UniProtKB - Q9GZR2 (REXO4_HUMAN)
Protein
RNA exonuclease 4
Gene
REXO4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- 3'-5' exonuclease activity Source: ARUK-UCL
- double-stranded DNA binding Source: ARUK-UCL
- endonuclease activity Source: ARUK-UCL
- exonuclease activity Source: GO_Central
- RNA binding Source: UniProtKB
- single-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- DNA catabolic process, endonucleolytic Source: ARUK-UCL
- DNA catabolic process, exonucleolytic Source: ARUK-UCL
- non-recombinational repair Source: ARUK-UCL
- regulation of transcription, DNA-templated Source: UniProtKB
- rRNA processing Source: InterPro
Keywordsi
Molecular function | Exonuclease, Hydrolase, Nuclease |
Enzyme and pathway databases
PathwayCommonsi | Q9GZR2 |
Names & Taxonomyi
Protein namesi | Recommended name: RNA exonuclease 4 (EC:3.1.-.-)Alternative name(s): Exonuclease XPMC2 Prevents mitotic catastrophe 2 protein homolog Short name: hPMC2 |
Gene namesi | Name:REXO4 Synonyms:PMC2, XPMC2H |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12820, REXO4 |
MIMi | 602930, gene |
neXtProti | NX_Q9GZR2 |
VEuPathDBi | HostDB:ENSG00000148300.11 |
Subcellular locationi
Nucleus
- nucleolus 2 Publications
Nucleus
- nuclear speck Source: HPA
- nucleolus Source: LIFEdb
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 57109 |
OpenTargetsi | ENSG00000148300 |
PharmGKBi | PA37414 |
Miscellaneous databases
Pharosi | Q9GZR2, Tbio |
Genetic variation databases
BioMutai | REXO4 |
DMDMi | 71153418 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000131703 | 1 – 422 | RNA exonuclease 4Add BLAST | 422 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 15 | PhosphoserineCombined sources | 1 | |
Modified residuei | 96 | PhosphoserineCombined sources | 1 | |
Modified residuei | 111 | PhosphoserineCombined sources | 1 | |
Cross-linki | 115 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9GZR2 |
jPOSTi | Q9GZR2 |
MassIVEi | Q9GZR2 |
MaxQBi | Q9GZR2 |
PaxDbi | Q9GZR2 |
PeptideAtlasi | Q9GZR2 |
PRIDEi | Q9GZR2 |
ProteomicsDBi | 80118 [Q9GZR2-1] 80119 [Q9GZR2-2] |
2D gel databases
SWISS-2DPAGEi | Q9GZR2 |
PTM databases
iPTMneti | Q9GZR2 |
PhosphoSitePlusi | Q9GZR2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000148300, Expressed in sural nerve and 162 other tissues |
ExpressionAtlasi | Q9GZR2, baseline and differential |
Genevisiblei | Q9GZR2, HS |
Organism-specific databases
HPAi | ENSG00000148300, Low tissue specificity |
Interactioni
Subunit structurei
Can bind ESR1 and ESR2. This interaction is abrogated by estrogen and augmented by tamoxifen treatment.
Binary interactionsi
Hide detailsQ9GZR2
With | #Exp. | IntAct |
---|---|---|
DNM2 - isoform 2 [P50570-2] | 3 | EBI-2856313,EBI-10968534 |
HSF2BP [O75031] | 3 | EBI-2856313,EBI-7116203 |
HTT [P42858] | 3 | EBI-2856313,EBI-466029 |
NOS3 [P29474] | 3 | EBI-2856313,EBI-1391623 |
Protein-protein interaction databases
BioGRIDi | 121375, 57 interactors |
IntActi | Q9GZR2, 38 interactors |
MINTi | Q9GZR2 |
STRINGi | 9606.ENSP00000361010 |
Miscellaneous databases
RNActi | Q9GZR2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 243 – 394 | ExonucleaseAdd BLAST | 152 |
Sequence similaritiesi
Belongs to the REXO4 family.Curated
Phylogenomic databases
eggNOGi | KOG2249, Eukaryota |
GeneTreei | ENSGT00940000159607 |
HOGENOMi | CLU_1111086_0_0_1 |
InParanoidi | Q9GZR2 |
OMAi | CVYDKYI |
OrthoDBi | 1562214at2759 |
PhylomeDBi | Q9GZR2 |
