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Protein

Actin-related protein 6

Gene

ACTR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ9GZN1

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 6
Short name:
hArp6
Alternative name(s):
hARPX
Gene namesi
Name:ACTR6
ORF Names:CDA12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000075089.9
HGNCiHGNC:24025 ACTR6
neXtProtiNX_Q9GZN1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000075089
PharmGKBiPA134984466

Polymorphism and mutation databases

BioMutaiACTR6
DMDMi27923737

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000891052 – 396Actin-related protein 6Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1
Modified residuei260N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9GZN1
MaxQBiQ9GZN1
PaxDbiQ9GZN1
PeptideAtlasiQ9GZN1
PRIDEiQ9GZN1
ProteomicsDBi80095

PTM databases

iPTMnetiQ9GZN1
PhosphoSitePlusiQ9GZN1

Expressioni

Gene expression databases

BgeeiENSG00000075089 Expressed in 217 organ(s), highest expression level in caudate nucleus
CleanExiHS_ACTR6
ExpressionAtlasiQ9GZN1 baseline and differential
GenevisibleiQ9GZN1 HS

Organism-specific databases

HPAiHPA038587
HPA038588

Interactioni

Subunit structurei

Interacts with CBX1, CBX3 and CBX5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ZNHIT1O432574EBI-769329,EBI-347522

Protein-protein interaction databases

BioGridi122179, 22 interactors
ComplexPortaliCPX-974 SRCAP histone exchanging complex
CORUMiQ9GZN1
IntActiQ9GZN1, 8 interactors
MINTiQ9GZN1
STRINGi9606.ENSP00000188312

Structurei

3D structure databases

ProteinModelPortaliQ9GZN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP6 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0680 Eukaryota
ENOG410XPT5 LUCA
GeneTreeiENSGT00720000108833
HOGENOMiHOG000070006
HOVERGENiHBG097980
InParanoidiQ9GZN1
KOiK11662
OMAiEPYFNLP
OrthoDBiEOG091G09HG
PhylomeDBiQ9GZN1
TreeFamiTF105780

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR030054 Arp6
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF47 PTHR11937:SF47, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9GZN1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTLVLDNGA YNAKIGYSHE NVSVIPNCQF RSKTARLKTF TANQIDEIKD
60 70 80 90 100
PSGLFYILPF QKGYLVNWDV QRQVWDYLFG KEMYQVDFLD TNIIITEPYF
110 120 130 140 150
NFTSIQESMN EILFEEYQFQ AVLRVNAGAL SAHRYFRDNP SELCCIIVDS
160 170 180 190 200
GYSFTHIVPY CRSKKKKEAI IRINVGGKLL TNHLKEIISY RQLHVMDETH
210 220 230 240 250
VINQVKEDVC YVSQDFYRDM DIAKLKGEEN TVMIDYVLPD FSTIKKGFCK
260 270 280 290 300
PREEMVLSGK YKSGEQILRL ANERFAVPEI LFNPSDIGIQ EMGIPEAIVY
310 320 330 340 350
SIQNLPEEMQ PHFFKNIVLT GGNSLFPGFR DRVYSEVRCL TPTDYDVSVV
360 370 380 390
LPENPITYAW EGGKLISEND DFEDMVVTRE DYEENGHSVC EEKFDI
Length:396
Mass (Da):45,810
Last modified:March 1, 2001 - v1
Checksum:iE7F77190F60D1700
GO
Isoform 2 (identifier: Q9GZN1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-182: AGALSAHRYF...INVGGKLLTN → GEFKFSLKLS...AEASRSLEFR
     183-395: Missing.

Note: No experimental confirmation available.
Show »
Length:183
Mass (Da):21,628
Checksum:i9587D94A1EF4499A
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W057F8W057_HUMAN
Actin-related protein 6
ACTR6
376Annotation score:
F8VSD1F8VSD1_HUMAN
Actin-related protein 6
ACTR6
294Annotation score:
G3V1Y1G3V1Y1_HUMAN
ARP6 actin-related protein 6 homolo...
ACTR6 hCG_21802
314Annotation score:
F8VRL1F8VRL1_HUMAN
Actin-related protein 6
ACTR6
192Annotation score:
F8W0Q1F8W0Q1_HUMAN
Actin-related protein 6
ACTR6
144Annotation score:
F8W043F8W043_HUMAN
Actin-related protein 6
ACTR6
127Annotation score:
F8VP72F8VP72_HUMAN
Actin-related protein 6
ACTR6
88Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218R → G in BAD96679 (Ref. 4) Curated1
Sequence conflicti226K → E in AAK14934 (Ref. 2) Curated1
Sequence conflicti237V → A in AAK14934 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054637127 – 182AGALS…KLLTN → GEFKFSLKLSYMTMDMNRVI LIKSQNIKWHSWLAQWLTPV TPSVWEAEASRSLEFR in isoform 2. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_054638183 – 395Missing in isoform 2. 1 PublicationAdd BLAST213

