UniProtKB - Q9GZP9 (DERL2_HUMAN)
Derlin-2
DERL2
Functioni
GO - Molecular functioni
- misfolded protein binding Source: GO_Central
- ubiquitin-specific protease binding Source: GO_Central
GO - Biological processi
- endoplasmic reticulum mannose trimming Source: Reactome
- endoplasmic reticulum unfolded protein response Source: UniProtKB
- negative regulation of retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
- positive regulation of cell growth Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- retrograde protein transport, ER to cytosol Source: UniProtKB
- suckling behavior Source: Ensembl
- ubiquitin-dependent ERAD pathway Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction, Unfolded protein response |
Enzyme and pathway databases
PathwayCommonsi | Q9GZP9 |
Reactomei | R-HSA-382556, ABC-family proteins mediated transport R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-901032, ER Quality Control Compartment (ERQC) |
Protein family/group databases
TCDBi | 3.A.16.1.4, the endoplasmic reticular retrotranslocon (er-rt) family |
Names & Taxonomyi
Protein namesi | Recommended name: Derlin-21 PublicationAlternative name(s): Degradation in endoplasmic reticulum protein 2 Short name: DERtrin-2 Der1-like protein 21 Publication F-LAN-1Imported F-LANa1 Publication |
Gene namesi | ORF Names:CGI-101Imported, SBBI53Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17943, DERL2 |
MIMi | 610304, gene |
neXtProti | NX_Q9GZP9 |
VEuPathDBi | HostDB:ENSG00000072849.10 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Multi-pass membrane protein 2 Publications
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: Reactome
- endoplasmic reticulum quality control compartment Source: GOC
- Hrd1p ubiquitin ligase ERAD-L complex Source: GO_Central
- integral component of endoplasmic reticulum membrane Source: UniProtKB
Endosome
- early endosome Source: Ensembl
- late endosome Source: Ensembl
Other locations
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 57 | CytoplasmicSequence analysisAdd BLAST | 57 | |
Transmembranei | 58 – 78 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 79 – 96 | LumenalSequence analysisAdd BLAST | 18 | |
Transmembranei | 97 – 117 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 118 – 150 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 151 – 171 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 172 | LumenalSequence analysis | 1 | |
Transmembranei | 173 – 193 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 194 – 239 | CytoplasmicSequence analysisAdd BLAST | 46 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 51009 |
OpenTargetsi | ENSG00000072849 |
PharmGKBi | PA134896343 |
Miscellaneous databases
Pharosi | Q9GZP9, Tbio |
Genetic variation databases
BioMutai | DERL2 |
DMDMi | 50400648 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219045 | 1 – 239 | Derlin-2Add BLAST | 239 |
Proteomic databases
EPDi | Q9GZP9 |
jPOSTi | Q9GZP9 |
MassIVEi | Q9GZP9 |
MaxQBi | Q9GZP9 |
PaxDbi | Q9GZP9 |
PeptideAtlasi | Q9GZP9 |
PRIDEi | Q9GZP9 |
ProteomicsDBi | 80110 |
PTM databases
iPTMneti | Q9GZP9 |
PhosphoSitePlusi | Q9GZP9 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000072849, Expressed in right testis and 233 other tissues |
ExpressionAtlasi | Q9GZP9, baseline and differential |
Genevisiblei | Q9GZP9, HS |
Organism-specific databases
HPAi | ENSG00000072849, Low tissue specificity |
Interactioni
Subunit structurei
Forms homo- and heterooligomers with DERL3 and, to a lesser extent, with DERL1 (PubMed:16186509).
Interacts with the SEL1L/SYVN1 and VCP/SELENOS protein complexes (PubMed:16186509). Mediates association between VCP and EDEM1, as well as that between VCP and the misfolded glycoproteins (PubMed:16449189).
Interacts with OS9 (PubMed:19084021).
Interacts with SELENOK and SELENOS (PubMed:22016385).
Interacts with the signal recognition particle/SRP and the SRP receptor; in the process of endoplasmic reticulum stress-induced pre-emptive quality control (PubMed:26565908).
Interacts with CCDC47 (By similarity).
