UniProtKB - Q9GZR2 (REXO4_HUMAN)

BLAST

>sp|Q9GZR2|REXO4_HUMAN RNA exonuclease 4 OS=Homo sapiens OX=9606 GN=REXO4 PE=1 SV=2
MGKAKVPASKRAPSSPVAKPGPVKTLTRKKNKKKKRFWKSKAREVSKKPASGPGAVVRPP
KAPEDFSQNWKALQEWLLKQKSQAPEKPLVISQMGSKKKPKIIQQNKKETSPQVKGEEMP
AGKDQEASRGSVPSGSKMDRRAPVPRTKASGTEHNKKGTKERTNGDIVPERGDIEHKKRK
AKEAAPAPPTEEDIWFDDVDPADIEAAIGPEAAKIARKQLGQSEGSVSLSLVKEQAFGGL
TRALALDCEMVGVGPKGEESMAARVSIVNQYGKCVYDKYVKPTEPVTDYRTAVSGIRPEN
LKQGEELEVVQKEVAEMLKGRILVGHALHNDLKVLFLDHPKKKIRDTQKYKPFKSQVKSG
RPSLRLLSEKILGLQVQQAEHCSIQDAQAAMRLYVMVKKEWESMARDRRPLLTAPDHCSD
DA

Align

Format
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History
Entry version 147 (07 Nov 2018)
Sequence version 2 (19 Jul 2005)
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Protein

RNA exonuclease 4

Gene

REXO4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

3'-5' exonuclease activity Source: InterPro
DNA-binding transcription factor activity
Source: UniProtKB
Non-traceable author statementⁱ
- 10908561
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated
Source: UniProtKB
Non-traceable author statementⁱ
- 10908561
rRNA processing Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Exonuclease, Hydrolase, Nuclease

Molecular function

Exonuclease, Hydrolase, Nuclease

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: RNA exonuclease 4 (EC:3.1.-.-) Alternative name(s): Exonuclease XPMC2 Prevents mitotic catastrophe 2 protein homolog Short name: hPMC2
Gene namesⁱ	Name:REXO4 Synonyms:PMC2, XPMC2H
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000148300.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12820 REXO4
MIMⁱ	602930 gene
neXtProtⁱ	NX_Q9GZR2

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57109
Open Targets More...OpenTargetsⁱ	ENSG00000148300
PharmGKBⁱ	PA37414

Polymorphism and mutation databases

BioMutaⁱ	REXO4
DMDMⁱ	71153418

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000131703	1 – 422	RNA exonuclease 4Add BLAST		422

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	15	PhosphoserineCombined sources	1
Modified residueⁱ	96	PhosphoserineCombined sources	1
Modified residueⁱ	111	PhosphoserineCombined sources	1
Cross-linkⁱ	115	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9GZR2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9GZR2
PaxDbⁱ	Q9GZR2
PeptideAtlas More...PeptideAtlasⁱ	Q9GZR2
PRIDEⁱ	Q9GZR2
ProteomicsDBⁱ	80118 80119 [Q9GZR2-2]

2D gel databases

SWISS-2DPAGEⁱ	Q9GZR2

SWISS-2DPAGEⁱ

Q9GZR2

PTM databases

iPTMnetⁱ	Q9GZR2
PhosphoSitePlusⁱ	Q9GZR2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000148300 Expressed in 149 organ(s), highest expression level in gastrocnemius
CleanExⁱ	HS_REXO4
ExpressionAtlasⁱ	Q9GZR2 baseline and differential
Genevisibleⁱ	Q9GZR2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047006

HPAⁱ

HPA047006

Interactionⁱ

Subunit structureⁱ

Can bind ESR1 and ESR2. This interaction is abrogated by estrogen and augmented by tamoxifen treatment.

