UniProtKB - Q9GZN0 (GPR88_HUMAN)
Protein
Probable G-protein coupled receptor 88
Gene
GPR88
Organism
Homo sapiens (Human)
Status
Functioni
Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function.By similarity
GO - Molecular functioni
- G protein-coupled photoreceptor activity Source: GO_Central
- motor activity Source: UniProtKB
GO - Biological processi
- cellular response to light stimulus Source: GO_Central
- G protein-coupled receptor signaling pathway Source: GO_Central
- locomotory behavior Source: Ensembl
- motor learning Source: UniProtKB
- neuromuscular process controlling balance Source: Ensembl
- neuronal action potential Source: Ensembl
- phototransduction Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q9GZN0 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 88Alternative name(s): Striatum-specific G-protein coupled receptor |
Gene namesi | Name:GPR88 Synonyms:STRG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4539, GPR88 |
MIMi | 607468, gene |
neXtProti | NX_Q9GZN0 |
VEuPathDBi | HostDB:ENSG00000181656.6 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Other locations
- Cytoplasm By similarity
Note: During cortical lamination, subcellular location shifts, on the day of birth, from expression at the plasma membrane and in the cytoplasm to the nuclei of neurons. This intranuclear localization remains throughout adulthood.By similarity
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 35 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 36 – 56 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 57 – 73 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 74 – 94 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 95 – 116 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 117 – 136 | Helical; Name=3Sequence analysisAdd BLAST | 20 | |
Topological domaini | 137 – 158 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 159 – 179 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 180 – 195 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 196 – 216 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 217 – 285 | CytoplasmicSequence analysisAdd BLAST | 69 | |
Transmembranei | 286 – 306 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 307 – 310 | ExtracellularSequence analysis | 4 | |
Transmembranei | 311 – 331 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 332 – 384 | CytoplasmicSequence analysisAdd BLAST | 53 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Chorea, childhood-onset, with psychomotor retardation (COCPMR)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurodevelopmental disorder characterized by abnormal involuntary movements, marked speech delay, intellectual disability and learning difficulties.
Related information in OMIMKeywords - Diseasei
Mental retardationOrganism-specific databases
DisGeNETi | 54112 |
MalaCardsi | GPR88 |
MIMi | 616939, phenotype |
OpenTargetsi | ENSG00000181656 |
PharmGKBi | PA28932 |
Miscellaneous databases
Pharosi | Q9GZN0, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3399910 |
GuidetoPHARMACOLOGYi | 123 |
Genetic variation databases
BioMutai | GPR88 |
DMDMi | 229464740 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069597 | 1 – 384 | Probable G-protein coupled receptor 88Add BLAST | 384 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 3 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q9GZN0 |
PeptideAtlasi | Q9GZN0 |
PRIDEi | Q9GZN0 |
ProteomicsDBi | 80094 |
PTM databases
GlyGeni | Q9GZN0, 1 site |
iPTMneti | Q9GZN0 |
PhosphoSitePlusi | Q9GZN0 |
Expressioni
Tissue specificityi
Expressed predominantly in the striatum.1 Publication
Gene expression databases
Bgeei | ENSG00000181656, Expressed in caudate nucleus and 112 other tissues |
Genevisiblei | Q9GZN0, HS |
Organism-specific databases
HPAi | ENSG00000181656, Tissue enriched (brain) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000314223 |
Chemistry databases