By similarity5 PublicationsBinary interactionsi
Hide detailsQ9GZP9
GO - Molecular functioni
- misfolded protein binding Source: GO_Central
- ubiquitin-specific protease binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 119216, 68 interactors |
CORUMi | Q9GZP9 |
IntActi | Q9GZP9, 57 interactors |
MINTi | Q9GZP9 |
STRINGi | 9606.ENSP00000158771 |
Miscellaneous databases
RNActi | Q9GZP9, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0858, Eukaryota |
GeneTreei | ENSGT00530000063156 |
HOGENOMi | CLU_051898_5_2_1 |
InParanoidi | Q9GZP9 |
OMAi | IVVGHIW |
OrthoDBi | 1609512at2759 |
PhylomeDBi | Q9GZP9 |
TreeFami | TF314715 |
Family and domain databases
InterProi | View protein in InterPro IPR007599, DER1 |
Pfami | View protein in Pfam PF04511, DER1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAYQSLRLEY LQIPPVSRAY TTACVLTTAA VQLELITPFQ LYFNPELIFK
60 70 80 90 100
HFQIWRLITN FLFFGPVGFN FLFNMIFLYR YCRMLEEGSF RGRTADFVFM
110 120 130 140 150
FLFGGFLMTL FGLFVSLVFL GQAFTIMLVY VWSRRNPYVR MNFFGLLNFQ
160 170 180 190 200
APFLPWVLMG FSLLLGNSII VDLLGIAVGH IYFFLEDVFP NQPGGIRILK
210 220 230
TPSILKAIFD TPDEDPNYNP LPEERPGGFA WGEGQRLGG
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L1T3 | I3L1T3_HUMAN | Derlin | DERL2 | 158 | Annotation score: | ||
I3L1S8 | I3L1S8_HUMAN | Derlin | DERL2 | 144 | Annotation score: | ||
I3L0R8 | I3L0R8_HUMAN | Derlin | DERL2 | 200 | Annotation score: | ||
I3L4W7 | I3L4W7_HUMAN | Derlin-2 | DERL2 | 79 | Annotation score: | ||
K7EQE8 | K7EQE8_HUMAN | Derlin-2 | DERL2 | 82 | Annotation score: | ||
I3L3R8 | I3L3R8_HUMAN | Derlin-2 | DERL2 | 74 | Annotation score: | ||
I3L1W3 | I3L1W3_HUMAN | Derlin-2 | DERL2 | 103 | Annotation score: |
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF132289 mRNA Translation: AAG43049.1 AF208065 mRNA Translation: AAL14869.1 AF151859 mRNA Translation: AAD34096.1 Frameshift. AF242523 mRNA Translation: AAF99603.1 CR457202 mRNA Translation: CAG33483.1 BC010890 mRNA Translation: AAH10890.1 |
CCDSi | CCDS11073.1 |
PIRi | JC7752 |
RefSeqi | NP_001291708.1, NM_001304779.1 NP_057125.2, NM_016041.4 |
Genome annotation databases
Ensembli | ENST00000158771; ENSP00000158771; ENSG00000072849 |
GeneIDi | 51009 |
KEGGi | hsa:51009 |
UCSCi | uc002gcc.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF132289 mRNA Translation: AAG43049.1 AF208065 mRNA Translation: AAL14869.1 AF151859 mRNA Translation: AAD34096.1 Frameshift. AF242523 mRNA Translation: AAF99603.1 CR457202 mRNA Translation: CAG33483.1 BC010890 mRNA Translation: AAH10890.1 |
CCDSi | CCDS11073.1 |
PIRi | JC7752 |
RefSeqi | NP_001291708.1, NM_001304779.1 NP_057125.2, NM_016041.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119216, 68 interactors |
CORUMi | Q9GZP9 |
IntActi | Q9GZP9, 57 interactors |
MINTi | Q9GZP9 |
STRINGi | 9606.ENSP00000158771 |
Protein family/group databases
TCDBi | 3.A.16.1.4, the endoplasmic reticular retrotranslocon (er-rt) family |
PTM databases
iPTMneti | Q9GZP9 |
PhosphoSitePlusi | Q9GZP9 |
Genetic variation databases
BioMutai | DERL2 |
DMDMi | 50400648 |
Proteomic databases
EPDi | Q9GZP9 |
jPOSTi | Q9GZP9 |
MassIVEi | Q9GZP9 |
MaxQBi | Q9GZP9 |
PaxDbi | Q9GZP9 |
PeptideAtlasi | Q9GZP9 |
PRIDEi | Q9GZP9 |
ProteomicsDBi | 80110 |
Protocols and materials databases
Antibodypediai | 23707, 138 antibodies |
DNASUi | 51009 |
Genome annotation databases
Ensembli | ENST00000158771; ENSP00000158771; ENSG00000072849 |
GeneIDi | 51009 |
KEGGi | hsa:51009 |
UCSCi | uc002gcc.2, human |
Organism-specific databases
CTDi | 51009 |
DisGeNETi | 51009 |
GeneCardsi | DERL2 |
HGNCi | HGNC:17943, DERL2 |
HPAi | ENSG00000072849, Low tissue specificity |
MIMi | 610304, gene |
neXtProti | NX_Q9GZP9 |
OpenTargetsi | ENSG00000072849 |
PharmGKBi | PA134896343 |
VEuPathDBi | HostDB:ENSG00000072849.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0858, Eukaryota |
GeneTreei | ENSGT00530000063156 |
HOGENOMi | CLU_051898_5_2_1 |
InParanoidi | Q9GZP9 |
OMAi | IVVGHIW |
OrthoDBi | 1609512at2759 |
PhylomeDBi | Q9GZP9 |
TreeFami | TF314715 |
Enzyme and pathway databases
PathwayCommonsi | Q9GZP9 |
Reactomei | R-HSA-382556, ABC-family proteins mediated transport R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-901032, ER Quality Control Compartment (ERQC) |
Miscellaneous databases
BioGRID-ORCSi | 51009, 152 hits in 875 CRISPR screens |
ChiTaRSi | DERL2, human |
GeneWikii | Derlin-2 |
GenomeRNAii | 51009 |
Pharosi | Q9GZP9, Tbio |
PROi | PR:Q9GZP9 |
RNActi | Q9GZP9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000072849, Expressed in right testis and 233 other tissues |
ExpressionAtlasi | Q9GZP9, baseline and differential |
Genevisiblei | Q9GZP9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007599, DER1 |
Pfami | View protein in Pfam PF04511, DER1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DERL2_HUMAN | |
Accessioni | Q9GZP9Primary (citable) accession number: Q9GZP9 Secondary accession number(s): Q9Y3A7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM