UniProtKB - Q9GZN6 (S6A16_HUMAN)
Protein
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5
Gene
SLC6A16
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- neurotransmitter transmembrane transporter activity Source: UniProtKB
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- neurotransmitter transport Source: UniProtKB
- sodium ion transmembrane transport Source: GO_Central
Keywordsi
Biological process | Neurotransmitter transport, Symport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9GZN6 |
Protein family/group databases
TCDBi | 2.A.22.6.5, the neurotransmitter:sodium symporter (nss) family |
Names & Taxonomyi
Protein namesi | Recommended name: Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5Alternative name(s): Solute carrier family 6 member 16 |
Gene namesi | Name:SLC6A16 Synonyms:NTT5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13622, SLC6A16 |
MIMi | 607972, gene |
neXtProti | NX_Q9GZN6 |
VEuPathDBi | HostDB:ENSG00000063127.15 |
Subcellular locationi
Other locations
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 138 | CytoplasmicSequence analysisAdd BLAST | 138 | |
Transmembranei | 139 – 159 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 177 – 197 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 199 – 219 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 220 – 263 | ExtracellularSequence analysisAdd BLAST | 44 | |
Transmembranei | 264 – 284 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 290 – 310 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 338 – 358 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Transmembranei | 383 – 403 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 404 – 495 | ExtracellularSequence analysisAdd BLAST | 92 | |
Transmembranei | 496 – 516 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Transmembranei | 534 – 554 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Transmembranei | 568 – 588 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Transmembranei | 609 – 629 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Transmembranei | 659 – 679 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 680 – 736 | CytoplasmicSequence analysisAdd BLAST | 57 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 28968 |
OpenTargetsi | ENSG00000063127 |
PharmGKBi | PA37800 |
Miscellaneous databases
Pharosi | Q9GZN6, Tdark |
Genetic variation databases
BioMutai | SLC6A16 |
DMDMi | 18202928 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000214801 | 1 – 736 | Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5Add BLAST | 736 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 229 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q9GZN6 |
PaxDbi | Q9GZN6 |
PeptideAtlasi | Q9GZN6 |
PRIDEi | Q9GZN6 |
ProteomicsDBi | 71245 80098 [Q9GZN6-1] |
PTM databases
GlyGeni | Q9GZN6, 1 site |
iPTMneti | Q9GZN6 |
PhosphoSitePlusi | Q9GZN6 |
Expressioni
Tissue specificityi
Highly expressed in peripheral tissues, particularly in testis, pancreas, and prostate.
Gene expression databases
Bgeei | ENSG00000063127, Expressed in testis and 138 other tissues |
ExpressionAtlasi | Q9GZN6, baseline and differential |
Genevisiblei | Q9GZN6, HS |
Organism-specific databases