Protein-protein interaction databases

BioGridⁱ	121375, 34 interactors
IntActⁱ	Q9GZR2, 11 interactors
Molecular INTeraction database More...MINTⁱ	Q9GZR2
STRINGⁱ	9606.ENSP00000361010

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9GZR2
SMRⁱ	Q9GZR2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	243 – 394	ExonucleaseAdd BLAST		152

Sequence similaritiesⁱ

Belongs to the REXO4 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2249 Eukaryota COG0847 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00520000055542
HOGENOMⁱ	HOG000231626
HOVERGENⁱ	HBG000999
InParanoidⁱ	Q9GZR2
KEGG Orthology (KO) More...KOⁱ	K18327
OMAⁱ	KALAMDC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I6S
PhylomeDBⁱ	Q9GZR2
TreeFamⁱ	TF313504

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06144 REX4_like, 1 hit
Gene3Dⁱ	3.30.420.10, 1 hit
InterProⁱ	View protein in InterPro IPR013520 Exonuclease_RNaseT/DNA_pol3 IPR037431 REX4_DEDDh_dom IPR012337 RNaseH-like_sf IPR036397 RNaseH_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00929 RNase_T, 1 hit
SMARTⁱ	View protein in SMART SM00479 EXOIII, 1 hit
SUPFAMⁱ	SSF53098 SSF53098, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9GZR2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKAKVPASK RAPSSPVAKP GPVKTLTRKK NKKKKRFWKS KAREVSKKPA 
        60         70         80         90        100
SGPGAVVRPP KAPEDFSQNW KALQEWLLKQ KSQAPEKPLV ISQMGSKKKP 
       110        120        130        140        150
KIIQQNKKET SPQVKGEEMP AGKDQEASRG SVPSGSKMDR RAPVPRTKAS 
       160        170        180        190        200
GTEHNKKGTK ERTNGDIVPE RGDIEHKKRK AKEAAPAPPT EEDIWFDDVD 
       210        220        230        240        250
PADIEAAIGP EAAKIARKQL GQSEGSVSLS LVKEQAFGGL TRALALDCEM 
       260        270        280        290        300
VGVGPKGEES MAARVSIVNQ YGKCVYDKYV KPTEPVTDYR TAVSGIRPEN 
       310        320        330        340        350
LKQGEELEVV QKEVAEMLKG RILVGHALHN DLKVLFLDHP KKKIRDTQKY 
       360        370        380        390        400
KPFKSQVKSG RPSLRLLSEK ILGLQVQQAE HCSIQDAQAA MRLYVMVKKE 
       410        420 
WESMARDRRP LLTAPDHCSD DA

Length:422

Mass (Da):46,672

Last modified:July 19, 2005 - v2

Checksum:ⁱ5994D59678B17C21

Isoform 2 (identifier: Q9GZR2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
76-132: WLLKQKSQAP...KDQEASRGSV → VPRWTGGRQY...RRQPQPHPPR
133-304: Missing.

« Hide

        10         20         30         40         50
MGKAKVPASK RAPSSPVAKP GPVKTLTRKK NKKKKRFWKS KAREVSKKPA 
        60         70         80         90        100
SGPGAVVRPP KAPEDFSQNW KALQEVPRWT GGRQYLAPRP VEQSTIRKEP 
       110        120        130        140        150
RKGQMVILFQ NEGTSSIRSG KLRRQPQPHP PREELEVVQK EVAEMLKGRI 
       160        170        180        190        200
LVGHALHNDL KVLFLDHPKK KIRDTQKYKP FKSQVKSGRP SLRLLSEKIL 
       210        220        230        240        250
GLQVQQAEHC SIQDAQAAMR LYVMVKKEWE SMARDRRPLL TAPDHCSDDA

Note: Gene prediction based on EST data. No experimental confirmation available.

Show »

Length:250

Mass (Da):28,390

Checksum:ⁱF2F05F07242D6EFE

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0C4DG22	A0A0C4DG22_HUMAN	RNA exonuclease 4 RNA exonuclease 4	REXO4	189	Annotation score:
A0A0C4DG31	A0A0C4DG31_HUMAN	RNA exonuclease 4 RNA exonuclease 4	REXO4	233	Annotation score:

Sequence cautionⁱ

The sequence CAI12845 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence CAI12847 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence CAI12848 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	202	A → P (PubMed:9325058).Curated		1
Sequence conflictⁱ	202	A → P (PubMed:10908561).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_023067	141	R → K. Corresponds to variant dbSNP:rs6597630Ensembl.		1
Natural variantⁱVAR_023068	283	T → A1 PublicationCorresponds to variant dbSNP:rs2285487Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_014796	76 – 132	WLLKQ…SRGSV → VPRWTGGRQYLAPRPVEQST IRKEPRKGQMVILFQNEGTS SIRSGKLRRQPQPHPPR in isoform 2. CuratedAdd BLAST		57
Alternative sequenceⁱVSP_014797	133 – 304	Missing in isoform 2. CuratedAdd BLAST		172

