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Protein

Homeobox protein TGIF2

Gene

TGIF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.1 Publication

Miscellaneous

TGIF2 is amplified and overexpressed in several ovarian cancer cell lines.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi16 – 79Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein TGIF2
Alternative name(s):
5'-TG-3'-interacting factor 2
TGF-beta-induced transcription factor 2
Short name:
TGFB-induced factor 2
Gene namesi
Name:TGIF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000118707.9
HGNCiHGNC:15764 TGIF2
MIMi607294 gene
neXtProtiNX_Q9GZN2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi182T → V: Decrease of phosphorylation. Strong decrease of phosphorylation; when associated with V-186. 1 Publication1
Mutagenesisi186T → V: Decrease of phosphorylation. Strong decrease of phosphorylation; when associated with V-182. 1 Publication1

Organism-specific databases

DisGeNETi60436
OpenTargetsiENSG00000118707
PharmGKBiPA38035

Polymorphism and mutation databases

BioMutaiTGIF2
DMDMi27805750

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493211 – 237Homeobox protein TGIF2Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei182Phosphothreonine1 Publication1
Modified residuei186Phosphothreonine1 Publication1

Post-translational modificationi

The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9GZN2
MaxQBiQ9GZN2
PaxDbiQ9GZN2
PeptideAtlasiQ9GZN2
PRIDEiQ9GZN2
ProteomicsDBi80096

PTM databases

iPTMnetiQ9GZN2
PhosphoSitePlusiQ9GZN2

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.

Gene expression databases

BgeeiENSG00000118707 Expressed in 194 organ(s), highest expression level in female gonad
CleanExiHS_TGIF2
ExpressionAtlasiQ9GZN2 baseline and differential
GenevisibleiQ9GZN2 HS

Organism-specific databases

HPAiHPA053786

Interactioni

Subunit structurei

Interacts with the transcriptional modulator SMAD3 and the histone deacetylase HDAC1.1 Publication

Protein-protein interaction databases

BioGridi121908, 22 interactors
1529332, 2 interactors
STRINGi9606.ENSP00000362979

Structurei

3D structure databases

ProteinModelPortaliQ9GZN2
SMRiQ9GZN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni103 – 237Repressive functionAdd BLAST135

Sequence similaritiesi

Belongs to the TALE/TGIF homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00390000004786
ENSGT00550000074260
HOGENOMiHOG000232039
HOVERGENiHBG001143
InParanoidiQ9GZN2
KOiK19553
OMAiMCSMPLH
OrthoDBiEOG091G0N1F
PhylomeDBiQ9GZN2
TreeFamiTF314558
TF318093

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9GZN2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDSDLGEDE GLLSLAGKRK RRGNLPKESV KILRDWLYLH RYNAYPSEQE
60 70 80 90 100
KLSLSGQTNL SVLQICNWFI NARRRLLPDM LRKDGKDPNQ FTISRRGGKA
110 120 130 140 150
SDVALPRGSS PSVLAVSVPA PTNVLSLSVC SMPLHSGQGE KPAAPFPRGE
160 170 180 190 200
LESPKPLVTP GSTLTLLTRA EAGSPTGGLF NTPPPTPPEQ DKEDFSSFQL
210 220 230
LVEVALQRAA EMELQKQQDP SLPLLHTPIP LVSENPQ
Length:237
Mass (Da):25,878
Last modified:March 1, 2001 - v1
Checksum:iE78101CF7EF12555
GO
Isoform 2 (identifier: Q9GZN2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-155: ICNWFINARR...FPRGELESPK → DEFLDVIYWF...IIFYTAIHYD
     156-237: Missing.

Note: No experimental confirmation available.
Show »
Length:155
Mass (Da):17,908
Checksum:i8F3B33FF9F059D71
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKN5H0YKN5_HUMAN
Homeobox protein TGIF2
TGIF2
174Annotation score:
U3KQS0U3KQS0_HUMAN
Homeobox protein TGIF2
TGIF2
111Annotation score:
U3KQB5U3KQB5_HUMAN
Homeobox protein TGIF2
TGIF2
92Annotation score:
U3KQ25U3KQ25_HUMAN
Homeobox protein TGIF2
TGIF2
35Annotation score:

