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Protein

Neuromedin-U receptor 2

Gene

NMUR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the neuromedin-U and neuromedin-S neuropeptides.By similarity1 Publication

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
SIGNORiQ9GZQ4

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U receptor 2
Short name:
NMU-R2
Alternative name(s):
G-protein coupled receptor FM-4
G-protein coupled receptor TGR-1
Gene namesi
Name:NMUR2
Synonyms:NMU2R, TGR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000132911.4
HGNCiHGNC:16454 NMUR2
MIMi605108 gene
neXtProtiNX_Q9GZQ4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49ExtracellularSequence analysisAdd BLAST49
Transmembranei50 – 70Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini71 – 82CytoplasmicSequence analysisAdd BLAST12
Transmembranei83 – 103Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini104 – 123ExtracellularSequence analysisAdd BLAST20
Transmembranei124 – 146Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini147 – 165CytoplasmicSequence analysisAdd BLAST19
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini187 – 214ExtracellularSequence analysisAdd BLAST28
Transmembranei215 – 235Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini236 – 265CytoplasmicSequence analysisAdd BLAST30
Transmembranei266 – 286Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini287 – 301ExtracellularSequence analysisAdd BLAST15
Transmembranei302 – 322Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini323 – 415CytoplasmicSequence analysisAdd BLAST93

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56923
OpenTargetsiENSG00000132911
PharmGKBiPA31664

Chemistry databases

ChEMBLiCHEMBL1075144
GuidetoPHARMACOLOGYi299

Polymorphism and mutation databases

BioMutaiNMUR2
DMDMi311033403

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699101 – 415Neuromedin-U receptor 2Add BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi119 ↔ 204PROSITE-ProRule annotation
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZQ4
PeptideAtlasiQ9GZQ4
PRIDEiQ9GZQ4
ProteomicsDBi80112

PTM databases

iPTMnetiQ9GZQ4
PhosphoSitePlusiQ9GZQ4

Expressioni

Tissue specificityi

Predominantly expressed in the CNS, particularly in the medulla oblongata, pontine reticular formation, spinal cord, and thalamus. High level in testis whereas lower levels are present in a variety of peripheral tissues including the gastrointestinal tract, genitourinary tract, liver, pancreas, adrenal gland, thyroid gland, lung, trachea, spleen and thymus.4 Publications

Gene expression databases

BgeeiENSG00000132911 Expressed in 46 organ(s), highest expression level in corpus callosum
CleanExiHS_NMUR2
GenevisibleiQ9GZQ4 HS

Organism-specific databases

HPAiHPA045836

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi121250, 28 interactors
IntActiQ9GZQ4, 4 interactors
STRINGi9606.ENSP00000255262

Chemistry databases

BindingDBiQ9GZQ4

Structurei

3D structure databases

ProteinModelPortaliQ9GZQ4
SMRiQ9GZQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00700000104070
HOGENOMiHOG000113804
HOVERGENiHBG103506
InParanoidiQ9GZQ4
KOiK05053
OMAiSQYAMIN
OrthoDBiEOG091G0ZDG
PhylomeDBiQ9GZQ4
TreeFamiTF318522

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005390 NeuromedU_rcpt
IPR005392 NeuromedU_rcpt_2
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01565 NEUROMEDINUR
PR01567 NEUROMEDNU2R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9GZQ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGMEKLQNA SWIYQQKLED PFQKHLNSTE EYLAFLCGPR RSHFFLPVSV
60 70 80 90 100
VYVPIFVVGV IGNVLVCLVI LQHQAMKTPT NYYLFSLAVS DLLVLLLGMP
110 120 130 140 150
LEVYEMWRNY PFLFGPVGCY FKTALFETVC FASILSITTV SVERYVAILH
160 170 180 190 200
PFRAKLQSTR RRALRILGIV WGFSVLFSLP NTSIHGIKFH YFPNGSLVPG
210 220 230 240 250
SATCTVIKPM WIYNFIIQVT SFLFYLLPMT VISVLYYLMA LRLKKDKSLE
260 270 280 290 300
ADEGNANIQR PCRKSVNKML FVLVLVFAIC WAPFHIDRLF FSFVEEWSES
310 320 330 340 350
LAAVFNLVHV VSGVFFYLSS AVNPIIYNLL SRRFQAAFQN VISSFHKQWH
360 370 380 390 400
SQHDPQLPPA QRNIFLTECH FVELTEDIGP QFPCQSSMHN SHLPAALSSE
410
QMSRTNYQSF HFNKT
Length:415
Mass (Da):47,696
Last modified:November 2, 2010 - v2
Checksum:iC2BACD84A812890F
GO