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF295774 mRNA Translation: AAG02123.1 AF273304 mRNA Translation: AAF98162.1 AL136894 mRNA Translation: CAB66828.1 AK025493 mRNA Translation: BAB15152.1 AK314333 mRNA Translation: BAG36979.1 AL158826 Genomic DNA Translation: CAI12845.1 Sequence problems. AL158826 Genomic DNA Translation: CAI12847.1 Sequence problems. AL158826 Genomic DNA Translation: CAI12848.1 Sequence problems. AL158826 Genomic DNA Translation: CAI12849.1 CH471090 Genomic DNA Translation: EAW88082.1 BC009274 mRNA Translation: AAH09274.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS65179.1 [Q9GZR2-2] CCDS6969.1 [Q9GZR2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001266278.1, NM_001279349.1 [Q9GZR2-2] NP_001266279.1, NM_001279350.1 NP_001266280.1, NM_001279351.1 NP_065118.2, NM_020385.3 [Q9GZR2-1]
UniGeneⁱ	Hs.438409

Genome annotation databases

Ensemblⁱ	ENST00000371935; ENSP00000361003; ENSG00000148300 [Q9GZR2-2] ENST00000371942; ENSP00000361010; ENSG00000148300 [Q9GZR2-1] ENST00000628678; ENSP00000487504; ENSG00000280706 [Q9GZR2-2] ENST00000630460; ENSP00000486065; ENSG00000280706 [Q9GZR2-1]
GeneIDⁱ	57109
KEGGⁱ	hsa:57109
UCSC genome browser More...UCSCⁱ	uc004cdm.5 human [Q9GZR2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9GZR2	RNA exonuclease 4 (Fragment)		HUMAN		189	UniRef100_Q9GZR2
cDNA FLJ55848, highly similar to RNA exonuclease 4		HUMAN		329
cDNA FLJ50372, highly similar to RNA exonuclease 4		HUMAN		285
Q9GZR2-2	RNA exonuclease 4 (Fragment)		HUMAN		233	UniRef100_Q9GZR2-2

Protein	Similar proteins		Species	Score	Length	Source
Q9GZR2	RNA exonuclease 4 (Fragment)		HUMAN		189	UniRef90_Q9GZR2
REX4 homolog, 3'-5' exonuclease		CALJA		422
REXO4 isoform 2		PONAB		422
Uncharacterized protein		PAPAN		422
Uncharacterized protein		PANPA		422
+14
Q9GZR2-2	RNA exonuclease 4 (Fragment)		HUMAN		233	UniRef90_Q9GZR2-2
Uncharacterized protein		NOMLE		251
REX4 homolog, 3'-5' exonuclease		PANTR		250
Uncharacterized protein		MACMU		250
Uncharacterized protein		COLAP		250
+10

Protein	Similar proteins		Species	Score	Length	Source
Q9GZR2	RNA exonuclease 4		MOUSE		432	UniRef50_Q9GZR2
RNA exonuclease 4 (Fragment)		HUMAN		189
REX4 homolog, 3'-5' exonuclease		GORGO		422
REX4 homolog, 3'-5' exonuclease		PANTR		422
Uncharacterized protein		MACFA		422
+176
Q9GZR2-2	RNA exonuclease 4 (Fragment)		HUMAN		233	UniRef50_Q9GZR2-2
Uncharacterized protein		NOMLE		251
REXO4 isoform 1		PONAB		250
Uncharacterized protein		MACNE		250
Uncharacterized protein		COLAP		250
+23

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF295774 mRNA Translation: AAG02123.1 AF273304 mRNA Translation: AAF98162.1 AL136894 mRNA Translation: CAB66828.1 AK025493 mRNA Translation: BAB15152.1 AK314333 mRNA Translation: BAG36979.1 AL158826 Genomic DNA Translation: CAI12845.1 Sequence problems. AL158826 Genomic DNA Translation: CAI12847.1 Sequence problems. AL158826 Genomic DNA Translation: CAI12848.1 Sequence problems. AL158826 Genomic DNA Translation: CAI12849.1 CH471090 Genomic DNA Translation: EAW88082.1 BC009274 mRNA Translation: AAH09274.1
CCDSⁱ	CCDS65179.1 [Q9GZR2-2] CCDS6969.1 [Q9GZR2-1]
RefSeqⁱ	NP_001266278.1, NM_001279349.1 [Q9GZR2-2] NP_001266279.1, NM_001279350.1 NP_001266280.1, NM_001279351.1 NP_065118.2, NM_020385.3 [Q9GZR2-1]
UniGeneⁱ	Hs.438409

