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Protein

UPF0687 protein C20orf27

Gene

C20orf27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0687 protein C20orf27
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101220.17
HGNCiHGNC:15873 C20orf27
neXtProtiNX_Q9GZN8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101220
PharmGKBiPA25742

Polymorphism and mutation databases

BioMutaiC20orf27

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000794192 – 174UPF0687 protein C20orf27Add BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei147PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9GZN8
MaxQBiQ9GZN8
PaxDbiQ9GZN8
PeptideAtlasiQ9GZN8
PRIDEiQ9GZN8
ProteomicsDBi80100
80101 [Q9GZN8-2]

PTM databases

iPTMnetiQ9GZN8
PhosphoSitePlusiQ9GZN8

Expressioni

Gene expression databases

BgeeiENSG00000101220 Expressed in 213 organ(s), highest expression level in lower esophagus muscularis layer
CleanExiHS_C20orf27
ExpressionAtlasiQ9GZN8 baseline and differential
GenevisibleiQ9GZN8 HS

Organism-specific databases

HPAiHPA047483

Interactioni

Protein-protein interaction databases

BioGridi120312, 8 interactors
IntActiQ9GZN8, 6 interactors
STRINGi9606.ENSP00000217195

Structurei

3D structure databases

ProteinModelPortaliQ9GZN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0687 family.Curated

Phylogenomic databases

eggNOGiENOG410IXFR Eukaryota
ENOG4111MWE LUCA
GeneTreeiENSGT00390000008711
HOGENOMiHOG000231708
HOVERGENiHBG051155
InParanoidiQ9GZN8
OMAiEHDFYEM
OrthoDBiEOG091G0QBP
PhylomeDBiQ9GZN8
TreeFamiTF323780

Family and domain databases

InterProiView protein in InterPro
IPR026794 UPF0687
PANTHERiPTHR13287 PTHR13287, 1 hit
PfamiView protein in Pfam
PF15006 DUF4517, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9GZN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAANKGNKP RVRSIRFAAG HDAEGSHSHV HFDEKLHDSV VMVTQESDSS
60 70 80 90 100
FLVKVGFLKI LHRYEITFTL PPVHRLSKDV REAPVPSLHL KLLSVVPVPE
110 120 130 140 150
GYSVKCEYSA HKEGVLKEEI LLACEGGTGT CVRVTVQARV MDRHHGTPML
160 170
LDGVKCVGAE LEYDSEHSDW HGFD
Length:174
Mass (Da):19,291
Last modified:January 23, 2007 - v3
Checksum:iDD114F2C1A7D8B97
GO
Isoform 2 (identifier: Q9GZN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-6: K → KGKCLPGVVGLAQALPVGPGRRAIAA

Show »
Length:199
Mass (Da):21,645
Checksum:iB3D49626EDF72968
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BYU9H7BYU9_HUMAN
UPF0687 protein C20orf27
C20orf27
127Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14S → G in BAA91252 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0402936K → KGKCLPGVVGLAQALPVGPG RRAIAA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000557 mRNA Translation: BAA91252.1
AK024220 mRNA Translation: BAB14854.1
AK097645 mRNA Translation: BAG53501.1
AK290955 mRNA Translation: BAF83644.1
CR615129 mRNA No translation available.
AL109804 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10508.1
CH471133 Genomic DNA Translation: EAX10510.1
CH471133 Genomic DNA Translation: EAX10511.1
BC012196 mRNA Translation: AAH12196.1
BC024036 mRNA Translation: AAH24036.1
CCDSiCCDS33436.1 [Q9GZN8-2]
CCDS58763.1 [Q9GZN8-1]
RefSeqiNP_001034229.1, NM_001039140.2 [Q9GZN8-2]
NP_001245358.1, NM_001258429.1 [Q9GZN8-1]
NP_001245359.1, NM_001258430.1 [Q9GZN8-1]
UniGeneiHs.274422

