UniProtKB - Q9GZR1 (SENP6_HUMAN)
Protein
Sentrin-specific protease 6
Gene
SENP6
Organism
Homo sapiens (Human)
Status
Functioni
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.6 Publications
: protein sumoylation Pathwayi
This protein is involved in the pathway protein sumoylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 765 | By similarity | 1 | |
Active sitei | 917 | By similarity | 1 | |
Active sitei | 1030 | By similarity | 1 |
GO - Molecular functioni
- SUMO-specific endopeptidase activity Source: UniProtKB
GO - Biological processi
- protein desumoylation Source: UniProtKB
- protein modification by small protein removal Source: UniProtKB
- protein sumoylation Source: UniProtKB-UniPathway
- regulation of kinetochore assembly Source: UniProtKB
- regulation of spindle assembly Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
BRENDAi | 3.4.22.B74, 2681 |
PathwayCommonsi | Q9GZR1 |
UniPathwayi | UPA00886 |
Protein family/group databases
MEROPSi | C48.004 |
Names & Taxonomyi
Protein namesi | Recommended name: Sentrin-specific protease 6 (EC:3.4.22.-1 Publication)Alternative name(s): SUMO-1-specific protease 1 Sentrin/SUMO-specific protease SENP6 |
Gene namesi | Name:SENP6 Synonyms:KIAA0797, SSP1, SUSP1 ORF Names:FKSG6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20944, SENP6 |
MIMi | 605003, gene |
neXtProti | NX_Q9GZR1 |
VEuPathDBi | HostDB:ENSG00000112701.17 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1030 | C → S: Abolishes enzymatic activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 26054 |
OpenTargetsi | ENSG00000112701 |
PharmGKBi | PA134893291 |
Miscellaneous databases
Pharosi | Q9GZR1, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1741215 |
Genetic variation databases
BioMutai | SENP6 |
DMDMi | 119370526 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000101725 | 1 – 1112 | Sentrin-specific protease 6Add BLAST | 1112 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 42 | PhosphoserineCombined sources | 1 | |
Modified residuei | 335 | PhosphoserineCombined sources | 1 | |
Modified residuei | 336 | PhosphoserineCombined sources | 1 | |
Modified residuei | 350 | PhosphoserineCombined sources | 1 | |
Modified residuei | 352 | PhosphoserineCombined sources | 1 | |
Modified residuei | 416 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 628 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 919 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1111 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9GZR1 |
jPOSTi | Q9GZR1 |
MassIVEi | Q9GZR1 |
MaxQBi | Q9GZR1 |
PaxDbi | Q9GZR1 |
PeptideAtlasi | Q9GZR1 |
PRIDEi | Q9GZR1 |
ProteomicsDBi | 80116 [Q9GZR1-1] 80117 [Q9GZR1-2] |
PTM databases
iPTMneti | Q9GZR1 |
PhosphoSitePlusi | Q9GZR1 |
Expressioni
Tissue specificityi
Highly expressed in reproductive organs, such as testis, ovary and prostate.
Gene expression databases
Bgeei | ENSG00000112701, Expressed in intestine and 241 other tissues |
ExpressionAtlasi | Q9GZR1, baseline and differential |
Genevisiblei | Q9GZR1, HS |
Organism-specific databases
HPAi | ENSG00000112701, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RXRA.
Forms a complex with KAT5-TIP60 and UBE2I in response to UV irradiation.
Interacts with RPA1 to maintain it in hyposumoylated state during S phase preventing DNA repair initiation.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 117517, 18 interactors |
IntActi | Q9GZR1, 11 interactors |
STRINGi | 9606.ENSP00000402527 |
Chemistry databases
BindingDBi | Q9GZR1 |
Miscellaneous databases
RNActi | Q9GZR1, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 666 – 1112 | ProteaseAdd BLAST | 447 |
Sequence similaritiesi
Belongs to the peptidase C48 family.Curated
Phylogenomic databases
eggNOGi | KOG0779, Eukaryota |
GeneTreei | ENSGT00940000155724 |
HOGENOMi | CLU_009561_0_0_1 |