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038229 mRNA Translation: BAB20762.1
AF212251 mRNA Translation: AAK14934.1
AK023495 mRNA Translation: BAB14588.1
AK023684 mRNA Translation: BAB14640.1
AK124075 mRNA Translation: BAG53999.1
AK296991 mRNA Translation: BAG59531.1
AK222959 mRNA Translation: BAD96679.1
CH471054 Genomic DNA Translation: EAW97623.1
BC015107 mRNA Translation: AAH15107.1
CCDSiCCDS9074.1 [Q9GZN1-1]
RefSeqiNP_071941.1, NM_022496.4 [Q9GZN1-1]
XP_016875310.1, XM_017019821.1
UniGeneiHs.115088

Genome annotation databases

EnsembliENST00000188312; ENSP00000188312; ENSG00000075089 [Q9GZN1-1]
GeneIDi64431
KEGGihsa:64431
UCSCiuc001thb.3 human [Q9GZN1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038229 mRNA Translation: BAB20762.1
AF212251 mRNA Translation: AAK14934.1
AK023495 mRNA Translation: BAB14588.1
AK023684 mRNA Translation: BAB14640.1
AK124075 mRNA Translation: BAG53999.1
AK296991 mRNA Translation: BAG59531.1
AK222959 mRNA Translation: BAD96679.1
CH471054 Genomic DNA Translation: EAW97623.1
BC015107 mRNA Translation: AAH15107.1
CCDSiCCDS9074.1 [Q9GZN1-1]
RefSeqiNP_071941.1, NM_022496.4 [Q9GZN1-1]
XP_016875310.1, XM_017019821.1
UniGeneiHs.115088

3D structure databases

ProteinModelPortaliQ9GZN1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122179, 22 interactors
ComplexPortaliCPX-974 SRCAP histone exchanging complex
CORUMiQ9GZN1
IntActiQ9GZN1, 8 interactors
MINTiQ9GZN1
STRINGi9606.ENSP00000188312

PTM databases

iPTMnetiQ9GZN1
PhosphoSitePlusiQ9GZN1

Polymorphism and mutation databases

BioMutaiACTR6
DMDMi27923737

Proteomic databases

EPDiQ9GZN1
MaxQBiQ9GZN1
PaxDbiQ9GZN1
PeptideAtlasiQ9GZN1
PRIDEiQ9GZN1
ProteomicsDBi80095

Protocols and materials databases

DNASUi64431
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000188312; ENSP00000188312; ENSG00000075089 [Q9GZN1-1]
GeneIDi64431
KEGGihsa:64431
UCSCiuc001thb.3 human [Q9GZN1-1]

Organism-specific databases

CTDi64431
EuPathDBiHostDB:ENSG00000075089.9
GeneCardsiACTR6
HGNCiHGNC:24025 ACTR6
HPAiHPA038587
HPA038588
neXtProtiNX_Q9GZN1
OpenTargetsiENSG00000075089
PharmGKBiPA134984466
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0680 Eukaryota
ENOG410XPT5 LUCA
GeneTreeiENSGT00720000108833
HOGENOMiHOG000070006
HOVERGENiHBG097980
InParanoidiQ9GZN1
KOiK11662
OMAiEPYFNLP
OrthoDBiEOG091G09HG
PhylomeDBiQ9GZN1
TreeFamiTF105780

Enzyme and pathway databases

SignaLinkiQ9GZN1

Miscellaneous databases

ChiTaRSiACTR6 human
GenomeRNAii64431
PROiPR:Q9GZN1

Gene expression databases

BgeeiENSG00000075089 Expressed in 217 organ(s), highest expression level in caudate nucleus
CleanExiHS_ACTR6
ExpressionAtlasiQ9GZN1 baseline and differential
GenevisibleiQ9GZN1 HS

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR030054 Arp6
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF47 PTHR11937:SF47, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARP6_HUMAN
AccessioniPrimary (citable) accession number: Q9GZN1
Secondary accession number(s): B3KW37
, B4DLG9, Q53GH2, Q9BY39, Q9H8H6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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