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UniProtKB - Q9GZR1 (SENP6_HUMAN)

Entry version 173 (10 Feb 2021)
Sequence version 2 (12 Dec 2006)
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Protein

Sentrin-specific protease 6

Gene

SENP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein sumoylation

This protein is involved in the pathway protein sumoylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei765By similarity1
Active sitei917By similarity1
Active sitei1030By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • SUMO-specific endopeptidase activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.22.B74, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9GZR1

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00886

Protein family/group databases

MEROPS protease database

More...MEROPSi		C48.004

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sentrin-specific protease 6 (EC:3.4.22.-1 Publication)
Alternative name(s):
SUMO-1-specific protease 1
Sentrin/SUMO-specific protease SENP6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SENP6
Synonyms:KIAA0797, SSP1, SUSP1
ORF Names:FKSG6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20944, SENP6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605003, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9GZR1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000112701.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1030C → S: Abolishes enzymatic activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		26054

Open Targets

More...OpenTargetsi		ENSG00000112701

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134893291

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9GZR1, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1741215

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SENP6

Domain mapping of disease mutations (DMDM)

More...DMDMi		119370526

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001017251 – 1112Sentrin-specific protease 6Add BLAST1112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei42PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei350PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei416PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki628Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei919PhosphoserineCombined sources1
Modified residuei1111PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9GZR1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9GZR1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9GZR1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9GZR1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9GZR1

PeptideAtlas

More...PeptideAtlasi		Q9GZR1

PRoteomics IDEntifications database

More...PRIDEi		Q9GZR1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80116 [Q9GZR1-1]
80117 [Q9GZR1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9GZR1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9GZR1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in reproductive organs, such as testis, ovary and prostate.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000112701, Expressed in intestine and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9GZR1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9GZR1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000112701, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RXRA.

Forms a complex with KAT5-TIP60 and UBE2I in response to UV irradiation.

Interacts with RPA1 to maintain it in hyposumoylated state during S phase preventing DNA repair initiation.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117517, 17 interactors

Protein interaction database and analysis system

More...IntActi		Q9GZR1, 11 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000402527

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9GZR1

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9GZR1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9GZR1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni666 – 1112ProteaseAdd BLAST447

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C48 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0779, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155724

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009561_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9GZR1