TreeFami | TF313504 |
Family and domain databases
CDDi | cd06144, REX4_like, 1 hit |
Gene3Di | 3.30.420.10, 1 hit |
InterProi | View protein in InterPro IPR013520, Exonuclease_RNaseT/DNA_pol3 IPR034920, Rex4 IPR037431, REX4_DEDDh_dom IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
PANTHERi | PTHR12801:SF130, PTHR12801:SF130, 1 hit |
Pfami | View protein in Pfam PF00929, RNase_T, 1 hit |
SMARTi | View protein in SMART SM00479, EXOIII, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9GZR2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGKAKVPASK RAPSSPVAKP GPVKTLTRKK NKKKKRFWKS KAREVSKKPA
60 70 80 90 100
SGPGAVVRPP KAPEDFSQNW KALQEWLLKQ KSQAPEKPLV ISQMGSKKKP
110 120 130 140 150
KIIQQNKKET SPQVKGEEMP AGKDQEASRG SVPSGSKMDR RAPVPRTKAS
160 170 180 190 200
GTEHNKKGTK ERTNGDIVPE RGDIEHKKRK AKEAAPAPPT EEDIWFDDVD
210 220 230 240 250
PADIEAAIGP EAAKIARKQL GQSEGSVSLS LVKEQAFGGL TRALALDCEM
260 270 280 290 300
VGVGPKGEES MAARVSIVNQ YGKCVYDKYV KPTEPVTDYR TAVSGIRPEN
310 320 330 340 350
LKQGEELEVV QKEVAEMLKG RILVGHALHN DLKVLFLDHP KKKIRDTQKY
360 370 380 390 400
KPFKSQVKSG RPSLRLLSEK ILGLQVQQAE HCSIQDAQAA MRLYVMVKKE
410 420
WESMARDRRP LLTAPDHCSD DA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DG22 | A0A0C4DG22_HUMAN | RNA exonuclease 4 | REXO4 | 189 | Annotation score: | ||
A0A0C4DG31 | A0A0C4DG31_HUMAN | RNA exonuclease 4 | REXO4 | 233 | Annotation score: |
Sequence cautioni
The sequence CAI12845 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI12847 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI12848 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 202 | A → P (PubMed:9325058).Curated | 1 | |
Sequence conflicti | 202 | A → P (PubMed:10908561).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023067 | 141 | R → K. Corresponds to variant dbSNP:rs6597630Ensembl. | 1 | |
Natural variantiVAR_023068 | 283 | T → A1 PublicationCorresponds to variant dbSNP:rs2285487Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014796 | 76 – 132 | WLLKQ…SRGSV → VPRWTGGRQYLAPRPVEQST IRKEPRKGQMVILFQNEGTS SIRSGKLRRQPQPHPPR in isoform 2. CuratedAdd BLAST | 57 | |
Alternative sequenceiVSP_014797 | 133 – 304 | Missing in isoform 2. CuratedAdd BLAST | 172 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF295774 mRNA Translation: AAG02123.1 AF273304 mRNA Translation: AAF98162.1 AL136894 mRNA Translation: CAB66828.1 AK025493 mRNA Translation: BAB15152.1 AK314333 mRNA Translation: BAG36979.1 AL158826 Genomic DNA Translation: CAI12845.1 Sequence problems. AL158826 Genomic DNA Translation: CAI12847.1 Sequence problems. AL158826 Genomic DNA Translation: CAI12848.1 Sequence problems. AL158826 Genomic DNA Translation: CAI12849.1 CH471090 Genomic DNA Translation: EAW88082.1 BC009274 mRNA Translation: AAH09274.1 |
CCDSi | CCDS65179.1 [Q9GZR2-2] CCDS6969.1 [Q9GZR2-1] |
RefSeqi | NP_001266278.1, NM_001279349.1 [Q9GZR2-2] NP_001266279.1, NM_001279350.1 NP_001266280.1, NM_001279351.1 NP_065118.2, NM_020385.3 [Q9GZR2-1] |
Genome annotation databases
Ensembli | ENST00000371935; ENSP00000361003; ENSG00000148300 [Q9GZR2-2] ENST00000371942; ENSP00000361010; ENSG00000148300 [Q9GZR2-1] ENST00000628678; ENSP00000487504; ENSG00000280706 [Q9GZR2-2] ENST00000630460; ENSP00000486065; ENSG00000280706 [Q9GZR2-1] |
GeneIDi | 57109 |
KEGGi | hsa:57109 |