HPAi | ENSG00000063127, Tissue enriched (testis) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000338627 |
Miscellaneous databases
RNActi | Q9GZN6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A16 subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3659, Eukaryota |
GeneTreei | ENSGT00940000163283 |
HOGENOMi | CLU_006855_7_2_1 |
InParanoidi | Q9GZN6 |
OMAi | WATIITH |
OrthoDBi | 250396at2759 |
PhylomeDBi | Q9GZN6 |
TreeFami | TF352709 |
Family and domain databases
InterProi | View protein in InterPro IPR000175, Na/ntran_symport IPR037272, SNS_sf |
PANTHERi | PTHR11616, PTHR11616, 1 hit |
Pfami | View protein in Pfam PF00209, SNF, 1 hit |
PRINTSi | PR00176, NANEUSMPORT |
SUPFAMi | SSF161070, SSF161070, 1 hit |
PROSITEi | View protein in PROSITE PS00610, NA_NEUROTRAN_SYMP_1, 1 hit PS00754, NA_NEUROTRAN_SYMP_2, 1 hit PS50267, NA_NEUROTRAN_SYMP_3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9GZN6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKTEAQPSTS LLANTSWTGT VISDSVPGSQ TWEDKGSLTR SATSWTSEAQ
60 70 80 90 100
VSAARVAEAQ ARTSQPKQIS VLEALTASAL NQKPTHEKVQ MTEKKESEVL
110 120 130 140 150
LARPFWSSKT EYILAQVGFS MKPSCLWRFA YLWLNSGGCS FAAIYIFMLF
160 170 180 190 200
LVGVPLLFLE MAAGQSMRQG GMGVWKIIAP WIGGVGYSSF MVCFILGLYF
210 220 230 240 250
NVVNSWIIFY MSQSFQFPVP WEKCPLTMNS SGFDPECERT TPSIYFWYQQ
260 270 280 290 300
ALKASDRIED GGSPVYSLVL PFFLCWCLVG AFMINGLKST GKVIYVLVLL
310 320 330 340 350
PCFIIVGFFI RTLLLEGAKF GLQQLVVAKI SDVYNMSVWS LAGGQVLSNT
360 370 380 390 400
GIGLGSVASL ASYMPQSNNC LSDAFLVSVI NLLTLLVFTS FNFCVLGFWA
410 420 430 440 450
TVITHRCCER NAEILLKLIN LGKLPPDAKP PVNLLYNPTS IYNAWLSGLP
460 470 480 490 500
QHIKSMVLRE VTECNIETQF LKASEGPKFA FLSFVEAMSF LPPSVFWSFI
510 520 530 540 550
FFLMLLAMGL SSAIGIMQGI ITPLQDTFSF FRKHTKLLIV GVFLLMFVCG
560 570 580 590 600
LFFTRPSGSY FIRLLSDYWI VFPIIVVVVF ETMAVSWAYG ARRFLADLTI
610 620 630 640 650
LLGHPISPIF GWLWPHLCPV VLLIIFVTMM VHLCMKPITY MSWDSSTSKE
660 670 680 690 700
VLRPYPPWAL LLMITLFAIV ILPIPAYFVY CRIHRIPFRP KSGDGPMTAS
710 720 730
TSLPLSHQLT PSKEVQKEEI LQVDETKYPS TCNVTS
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QYK3 | M0QYK3_HUMAN | Orphan sodium- and chloride-depende... | SLC6A16 | 163 | Annotation score: | ||
M0R2R5 | M0R2R5_HUMAN | Orphan sodium- and chloride-depende... | SLC6A16 | 147 | Annotation score: | ||
M0R1Y6 | M0R1Y6_HUMAN | Orphan sodium- and chloride-depende... | SLC6A16 | 136 | Annotation score: | ||
M0QZL4 | M0QZL4_HUMAN | Orphan sodium- and chloride-depende... | SLC6A16 | 33 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 181 | W → R in AAD38044 (Ref. 1) Curated | 1 | |
Sequence conflicti | 307 | G → GG in AAD38044 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052067 | 108 | S → R. Corresponds to variant dbSNP:rs35860981Ensembl. | 1 | |
Natural variantiVAR_064753 | 236 | E → K Found in a renal cell carcinoma sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056317 | 648 – 736 | SKEVL…CNVTS → VSLPQDPEPLWE in isoform 2. 1 PublicationAdd BLAST | 89 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151977 mRNA Translation: AAD38044.1 AF265578 mRNA Translation: AAG41362.1 AL136856 mRNA Translation: CAB66790.1 AC011450 Genomic DNA No translation available. BC034948 mRNA Translation: AAH34948.1 |