3D structure databases

ProteinModelPortalⁱ	Q9GZR2
SMRⁱ	Q9GZR2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121375, 34 interactors
IntActⁱ	Q9GZR2, 11 interactors
MINTⁱ	Q9GZR2
STRINGⁱ	9606.ENSP00000361010

PTM databases

iPTMnetⁱ	Q9GZR2
PhosphoSitePlusⁱ	Q9GZR2

Polymorphism and mutation databases

BioMutaⁱ	REXO4
DMDMⁱ	71153418

2D gel databases

SWISS-2DPAGEⁱ	Q9GZR2

SWISS-2DPAGEⁱ

Q9GZR2

Proteomic databases

EPDⁱ	Q9GZR2
MaxQBⁱ	Q9GZR2
PaxDbⁱ	Q9GZR2
PeptideAtlasⁱ	Q9GZR2
PRIDEⁱ	Q9GZR2
ProteomicsDBⁱ	80118 80119 [Q9GZR2-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	57109
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000371935; ENSP00000361003; ENSG00000148300 [Q9GZR2-2] ENST00000371942; ENSP00000361010; ENSG00000148300 [Q9GZR2-1] ENST00000628678; ENSP00000487504; ENSG00000280706 [Q9GZR2-2] ENST00000630460; ENSP00000486065; ENSG00000280706 [Q9GZR2-1]
GeneIDⁱ	57109
KEGGⁱ	hsa:57109
UCSCⁱ	uc004cdm.5 human [Q9GZR2-1]

Organism-specific databases

CTDⁱ	57109
DisGeNETⁱ	57109
EuPathDBⁱ	HostDB:ENSG00000148300.11
GeneCardsⁱ	REXO4
HGNCⁱ	HGNC:12820 REXO4
HPAⁱ	HPA047006
MIMⁱ	602930 gene
neXtProtⁱ	NX_Q9GZR2
OpenTargetsⁱ	ENSG00000148300
PharmGKBⁱ	PA37414
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2249 Eukaryota COG0847 LUCA
GeneTreeⁱ	ENSGT00520000055542
HOGENOMⁱ	HOG000231626
HOVERGENⁱ	HBG000999
InParanoidⁱ	Q9GZR2
KOⁱ	K18327
OMAⁱ	KALAMDC
OrthoDBⁱ	EOG091G0I6S
PhylomeDBⁱ	Q9GZR2
TreeFamⁱ	TF313504

Miscellaneous databases

ChiTaRSⁱ	REXO4 human
GeneWikiⁱ	REXO4
GenomeRNAiⁱ	57109
Protein Ontology More...PROⁱ	PR:Q9GZR2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000148300 Expressed in 149 organ(s), highest expression level in gastrocnemius
CleanExⁱ	HS_REXO4
ExpressionAtlasⁱ	Q9GZR2 baseline and differential
Genevisibleⁱ	Q9GZR2 HS

Family and domain databases

CDDⁱ	cd06144 REX4_like, 1 hit
Gene3Dⁱ	3.30.420.10, 1 hit
InterProⁱ	View protein in InterPro IPR013520 Exonuclease_RNaseT/DNA_pol3 IPR037431 REX4_DEDDh_dom IPR012337 RNaseH-like_sf IPR036397 RNaseH_sf
Pfamⁱ	View protein in Pfam PF00929 RNase_T, 1 hit
SMARTⁱ	View protein in SMART SM00479 EXOIII, 1 hit
SUPFAMⁱ	SSF53098 SSF53098, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	REXO4_HUMAN
Accessionⁱ	Q9GZR2Primary (citable) accession number: Q9GZR2 Secondary accession number(s): B2RAT2 , Q5T8S4, Q5T8S5, Q5T8S6, Q9GZW3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
	Last sequence update:	July 19, 2005
	Last modified:	November 7, 2018
	This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - Q9GZR2 (REXO4_HUMAN)

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RNA exonuclease 4

REXO4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