA LNAVRSLVPD ALERKPKAVV THSSGNHGQA LTYAAKLEGI
110 120 130 140 150
PAYIVVPQTA PDCKKLAIQA YGASIVYCEP SDESRENVAK RVTEETEGIM
160 170 180 190 200
VHPNQEPAVI AGQGTIALEV LNQVPLVDAL VVPVGGGGML AGIAITVKAL
210 220 230 240 250
KPSVKVYAAE PSNADDCYQS KLKGKLMPNL YPPETIADGV KSSIGLNTWP
260 270 280 290 300
IIRDLVDDIF TVTEDEIKCA TQLVWERMKL LIEPTAGVGV AAVLSQHFQT
310 320 330 340
VSPEVKNICI VLSGGNVDLT SSITWVKQAE RPASYQSVSV
Length:340
Mass (Da):36,566
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i873342C62D5D7B9D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3ZK31Q3ZK31_HUMAN
L-serine ammonia-lyase
SRR
66Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3N0I3L3N0_HUMAN
L-serine ammonia-lyase
SRR
100Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4W4I3L4W4_HUMAN
L-serine ammonia-lyase
SRR
93Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4B4I3L4B4_HUMAN
L-serine ammonia-lyase
SRR
150Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4L3I3L4L3_HUMAN
Serine racemase
SRR
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYE8V9GYE8_HUMAN
Serine racemase
SRR
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF169974 mRNA Translation: AAG27081.1
AY034081 mRNA Translation: AAK58495.1
AK023169 mRNA Translation: BAB14442.1
CR457300 mRNA Translation: CAG33581.1
CH471108 Genomic DNA Translation: EAW90553.1
CH471108 Genomic DNA Translation: EAW90554.1
CH471108 Genomic DNA Translation: EAW90555.1
BC074728 mRNA Translation: AAH74728.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11017.1

NCBI Reference Sequences

More...
RefSeqi
NP_068766.1, NM_021947.2
XP_006721628.1, XM_006721565.3
XP_006721629.1, XM_006721566.3
XP_011522276.1, XM_011523974.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344595.10; ENSP00000339435.5; ENSG00000167720.13

Database of genes from NCBI RefSeq genomes

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GeneIDi
63826

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:63826

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...
MANE-Selecti
ENST00000344595.10; ENSP00000339435.5; NM_021947.3; NP_068766.1

UCSC genome browser

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UCSCi
uc002fue.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169974 mRNA Translation: AAG27081.1
AY034081 mRNA Translation: AAK58495.1
AK023169 mRNA Translation: BAB14442.1
CR457300 mRNA Translation: CAG33581.1
CH471108 Genomic DNA Translation: EAW90553.1
CH471108 Genomic DNA Translation: EAW90554.1
CH471108 Genomic DNA Translation: EAW90555.1
BC074728 mRNA Translation: AAH74728.1
CCDSiCCDS11017.1
RefSeqiNP_068766.1, NM_021947.2
XP_006721628.1, XM_006721565.3
XP_006721629.1, XM_006721566.3
XP_011522276.1, XM_011523974.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L6BX-ray1.50A1-340[»]
3L6RX-ray1.70A1-340[»]
5X2LX-ray1.81A/B1-340[»]
6SLHX-ray1.89AAA/BBB/CCC/DDD1-340[»]
6ZSPX-ray1.60AAA/BBB1-340[»]
6ZUJX-ray1.80AAA/BBB/CCC/DDD1-340[»]
7NBCX-ray1.71AAA/BBB/CCC/DDD1-340[»]
7NBDX-ray1.86AAA/BBB/CCC/DDD1-340[»]
7NBFX-ray1.60AAA/BBB/CCC/DDD1-340[»]
7NBGX-ray1.53AAA/BBB/CCC/DDD1-340[»]
7NBHX-ray1.77AAA/BBB/CCC/DDD1-340[»]
AlphaFoldDBiQ9GZT4
SMRiQ9GZT4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121963, 28 interactors
IntActiQ9GZT4, 8 interactors
MINTiQ9GZT4
STRINGi9606.ENSP00000339435

Chemistry databases

BindingDBiQ9GZT4
ChEMBLiCHEMBL4460
DrugBankiDB00114, Pyridoxal phosphate
DB00133, Serine

PTM databases

iPTMnetiQ9GZT4
PhosphoSitePlusiQ9GZT4

Genetic variation databases

BioMutaiSRR
DMDMi20139924

Proteomic databases

EPDiQ9GZT4
jPOSTiQ9GZT4
MassIVEiQ9GZT4
MaxQBiQ9GZT4
PaxDbiQ9GZT4
PeptideAtlasiQ9GZT4
PRIDEiQ9GZT4
ProteomicsDBi80131

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
4201, 311 antibodies from 28 providers

The DNASU plasmid repository

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DNASUi
63826

Genome annotation databases

EnsembliENST00000344595.10; ENSP00000339435.5; ENSG00000167720.13
GeneIDi63826
KEGGihsa:63826
MANE-SelectiENST00000344595.10; ENSP00000339435.5; NM_021947.3; NP_068766.1
UCSCiuc002fue.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
63826
DisGeNETi63826

GeneCards: human genes, protein and diseases

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GeneCardsi
SRR
HGNCiHGNC:14398, SRR
HPAiENSG00000167720, Low tissue specificity
MIMi606477, gene
neXtProtiNX_Q9GZT4
OpenTargetsiENSG00000167720
PharmGKBiPA37877
VEuPathDBiHostDB:ENSG00000167720

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1251, Eukaryota
GeneTreeiENSGT00550000075026
HOGENOMiCLU_021152_4_2_1
InParanoidiQ9GZT4
OMAiLIHPFDH
OrthoDBi943371at2759
PhylomeDBiQ9GZT4
TreeFamiTF313346

Enzyme and pathway databases

BRENDAi5.1.1.18, 2681
PathwayCommonsiQ9GZT4
ReactomeiR-HSA-977347, Serine biosynthesis
SABIO-RKiQ9GZT4
SignaLinkiQ9GZT4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
63826, 8 hits in 1079 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SRR, human
EvolutionaryTraceiQ9GZT4

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Serine_racemase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
63826
PharosiQ9GZT4, Tbio

Protein Ontology

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PROi
PR:Q9GZT4
RNActiQ9GZT4, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167720, Expressed in subventricular zone (inner) (primate) and 209 other tissues
ExpressionAtlasiQ9GZT4, baseline and differential
GenevisibleiQ9GZT4, HS

Family and domain databases

Gene3Di3.40.50.1100, 2 hits
InterProiView protein in InterPro
IPR001926, PLP-dep
IPR000634, Ser/Thr_deHydtase_PyrdxlP-BS
IPR036052, Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291, PALP, 1 hit
SUPFAMiSSF53686, SSF53686, 1 hit
PROSITEiView protein in PROSITE
PS00165, DEHYDRATASE_SER_THR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZT4
Secondary accession number(s): D3DTI5, Q6IA55
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: March 1, 2001
Last modified: May 25, 2022
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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