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UniProtKB - Q9GZN6 (S6A16_HUMAN)

Entry version 141 (11 Dec 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

Gene

SLC6A16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNeurotransmitter transport, Symport, Transport

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.22.6.5 the neurotransmitter:sodium symporter (nss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5
Alternative name(s):
Solute carrier family 6 member 16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC6A16
Synonyms:NTT5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000063127.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:13622 SLC6A16

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607972 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9GZN6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 138CytoplasmicSequence analysisAdd BLAST138
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei139 – 159Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei177 – 197Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei199 – 219Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini220 – 263ExtracellularSequence analysisAdd BLAST44
Transmembranei264 – 284Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei290 – 310Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei338 – 358Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei383 – 403Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini404 – 495ExtracellularSequence analysisAdd BLAST92
Transmembranei496 – 516Helical; Name=8Sequence analysisAdd BLAST21
Transmembranei534 – 554Helical; Name=9Sequence analysisAdd BLAST21
Transmembranei568 – 588Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei609 – 629Helical; Name=11Sequence analysisAdd BLAST21
Transmembranei659 – 679Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini680 – 736CytoplasmicSequence analysisAdd BLAST57

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		28968

Open Targets

More...OpenTargetsi		ENSG00000063127

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37800

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9GZN6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC6A16

Domain mapping of disease mutations (DMDM)

More...DMDMi		18202928

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002148011 – 736Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5Add BLAST736

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9GZN6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9GZN6

PeptideAtlas

More...PeptideAtlasi		Q9GZN6

PRoteomics IDEntifications database

More...PRIDEi		Q9GZN6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71245
80098 [Q9GZN6-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9GZN6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9GZN6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in peripheral tissues, particularly in testis, pancreas, and prostate.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000063127 Expressed in 116 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9GZN6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9GZN6 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA076812

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000338627

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9GZN6 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A16 subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3659 Eukaryota
COG0733 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163283

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000116406

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9GZN6

KEGG Orthology (KO)

More...KOi		K05048

Identification of Orthologs from Complete Genome Data

More...OMAi		WATIITH

Database of Orthologous Groups

More...OrthoDBi		250396at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9GZN6

TreeFam database of animal gene trees

More...TreeFami		TF352709

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000175 Na/ntran_symport
IPR037272 SNS_sf

The PANTHER Classification System

More...PANTHERi		PTHR11616 PTHR11616, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00209 SNF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00176 NANEUSMPORT

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF161070 SSF161070, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9GZN6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKTEAQPSTS LLANTSWTGT VISDSVPGSQ TWEDKGSLTR SATSWTSEAQ 
        60         70         80         90        100
VSAARVAEAQ ARTSQPKQIS VLEALTASAL NQKPTHEKVQ MTEKKESEVL 
       110        120        130        140        150
LARPFWSSKT EYILAQVGFS MKPSCLWRFA YLWLNSGGCS FAAIYIFMLF 
       160        170        180        190        200
LVGVPLLFLE MAAGQSMRQG GMGVWKIIAP WIGGVGYSSF MVCFILGLYF 
       210        220        230        240        250
NVVNSWIIFY MSQSFQFPVP WEKCPLTMNS SGFDPECERT TPSIYFWYQQ 
       260        270        280        290        300
ALKASDRIED GGSPVYSLVL PFFLCWCLVG AFMINGLKST GKVIYVLVLL 
       310        320        330        340        350
PCFIIVGFFI RTLLLEGAKF GLQQLVVAKI SDVYNMSVWS LAGGQVLSNT 
       360        370        380        390        400
GIGLGSVASL ASYMPQSNNC LSDAFLVSVI NLLTLLVFTS FNFCVLGFWA 
       410        420        430        440        450
TVITHRCCER NAEILLKLIN LGKLPPDAKP PVNLLYNPTS IYNAWLSGLP 
       460        470        480        490        500
QHIKSMVLRE VTECNIETQF LKASEGPKFA FLSFVEAMSF LPPSVFWSFI 
       510        520        530        540        550
FFLMLLAMGL SSAIGIMQGI ITPLQDTFSF FRKHTKLLIV GVFLLMFVCG 
       560        570        580        590        600
LFFTRPSGSY FIRLLSDYWI VFPIIVVVVF ETMAVSWAYG ARRFLADLTI 
       610        620        630        640        650
LLGHPISPIF GWLWPHLCPV VLLIIFVTMM VHLCMKPITY MSWDSSTSKE 
       660        670        680        690        700
VLRPYPPWAL LLMITLFAIV ILPIPAYFVY CRIHRIPFRP KSGDGPMTAS 
       710        720        730 
TSLPLSHQLT PSKEVQKEEI LQVDETKYPS TCNVTS
Length:736
Mass (Da):82,200
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE21EA16515446C35
GO
Isoform 2 (identifier: Q9GZN6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     648-736: SKEVLRPYPP...KYPSTCNVTS → VSLPQDPEPLWE

Show »
Length:659
Mass (Da):73,539
Checksum:i11C801151E9BAA07
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYK3M0QYK3_HUMAN
Orphan sodium- and chloride-depende...
SLC6A16
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1Y6M0R1Y6_HUMAN
Orphan sodium- and chloride-depende...
SLC6A16
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2R5M0R2R5_HUMAN
Orphan sodium- and chloride-depende...
SLC6A16
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZL4M0QZL4_HUMAN
Orphan sodium- and chloride-depende...
SLC6A16
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti181W → R in AAD38044 (Ref. 1) Curated1
Sequence conflicti307G → GG in AAD38044 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052067108S → R. Corresponds to variant dbSNP:rs35860981Ensembl.1
Natural variantiVAR_064753236E → K Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056317648 – 736SKEVL…CNVTS → VSLPQDPEPLWE in isoform 2. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF151977 mRNA Translation: AAD38044.1
AF265578 mRNA Translation: AAG41362.1
AL136856 mRNA Translation: CAB66790.1
AC011450 Genomic DNA No translation available.
BC034948 mRNA Translation: AAH34948.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42590.1 [Q9GZN6-1]

NCBI Reference Sequences

More...RefSeqi		NP_054756.2, NM_014037.2 [Q9GZN6-1]
XP_005258877.1, XM_005258820.2 [Q9GZN6-1]
XP_006723231.1, XM_006723168.3 [Q9GZN6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000335875; ENSP00000338627; ENSG00000063127 [Q9GZN6-1]
ENST00000454748; ENSP00000404022; ENSG00000063127 [Q9GZN6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		28968

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:28968

UCSC genome browser

More...UCSCi		uc002pmz.4 human [Q9GZN6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151977 mRNA Translation: AAD38044.1
AF265578 mRNA Translation: AAG41362.1
AL136856 mRNA Translation: CAB66790.1
AC011450 Genomic DNA No translation available.
BC034948 mRNA Translation: AAH34948.1
CCDSiCCDS42590.1 [Q9GZN6-1]
RefSeqiNP_054756.2, NM_014037.2 [Q9GZN6-1]
XP_005258877.1, XM_005258820.2 [Q9GZN6-1]
XP_006723231.1, XM_006723168.3 [Q9GZN6-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000338627

Protein family/group databases

TCDBi2.A.22.6.5 the neurotransmitter:sodium symporter (nss) family

PTM databases

iPTMnetiQ9GZN6
PhosphoSitePlusiQ9GZN6

Polymorphism and mutation databases

BioMutaiSLC6A16
DMDMi18202928

Proteomic databases

MassIVEiQ9GZN6
PaxDbiQ9GZN6
PeptideAtlasiQ9GZN6
PRIDEiQ9GZN6
ProteomicsDBi71245
80098 [Q9GZN6-1]

Genome annotation databases

EnsembliENST00000335875; ENSP00000338627; ENSG00000063127 [Q9GZN6-1]
ENST00000454748; ENSP00000404022; ENSG00000063127 [Q9GZN6-2]
GeneIDi28968
KEGGihsa:28968
UCSCiuc002pmz.4 human [Q9GZN6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		28968
DisGeNETi28968
EuPathDBiHostDB:ENSG00000063127.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC6A16
HGNCiHGNC:13622 SLC6A16
HPAiHPA076812
MIMi607972 gene
neXtProtiNX_Q9GZN6
OpenTargetsiENSG00000063127
PharmGKBiPA37800

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00940000163283
HOGENOMiHOG000116406
InParanoidiQ9GZN6
KOiK05048
OMAiWATIITH
OrthoDBi250396at2759
PhylomeDBiQ9GZN6
TreeFamiTF352709

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC6A16 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		28968
PharosiQ9GZN6 Tdark

Protein Ontology

More...PROi		PR:Q9GZN6
RNActiQ9GZN6 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000063127 Expressed in 116 organ(s), highest expression level in testis
ExpressionAtlasiQ9GZN6 baseline and differential
GenevisibleiQ9GZN6 HS

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS6A16_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZN6
Secondary accession number(s): Q8IYV4, Q9Y5I9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: December 11, 2019
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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