CCDSi | CCDS42590.1 [Q9GZN6-1] |
RefSeqi | NP_054756.2, NM_014037.2 [Q9GZN6-1] XP_005258877.1, XM_005258820.2 [Q9GZN6-1] XP_006723231.1, XM_006723168.3 [Q9GZN6-1] |
Genome annotation databases
Ensembli | ENST00000335875; ENSP00000338627; ENSG00000063127 [Q9GZN6-1] ENST00000454748; ENSP00000404022; ENSG00000063127 [Q9GZN6-2] |
GeneIDi | 28968 |
KEGGi | hsa:28968 |
UCSCi | uc002pmz.4, human [Q9GZN6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151977 mRNA Translation: AAD38044.1 AF265578 mRNA Translation: AAG41362.1 AL136856 mRNA Translation: CAB66790.1 AC011450 Genomic DNA No translation available. BC034948 mRNA Translation: AAH34948.1 |
CCDSi | CCDS42590.1 [Q9GZN6-1] |
RefSeqi | NP_054756.2, NM_014037.2 [Q9GZN6-1] XP_005258877.1, XM_005258820.2 [Q9GZN6-1] XP_006723231.1, XM_006723168.3 [Q9GZN6-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000338627 |
Protein family/group databases
TCDBi | 2.A.22.6.5, the neurotransmitter:sodium symporter (nss) family |
PTM databases
GlyGeni | Q9GZN6, 1 site |
iPTMneti | Q9GZN6 |
PhosphoSitePlusi | Q9GZN6 |
Genetic variation databases
BioMutai | SLC6A16 |
DMDMi | 18202928 |
Proteomic databases
MassIVEi | Q9GZN6 |
PaxDbi | Q9GZN6 |
PeptideAtlasi | Q9GZN6 |
PRIDEi | Q9GZN6 |
ProteomicsDBi | 71245 80098 [Q9GZN6-1] |
Protocols and materials databases
Antibodypediai | 31965, 78 antibodies |
Genome annotation databases
Ensembli | ENST00000335875; ENSP00000338627; ENSG00000063127 [Q9GZN6-1] ENST00000454748; ENSP00000404022; ENSG00000063127 [Q9GZN6-2] |
GeneIDi | 28968 |
KEGGi | hsa:28968 |
UCSCi | uc002pmz.4, human [Q9GZN6-1] |
Organism-specific databases
CTDi | 28968 |
DisGeNETi | 28968 |
GeneCardsi | SLC6A16 |
HGNCi | HGNC:13622, SLC6A16 |
HPAi | ENSG00000063127, Tissue enriched (testis) |
MIMi | 607972, gene |
neXtProti | NX_Q9GZN6 |
OpenTargetsi | ENSG00000063127 |
PharmGKBi | PA37800 |
VEuPathDBi | HostDB:ENSG00000063127.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3659, Eukaryota |
GeneTreei | ENSGT00940000163283 |
HOGENOMi | CLU_006855_7_2_1 |
InParanoidi | Q9GZN6 |
OMAi | WATIITH |
OrthoDBi | 250396at2759 |
PhylomeDBi | Q9GZN6 |
TreeFami | TF352709 |
Enzyme and pathway databases
PathwayCommonsi | Q9GZN6 |
Miscellaneous databases
BioGRID-ORCSi | 28968, 7 hits in 992 CRISPR screens |
ChiTaRSi | SLC6A16, human |
GenomeRNAii | 28968 |
Pharosi | Q9GZN6, Tdark |
PROi | PR:Q9GZN6 |
RNActi | Q9GZN6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000063127, Expressed in testis and 138 other tissues |
ExpressionAtlasi | Q9GZN6, baseline and differential |
Genevisiblei | Q9GZN6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000175, Na/ntran_symport IPR037272, SNS_sf |
PANTHERi | PTHR11616, PTHR11616, 1 hit |
Pfami | View protein in Pfam PF00209, SNF, 1 hit |
PRINTSi | PR00176, NANEUSMPORT |
SUPFAMi | SSF161070, SSF161070, 1 hit |
PROSITEi | View protein in PROSITE PS00610, NA_NEUROTRAN_SYMP_1, 1 hit PS00754, NA_NEUROTRAN_SYMP_2, 1 hit PS50267, NA_NEUROTRAN_SYMP_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S6A16_HUMAN | |
Accessioni | Q9GZN6Primary (citable) accession number: Q9GZN6 Secondary accession number(s): Q8IYV4, Q9Y5I9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families