InParanoidi | Q9GZR1 |
OMAi | PFDEANS |
PhylomeDBi | Q9GZR1 |
TreeFami | TF350136 |
Family and domain databases
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR003653, Peptidase_C48_C |
Pfami | View protein in Pfam PF02902, Peptidase_C48, 2 hits |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS50600, ULP_PROTEASE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9GZR1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAGKSGGSA GEITFLEALA RSESKRDGGF KNNWSFDHEE ESEGDTDKDG
60 70 80 90 100
TNLLSVDEDE DSETSKGKKL NRRSEIVANS SGEFILKTYV RRNKSESFKT
110 120 130 140 150
LKGNPIGLNM LSNNKKLSEN TQNTSLCSGT VVHGRRFHHA HAQIPVVKTA
160 170 180 190 200
AQSSLDRKER KEYPPHVQKV EINPVRLSRL QGVERIMKKT EESESQVEPE
210 220 230 240 250
IKRKVQQKRH CSTYQPTPPL SPASKKCLTH LEDLQRNCRQ AITLNESTGP
260 270 280 290 300
LLRTSIHQNS GGQKSQNTGL TTKKFYGNNV EKVPIDIIVN CDDSKHTYLQ
310 320 330 340 350
TNGKVILPGA KIPKITNLKE RKTSLSDLND PIILSSDDDD DNDRTNRRES
360 370 380 390 400
ISPQPADSAC SSPAPSTGKV EAALNENTCR AERELRSIPE DSELNTVTLP
410 420 430 440 450
RKARMKDQFG NSIINTPLKR RKVFSQEPPD ALALSCQSSF DSVILNCRSI
460 470 480 490 500
RVGTLFRLLI EPVIFCLDFI KIQLDEPDHD PVEIILNTSD LTKCEWCNVR
510 520 530 540 550
KLPVVFLQAI PAVYQKLSIQ LQMNKEDKVW NDCKGVNKLT NLEEQYIILI
560 570 580 590 600
FQNGLDPPAN MVFESIINEI GIKNNISNFF AKIPFEEANG RLVACTRTYE
610 620 630 640 650
ESIKGSCGQK ENKIKTVSFE SKIQLRSKQE FQFFDEEEET GENHTIFIGP
660 670 680 690 700
VEKLIVYPPP PAKGGISVTN EDLHCLNEGE FLNDVIIDFY LKYLVLEKLK
710 720 730 740 750
KEDADRIHIF SSFFYKRLNQ RERRNHETTN LSIQQKRHGR VKTWTRHVDI
760 770 780 790 800
FEKDFIFVPL NEAAHWFLAV VCFPGLEKPK YEPNPHYHEN AVIQKCSTVE
810 820 830 840 850
DSCISSSASE MESCSQNSSA KPVIKKMLNK KHCIAVIDSN PGQEESDPRY
860 870 880 890 900
KRNICSVKYS VKKINHTASE NEEFNKGEST SQKVADRTKS ENGLQNESLS
910 920 930 940 950
STHHTDGLSK IRLNYSDESP EAGKMLEDEL VDFSEDQDNQ DDSSDDGFLA
960 970 980 990 1000
DDNCSSEIGQ WHLKPTICKQ PCILLMDSLR GPSRSNVVKI LREYLEVEWE
1010 1020 1030 1040 1050
VKKGSKRSFS KDVMKGSNPK VPQQNNFSDC GVYVLQYVES FFENPILSFE
1060 1070 1080 1090 1100
LPMNLANWFP PPRMRTKREE IRNIILKLQE DQSKEKRKHK DTYSTEAPLG
1110
EGTEQYVNSI SD
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W6D9 | F8W6D9_HUMAN | Sentrin-specific protease 6 | SENP6 | 685 | Annotation score: | ||
H0Y4F4 | H0Y4F4_HUMAN | Sentrin-specific protease 6 | SENP6 | 582 | Annotation score: | ||
H0Y8Y8 | H0Y8Y8_HUMAN | Sentrin-specific protease 6 | SENP6 | 388 | Annotation score: | ||
D6RG09 | D6RG09_HUMAN | Sentrin-specific protease 6 | SENP6 | 220 | Annotation score: | ||
D6RJH1 | D6RJH1_HUMAN | Sentrin-specific protease 6 | SENP6 | 74 | Annotation score: |
Sequence cautioni
The sequence BAA34517 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 293 | D → V in BAC04794 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1043 | E → Q in AAG29831 (PubMed:10806345).Curated | 1 | |
Sequence conflicti | 1043 | E → Q in AAG30253 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029653 | 121 | T → M2 PublicationsCorresponds to variant dbSNP:rs17414086Ensembl. | 1 | |
Natural variantiVAR_029654 | 637 | E → K. Corresponds to variant dbSNP:rs1061347Ensembl. | 1 | |
Natural variantiVAR_029655 | 717 | R → P. Corresponds to variant dbSNP:rs12195603Ensembl. | 1 | |
Natural variantiVAR_051545 | 820 | A → V. Corresponds to variant dbSNP:rs34045941Ensembl. | 1 | |
Natural variantiVAR_016096 | 1106 | Y → C2 PublicationsCorresponds to variant dbSNP:rs9250Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005274 | 153 – 159 | Missing in isoform 2. 2 Publications | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF196304 mRNA Translation: AAF04852.1 AF307849 mRNA Translation: AAG29831.1 AF306508 mRNA Translation: AAG30253.1 AB018340 mRNA Translation: BAA34517.2 Different initiation. AL109897 Genomic DNA No translation available. AL355797 Genomic DNA No translation available. AL356057 Genomic DNA No translation available. AL589656 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48734.1 BC028583 mRNA Translation: AAH28583.1 AK096455 mRNA Translation: BAC04794.1 |
