UniProtKB - Q9GZP0 (PDGFD_HUMAN)
Platelet-derived growth factor D
PDGFD
Functioni
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity).
By similarity2 PublicationsGO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- growth factor receptor binding Source: GO_Central
- platelet-derived growth factor receptor binding Source: GO_Central
GO - Biological processi
- cellular response to amino acid stimulus Source: Ensembl
- cellular response to hydrogen peroxide Source: Ensembl
- cellular response to platelet-derived growth factor stimulus Source: Ensembl
- cellular response to transforming growth factor beta stimulus Source: Ensembl
- platelet-derived growth factor receptor signaling pathway Source: GO_Central
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell migration Source: GO_Central
- positive regulation of cell population proliferation Source: GO_Central
- positive regulation of ERK1 and ERK2 cascade Source: GO_Central
- positive regulation of fibroblast proliferation Source: Ensembl
- positive regulation of glomerular mesangial cell proliferation Source: Ensembl
- positive regulation of MAP kinase activity Source: GO_Central
- positive regulation of monocyte extravasation Source: Ensembl
- positive regulation of phosphatidylinositol 3-kinase signaling Source: GO_Central
- positive regulation of protein autophosphorylation Source: GO_Central
- positive regulation of smooth muscle cell chemotaxis Source: Ensembl
- positive regulation of smooth muscle cell proliferation Source: Ensembl
- regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
Keywordsi
Molecular function | Developmental protein, Growth factor, Mitogen |
Enzyme and pathway databases
PathwayCommonsi | Q9GZP0 |
Reactomei | R-HSA-186797, Signaling by PDGF |
SignaLinki | Q9GZP0 |
Names & Taxonomyi
Protein namesi | Recommended name: Platelet-derived growth factor DShort name: PDGF-D Alternative name(s): Iris-expressed growth factor Spinal cord-derived growth factor B Short name: SCDGF-B Cleaved into the following 2 chains: |
Gene namesi | Name:PDGFD Synonyms:IEGF, SCDGFB ORF Names:MSTP036, UNQ1899/PRO4345 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30620, PDGFD |
MIMi | 609673, gene |
neXtProti | NX_Q9GZP0 |
VEuPathDBi | HostDB:ENSG00000170962 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Note: Released by platelets upon wounding.
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Golgi apparatus
- Golgi membrane Source: Reactome
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 247 | R → A: Abolishes cleavage into active form; when associated with A-249. 1 Publication | 1 | |
Mutagenesisi | 249 | R → A: Abolishes cleavage into active form; when associated with A-247. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 80310 |
OpenTargetsi | ENSG00000170962 |
PharmGKBi | PA134892327 |
Miscellaneous databases
Pharosi | Q9GZP0, Tbio |
Chemistry databases
DrugBanki | DB05139, CR002 DB05465, Tandutinib |
Genetic variation databases
BioMutai | PDGFD |
DMDMi | 74717921 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000250188 | 19 – 370 | Platelet-derived growth factor D, latent formAdd BLAST | 352 | |
ChainiPRO_0000250189 | 250 – 370 | Platelet-derived growth factor D, receptor-binding formSequence analysisAdd BLAST | 121 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 109 ↔ 131 | PROSITE-ProRule annotation | ||
Glycosylationi | 276 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 296 | InterchainPROSITE-ProRule annotation | ||
Disulfide bondi | 302 ↔ 360 | PROSITE-ProRule annotation | ||
Disulfide bondi | 306 ↔ 362 | PROSITE-ProRule annotation |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 247 – 248 | CleavageSequence analysis | 2 | |
Sitei | 249 – 250 | CleavageSequence analysis | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q9GZP0 |
PaxDbi | Q9GZP0 |
PeptideAtlasi | Q9GZP0 |
PRIDEi | Q9GZP0 |
ProteomicsDBi | 80102 [Q9GZP0-1] 80103 [Q9GZP0-2] |
PTM databases
GlyGeni | Q9GZP0, 5 sites, 3 O-linked glycans (4 sites) |
iPTMneti | Q9GZP0 |
PhosphoSitePlusi | Q9GZP0 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000170962, Expressed in adrenal gland and 213 other tissues |
ExpressionAtlasi | Q9GZP0, baseline and differential |
Genevisiblei | Q9GZP0, HS |
Organism-specific databases
HPAi | ENSG00000170962, Tissue enhanced (adrenal gland, ovary) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.
