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Entry version 151 (13 Feb 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Nuclear distribution protein nudE-like 1

Gene

NDEL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity).By similarity4 Publications

Caution

Was originally thought to function as an oligopeptidase (NUDEL-oligopeptidase or endooligopeptidase A) which could regulate peptide levels relevant to brain function.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • alpha-tubulin binding Source: Ensembl
  • beta-tubulin binding Source: Ensembl
  • identical protein binding Source: IntAct
  • microtubule binding Source: GO_Central
  • oligopeptidase activity Source: Ensembl
  • protein-containing complex binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9GZM8

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
Q9GZM8 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear distribution protein nudE-like 1
Short name:
Protein Nudel
Alternative name(s):
Mitosin-associated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NDEL1
Synonyms:EOPA, MITAP1, NUDEL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166579.15

Human Gene Nomenclature Database

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HGNCi
HGNC:17620 NDEL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607538 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9GZM8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi198S → A: Abrogates mitotic phosphorylation; when associated with V-219; A-231; A-242 and V-245. Abrogates phosphorylation by CDK5; when associated with A-219 and A-231. 2 Publications1
Mutagenesisi198S → E: Enhances interaction with PAFAH1B1 and impairs centrosomal localization; when associated with E-219; E-231; E-242 and E-245. 2 Publications1
Mutagenesisi219T → A: Abrogates phosphorylation by CDK5; when associated with A-198 and A-231. 2 Publications1
Mutagenesisi219T → E: Enhances interaction with PAFAH1B1 and impairs centrosomal localization; when associated with E-198; E-231; E-242 and E-245. 2 Publications1
Mutagenesisi219T → V: Abrogates mitotic phosphorylation; when associated with A-198; A-231; A-242 and V-245. 2 Publications1
Mutagenesisi231S → A: Abrogates mitotic phosphorylation; when associated with A-198; V-219; A-242 and V-245. Abrogates phosphorylation by CDK5; when associated with A-198 and A-219. 2 Publications1
Mutagenesisi231S → E: Enhances interaction with PAFAH1B1 and impairs centrosomal localization; when associated with E-198; E-219; E-242 and E-245. 2 Publications1
Mutagenesisi242S → A: Abrogates mitotic phosphorylation; when associated with A-198; V-219; A-231 and V-245. 1 Publication1
Mutagenesisi242S → E: Enhances interaction with PAFAH1B1 and impairs centrosomal localization; when associated with E-198; E-219; E-231 and E-245. 1 Publication1
Mutagenesisi245T → E: Enhances interaction with PAFAH1B1 and impairs centrosomal localization; when associated with E-198; E-219; E-231 and E-242. 1 Publication1
Mutagenesisi245T → V: Abrogates mitotic phosphorylation; when associated with A-198; V-219; A-231 and A-242. 1 Publication1
Mutagenesisi266L → A: Abolishes interaction with DISC1; when associated with A-267. 1 Publication1
Mutagenesisi267E → A: Abolishes interaction with DISC1; when associated with A-266. 1 Publication1
Mutagenesisi273C → A: Abolishes oligopeptidase activity. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
81565

Open Targets

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OpenTargetsi
ENSG00000166579

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134887314

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NDEL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74725006

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002402101 – 345Nuclear distribution protein nudE-like 1Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei215PhosphoserineCombined sources1
Modified residuei219Phosphothreonine; by CDK1 and MAPK1Combined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei242Phosphoserine; by CDK1Combined sources1
Modified residuei245Phosphothreonine; by CDK1 and MAPK1Combined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi273S-palmitoyl cysteine; by ZDHHC2, ZDHHC3 and ZDHHC71 Publication1
Modified residuei344PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE.3 Publications
Palmitoylation at Cys-273 reduces affinity for dynein.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9GZM8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9GZM8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9GZM8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9GZM8

PeptideAtlas

More...
PeptideAtlasi
Q9GZM8

PRoteomics IDEntifications database

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PRIDEi
Q9GZM8

ProteomicsDB human proteome resource

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ProteomicsDBi
80092
80093 [Q9GZM8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9GZM8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9GZM8

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q9GZM8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression peaks in mitosis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000166579 Expressed in 233 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9GZM8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9GZM8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017916

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PLEKHM1 (via N- and C-terminus) (By similarity). Interacts with YWHAE. Interacts directly with NEFL and indirectly with NEFH. Interacts with microtubules (By similarity). Self-associates. Interacts with DISC1, dynein, dynactin, tubulin gamma, KATNA1, KATNB1, PAFAH1B1, PCM1 and PCNT. Interacts (via C-terminus) with CENPF. Interacts with ZNF365.By similarity13 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123527, 127 interactors