Identification of Orthologs from Complete Genome Data

More...OMAi		PFDEANS

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9GZR1

TreeFam database of animal gene trees

More...TreeFami		TF350136

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR003653, Peptidase_C48_C

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02902, Peptidase_C48, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50600, ULP_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9GZR1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGKSGGSA GEITFLEALA RSESKRDGGF KNNWSFDHEE ESEGDTDKDG 
        60         70         80         90        100
TNLLSVDEDE DSETSKGKKL NRRSEIVANS SGEFILKTYV RRNKSESFKT 
       110        120        130        140        150
LKGNPIGLNM LSNNKKLSEN TQNTSLCSGT VVHGRRFHHA HAQIPVVKTA 
       160        170        180        190        200
AQSSLDRKER KEYPPHVQKV EINPVRLSRL QGVERIMKKT EESESQVEPE 
       210        220        230        240        250
IKRKVQQKRH CSTYQPTPPL SPASKKCLTH LEDLQRNCRQ AITLNESTGP 
       260        270        280        290        300
LLRTSIHQNS GGQKSQNTGL TTKKFYGNNV EKVPIDIIVN CDDSKHTYLQ 
       310        320        330        340        350
TNGKVILPGA KIPKITNLKE RKTSLSDLND PIILSSDDDD DNDRTNRRES 
       360        370        380        390        400
ISPQPADSAC SSPAPSTGKV EAALNENTCR AERELRSIPE DSELNTVTLP 
       410        420        430        440        450
RKARMKDQFG NSIINTPLKR RKVFSQEPPD ALALSCQSSF DSVILNCRSI 
       460        470        480        490        500
RVGTLFRLLI EPVIFCLDFI KIQLDEPDHD PVEIILNTSD LTKCEWCNVR 
       510        520        530        540        550
KLPVVFLQAI PAVYQKLSIQ LQMNKEDKVW NDCKGVNKLT NLEEQYIILI 
       560        570        580        590        600
FQNGLDPPAN MVFESIINEI GIKNNISNFF AKIPFEEANG RLVACTRTYE 
       610        620        630        640        650
ESIKGSCGQK ENKIKTVSFE SKIQLRSKQE FQFFDEEEET GENHTIFIGP 
       660        670        680        690        700
VEKLIVYPPP PAKGGISVTN EDLHCLNEGE FLNDVIIDFY LKYLVLEKLK 
       710        720        730        740        750
KEDADRIHIF SSFFYKRLNQ RERRNHETTN LSIQQKRHGR VKTWTRHVDI 
       760        770        780        790        800
FEKDFIFVPL NEAAHWFLAV VCFPGLEKPK YEPNPHYHEN AVIQKCSTVE 
       810        820        830        840        850
DSCISSSASE MESCSQNSSA KPVIKKMLNK KHCIAVIDSN PGQEESDPRY 
       860        870        880        890        900
KRNICSVKYS VKKINHTASE NEEFNKGEST SQKVADRTKS ENGLQNESLS 
       910        920        930        940        950
STHHTDGLSK IRLNYSDESP EAGKMLEDEL VDFSEDQDNQ DDSSDDGFLA 
       960        970        980        990       1000
DDNCSSEIGQ WHLKPTICKQ PCILLMDSLR GPSRSNVVKI LREYLEVEWE 
      1010       1020       1030       1040       1050
VKKGSKRSFS KDVMKGSNPK VPQQNNFSDC GVYVLQYVES FFENPILSFE 
      1060       1070       1080       1090       1100
LPMNLANWFP PPRMRTKREE IRNIILKLQE DQSKEKRKHK DTYSTEAPLG 
      1110 
EGTEQYVNSI SD
Length:1,112
Mass (Da):126,146
Last modified:December 12, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7B07C75C39EE786
GO
Isoform 2 (identifier: Q9GZR1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-159: Missing.

Show »
Length:1,105
Mass (Da):125,330
Checksum:i7C0F2FF3E8BE3D46
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W6D9F8W6D9_HUMAN
Sentrin-specific protease 6
SENP6
685Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4F4H0Y4F4_HUMAN
Sentrin-specific protease 6
SENP6
582Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8Y8H0Y8Y8_HUMAN
Sentrin-specific protease 6
SENP6
388Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RG09D6RG09_HUMAN
Sentrin-specific protease 6
SENP6
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJH1D6RJH1_HUMAN
Sentrin-specific protease 6
SENP6
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34517 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti293D → V in BAC04794 (PubMed:14702039).Curated1
Sequence conflicti1043E → Q in AAG29831 (PubMed:10806345).Curated1
Sequence conflicti1043E → Q in AAG30253 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029653121T → M2 PublicationsCorresponds to variant dbSNP:rs17414086Ensembl.1
Natural variantiVAR_029654637E → K. Corresponds to variant dbSNP:rs1061347Ensembl.1
Natural variantiVAR_029655717R → P. Corresponds to variant dbSNP:rs12195603Ensembl.1
Natural variantiVAR_051545820A → V. Corresponds to variant dbSNP:rs34045941Ensembl.1
Natural variantiVAR_0160961106Y → C2 PublicationsCorresponds to variant dbSNP:rs9250Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005274153 – 159Missing in isoform 2. 2 Publications7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF196304 mRNA Translation: AAF04852.1
AF307849 mRNA Translation: AAG29831.1
AF306508 mRNA Translation: AAG30253.1
AB018340 mRNA Translation: BAA34517.2 Different initiation.
AL109897 Genomic DNA No translation available.
AL355797 Genomic DNA No translation available.
AL356057 Genomic DNA No translation available.
AL589656 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48734.1
BC028583 mRNA Translation: AAH28583.1
AK096455 mRNA Translation: BAC04794.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43483.1 [Q9GZR1-2]
CCDS47454.1 [Q9GZR1-1]

