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Protein

Neurensin-2

Gene

NRSN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in maintenance and/or transport of vesicles.

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

GO - Biological processi

  • nervous system development Source: GO_Central

Protein family/group databases

TCDBi9.B.189.1.2 the vesicular membrane neurensin (neurensin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Neurensin-2
Gene namesi
Name:NRSN2
Synonyms:C20orf98
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125841.12
HGNCiHGNC:16229 NRSN2
MIMi610666 gene
neXtProtiNX_Q9GZP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi80023
OpenTargetsiENSG00000125841
PharmGKBiPA25805

Polymorphism and mutation databases

BioMutaiNRSN2
DMDMi25008324

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002216751 – 204Neurensin-2Add BLAST204

Proteomic databases

PaxDbiQ9GZP1
PeptideAtlasiQ9GZP1
PRIDEiQ9GZP1
ProteomicsDBi80104

PTM databases

iPTMnetiQ9GZP1
PhosphoSitePlusiQ9GZP1
SwissPalmiQ9GZP1

Expressioni

Gene expression databases

BgeeiENSG00000125841 Expressed in 139 organ(s), highest expression level in right frontal lobe
CleanExiHS_NRSN2
ExpressionAtlasiQ9GZP1 baseline and differential
GenevisibleiQ9GZP1 HS

Organism-specific databases

HPAiHPA015967

Interactioni

Protein-protein interaction databases

BioGridi123077, 5 interactors
IntActiQ9GZP1, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9GZP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHGJ Eukaryota
ENOG4111B0E LUCA
GeneTreeiENSGT00530000063877
HOGENOMiHOG000231873
HOVERGENiHBG080467
InParanoidiQ9GZP1
OMAiSWFSPPA
OrthoDBiEOG091G0K9J
PhylomeDBiQ9GZP1
TreeFamiTF332090

Family and domain databases

InterProiView protein in InterPro
IPR024883 Neurensin
IPR029701 Nrsn2
PANTHERiPTHR14796 PTHR14796, 1 hit
PTHR14796:SF5 PTHR14796:SF5, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q9GZP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMPSCNRSCS CSRGPSVEDG KWYGVRSYLH LFYEDCAGTA LSDDPEGPPV
60 70 80 90 100
LCPRRPWPSL CWKISLSSGT LLLLLGVAAL TTGYAVPPKL EGIGEGEFLV
110 120 130 140 150
LDQRAADYNQ ALGTCRLAGT ALCVAAGVLL AICLFWAMIG WLSQDTKAEP
160 170 180 190 200
LDPEADSHVE VFGDEPEQQL SPIFRNASGQ SWFSPPASPF GQSSVQTIQP

KRDS
Length:204
Mass (Da):21,983
Last modified:March 1, 2001 - v1
Checksum:iD20FAAE67C0FF16D
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYN1V9GYN1_HUMAN
Neurensin-2
NRSN2
161Annotation score:
V9GYV8V9GYV8_HUMAN
Neurensin-2
NRSN2
113Annotation score:
V9GY99V9GY99_HUMAN
Neurensin-2
NRSN2
69Annotation score:
V9GZ28V9GZ28_HUMAN
Neurensin-2
NRSN2
116Annotation score:
V9GYY0V9GYY0_HUMAN
Neurensin-2
NRSN2
82Annotation score:
A0A087WVS5A0A087WVS5_HUMAN
Neurensin-2
NRSN2
65Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05373841L → V. Corresponds to variant dbSNP:rs11556643Ensembl.1
Natural variantiVAR_05373965S → C. Corresponds to variant dbSNP:rs17762763Ensembl.1
Natural variantiVAR_062158160E → Q. Corresponds to variant dbSNP:rs35731713Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136915 mRNA Translation: CAB66849.1
AK026982 mRNA Translation: BAB15613.1
AK290527 mRNA Translation: BAF83216.1
CR533441 mRNA Translation: CAG38472.1
AL034548 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10680.1
BC001963 mRNA Translation: AAH01963.1
CCDSiCCDS12996.1
RefSeqiNP_001310608.1, NM_001323679.1
NP_001310609.1, NM_001323680.1
NP_001310610.1, NM_001323681.1
NP_001310611.1, NM_001323682.1
NP_001310612.1, NM_001323683.1
NP_001310613.1, NM_001323684.1
NP_001310614.1, NM_001323685.1
NP_079234.1, NM_024958.2
XP_006723693.1, XM_006723630.3
XP_011527662.1, XM_011529360.1
XP_011527664.1, XM_011529362.2
XP_011527665.1, XM_011529363.2
XP_016883562.1, XM_017028073.1
XP_016883563.1, XM_017028074.1
XP_016883564.1, XM_017028075.1
UniGeneiHs.416024

