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Protein

COMM domain-containing protein 5

Gene

COMMD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966).By similarity1 Publication1 Publication

Keywordsi

Biological processTranscription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 5
Alternative name(s):
Hypertension-related calcium-regulated gene protein
Short name:
HCaRG
Gene namesi
Name:COMMD5
ORF Names:HT002
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000170619.9
HGNCiHGNC:17902 COMMD5
MIMi608216 gene
neXtProtiNX_Q9GZQ3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi28991
OpenTargetsiENSG00000170619
PharmGKBiPA134873412

Polymorphism and mutation databases

BioMutaiCOMMD5
DMDMi51316093

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000773952 – 224COMM domain-containing protein 5Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9GZQ3
MaxQBiQ9GZQ3
PaxDbiQ9GZQ3
PeptideAtlasiQ9GZQ3
PRIDEiQ9GZQ3
ProteomicsDBi80111

PTM databases

iPTMnetiQ9GZQ3
PhosphoSitePlusiQ9GZQ3

Expressioni

Tissue specificityi

Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver.2 Publications

Gene expression databases

BgeeiENSG00000170619 Expressed in 177 organ(s), highest expression level in vagina
CleanExiHS_COMMD5
ExpressionAtlasiQ9GZQ3 baseline and differential
GenevisibleiQ9GZQ3 HS

Organism-specific databases

HPAiHPA046905

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL2, CUL3, CUL4A, CUL4B, CUL7.5 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi118812, 20 interactors
CORUMiQ9GZQ3
IntActiQ9GZQ3, 9 interactors
STRINGi9606.ENSP00000304544

Structurei

3D structure databases

ProteinModelPortaliQ9GZQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini151 – 215COMMPROSITE-ProRule annotationAdd BLAST65

Phylogenomic databases

eggNOGiENOG410IFHH Eukaryota
ENOG4111FTK LUCA
GeneTreeiENSGT00390000013770
HOGENOMiHOG000007429
HOVERGENiHBG051070
InParanoidiQ9GZQ3
KOiK22561
OMAiTPYLHHP
OrthoDBiEOG091G0ZTA
PhylomeDBiQ9GZQ3
TreeFamiTF323880

Family and domain databases

InterProiView protein in InterPro
IPR017920 COMM
IPR037357 COMMD5
PANTHERiPTHR15666 PTHR15666, 1 hit
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9GZQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAVGAATPY LHHPGDSHSG RVSFLGAQLP PEVAAMARLL GDLDRSTFRK
60 70 80 90 100
LLKFVVSSLQ GEDCREAVQR LGVSANLPEE QLGALLAGMH TLLQQALRLP
110 120 130 140 150
PTSLKPDTFR DQLQELCIPQ DLVGDLASVV FGSQRPLLDS VAQQQGAWLP
160 170 180 190 200
HVADFRWRVD VAISTSALAR SLQPSVLMQL KLSDGSAYRF EVPTAKFQEL
210 220
RYSVALVLKE MADLEKRCER RLQD
Length:224
Mass (Da):24,670
Last modified:March 1, 2001 - v1
Checksum:iC4CC0563B9FA3240
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PJE4E9PJE4_HUMAN
COMM domain-containing protein 5
COMMD5
171Annotation score:
H0YEQ6H0YEQ6_HUMAN
COMM domain-containing protein 5
COMMD5
170Annotation score:

Sequence cautioni

The sequence AAF14877 differs from that shown. Reason: Frameshift at positions 66, 84, 112 and 136.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108T → I in BAA91714 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0201306A → T1 PublicationCorresponds to variant dbSNP:rs1209879Ensembl.1
Natural variantiVAR_04881269Q → H. Corresponds to variant dbSNP:rs421427Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF290195 mRNA Translation: AAG09915.1
AF113540 mRNA Translation: AAF14877.1 Frameshift.
AK001477 mRNA Translation: BAA91714.1
AK023070 mRNA Translation: BAB14389.1
CH471162 Genomic DNA Translation: EAW82033.1
CH471162 Genomic DNA Translation: EAW82034.1
CH471162 Genomic DNA Translation: EAW82035.1
CH471162 Genomic DNA Translation: EAW82036.1
CH471162 Genomic DNA Translation: EAW82037.1
BC002672 mRNA Translation: AAH02672.1
BC003055 mRNA Translation: AAH03055.1
BC065729 mRNA Translation: AAH65729.1
CCDSiCCDS6436.1
RefSeqiNP_001074472.1, NM_001081003.2
NP_001074473.1, NM_001081004.2
NP_001274166.1, NM_001287237.1
NP_054785.2, NM_014066.3
UniGeneiHs.493218
Hs.631856