Genome annotation databases

EnsembliENST00000217195; ENSP00000217195; ENSG00000101220 [Q9GZN8-2]
ENST00000379772; ENSP00000369097; ENSG00000101220 [Q9GZN8-1]
ENST00000399672; ENSP00000382580; ENSG00000101220 [Q9GZN8-1]
GeneIDi54976
KEGGihsa:54976
UCSCiuc002wjh.3 human [Q9GZN8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000557 mRNA Translation: BAA91252.1
AK024220 mRNA Translation: BAB14854.1
AK097645 mRNA Translation: BAG53501.1
AK290955 mRNA Translation: BAF83644.1
CR615129 mRNA No translation available.
AL109804 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10508.1
CH471133 Genomic DNA Translation: EAX10510.1
CH471133 Genomic DNA Translation: EAX10511.1
BC012196 mRNA Translation: AAH12196.1
BC024036 mRNA Translation: AAH24036.1
CCDSiCCDS33436.1 [Q9GZN8-2]
CCDS58763.1 [Q9GZN8-1]
RefSeqiNP_001034229.1, NM_001039140.2 [Q9GZN8-2]
NP_001245358.1, NM_001258429.1 [Q9GZN8-1]
NP_001245359.1, NM_001258430.1 [Q9GZN8-1]
UniGeneiHs.274422

3D structure databases

ProteinModelPortaliQ9GZN8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120312, 8 interactors
IntActiQ9GZN8, 6 interactors
STRINGi9606.ENSP00000217195

PTM databases

iPTMnetiQ9GZN8
PhosphoSitePlusiQ9GZN8

Polymorphism and mutation databases

BioMutaiC20orf27

Proteomic databases

EPDiQ9GZN8
MaxQBiQ9GZN8
PaxDbiQ9GZN8
PeptideAtlasiQ9GZN8
PRIDEiQ9GZN8
ProteomicsDBi80100
80101 [Q9GZN8-2]

Protocols and materials databases

DNASUi54976
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217195; ENSP00000217195; ENSG00000101220 [Q9GZN8-2]
ENST00000379772; ENSP00000369097; ENSG00000101220 [Q9GZN8-1]
ENST00000399672; ENSP00000382580; ENSG00000101220 [Q9GZN8-1]
GeneIDi54976
KEGGihsa:54976
UCSCiuc002wjh.3 human [Q9GZN8-1]

Organism-specific databases

CTDi54976
EuPathDBiHostDB:ENSG00000101220.17
GeneCardsiC20orf27
H-InvDBiHIX0015601
HGNCiHGNC:15873 C20orf27
HPAiHPA047483
neXtProtiNX_Q9GZN8
OpenTargetsiENSG00000101220
PharmGKBiPA25742
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXFR Eukaryota
ENOG4111MWE LUCA
GeneTreeiENSGT00390000008711
HOGENOMiHOG000231708
HOVERGENiHBG051155
InParanoidiQ9GZN8
OMAiEHDFYEM
OrthoDBiEOG091G0QBP
PhylomeDBiQ9GZN8
TreeFamiTF323780

Miscellaneous databases

ChiTaRSiC20orf27 human
GeneWikiiC20orf27
GenomeRNAii54976
PROiPR:Q9GZN8

Gene expression databases

BgeeiENSG00000101220 Expressed in 213 organ(s), highest expression level in lower esophagus muscularis layer
CleanExiHS_C20orf27
ExpressionAtlasiQ9GZN8 baseline and differential
GenevisibleiQ9GZN8 HS

Family and domain databases

InterProiView protein in InterPro
IPR026794 UPF0687
PANTHERiPTHR13287 PTHR13287, 1 hit
PfamiView protein in Pfam
PF15006 DUF4517, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCT027_HUMAN
AccessioniPrimary (citable) accession number: Q9GZN8
Secondary accession number(s): A8K4J0
, D3DVX8, Q5JX81, Q9NWX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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