Database of interacting proteins

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DIPi
DIP-29554N

Protein interaction database and analysis system

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IntActi
Q9GZM8, 85 interactors

Molecular INTeraction database

More...
MINTi
Q9GZM8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000333982

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V66X-ray2.10B/C/D/E58-168[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9GZM8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9GZM8

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9GZM8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni56 – 166Self-associationBy similarityAdd BLAST111
Regioni64 – 189Interaction with KATNB1By similarityAdd BLAST126
Regioni114 – 133Required for interaction with PAFAH1B1Add BLAST20
Regioni175 – 345Interaction with CENPF1 PublicationAdd BLAST171
Regioni189 – 256Interaction with YWHAEBy similarityAdd BLAST68
Regioni191 – 345Interaction with NEFLBy similarityAdd BLAST155
Regioni195 – 256Interaction with KATNA1By similarityAdd BLAST62
Regioni241 – 280Interaction with DISC1Add BLAST40
Regioni256 – 291Required for localization to the centrosome and interaction with dynein, dynactin, tubulin gamma, PCM1 and PCNT1 PublicationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili28 – 190Sequence analysisAdd BLAST163

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nudE family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1853 Eukaryota
ENOG410XPMP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000000111

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000280681

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG082010

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9GZM8

KEGG Orthology (KO)

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KOi
K16739

Identification of Orthologs from Complete Genome Data

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OMAi
APPMFNS

Database of Orthologous Groups

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OrthoDBi
1082224at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9GZM8

TreeFam database of animal gene trees

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TreeFami
TF325693

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR033493 NDEL1
IPR033494 NUDE
IPR006964 NUDE_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10921 PTHR10921, 1 hit
PTHR10921:SF0 PTHR10921:SF0, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04880 NUDE_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9GZM8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGEDIPDFS SLKEETAYWK ELSLKYKQSF QEARDELVEF QEGSRELEAE
60 70 80 90 100
LEAQLVQAEQ RNRDLQADNQ RLKYEVEALK EKLEHQYAQS YKQVSVLEDD
110 120 130 140 150
LSQTRAIKEQ LHKYVRELEQ ANDDLERAKR ATIVSLEDFE QRLNQAIERN
160 170 180 190 200
AFLESELDEK ESLLVSVQRL KDEARDLRQE LAVRERQQEV TRKSAPSSPT
210 220 230 240 250
LDCEKMDSAV QASLSLPATP VGKGTENTFP SPKAIPNGFG TSPLTPSARI
260 270 280 290 300
SALNIVGDLL RKVGALESKL AACRNFAKDQ ASRKSYISGN VNCGVLNGNG
310 320 330 340
TKFSRSGHTS FFDKGAVNGF DPAPPPPGLG SSRPSSAPGM LPLSV
Length:345
Mass (Da):38,375
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE91EA053FCA315D7
GO
Isoform 2 (identifier: Q9GZM8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-345: AVNGFDPAPPPPGLGSSRPSSAPGMLPLSV → SSSSCAIRAS...APPPTLLLET

Note: No experimental confirmation available.
Show »
Length:367
Mass (Da):40,616
Checksum:iEC939E90FAB014BC
GO
Isoform 3 (identifier: Q9GZM8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-345: AVNGFDPAPPPPGLGSSRPSSAPGMLPLSV → QEKVIFPTLFMGQ

Note: No experimental confirmation available.
Show »
Length:328
Mass (Da):37,039
Checksum:iD897B2D19656D061
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NIZ0A6NIZ0_HUMAN
Nuclear distribution protein nudE-l...
NDEL1
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL85J3QL85_HUMAN
Nuclear distribution protein nudE-l...
NDEL1
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRZ1J3QRZ1_HUMAN
Nuclear distribution protein nudE-l...
NDEL1
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLD0J3QLD0_HUMAN
Nuclear distribution protein nudE-l...
NDEL1
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KT16J3KT16_HUMAN
Nuclear distribution protein nudE-l...
NDEL1
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRK9J3KRK9_HUMAN
Nuclear distribution protein nudE-l...
NDEL1
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL31J3QL31_HUMAN
Nuclear distribution protein nudE-l...
NDEL1
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSD2J3QSD2_HUMAN
Nuclear distribution protein nudE-l...
NDEL1
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSF2J3KSF2_HUMAN
Nuclear distribution protein nudE-l...
NDEL1
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRD2J3QRD2_HUMAN
Nuclear distribution protein nudE-l...
NDEL1
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti322P → T in AAH26101 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019310316 – 345AVNGF…LPLSV → SSSSCAIRASRRRFSSSSAD LAGRGGGDGSIPAQHSTGAS GKAPPPTLLLET in isoform 2. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_047509316 – 345AVNGF…LPLSV → QEKVIFPTLFMGQ in isoform 3. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY004871 mRNA Translation: AAF97497.1
AF182078 mRNA Translation: AAG43425.1
AF217798 mRNA Translation: AAF24516.3
AK056014 mRNA Translation: BAG51605.1
DA256375 mRNA No translation available.
AL832648 mRNA Translation: CAD89957.3
AC026130 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90051.1
CH471108 Genomic DNA Translation: EAW90052.1
BC026101 mRNA Translation: AAH26101.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11143.1 [Q9GZM8-1]
CCDS32564.1 [Q9GZM8-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001020750.1, NM_001025579.2 [Q9GZM8-3]
NP_110435.1, NM_030808.4 [Q9GZM8-1]
XP_016880674.1, XM_017025185.1 [Q9GZM8-1]
XP_016880676.1, XM_017025187.1 [Q9GZM8-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.372123
Hs.740680