2 PublicationsGO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- growth factor receptor binding Source: GO_Central
- platelet-derived growth factor receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 123223, 22 interactors |
ComplexPortali | CPX-2880, Platelet-derived growth factor DD complex CPX-2889, PDGF receptor beta - PDGF-DD complex CPX-2890, PDGF receptor alpha-beta - PDGF-DD complex |
IntActi | Q9GZP0, 19 interactors |
STRINGi | 9606.ENSP00000376865 |
Miscellaneous databases
RNActi | Q9GZP0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 52 – 170 | CUBPROSITE-ProRule annotationAdd BLAST | 119 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QPQY, Eukaryota |
GeneTreei | ENSGT00940000159575 |
HOGENOMi | CLU_037859_1_0_1 |
InParanoidi | Q9GZP0 |
OMAi | FVYTLVC |
OrthoDBi | 962163at2759 |
PhylomeDBi | Q9GZP0 |
TreeFami | TF332130 |
Family and domain databases
CDDi | cd00041, CUB, 1 hit cd00135, PDGF, 1 hit |
Gene3Di | 2.10.90.10, 1 hit 2.60.120.290, 1 hit |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR029034, Cystine-knot_cytokine IPR000072, PDGF/VEGF_dom IPR027123, PDGFD IPR035914, Sperma_CUB_dom_sf |
PANTHERi | PTHR11633:SF4, PTHR11633:SF4, 1 hit |
Pfami | View protein in Pfam PF00431, CUB, 1 hit PF00341, PDGF, 1 hit |
SMARTi | View protein in SMART SM00042, CUB, 1 hit |
SUPFAMi | SSF49854, SSF49854, 1 hit SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 1 hit PS50278, PDGF_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MHRLIFVYTL ICANFCSCRD TSATPQSASI KALRNANLRR DESNHLTDLY
60 70 80 90 100
RRDETIQVKG NGYVQSPRFP NSYPRNLLLT WRLHSQENTR IQLVFDNQFG
110 120 130 140 150
LEEAENDICR YDFVEVEDIS ETSTIIRGRW CGHKEVPPRI KSRTNQIKIT
160 170 180 190 200
FKSDDYFVAK PGFKIYYSLL EDFQPAAASE TNWESVTSSI SGVSYNSPSV
210 220 230 240 250
TDPTLIADAL DKKIAEFDTV EDLLKYFNPE SWQEDLENMY LDTPRYRGRS
260 270 280 290 300
YHDRKSKVDL DRLNDDAKRY SCTPRNYSVN IREELKLANV VFFPRCLLVQ
310 320 330 340 350
RCGGNCGCGT VNWRSCTCNS GKTVKKYHEV LQFEPGHIKR RGRAKTMALV
360 370
DIQLDHHERC DCICSSRPPR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YD37 | H0YD37_HUMAN | Platelet-derived growth factor D | PDGFD | 206 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051563 | 190 | I → V. Corresponds to variant dbSNP:rs35045740Ensembl. | 1 | |
Natural variantiVAR_036418 | 202 | D → Y in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020615 | 42 – 47 | Missing in isoform 2. 4 Publications | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033832 mRNA Translation: BAB18903.1 AF336376 mRNA Translation: AAK56136.1 AF335584 mRNA Translation: AAK38840.1 AY027517 mRNA Translation: AAK20081.1 AY027518 mRNA Translation: AAK20082.1 AF113216 mRNA Translation: AAG39287.1 AY359116 mRNA Translation: AAQ89474.1 AK292801 mRNA Translation: BAF85490.1 CH471065 Genomic DNA Translation: EAW67045.1 BC030645 mRNA Translation: AAH30645.1 |
CCDSi | CCDS41703.1 [Q9GZP0-1] CCDS8326.1 [Q9GZP0-2] |
PIRi | JC7591 |
RefSeqi | NP_079484.1, NM_025208.4 [Q9GZP0-1] NP_149126.1, NM_033135.3 [Q9GZP0-2] |
Genome annotation databases
Ensembli | ENST00000302251.9; ENSP00000302193.5; ENSG00000170962.13 [Q9GZP0-2] ENST00000393158.7; ENSP00000376865.2; ENSG00000170962.13 |
GeneIDi | 80310 |
KEGGi | hsa:80310 |
MANE-Selecti | ENST00000393158.7; ENSP00000376865.2; NM_025208.5; NP_079484.1 |
UCSCi | uc001php.4, human [Q9GZP0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033832 mRNA Translation: BAB18903.1 AF336376 mRNA Translation: AAK56136.1 AF335584 mRNA Translation: AAK38840.1 AY027517 mRNA Translation: AAK20081.1 AY027518 mRNA Translation: AAK20082.1 AF113216 mRNA Translation: AAG39287.1 AY359116 mRNA Translation: AAQ89474.1 AK292801 mRNA Translation: BAF85490.1 CH471065 Genomic DNA Translation: EAW67045.1 BC030645 mRNA Translation: AAH30645.1 |
