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Entry version 140 (02 Dec 2020)
Sequence version 1 (01 Mar 2001)
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Protein

COMM domain-containing protein 5

Gene

COMMD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966).By similarity1 Publication1 Publication

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9GZQ3

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8951664, Neddylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
COMM domain-containing protein 5
Alternative name(s):
Hypertension-related calcium-regulated gene protein
Short name:
HCaRG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COMMD5
ORF Names:HT002
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000170619.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17902, COMMD5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608216, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9GZQ3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
28991

Open Targets

More...
OpenTargetsi
ENSG00000170619

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134873412

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9GZQ3, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COMMD5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51316093

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000773952 – 224COMM domain-containing protein 5Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9GZQ3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9GZQ3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9GZQ3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9GZQ3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9GZQ3

PeptideAtlas

More...
PeptideAtlasi
Q9GZQ3

PRoteomics IDEntifications database

More...
PRIDEi
Q9GZQ3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80111

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9GZQ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9GZQ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170619, Expressed in vagina and 193 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9GZQ3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9GZQ3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000170619, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain).

Interacts with RELA, RELB, NFKB1/p105.

Interacts with CCDC22, CCDC93, SCNN1B, CUL2, CUL3, CUL4A, CUL4B, CUL7.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
118812, 20 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9GZQ3

Protein interaction database and analysis system

More...
IntActi
Q9GZQ3, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000394331

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9GZQ3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9GZQ3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini151 – 215COMMPROSITE-ProRule annotationAdd BLAST65

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RCJ6, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013770

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9GZQ3

Identification of Orthologs from Complete Genome Data

More...
OMAi
DCQEAVQ

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9GZQ3

TreeFam database of animal gene trees

More...
TreeFami
TF323880

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017920, COMM
IPR037357, COMMD5

The PANTHER Classification System

More...
PANTHERi
PTHR15666, PTHR15666, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07258, COMM_domain, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51269, COMM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9GZQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAVGAATPY LHHPGDSHSG RVSFLGAQLP PEVAAMARLL GDLDRSTFRK
60 70 80 90 100
LLKFVVSSLQ GEDCREAVQR LGVSANLPEE QLGALLAGMH TLLQQALRLP
110 120 130 140 150
PTSLKPDTFR DQLQELCIPQ DLVGDLASVV FGSQRPLLDS VAQQQGAWLP
160 170 180 190 200
HVADFRWRVD VAISTSALAR SLQPSVLMQL KLSDGSAYRF EVPTAKFQEL
210 220
RYSVALVLKE MADLEKRCER RLQD
Length:224
Mass (Da):24,670
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC4CC0563B9FA3240
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PJE4E9PJE4_HUMAN
COMM domain-containing protein 5
COMMD5
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEQ6H0YEQ6_HUMAN
COMM domain-containing protein 5
COMMD5
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF14877 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti108T → I in BAA91714 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0201306A → T1 PublicationCorresponds to variant dbSNP:rs1209879Ensembl.1
Natural variantiVAR_04881269Q → H. Corresponds to variant dbSNP:rs421427Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF290195 mRNA Translation: AAG09915.1
AF113540 mRNA Translation: AAF14877.1 Frameshift.
AK001477 mRNA Translation: BAA91714.1
AK023070 mRNA Translation: BAB14389.1
CH471162 Genomic DNA Translation: EAW82033.1
CH471162 Genomic DNA Translation: EAW82034.1
CH471162 Genomic DNA Translation: EAW82035.1
CH471162 Genomic DNA Translation: EAW82036.1
CH471162 Genomic DNA Translation: EAW82037.1
BC002672 mRNA Translation: AAH02672.1
BC003055 mRNA Translation: AAH03055.1
BC065729 mRNA Translation: AAH65729.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6436.1