Sequence cautioni

The sequence BX377269 differs from that shown. Reason: Frameshift at positions 87 and 118.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04734665 – 155ICNWF…LESPK → DEFLDVIYWFRQIIAVVLGV IWGVLPLRGFLGIAGFCLIN AGVLYLYFSNYLQIDEEEYG GTWELTKEGFMTSFALFMVI WIIFYTAIHYD in isoform 2. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_047347156 – 237Missing in isoform 2. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042646 mRNA Translation: BAB16424.1
BX377269 mRNA No translation available.
AK074802 mRNA Translation: BAC11216.1
AK313919 mRNA Translation: BAG36640.1
AL050318 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76127.1
CH471077 Genomic DNA Translation: EAW76128.1
BC006549 mRNA Translation: AAH06549.1
BC012816 mRNA Translation: AAH12816.1
CCDSiCCDS13278.1 [Q9GZN2-1]
PIRiJC7392
RefSeqiNP_001186442.1, NM_001199513.1 [Q9GZN2-1]
NP_001186443.1, NM_001199514.1 [Q9GZN2-1]
NP_001186444.1, NM_001199515.1 [Q9GZN2-1]
NP_068581.1, NM_021809.6 [Q9GZN2-1]
UniGeneiHs.632264

Genome annotation databases

EnsembliENST00000373872; ENSP00000362979; ENSG00000118707 [Q9GZN2-1]
ENST00000373874; ENSP00000362981; ENSG00000118707 [Q9GZN2-1]
ENST00000560025; ENSP00000453773; ENSG00000118707 [Q9GZN2-1]
ENST00000611732; ENSP00000481787; ENSG00000118707 [Q9GZN2-1]
GeneIDi60436
KEGGihsa:60436
UCSCiuc002xfn.4 human [Q9GZN2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042646 mRNA Translation: BAB16424.1
BX377269 mRNA No translation available.
AK074802 mRNA Translation: BAC11216.1
AK313919 mRNA Translation: BAG36640.1
AL050318 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76127.1
CH471077 Genomic DNA Translation: EAW76128.1
BC006549 mRNA Translation: AAH06549.1
BC012816 mRNA Translation: AAH12816.1
CCDSiCCDS13278.1 [Q9GZN2-1]
PIRiJC7392
RefSeqiNP_001186442.1, NM_001199513.1 [Q9GZN2-1]
NP_001186443.1, NM_001199514.1 [Q9GZN2-1]
NP_001186444.1, NM_001199515.1 [Q9GZN2-1]
NP_068581.1, NM_021809.6 [Q9GZN2-1]
UniGeneiHs.632264

3D structure databases

ProteinModelPortaliQ9GZN2
SMRiQ9GZN2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121908, 22 interactors
1529332, 2 interactors
STRINGi9606.ENSP00000362979

PTM databases

iPTMnetiQ9GZN2
PhosphoSitePlusiQ9GZN2

Polymorphism and mutation databases

BioMutaiTGIF2
DMDMi27805750

Proteomic databases

EPDiQ9GZN2
MaxQBiQ9GZN2
PaxDbiQ9GZN2
PeptideAtlasiQ9GZN2
PRIDEiQ9GZN2
ProteomicsDBi80096

Protocols and materials databases

DNASUi60436
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373872; ENSP00000362979; ENSG00000118707 [Q9GZN2-1]
ENST00000373874; ENSP00000362981; ENSG00000118707 [Q9GZN2-1]
ENST00000560025; ENSP00000453773; ENSG00000118707 [Q9GZN2-1]
ENST00000611732; ENSP00000481787; ENSG00000118707 [Q9GZN2-1]
GeneIDi60436
KEGGihsa:60436
UCSCiuc002xfn.4 human [Q9GZN2-1]

Organism-specific databases

CTDi60436
DisGeNETi60436
EuPathDBiHostDB:ENSG00000118707.9
GeneCardsiTGIF2
HGNCiHGNC:15764 TGIF2
HPAiHPA053786
MIMi607294 gene
neXtProtiNX_Q9GZN2
OpenTargetsiENSG00000118707
PharmGKBiPA38035
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00390000004786
ENSGT00550000074260
HOGENOMiHOG000232039
HOVERGENiHBG001143
InParanoidiQ9GZN2
KOiK19553
OMAiMCSMPLH
OrthoDBiEOG091G0N1F
PhylomeDBiQ9GZN2
TreeFamiTF314558
TF318093

Enzyme and pathway databases

ReactomeiR-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

Miscellaneous databases

ChiTaRSiTGIF2 human
GeneWikiiTGIF2
GenomeRNAii60436
PROiPR:Q9GZN2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118707 Expressed in 194 organ(s), highest expression level in female gonad
CleanExiHS_TGIF2
ExpressionAtlasiQ9GZN2 baseline and differential
GenevisibleiQ9GZN2 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTGIF2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZN2
Secondary accession number(s): B2R9U3, E1P5T9, H0YNI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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