Sentrin-specific protease 6

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• SUMO-specific endopeptidase activity Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 20212317

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• protein desumoylation Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 20212317
• protein modification by small protein removal Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 20212317
• protein sumoylation Source: UniProtKB-UniPathway
• regulation of kinetochore assembly Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 20212317
• regulation of spindle assembly Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 20212317

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MAAGKSGGSA GEITFLEALA RSESKRDGGF KNNWSFDHEE ESEGDTDKDG 
        60         70         80         90        100
TNLLSVDEDE DSETSKGKKL NRRSEIVANS SGEFILKTYV RRNKSESFKT 
       110        120        130        140        150
LKGNPIGLNM LSNNKKLSEN TQNTSLCSGT VVHGRRFHHA HAQIPVVKTA 
       160        170        180        190        200
AQSSLDRKER KEYPPHVQKV EINPVRLSRL QGVERIMKKT EESESQVEPE 
       210        220        230        240        250
IKRKVQQKRH CSTYQPTPPL SPASKKCLTH LEDLQRNCRQ AITLNESTGP 
       260        270        280        290        300
LLRTSIHQNS GGQKSQNTGL TTKKFYGNNV EKVPIDIIVN CDDSKHTYLQ 
       310        320        330        340        350
TNGKVILPGA KIPKITNLKE RKTSLSDLND PIILSSDDDD DNDRTNRRES 
       360        370        380        390        400
ISPQPADSAC SSPAPSTGKV EAALNENTCR AERELRSIPE DSELNTVTLP 
       410        420        430        440        450
RKARMKDQFG NSIINTPLKR RKVFSQEPPD ALALSCQSSF DSVILNCRSI 
       460        470        480        490        500
RVGTLFRLLI EPVIFCLDFI KIQLDEPDHD PVEIILNTSD LTKCEWCNVR 
       510        520        530        540        550
KLPVVFLQAI PAVYQKLSIQ LQMNKEDKVW NDCKGVNKLT NLEEQYIILI 
       560        570        580        590        600
FQNGLDPPAN MVFESIINEI GIKNNISNFF AKIPFEEANG RLVACTRTYE 
       610        620        630        640        650
ESIKGSCGQK ENKIKTVSFE SKIQLRSKQE FQFFDEEEET GENHTIFIGP 
       660        670        680        690        700
VEKLIVYPPP PAKGGISVTN EDLHCLNEGE FLNDVIIDFY LKYLVLEKLK 
       710        720        730        740        750
KEDADRIHIF SSFFYKRLNQ RERRNHETTN LSIQQKRHGR VKTWTRHVDI 
       760        770        780        790        800
FEKDFIFVPL NEAAHWFLAV VCFPGLEKPK YEPNPHYHEN AVIQKCSTVE 
       810        820        830        840        850
DSCISSSASE MESCSQNSSA KPVIKKMLNK KHCIAVIDSN PGQEESDPRY 
       860        870        880        890        900
KRNICSVKYS VKKINHTASE NEEFNKGEST SQKVADRTKS ENGLQNESLS 
       910        920        930        940        950
STHHTDGLSK IRLNYSDESP EAGKMLEDEL VDFSEDQDNQ DDSSDDGFLA 
       960        970        980        990       1000
DDNCSSEIGQ WHLKPTICKQ PCILLMDSLR GPSRSNVVKI LREYLEVEWE 
      1010       1020       1030       1040       1050
VKKGSKRSFS KDVMKGSNPK VPQQNNFSDC GVYVLQYVES FFENPILSFE 
      1060       1070       1080       1090       1100
LPMNLANWFP PPRMRTKREE IRNIILKLQE DQSKEKRKHK DTYSTEAPLG 
      1110 
EGTEQYVNSI SD                                          

        10         20         30         40         50
MAAGKSGGSA GEITFLEALA RSESKRDGGF KNNWSFDHEE ESEGDTDKDG 
        60         70         80         90        100
TNLLSVDEDE DSETSKGKKL NRRSEIVANS SGEFILKTYV RRNKSESFKT 
       110        120        130        140        150
LKGNPIGLNM LSNNKKLSEN TQNTSLCSGT VVHGRRFHHA HAQIPVVKTA 
       160        170        180        190        200
AQRKEYPPHV QKVEINPVRL SRLQGVERIM KKTEESESQV EPEIKRKVQQ 
       210        220        230        240        250
KRHCSTYQPT PPLSPASKKC LTHLEDLQRN CRQAITLNES TGPLLRTSIH 
       260        270        280        290        300
QNSGGQKSQN TGLTTKKFYG NNVEKVPIDI IVNCDDSKHT YLQTNGKVIL 
       310        320        330        340        350
PGAKIPKITN LKERKTSLSD LNDPIILSSD DDDDNDRTNR RESISPQPAD 
       360        370        380        390        400
SACSSPAPST GKVEAALNEN TCRAERELRS IPEDSELNTV TLPRKARMKD 
       410        420        430        440        450
QFGNSIINTP LKRRKVFSQE PPDALALSCQ SSFDSVILNC RSIRVGTLFR 
       460        470        480        490        500
LLIEPVIFCL DFIKIQLDEP DHDPVEIILN TSDLTKCEWC NVRKLPVVFL 
       510        520        530        540        550
QAIPAVYQKL SIQLQMNKED KVWNDCKGVN KLTNLEEQYI ILIFQNGLDP 
       560        570        580        590        600
PANMVFESII NEIGIKNNIS NFFAKIPFEE ANGRLVACTR TYEESIKGSC 
       610        620        630        640        650
GQKENKIKTV SFESKIQLRS KQEFQFFDEE EETGENHTIF IGPVEKLIVY 
       660        670        680        690        700
PPPPAKGGIS VTNEDLHCLN EGEFLNDVII DFYLKYLVLE KLKKEDADRI 
       710        720        730        740        750
HIFSSFFYKR LNQRERRNHE TTNLSIQQKR HGRVKTWTRH VDIFEKDFIF 
       760        770        780        790        800
VPLNEAAHWF LAVVCFPGLE KPKYEPNPHY HENAVIQKCS TVEDSCISSS 
       810        820        830        840        850
ASEMESCSQN SSAKPVIKKM LNKKHCIAVI DSNPGQEESD PRYKRNICSV 
       860        870        880        890        900
KYSVKKINHT ASENEEFNKG ESTSQKVADR TKSENGLQNE SLSSTHHTDG 
       910        920        930        940        950
LSKIRLNYSD ESPEAGKMLE DELVDFSEDQ DNQDDSSDDG FLADDNCSSE 
       960        970        980        990       1000
IGQWHLKPTI CKQPCILLMD SLRGPSRSNV VKILREYLEV EWEVKKGSKR 
      1010       1020       1030       1040       1050
SFSKDVMKGS NPKVPQQNNF SDCGVYVLQY VESFFENPIL SFELPMNLAN 
      1060       1070       1080       1090       1100
WFPPPRMRTK REEIRNIILK LQEDQSKEKR KHKDTYSTEA PLGEGTEQYV 

NSISD                                                  

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 6
   Human chromosome 6: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. PATHWAY comments
   Index of metabolic and biosynthesis pathways
6. Peptidase families
   Classification of peptidase families and list of entries
7. SIMILARITY comments
   Index of protein domains and families