NCBI Reference Sequences

More...
RefSeqi
NP_001074472.1, NM_001081003.2
NP_001074473.1, NM_001081004.2
NP_001274166.1, NM_001287237.1
NP_054785.2, NM_014066.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000305103; ENSP00000304544; ENSG00000170619
ENST00000402718; ENSP00000385793; ENSG00000170619
ENST00000450361; ENSP00000394331; ENSG00000170619
ENST00000543949; ENSP00000445840; ENSG00000170619

Database of genes from NCBI RefSeq genomes

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GeneIDi
28991

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:28991

UCSC genome browser

More...
UCSCi
uc003zem.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF290195 mRNA Translation: AAG09915.1
AF113540 mRNA Translation: AAF14877.1 Frameshift.
AK001477 mRNA Translation: BAA91714.1
AK023070 mRNA Translation: BAB14389.1
CH471162 Genomic DNA Translation: EAW82033.1
CH471162 Genomic DNA Translation: EAW82034.1
CH471162 Genomic DNA Translation: EAW82035.1
CH471162 Genomic DNA Translation: EAW82036.1
CH471162 Genomic DNA Translation: EAW82037.1
BC002672 mRNA Translation: AAH02672.1
BC003055 mRNA Translation: AAH03055.1
BC065729 mRNA Translation: AAH65729.1
CCDSiCCDS6436.1
RefSeqiNP_001074472.1, NM_001081003.2
NP_001074473.1, NM_001081004.2
NP_001274166.1, NM_001287237.1
NP_054785.2, NM_014066.3

3D structure databases

SMRiQ9GZQ3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi118812, 20 interactors
CORUMiQ9GZQ3
IntActiQ9GZQ3, 16 interactors
STRINGi9606.ENSP00000394331

PTM databases

iPTMnetiQ9GZQ3
PhosphoSitePlusiQ9GZQ3

Polymorphism and mutation databases

BioMutaiCOMMD5
DMDMi51316093

Proteomic databases

EPDiQ9GZQ3
jPOSTiQ9GZQ3
MassIVEiQ9GZQ3
MaxQBiQ9GZQ3
PaxDbiQ9GZQ3
PeptideAtlasiQ9GZQ3
PRIDEiQ9GZQ3
ProteomicsDBi80111

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28668, 41 antibodies

The DNASU plasmid repository

More...
DNASUi
28991

Genome annotation databases

EnsembliENST00000305103; ENSP00000304544; ENSG00000170619
ENST00000402718; ENSP00000385793; ENSG00000170619
ENST00000450361; ENSP00000394331; ENSG00000170619
ENST00000543949; ENSP00000445840; ENSG00000170619
GeneIDi28991
KEGGihsa:28991
UCSCiuc003zem.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
28991
DisGeNETi28991
EuPathDBiHostDB:ENSG00000170619.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
COMMD5
HGNCiHGNC:17902, COMMD5
HPAiENSG00000170619, Low tissue specificity
MIMi608216, gene
neXtProtiNX_Q9GZQ3
OpenTargetsiENSG00000170619
PharmGKBiPA134873412

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RCJ6, Eukaryota
GeneTreeiENSGT00390000013770
InParanoidiQ9GZQ3
OMAiDCQEAVQ
OrthoDBi1318335at2759
PhylomeDBiQ9GZQ3
TreeFamiTF323880

Enzyme and pathway databases

PathwayCommonsiQ9GZQ3
ReactomeiR-HSA-8951664, Neddylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
28991, 12 hits in 827 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COMMD5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
28991
PharosiQ9GZQ3, Tbio

Protein Ontology

More...
PROi
PR:Q9GZQ3
RNActiQ9GZQ3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170619, Expressed in vagina and 193 other tissues
ExpressionAtlasiQ9GZQ3, baseline and differential
GenevisibleiQ9GZQ3, HS

Family and domain databases

InterProiView protein in InterPro
IPR017920, COMM
IPR037357, COMMD5
PANTHERiPTHR15666, PTHR15666, 1 hit
PfamiView protein in Pfam
PF07258, COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269, COMM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOMD5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZQ3
Secondary accession number(s): D3DWN7, Q9NVN6, Q9UHX5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2001
Last modified: December 2, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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