UCSCi | uc004cdm.5, human [Q9GZR2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF295774 mRNA Translation: AAG02123.1 AF273304 mRNA Translation: AAF98162.1 AL136894 mRNA Translation: CAB66828.1 AK025493 mRNA Translation: BAB15152.1 AK314333 mRNA Translation: BAG36979.1 AL158826 Genomic DNA Translation: CAI12845.1 Sequence problems. AL158826 Genomic DNA Translation: CAI12847.1 Sequence problems. AL158826 Genomic DNA Translation: CAI12848.1 Sequence problems. AL158826 Genomic DNA Translation: CAI12849.1 CH471090 Genomic DNA Translation: EAW88082.1 BC009274 mRNA Translation: AAH09274.1 |
CCDSi | CCDS65179.1 [Q9GZR2-2] CCDS6969.1 [Q9GZR2-1] |
RefSeqi | NP_001266278.1, NM_001279349.1 [Q9GZR2-2] NP_001266279.1, NM_001279350.1 NP_001266280.1, NM_001279351.1 NP_065118.2, NM_020385.3 [Q9GZR2-1] |
3D structure databases
SMRi | Q9GZR2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121375, 57 interactors |
IntActi | Q9GZR2, 38 interactors |
MINTi | Q9GZR2 |
STRINGi | 9606.ENSP00000361010 |
PTM databases
iPTMneti | Q9GZR2 |
PhosphoSitePlusi | Q9GZR2 |
Genetic variation databases
BioMutai | REXO4 |
DMDMi | 71153418 |
2D gel databases
SWISS-2DPAGEi | Q9GZR2 |
Proteomic databases
EPDi | Q9GZR2 |
jPOSTi | Q9GZR2 |
MassIVEi | Q9GZR2 |
MaxQBi | Q9GZR2 |
PaxDbi | Q9GZR2 |
PeptideAtlasi | Q9GZR2 |
PRIDEi | Q9GZR2 |
ProteomicsDBi | 80118 [Q9GZR2-1] 80119 [Q9GZR2-2] |
Protocols and materials databases
Antibodypediai | 18377, 126 antibodies |
DNASUi | 57109 |
Genome annotation databases
Ensembli | ENST00000371935; ENSP00000361003; ENSG00000148300 [Q9GZR2-2] ENST00000371942; ENSP00000361010; ENSG00000148300 [Q9GZR2-1] ENST00000628678; ENSP00000487504; ENSG00000280706 [Q9GZR2-2] ENST00000630460; ENSP00000486065; ENSG00000280706 [Q9GZR2-1] |
GeneIDi | 57109 |
KEGGi | hsa:57109 |
UCSCi | uc004cdm.5, human [Q9GZR2-1] |
Organism-specific databases
CTDi | 57109 |
DisGeNETi | 57109 |
GeneCardsi | REXO4 |
HGNCi | HGNC:12820, REXO4 |
HPAi | ENSG00000148300, Low tissue specificity |
MIMi | 602930, gene |
neXtProti | NX_Q9GZR2 |
OpenTargetsi | ENSG00000148300 |
PharmGKBi | PA37414 |
VEuPathDBi | HostDB:ENSG00000148300.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2249, Eukaryota |
GeneTreei | ENSGT00940000159607 |
HOGENOMi | CLU_1111086_0_0_1 |
InParanoidi | Q9GZR2 |
OMAi | CVYDKYI |
OrthoDBi | 1562214at2759 |
PhylomeDBi | Q9GZR2 |
TreeFami | TF313504 |
Enzyme and pathway databases
PathwayCommonsi | Q9GZR2 |
Miscellaneous databases
BioGRID-ORCSi | 57109, 3 hits in 1000 CRISPR screens |
ChiTaRSi | REXO4, human |
GeneWikii | REXO4 |
GenomeRNAii | 57109 |
Pharosi | Q9GZR2, Tbio |
PROi | PR:Q9GZR2 |
RNActi | Q9GZR2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000148300, Expressed in sural nerve and 162 other tissues |
ExpressionAtlasi | Q9GZR2, baseline and differential |
Genevisiblei | Q9GZR2, HS |
Family and domain databases
CDDi | cd06144, REX4_like, 1 hit |
Gene3Di | 3.30.420.10, 1 hit |
InterProi | View protein in InterPro IPR013520, Exonuclease_RNaseT/DNA_pol3 IPR034920, Rex4 IPR037431, REX4_DEDDh_dom IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
PANTHERi | PTHR12801:SF130, PTHR12801:SF130, 1 hit |
Pfami | View protein in Pfam PF00929, RNase_T, 1 hit |
SMARTi | View protein in SMART SM00479, EXOIII, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | REXO4_HUMAN | |
Accessioni | Q9GZR2Primary (citable) accession number: Q9GZR2 Secondary accession number(s): B2RAT2 Q9GZW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | July 19, 2005 | |
Last modified: | April 7, 2021 | |
This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families