CCDSi | CCDS41703.1 [Q9GZP0-1] CCDS8326.1 [Q9GZP0-2] |
PIRi | JC7591 |
RefSeqi | NP_079484.1, NM_025208.4 [Q9GZP0-1] NP_149126.1, NM_033135.3 [Q9GZP0-2] |
3D structure databases
AlphaFoldDBi | Q9GZP0 |
SMRi | Q9GZP0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123223, 22 interactors |
ComplexPortali | CPX-2880, Platelet-derived growth factor DD complex CPX-2889, PDGF receptor beta - PDGF-DD complex CPX-2890, PDGF receptor alpha-beta - PDGF-DD complex |
IntActi | Q9GZP0, 19 interactors |
STRINGi | 9606.ENSP00000376865 |
Chemistry databases
DrugBanki | DB05139, CR002 DB05465, Tandutinib |
PTM databases
GlyGeni | Q9GZP0, 5 sites, 3 O-linked glycans (4 sites) |
iPTMneti | Q9GZP0 |
PhosphoSitePlusi | Q9GZP0 |
Genetic variation databases
BioMutai | PDGFD |
DMDMi | 74717921 |
Proteomic databases
MassIVEi | Q9GZP0 |
PaxDbi | Q9GZP0 |
PeptideAtlasi | Q9GZP0 |
PRIDEi | Q9GZP0 |
ProteomicsDBi | 80102 [Q9GZP0-1] 80103 [Q9GZP0-2] |
Protocols and materials databases
Antibodypediai | 31835, 296 antibodies from 27 providers |
DNASUi | 80310 |
Genome annotation databases
Ensembli | ENST00000302251.9; ENSP00000302193.5; ENSG00000170962.13 [Q9GZP0-2] ENST00000393158.7; ENSP00000376865.2; ENSG00000170962.13 |
GeneIDi | 80310 |
KEGGi | hsa:80310 |
MANE-Selecti | ENST00000393158.7; ENSP00000376865.2; NM_025208.5; NP_079484.1 |
UCSCi | uc001php.4, human [Q9GZP0-1] |
Organism-specific databases
CTDi | 80310 |
DisGeNETi | 80310 |
GeneCardsi | PDGFD |
HGNCi | HGNC:30620, PDGFD |
HPAi | ENSG00000170962, Tissue enhanced (adrenal gland, ovary) |
MIMi | 609673, gene |
neXtProti | NX_Q9GZP0 |
OpenTargetsi | ENSG00000170962 |
PharmGKBi | PA134892327 |
VEuPathDBi | HostDB:ENSG00000170962 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPQY, Eukaryota |
GeneTreei | ENSGT00940000159575 |
HOGENOMi | CLU_037859_1_0_1 |
InParanoidi | Q9GZP0 |
OMAi | FVYTLVC |
OrthoDBi | 962163at2759 |
PhylomeDBi | Q9GZP0 |
TreeFami | TF332130 |
Enzyme and pathway databases
PathwayCommonsi | Q9GZP0 |
Reactomei | R-HSA-186797, Signaling by PDGF |
SignaLinki | Q9GZP0 |
Miscellaneous databases
BioGRID-ORCSi | 80310, 10 hits in 1072 CRISPR screens |
ChiTaRSi | PDGFD, human |
GeneWikii | PDGFD |
GenomeRNAii | 80310 |
Pharosi | Q9GZP0, Tbio |
PROi | PR:Q9GZP0 |
RNActi | Q9GZP0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170962, Expressed in adrenal gland and 213 other tissues |
ExpressionAtlasi | Q9GZP0, baseline and differential |
Genevisiblei | Q9GZP0, HS |
Family and domain databases
CDDi | cd00041, CUB, 1 hit cd00135, PDGF, 1 hit |
Gene3Di | 2.10.90.10, 1 hit 2.60.120.290, 1 hit |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR029034, Cystine-knot_cytokine IPR000072, PDGF/VEGF_dom IPR027123, PDGFD IPR035914, Sperma_CUB_dom_sf |
PANTHERi | PTHR11633:SF4, PTHR11633:SF4, 1 hit |
Pfami | View protein in Pfam PF00431, CUB, 1 hit PF00341, PDGF, 1 hit |
SMARTi | View protein in SMART SM00042, CUB, 1 hit |
SUPFAMi | SSF49854, SSF49854, 1 hit SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 1 hit PS50278, PDGF_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PDGFD_HUMAN | |
Accessioni | Q9GZP0Primary (citable) accession number: Q9GZP0 Secondary accession number(s): A8K9T6, Q9BWV5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2006 |
Last sequence update: | March 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families