Genome annotation databases

EnsembliENST00000305103; ENSP00000304544; ENSG00000170619
ENST00000402718; ENSP00000385793; ENSG00000170619
ENST00000450361; ENSP00000394331; ENSG00000170619
ENST00000543949; ENSP00000445840; ENSG00000170619
GeneIDi28991
KEGGihsa:28991
UCSCiuc003zem.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF290195 mRNA Translation: AAG09915.1
AF113540 mRNA Translation: AAF14877.1 Frameshift.
AK001477 mRNA Translation: BAA91714.1
AK023070 mRNA Translation: BAB14389.1
CH471162 Genomic DNA Translation: EAW82033.1
CH471162 Genomic DNA Translation: EAW82034.1
CH471162 Genomic DNA Translation: EAW82035.1
CH471162 Genomic DNA Translation: EAW82036.1
CH471162 Genomic DNA Translation: EAW82037.1
BC002672 mRNA Translation: AAH02672.1
BC003055 mRNA Translation: AAH03055.1
BC065729 mRNA Translation: AAH65729.1
CCDSiCCDS6436.1
RefSeqiNP_001074472.1, NM_001081003.2
NP_001074473.1, NM_001081004.2
NP_001274166.1, NM_001287237.1
NP_054785.2, NM_014066.3
UniGeneiHs.493218
Hs.631856

3D structure databases

ProteinModelPortaliQ9GZQ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118812, 20 interactors
CORUMiQ9GZQ3
IntActiQ9GZQ3, 9 interactors
STRINGi9606.ENSP00000304544

PTM databases

iPTMnetiQ9GZQ3
PhosphoSitePlusiQ9GZQ3

Polymorphism and mutation databases

BioMutaiCOMMD5
DMDMi51316093

Proteomic databases

EPDiQ9GZQ3
MaxQBiQ9GZQ3
PaxDbiQ9GZQ3
PeptideAtlasiQ9GZQ3
PRIDEiQ9GZQ3
ProteomicsDBi80111

Protocols and materials databases

DNASUi28991
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305103; ENSP00000304544; ENSG00000170619
ENST00000402718; ENSP00000385793; ENSG00000170619
ENST00000450361; ENSP00000394331; ENSG00000170619
ENST00000543949; ENSP00000445840; ENSG00000170619
GeneIDi28991
KEGGihsa:28991
UCSCiuc003zem.4 human

Organism-specific databases

CTDi28991
DisGeNETi28991
EuPathDBiHostDB:ENSG00000170619.9
GeneCardsiCOMMD5
H-InvDBiHIX0007872
HGNCiHGNC:17902 COMMD5
HPAiHPA046905
MIMi608216 gene
neXtProtiNX_Q9GZQ3
OpenTargetsiENSG00000170619
PharmGKBiPA134873412
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFHH Eukaryota
ENOG4111FTK LUCA
GeneTreeiENSGT00390000013770
HOGENOMiHOG000007429
HOVERGENiHBG051070
InParanoidiQ9GZQ3
KOiK22561
OMAiTPYLHHP
OrthoDBiEOG091G0ZTA
PhylomeDBiQ9GZQ3
TreeFamiTF323880

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation

Miscellaneous databases

ChiTaRSiCOMMD5 human
GenomeRNAii28991
PROiPR:Q9GZQ3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170619 Expressed in 177 organ(s), highest expression level in vagina
CleanExiHS_COMMD5
ExpressionAtlasiQ9GZQ3 baseline and differential
GenevisibleiQ9GZQ3 HS

Family and domain databases

InterProiView protein in InterPro
IPR017920 COMM
IPR037357 COMMD5
PANTHERiPTHR15666 PTHR15666, 1 hit
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOMD5_HUMAN
AccessioniPrimary (citable) accession number: Q9GZQ3
Secondary accession number(s): D3DWN7, Q9NVN6, Q9UHX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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