NCBI Reference Sequences

More...RefSeqi		NP_001093879.1, NM_001100409.2 [Q9GZR1-2]
NP_001291721.1, NM_001304792.1
NP_056386.2, NM_015571.3 [Q9GZR1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000370010; ENSP00000359027; ENSG00000112701 [Q9GZR1-2]
ENST00000447266; ENSP00000402527; ENSG00000112701 [Q9GZR1-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26054

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26054

UCSC genome browser

More...UCSCi		uc003pid.5, human [Q9GZR1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196304 mRNA Translation: AAF04852.1
AF307849 mRNA Translation: AAG29831.1
AF306508 mRNA Translation: AAG30253.1
AB018340 mRNA Translation: BAA34517.2 Different initiation.
AL109897 Genomic DNA No translation available.
AL355797 Genomic DNA No translation available.
AL356057 Genomic DNA No translation available.
AL589656 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48734.1
BC028583 mRNA Translation: AAH28583.1
AK096455 mRNA Translation: BAC04794.1
CCDSiCCDS43483.1 [Q9GZR1-2]
CCDS47454.1 [Q9GZR1-1]
RefSeqiNP_001093879.1, NM_001100409.2 [Q9GZR1-2]
NP_001291721.1, NM_001304792.1
NP_056386.2, NM_015571.3 [Q9GZR1-1]

3D structure databases

SMRiQ9GZR1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117517, 17 interactors
IntActiQ9GZR1, 11 interactors
STRINGi9606.ENSP00000402527

Chemistry databases

BindingDBiQ9GZR1
ChEMBLiCHEMBL1741215

Protein family/group databases

MEROPSiC48.004

PTM databases

iPTMnetiQ9GZR1
PhosphoSitePlusiQ9GZR1

Genetic variation databases

BioMutaiSENP6
DMDMi119370526

Proteomic databases

EPDiQ9GZR1
jPOSTiQ9GZR1
MassIVEiQ9GZR1
MaxQBiQ9GZR1
PaxDbiQ9GZR1
PeptideAtlasiQ9GZR1
PRIDEiQ9GZR1
ProteomicsDBi80116 [Q9GZR1-1]
80117 [Q9GZR1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7742, 404 antibodies

Genome annotation databases

EnsembliENST00000370010; ENSP00000359027; ENSG00000112701 [Q9GZR1-2]
ENST00000447266; ENSP00000402527; ENSG00000112701 [Q9GZR1-1]
GeneIDi26054
KEGGihsa:26054
UCSCiuc003pid.5, human [Q9GZR1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26054
DisGeNETi26054

GeneCards: human genes, protein and diseases

More...GeneCardsi		SENP6
HGNCiHGNC:20944, SENP6
HPAiENSG00000112701, Low tissue specificity
MIMi605003, gene
neXtProtiNX_Q9GZR1
OpenTargetsiENSG00000112701
PharmGKBiPA134893291
VEuPathDBiHostDB:ENSG00000112701.17

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0779, Eukaryota
GeneTreeiENSGT00940000155724
HOGENOMiCLU_009561_0_0_1
InParanoidiQ9GZR1
OMAiPFDEANS
PhylomeDBiQ9GZR1
TreeFamiTF350136

Enzyme and pathway databases

UniPathwayiUPA00886
BRENDAi3.4.22.B74, 2681
PathwayCommonsiQ9GZR1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		26054, 674 hits in 882 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SENP6, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SENP6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26054
PharosiQ9GZR1, Tbio

Protein Ontology

More...PROi		PR:Q9GZR1
RNActiQ9GZR1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000112701, Expressed in intestine and 241 other tissues
ExpressionAtlasiQ9GZR1, baseline and differential
GenevisibleiQ9GZR1, HS

Family and domain databases

InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR003653, Peptidase_C48_C
PfamiView protein in Pfam
PF02902, Peptidase_C48, 2 hits
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50600, ULP_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSENP6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZR1
Secondary accession number(s): A6NNY9
, O94891, Q5VUL3, Q5VUL4, Q8TBY4, Q9UJV5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: December 12, 2006
Last modified: February 10, 2021
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  7. SIMILARITY comments
    Index of protein domains and families
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