BindingDBi | Q9GZN0 |
Miscellaneous databases
RNActi | Q9GZN0, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00390000009609 |
HOGENOMi | CLU_053532_0_0_1 |
InParanoidi | Q9GZN0 |
OMAi | EPPGDWD |
OrthoDBi | 1437332at2759 |
PhylomeDBi | Q9GZN0 |
TreeFami | TF336499 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9GZN0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTNSSSTSTS STTGGSLLLL CEEEESWAGR RIPVSLLYSG LAIGGTLANG
60 70 80 90 100
MVIYLVSSFR KLQTTSNAFI VNGCAADLSV CALWMPQEAV LGLLPTGSAE
110 120 130 140 150
PPADWDGAGG SYRLLRGGLL GLGLTVSLLS HCLVALNRYL LITRAPATYQ
160 170 180 190 200
ALYQRRHTAG MLALSWALAL GLVLLLPPWA PRPGAAPPRV HYPALLAAAA
210 220 230 240 250
LLAQTALLLH CYLGIVRRVR VSVKRVSVLN FHLLHQLPGC AAAAAAFPGA
260 270 280 290 300
QHAPGPGGAA HPAQAQPLPP ALHPRRAQRR LSGLSVLLLC CVFLLATQPL
310 320 330 340 350
VWVSLASGFS LPVPWGVQAA SWLLCCALSA LNPLLYTWRN EEFRRSVRSV
360 370 380
LPGVGDAAAA AVAATAVPAV SQAQLGTRAA GQHW
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054767 | 190 | V → I2 PublicationsCorresponds to variant dbSNP:rs2809819Ensembl. | 1 | |
Natural variantiVAR_054768 | 318 | Q → H1 PublicationCorresponds to variant dbSNP:rs3001995Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB042410 mRNA Translation: BAB18247.1 AB042411 Genomic DNA Translation: BAB18248.1 AY336999 Genomic DNA Translation: AAQ76787.1 AC099670 Genomic DNA No translation available. BC036775 mRNA Translation: AAH36775.1 |
CCDSi | CCDS772.1 |
RefSeqi | NP_071332.2, NM_022049.2 |
Genome annotation databases
Ensembli | ENST00000315033; ENSP00000314223; ENSG00000181656 |
GeneIDi | 54112 |
KEGGi | hsa:54112 |
UCSCi | uc001dth.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB042410 mRNA Translation: BAB18247.1 AB042411 Genomic DNA Translation: BAB18248.1 AY336999 Genomic DNA Translation: AAQ76787.1 AC099670 Genomic DNA No translation available. BC036775 mRNA Translation: AAH36775.1 |
CCDSi | CCDS772.1 |
RefSeqi | NP_071332.2, NM_022049.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000314223 |
Chemistry databases
BindingDBi | Q9GZN0 |
ChEMBLi | CHEMBL3399910 |
GuidetoPHARMACOLOGYi | 123 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9GZN0, 1 site |
iPTMneti | Q9GZN0 |
PhosphoSitePlusi | Q9GZN0 |
Genetic variation databases
BioMutai | GPR88 |
DMDMi | 229464740 |
Proteomic databases
PaxDbi | Q9GZN0 |
PeptideAtlasi | Q9GZN0 |
PRIDEi | Q9GZN0 |
ProteomicsDBi | 80094 |
Protocols and materials databases
Antibodypediai | 19999, 201 antibodies |
DNASUi | 54112 |
Genome annotation databases
Ensembli | ENST00000315033; ENSP00000314223; ENSG00000181656 |
GeneIDi | 54112 |
KEGGi | hsa:54112 |
UCSCi | uc001dth.4, human |
Organism-specific databases
CTDi | 54112 |
DisGeNETi | 54112 |
GeneCardsi | GPR88 |
HGNCi | HGNC:4539, GPR88 |
HPAi | ENSG00000181656, Tissue enriched (brain) |
MalaCardsi | GPR88 |
MIMi | 607468, gene 616939, phenotype |
neXtProti | NX_Q9GZN0 |
OpenTargetsi | ENSG00000181656 |
PharmGKBi | PA28932 |
VEuPathDBi | HostDB:ENSG00000181656.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00390000009609 |
HOGENOMi | CLU_053532_0_0_1 |
InParanoidi | Q9GZN0 |
OMAi | EPPGDWD |
OrthoDBi | 1437332at2759 |
PhylomeDBi | Q9GZN0 |
TreeFami | TF336499 |
Enzyme and pathway databases
PathwayCommonsi | Q9GZN0 |
Miscellaneous databases
BioGRID-ORCSi | 54112, 6 hits in 864 CRISPR screens |
GeneWikii | GPR88 |
GenomeRNAii | 54112 |
Pharosi | Q9GZN0, Tchem |
PROi | PR:Q9GZN0 |
RNActi | Q9GZN0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000181656, Expressed in caudate nucleus and 112 other tissues |
Genevisiblei | Q9GZN0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPR88_HUMAN | |
Accessioni | Q9GZN0Primary (citable) accession number: Q9GZN0 Secondary accession number(s): Q29S24, Q6VN48 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | March 24, 2009 | |
Last modified: | February 10, 2021 | |
This is version 126 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families