CCDSi | CCDS43483.1 [Q9GZR1-2] CCDS47454.1 [Q9GZR1-1] |
RefSeqi | NP_001093879.1, NM_001100409.2 [Q9GZR1-2] NP_001291721.1, NM_001304792.1 NP_056386.2, NM_015571.3 [Q9GZR1-1] |
Genome annotation databases
Ensembli | ENST00000370010; ENSP00000359027; ENSG00000112701 [Q9GZR1-2] ENST00000447266; ENSP00000402527; ENSG00000112701 [Q9GZR1-1] |
GeneIDi | 26054 |
KEGGi | hsa:26054 |
UCSCi | uc003pid.5, human [Q9GZR1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF196304 mRNA Translation: AAF04852.1 AF307849 mRNA Translation: AAG29831.1 AF306508 mRNA Translation: AAG30253.1 AB018340 mRNA Translation: BAA34517.2 Different initiation. AL109897 Genomic DNA No translation available. AL355797 Genomic DNA No translation available. AL356057 Genomic DNA No translation available. AL589656 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48734.1 BC028583 mRNA Translation: AAH28583.1 AK096455 mRNA Translation: BAC04794.1 |
CCDSi | CCDS43483.1 [Q9GZR1-2] CCDS47454.1 [Q9GZR1-1] |
RefSeqi | NP_001093879.1, NM_001100409.2 [Q9GZR1-2] NP_001291721.1, NM_001304792.1 NP_056386.2, NM_015571.3 [Q9GZR1-1] |
3D structure databases
SMRi | Q9GZR1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117517, 18 interactors |
IntActi | Q9GZR1, 11 interactors |
STRINGi | 9606.ENSP00000402527 |
Chemistry databases
BindingDBi | Q9GZR1 |
ChEMBLi | CHEMBL1741215 |
Protein family/group databases
MEROPSi | C48.004 |
PTM databases
iPTMneti | Q9GZR1 |
PhosphoSitePlusi | Q9GZR1 |
Genetic variation databases
BioMutai | SENP6 |
DMDMi | 119370526 |
Proteomic databases
EPDi | Q9GZR1 |
jPOSTi | Q9GZR1 |
MassIVEi | Q9GZR1 |
MaxQBi | Q9GZR1 |
PaxDbi | Q9GZR1 |
PeptideAtlasi | Q9GZR1 |
PRIDEi | Q9GZR1 |
ProteomicsDBi | 80116 [Q9GZR1-1] 80117 [Q9GZR1-2] |
Protocols and materials databases
Antibodypediai | 7742, 411 antibodies |
Genome annotation databases
Ensembli | ENST00000370010; ENSP00000359027; ENSG00000112701 [Q9GZR1-2] ENST00000447266; ENSP00000402527; ENSG00000112701 [Q9GZR1-1] |
GeneIDi | 26054 |
KEGGi | hsa:26054 |
UCSCi | uc003pid.5, human [Q9GZR1-1] |
Organism-specific databases
CTDi | 26054 |
DisGeNETi | 26054 |
GeneCardsi | SENP6 |
HGNCi | HGNC:20944, SENP6 |
HPAi | ENSG00000112701, Low tissue specificity |
MIMi | 605003, gene |
neXtProti | NX_Q9GZR1 |
OpenTargetsi | ENSG00000112701 |
PharmGKBi | PA134893291 |
VEuPathDBi | HostDB:ENSG00000112701.17 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0779, Eukaryota |
GeneTreei | ENSGT00940000155724 |
HOGENOMi | CLU_009561_0_0_1 |
InParanoidi | Q9GZR1 |
OMAi | PFDEANS |
PhylomeDBi | Q9GZR1 |
TreeFami | TF350136 |
Enzyme and pathway databases
UniPathwayi | UPA00886 |
BRENDAi | 3.4.22.B74, 2681 |
PathwayCommonsi | Q9GZR1 |
Miscellaneous databases
BioGRID-ORCSi | 26054, 690 hits in 1002 CRISPR screens |
ChiTaRSi | SENP6, human |
GeneWikii | SENP6 |
GenomeRNAii | 26054 |
Pharosi | Q9GZR1, Tbio |
PROi | PR:Q9GZR1 |
RNActi | Q9GZR1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112701, Expressed in intestine and 241 other tissues |
ExpressionAtlasi | Q9GZR1, baseline and differential |
Genevisiblei | Q9GZR1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR003653, Peptidase_C48_C |
Pfami | View protein in Pfam PF02902, Peptidase_C48, 2 hits |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS50600, ULP_PROTEASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SENP6_HUMAN | |
Accessioni | Q9GZR1Primary (citable) accession number: Q9GZR1 Secondary accession number(s): A6NNY9 Q9UJV5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | December 12, 2006 | |
Last modified: | April 7, 2021 | |
This is version 174 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families