Sequence cautioni

The sequence BAB13721 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204C → F in AAH16938 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023941298S → T. Corresponds to variant dbSNP:rs4958535Ensembl.1
Natural variantiVAR_023942315F → L. Corresponds to variant dbSNP:rs1895245Ensembl.1
Natural variantiVAR_032770383P → L. Corresponds to variant dbSNP:rs4958532Ensembl.1
Natural variantiVAR_023943388M → V. Corresponds to variant dbSNP:rs4958531Ensembl.1
Natural variantiVAR_023944395A → T5 PublicationsCorresponds to variant dbSNP:rs1363422Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041228 mRNA Translation: BAB13721.1 Different initiation.
AF272363 mRNA Translation: AAG24794.1
AF292402 mRNA Translation: AAG03064.1
AC008571 Genomic DNA No translation available.
BC016938 mRNA Translation: AAH16938.1
BC067776 mRNA Translation: AAH67776.1
AF242874 mRNA Translation: AAF82755.1
CCDSiCCDS4321.1
RefSeqiNP_064552.3, NM_020167.4
UniGeneiHs.731911

Genome annotation databases

EnsembliENST00000255262; ENSP00000255262; ENSG00000132911
GeneIDi56923
KEGGihsa:56923
UCSCiuc003luv.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041228 mRNA Translation: BAB13721.1 Different initiation.
AF272363 mRNA Translation: AAG24794.1
AF292402 mRNA Translation: AAG03064.1
AC008571 Genomic DNA No translation available.
BC016938 mRNA Translation: AAH16938.1
BC067776 mRNA Translation: AAH67776.1
AF242874 mRNA Translation: AAF82755.1
CCDSiCCDS4321.1
RefSeqiNP_064552.3, NM_020167.4
UniGeneiHs.731911

3D structure databases

ProteinModelPortaliQ9GZQ4
SMRiQ9GZQ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121250, 28 interactors
IntActiQ9GZQ4, 4 interactors
STRINGi9606.ENSP00000255262

Chemistry databases

BindingDBiQ9GZQ4
ChEMBLiCHEMBL1075144
GuidetoPHARMACOLOGYi299

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9GZQ4
PhosphoSitePlusiQ9GZQ4

Polymorphism and mutation databases

BioMutaiNMUR2
DMDMi311033403

Proteomic databases

PaxDbiQ9GZQ4
PeptideAtlasiQ9GZQ4
PRIDEiQ9GZQ4
ProteomicsDBi80112

Protocols and materials databases

DNASUi56923
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255262; ENSP00000255262; ENSG00000132911
GeneIDi56923
KEGGihsa:56923
UCSCiuc003luv.3 human

Organism-specific databases

CTDi56923
DisGeNETi56923
EuPathDBiHostDB:ENSG00000132911.4
GeneCardsiNMUR2
H-InvDBiHIX0005335
HGNCiHGNC:16454 NMUR2
HPAiHPA045836
MIMi605108 gene
neXtProtiNX_Q9GZQ4
OpenTargetsiENSG00000132911
PharmGKBiPA31664
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00700000104070
HOGENOMiHOG000113804
HOVERGENiHBG103506
InParanoidiQ9GZQ4
KOiK05053
OMAiSQYAMIN
OrthoDBiEOG091G0ZDG
PhylomeDBiQ9GZQ4
TreeFamiTF318522

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
SIGNORiQ9GZQ4

Miscellaneous databases

GeneWikiiNeuromedin_U_receptor_2
GenomeRNAii56923
PROiPR:Q9GZQ4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132911 Expressed in 46 organ(s), highest expression level in corpus callosum
CleanExiHS_NMUR2
GenevisibleiQ9GZQ4 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005390 NeuromedU_rcpt
IPR005392 NeuromedU_rcpt_2
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01565 NEUROMEDINUR
PR01567 NEUROMEDNU2R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNMUR2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZQ4
Secondary accession number(s): Q7LC54, Q96AM5, Q9NRA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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