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Entry version 125 (13 Feb 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Immortalization up-regulated protein

Gene

IMUP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immortalization up-regulated protein
Alternative name(s):
Hepatocyte growth factor activator inhibitor type 2-related small protein
Short name:
H2RSP
Short name:
HAI-2-related small protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IMUP
Synonyms:C19orf33
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000167644.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16668 C19orf33

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9GZP8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64073

Open Targets

More...
OpenTargetsi
ENSG00000167644

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134924870

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C19orf33

Domain mapping of disease mutations (DMDM)

More...
DMDMi
33516918

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000841911 – 106Immortalization up-regulated proteinAdd BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei29PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9GZP8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9GZP8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9GZP8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9GZP8

PeptideAtlas

More...
PeptideAtlasi
Q9GZP8

PRoteomics IDEntifications database

More...
PRIDEi
Q9GZP8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80108
80109 [Q9GZP8-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9GZP8-1 [Q9GZP8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9GZP8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9GZP8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167644 Expressed in 87 organ(s), highest expression level in lower esophagus mucosa

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9GZP8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA054406
HPA059696

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122043, 3 interactors

Protein interaction database and analysis system

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IntActi
Q9GZP8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301246

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9GZP8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KGY9 Eukaryota
ENOG4110RUH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163639

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113066

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG003574

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9GZP8

Identification of Orthologs from Complete Genome Data

More...
OMAi
PGPKQGH

Database of Orthologous Groups

More...
OrthoDBi
1256839at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9GZP8

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026621 IMUP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15761 IMUP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9GZP8-1) [UniParc]FASTAAdd to basket
Also known as: IMUP-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFDLGAALE PTSQKPGVGA GHGGDPKLSP HKVQGRSEAG AGPGPKQGHH
60 70 80 90 100
SSSDSSSSSS DSDTDVKSHA AGSKQHESIP GKAKKPKVKK KEKGKKEKGK

KKEAPH
Length:106
Mass (Da):10,897
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB0D3F56E1870DAE
GO
Isoform 2 (identifier: Q9GZP8-2) [UniParc]FASTAAdd to basket
Also known as: IMUP-2

The sequence of this isoform differs from the canonical sequence as follows:
     47-106: QGHHSSSDSS...EKGKKKEAPH → ASNFRGLGKG...AAAPAIRTRM

Show »
Length:85
Mass (Da):8,512
Checksum:i84DEB07CA492F467
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00791947 – 106QGHHS…KEAPH → ASNFRGLGKGRRLTAAPPSS KDTTALPTPAAAPAIRTRM in isoform 2. 2 PublicationsAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB038317 mRNA Translation: BAB18465.1
AB038318 mRNA Translation: BAB18466.1
AF213678 mRNA Translation: AAG43574.1
AF325216 Genomic DNA Translation: AAK01421.1
BC008888 mRNA No translation available.
CH471126 Genomic DNA Translation: EAW56770.1
BC014264 mRNA Translation: AAH14264.1
BC060319 mRNA Translation: AAH60319.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12511.1 [Q9GZP8-1]
CCDS82344.1 [Q9GZP8-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7778

NCBI Reference Sequences

More...
RefSeqi
NP_001304730.1, NM_001317801.1 [Q9GZP8-2]
NP_277055.1, NM_033520.2 [Q9GZP8-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.631544

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000301246; ENSP00000301246; ENSG00000167644 [Q9GZP8-1]
ENST00000588605; ENSP00000464940; ENSG00000167644 [Q9GZP8-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64073

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64073

UCSC genome browser

More...
UCSCi
uc002ohu.2 human [Q9GZP8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038317 mRNA Translation: BAB18465.1
AB038318 mRNA Translation: BAB18466.1
AF213678 mRNA Translation: AAG43574.1
AF325216 Genomic DNA Translation: AAK01421.1
BC008888 mRNA No translation available.
CH471126 Genomic DNA Translation: EAW56770.1
BC014264 mRNA Translation: AAH14264.1
BC060319 mRNA Translation: AAH60319.1
CCDSiCCDS12511.1 [Q9GZP8-1]
CCDS82344.1 [Q9GZP8-2]
PIRiJC7778
RefSeqiNP_001304730.1, NM_001317801.1 [Q9GZP8-2]
NP_277055.1, NM_033520.2 [Q9GZP8-1]
UniGeneiHs.631544

3D structure databases

ProteinModelPortaliQ9GZP8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122043, 3 interactors
IntActiQ9GZP8, 1 interactor
STRINGi9606.ENSP00000301246

PTM databases

iPTMnetiQ9GZP8
PhosphoSitePlusiQ9GZP8

Polymorphism and mutation databases

BioMutaiC19orf33
DMDMi33516918

Proteomic databases

EPDiQ9GZP8
jPOSTiQ9GZP8
MaxQBiQ9GZP8
PaxDbiQ9GZP8
PeptideAtlasiQ9GZP8
PRIDEiQ9GZP8
ProteomicsDBi80108
80109 [Q9GZP8-2]
TopDownProteomicsiQ9GZP8-1 [Q9GZP8-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301246; ENSP00000301246; ENSG00000167644 [Q9GZP8-1]
ENST00000588605; ENSP00000464940; ENSG00000167644 [Q9GZP8-2]
GeneIDi64073
KEGGihsa:64073
UCSCiuc002ohu.2 human [Q9GZP8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64073
DisGeNETi64073
EuPathDBiHostDB:ENSG00000167644.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C19orf33
HGNCiHGNC:16668 C19orf33
HPAiHPA054406
HPA059696
neXtProtiNX_Q9GZP8
OpenTargetsiENSG00000167644
PharmGKBiPA134924870

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410KGY9 Eukaryota
ENOG4110RUH LUCA
GeneTreeiENSGT00940000163639
HOGENOMiHOG000113066
HOVERGENiHBG003574
InParanoidiQ9GZP8
OMAiPGPKQGH
OrthoDBi1256839at2759
PhylomeDBiQ9GZP8

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64073

Protein Ontology

More...
PROi
PR:Q9GZP8

Gene expression databases

BgeeiENSG00000167644 Expressed in 87 organ(s), highest expression level in lower esophagus mucosa
GenevisibleiQ9GZP8 HS

Family and domain databases

InterProiView protein in InterPro
IPR026621 IMUP
PfamiView protein in Pfam
PF15761 IMUP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIMUP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZP8
Secondary accession number(s): Q0P6G2, Q96H58, Q9HCR4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: March 1, 2001
Last modified: February 13, 2019
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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