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UniProtKB - Q9GZR2 (REXO4_HUMAN)

Entry version 166 (07 Apr 2021)
Sequence version 2 (19 Jul 2005)
Previous versions | rss
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Protein

RNA exonuclease 4

Gene

REXO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9GZR2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA exonuclease 4 (EC:3.1.-.-)
Alternative name(s):
Exonuclease XPMC2
Prevents mitotic catastrophe 2 protein homolog
Short name:
hPMC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:REXO4
Synonyms:PMC2, XPMC2H
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12820, REXO4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602930, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9GZR2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000148300.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57109

Open Targets

More...OpenTargetsi		ENSG00000148300

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37414

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9GZR2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		REXO4

Domain mapping of disease mutations (DMDM)

More...DMDMi		71153418

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001317031 – 422RNA exonuclease 4Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei111PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9GZR2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9GZR2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9GZR2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9GZR2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9GZR2

PeptideAtlas

More...PeptideAtlasi		Q9GZR2

PRoteomics IDEntifications database

More...PRIDEi		Q9GZR2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80118 [Q9GZR2-1]
80119 [Q9GZR2-2]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		Q9GZR2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9GZR2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9GZR2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000148300, Expressed in sural nerve and 162 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9GZR2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9GZR2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000148300, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can bind ESR1 and ESR2. This interaction is abrogated by estrogen and augmented by tamoxifen treatment.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121375, 57 interactors

Protein interaction database and analysis system

More...IntActi		Q9GZR2, 38 interactors

Molecular INTeraction database

More...MINTi		Q9GZR2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361010

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9GZR2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9GZR2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini243 – 394ExonucleaseAdd BLAST152

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the REXO4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2249, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159607

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1111086_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9GZR2

Identification of Orthologs from Complete Genome Data

More...OMAi		CVYDKYI

Database of Orthologous Groups

More...OrthoDBi		1562214at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9GZR2

TreeFam database of animal gene trees

More...TreeFami		TF313504

Family and domain databases

Conserved Domains Database

More...CDDi		cd06144, REX4_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013520, Exonuclease_RNaseT/DNA_pol3
IPR034920, Rex4
IPR037431, REX4_DEDDh_dom
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf

The PANTHER Classification System

More...PANTHERi		PTHR12801:SF130, PTHR12801:SF130, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00929, RNase_T, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00479, EXOIII, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53098, SSF53098, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9GZR2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKAKVPASK RAPSSPVAKP GPVKTLTRKK NKKKKRFWKS KAREVSKKPA 
        60         70         80         90        100
SGPGAVVRPP KAPEDFSQNW KALQEWLLKQ KSQAPEKPLV ISQMGSKKKP 
       110        120        130        140        150
KIIQQNKKET SPQVKGEEMP AGKDQEASRG SVPSGSKMDR RAPVPRTKAS 
       160        170        180        190        200
GTEHNKKGTK ERTNGDIVPE RGDIEHKKRK AKEAAPAPPT EEDIWFDDVD 
       210        220        230        240        250
PADIEAAIGP EAAKIARKQL GQSEGSVSLS LVKEQAFGGL TRALALDCEM 
       260        270        280        290        300
VGVGPKGEES MAARVSIVNQ YGKCVYDKYV KPTEPVTDYR TAVSGIRPEN 
       310        320        330        340        350
LKQGEELEVV QKEVAEMLKG RILVGHALHN DLKVLFLDHP KKKIRDTQKY 
       360        370        380        390        400
KPFKSQVKSG RPSLRLLSEK ILGLQVQQAE HCSIQDAQAA MRLYVMVKKE 
       410        420 
WESMARDRRP LLTAPDHCSD DA
Length:422
Mass (Da):46,672
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5994D59678B17C21
GO
Isoform 2 (identifier: Q9GZR2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-132: WLLKQKSQAP...KDQEASRGSV → VPRWTGGRQY...RRQPQPHPPR
     133-304: Missing.

Show »
Length:250
Mass (Da):28,390
Checksum:iF2F05F07242D6EFE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DG22A0A0C4DG22_HUMAN
RNA exonuclease 4
REXO4
189Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG31A0A0C4DG31_HUMAN
RNA exonuclease 4
REXO4
233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAI12845 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI12847 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI12848 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti202A → P (PubMed:9325058).Curated1
Sequence conflicti202A → P (PubMed:10908561).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023067141R → K. Corresponds to variant dbSNP:rs6597630Ensembl.1
Natural variantiVAR_023068283T → A1 PublicationCorresponds to variant dbSNP:rs2285487Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01479676 – 132WLLKQ…SRGSV → VPRWTGGRQYLAPRPVEQST IRKEPRKGQMVILFQNEGTS SIRSGKLRRQPQPHPPR in isoform 2. CuratedAdd BLAST57
Alternative sequenceiVSP_014797133 – 304Missing in isoform 2. CuratedAdd BLAST172

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF295774 mRNA Translation: AAG02123.1
AF273304 mRNA Translation: AAF98162.1
AL136894 mRNA Translation: CAB66828.1
AK025493 mRNA Translation: BAB15152.1
AK314333 mRNA Translation: BAG36979.1
AL158826 Genomic DNA Translation: CAI12845.1 Sequence problems.
AL158826 Genomic DNA Translation: CAI12847.1 Sequence problems.
AL158826 Genomic DNA Translation: CAI12848.1 Sequence problems.
AL158826 Genomic DNA Translation: CAI12849.1
CH471090 Genomic DNA Translation: EAW88082.1
BC009274 mRNA Translation: AAH09274.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS65179.1 [Q9GZR2-2]
CCDS6969.1 [Q9GZR2-1]

NCBI Reference Sequences

More...RefSeqi		NP_001266278.1, NM_001279349.1 [Q9GZR2-2]
NP_001266279.1, NM_001279350.1
NP_001266280.1, NM_001279351.1
NP_065118.2, NM_020385.3 [Q9GZR2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000371935; ENSP00000361003; ENSG00000148300 [Q9GZR2-2]
ENST00000371942; ENSP00000361010; ENSG00000148300 [Q9GZR2-1]
ENST00000628678; ENSP00000487504; ENSG00000280706 [Q9GZR2-2]
ENST00000630460; ENSP00000486065; ENSG00000280706 [Q9GZR2-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57109

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57109

UCSC genome browser

More...UCSCi		uc004cdm.5, human [Q9GZR2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295774 mRNA Translation: AAG02123.1
AF273304 mRNA Translation: AAF98162.1
AL136894 mRNA Translation: CAB66828.1
AK025493 mRNA Translation: BAB15152.1
AK314333 mRNA Translation: BAG36979.1
AL158826 Genomic DNA Translation: CAI12845.1 Sequence problems.
AL158826 Genomic DNA Translation: CAI12847.1 Sequence problems.
AL158826 Genomic DNA Translation: CAI12848.1 Sequence problems.
AL158826 Genomic DNA Translation: CAI12849.1
CH471090 Genomic DNA Translation: EAW88082.1
BC009274 mRNA Translation: AAH09274.1
CCDSiCCDS65179.1 [Q9GZR2-2]
CCDS6969.1 [Q9GZR2-1]
RefSeqiNP_001266278.1, NM_001279349.1 [Q9GZR2-2]
NP_001266279.1, NM_001279350.1
NP_001266280.1, NM_001279351.1
NP_065118.2, NM_020385.3 [Q9GZR2-1]

3D structure databases

SMRiQ9GZR2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121375, 57 interactors
IntActiQ9GZR2, 38 interactors
MINTiQ9GZR2
STRINGi9606.ENSP00000361010

PTM databases

iPTMnetiQ9GZR2
PhosphoSitePlusiQ9GZR2

Genetic variation databases

BioMutaiREXO4
DMDMi71153418

2D gel databases

SWISS-2DPAGEiQ9GZR2

Proteomic databases

EPDiQ9GZR2
jPOSTiQ9GZR2
MassIVEiQ9GZR2
MaxQBiQ9GZR2
PaxDbiQ9GZR2
PeptideAtlasiQ9GZR2
PRIDEiQ9GZR2
ProteomicsDBi80118 [Q9GZR2-1]
80119 [Q9GZR2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18377, 126 antibodies

The DNASU plasmid repository

More...DNASUi		57109

Genome annotation databases

EnsembliENST00000371935; ENSP00000361003; ENSG00000148300 [Q9GZR2-2]
ENST00000371942; ENSP00000361010; ENSG00000148300 [Q9GZR2-1]
ENST00000628678; ENSP00000487504; ENSG00000280706 [Q9GZR2-2]
ENST00000630460; ENSP00000486065; ENSG00000280706 [Q9GZR2-1]
GeneIDi57109
KEGGihsa:57109
UCSCiuc004cdm.5, human [Q9GZR2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57109
DisGeNETi57109

GeneCards: human genes, protein and diseases

More...GeneCardsi		REXO4
HGNCiHGNC:12820, REXO4
HPAiENSG00000148300, Low tissue specificity
MIMi602930, gene
neXtProtiNX_Q9GZR2
OpenTargetsiENSG00000148300
PharmGKBiPA37414
VEuPathDBiHostDB:ENSG00000148300.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2249, Eukaryota
GeneTreeiENSGT00940000159607
HOGENOMiCLU_1111086_0_0_1
InParanoidiQ9GZR2
OMAiCVYDKYI
OrthoDBi1562214at2759
PhylomeDBiQ9GZR2
TreeFamiTF313504

Enzyme and pathway databases

PathwayCommonsiQ9GZR2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57109, 3 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		REXO4, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		REXO4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57109
PharosiQ9GZR2, Tbio

Protein Ontology

More...PROi		PR:Q9GZR2
RNActiQ9GZR2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000148300, Expressed in sural nerve and 162 other tissues
ExpressionAtlasiQ9GZR2, baseline and differential
GenevisibleiQ9GZR2, HS

Family and domain databases

CDDicd06144, REX4_like, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR013520, Exonuclease_RNaseT/DNA_pol3
IPR034920, Rex4
IPR037431, REX4_DEDDh_dom
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
PANTHERiPTHR12801:SF130, PTHR12801:SF130, 1 hit
PfamiView protein in Pfam
PF00929, RNase_T, 1 hit
SMARTiView protein in SMART
SM00479, EXOIII, 1 hit
SUPFAMiSSF53098, SSF53098, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiREXO4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZR2
Secondary accession number(s): B2RAT2
, Q5T8S4, Q5T8S5, Q5T8S6, Q9GZW3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: April 7, 2021
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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