Genome annotation databases

EnsembliENST00000382285; ENSP00000371722; ENSG00000125841
ENST00000382291; ENSP00000371728; ENSG00000125841
ENST00000621012; ENSP00000482706; ENSG00000125841
GeneIDi80023
KEGGihsa:80023
UCSCiuc002wdi.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136915 mRNA Translation: CAB66849.1
AK026982 mRNA Translation: BAB15613.1
AK290527 mRNA Translation: BAF83216.1
CR533441 mRNA Translation: CAG38472.1
AL034548 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10680.1
BC001963 mRNA Translation: AAH01963.1
CCDSiCCDS12996.1
RefSeqiNP_001310608.1, NM_001323679.1
NP_001310609.1, NM_001323680.1
NP_001310610.1, NM_001323681.1
NP_001310611.1, NM_001323682.1
NP_001310612.1, NM_001323683.1
NP_001310613.1, NM_001323684.1
NP_001310614.1, NM_001323685.1
NP_079234.1, NM_024958.2
XP_006723693.1, XM_006723630.3
XP_011527662.1, XM_011529360.1
XP_011527664.1, XM_011529362.2
XP_011527665.1, XM_011529363.2
XP_016883562.1, XM_017028073.1
XP_016883563.1, XM_017028074.1
XP_016883564.1, XM_017028075.1
UniGeneiHs.416024

3D structure databases

ProteinModelPortaliQ9GZP1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123077, 5 interactors
IntActiQ9GZP1, 3 interactors

Protein family/group databases

TCDBi9.B.189.1.2 the vesicular membrane neurensin (neurensin) family

PTM databases

iPTMnetiQ9GZP1
PhosphoSitePlusiQ9GZP1
SwissPalmiQ9GZP1

Polymorphism and mutation databases

BioMutaiNRSN2
DMDMi25008324

Proteomic databases

PaxDbiQ9GZP1
PeptideAtlasiQ9GZP1
PRIDEiQ9GZP1
ProteomicsDBi80104

Protocols and materials databases

DNASUi80023
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382285; ENSP00000371722; ENSG00000125841
ENST00000382291; ENSP00000371728; ENSG00000125841
ENST00000621012; ENSP00000482706; ENSG00000125841
GeneIDi80023
KEGGihsa:80023
UCSCiuc002wdi.5 human

Organism-specific databases

CTDi80023
DisGeNETi80023
EuPathDBiHostDB:ENSG00000125841.12
GeneCardsiNRSN2
HGNCiHGNC:16229 NRSN2
HPAiHPA015967
MIMi610666 gene
neXtProtiNX_Q9GZP1
OpenTargetsiENSG00000125841
PharmGKBiPA25805
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHGJ Eukaryota
ENOG4111B0E LUCA
GeneTreeiENSGT00530000063877
HOGENOMiHOG000231873
HOVERGENiHBG080467
InParanoidiQ9GZP1
OMAiSWFSPPA
OrthoDBiEOG091G0K9J
PhylomeDBiQ9GZP1
TreeFamiTF332090

Miscellaneous databases

ChiTaRSiNRSN2 human
GeneWikiiNRSN2
GenomeRNAii80023
PROiPR:Q9GZP1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125841 Expressed in 139 organ(s), highest expression level in right frontal lobe
CleanExiHS_NRSN2
ExpressionAtlasiQ9GZP1 baseline and differential
GenevisibleiQ9GZP1 HS

Family and domain databases

InterProiView protein in InterPro
IPR024883 Neurensin
IPR029701 Nrsn2
PANTHERiPTHR14796 PTHR14796, 1 hit
PTHR14796:SF5 PTHR14796:SF5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNRSN2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZP1
Secondary accession number(s): A8K3B2, Q6FII5, Q9NUD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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