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334527; ENSP00000333982; ENSG00000166579 [Q9GZM8-1]
ENST00000402554; ENSP00000384963; ENSG00000166579 [Q9GZM8-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
81565

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:81565

UCSC genome browser

More...
UCSCi
uc002gli.5 human [Q9GZM8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY004871 mRNA Translation: AAF97497.1
AF182078 mRNA Translation: AAG43425.1
AF217798 mRNA Translation: AAF24516.3
AK056014 mRNA Translation: BAG51605.1
DA256375 mRNA No translation available.
AL832648 mRNA Translation: CAD89957.3
AC026130 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90051.1
CH471108 Genomic DNA Translation: EAW90052.1
BC026101 mRNA Translation: AAH26101.1
CCDSiCCDS11143.1 [Q9GZM8-1]
CCDS32564.1 [Q9GZM8-3]
RefSeqiNP_001020750.1, NM_001025579.2 [Q9GZM8-3]
NP_110435.1, NM_030808.4 [Q9GZM8-1]
XP_016880674.1, XM_017025185.1 [Q9GZM8-1]
XP_016880676.1, XM_017025187.1 [Q9GZM8-3]
UniGeneiHs.372123
Hs.740680

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V66X-ray2.10B/C/D/E58-168[»]
ProteinModelPortaliQ9GZM8
SMRiQ9GZM8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123527, 127 interactors
DIPiDIP-29554N
IntActiQ9GZM8, 85 interactors
MINTiQ9GZM8
STRINGi9606.ENSP00000333982

Protein family/group databases

MoonDBiQ9GZM8 Predicted

PTM databases

iPTMnetiQ9GZM8
PhosphoSitePlusiQ9GZM8
SwissPalmiQ9GZM8

Polymorphism and mutation databases

BioMutaiNDEL1
DMDMi74725006

Proteomic databases

EPDiQ9GZM8
jPOSTiQ9GZM8
MaxQBiQ9GZM8
PaxDbiQ9GZM8
PeptideAtlasiQ9GZM8
PRIDEiQ9GZM8
ProteomicsDBi80092
80093 [Q9GZM8-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
81565
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334527; ENSP00000333982; ENSG00000166579 [Q9GZM8-1]
ENST00000402554; ENSP00000384963; ENSG00000166579 [Q9GZM8-3]
GeneIDi81565
KEGGihsa:81565
UCSCiuc002gli.5 human [Q9GZM8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
81565
DisGeNETi81565
EuPathDBiHostDB:ENSG00000166579.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NDEL1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0135343
HGNCiHGNC:17620 NDEL1
HPAiHPA017916
MIMi607538 gene
neXtProtiNX_Q9GZM8
OpenTargetsiENSG00000166579
PharmGKBiPA134887314

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1853 Eukaryota
ENOG410XPMP LUCA
GeneTreeiENSGT00390000000111
HOGENOMiHOG000280681
HOVERGENiHBG082010
InParanoidiQ9GZM8
KOiK16739
OMAiAPPMFNS
OrthoDBi1082224at2759
PhylomeDBiQ9GZM8
TreeFamiTF325693

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase
SIGNORiQ9GZM8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NDEL1 human
EvolutionaryTraceiQ9GZM8

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NDEL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
81565

Protein Ontology

More...
PROi
PR:Q9GZM8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166579 Expressed in 233 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ9GZM8 baseline and differential
GenevisibleiQ9GZM8 HS

Family and domain databases

InterProiView protein in InterPro
IPR033493 NDEL1
IPR033494 NUDE
IPR006964 NUDE_dom
PANTHERiPTHR10921 PTHR10921, 1 hit
PTHR10921:SF0 PTHR10921:SF0, 1 hit
PfamiView protein in Pfam
PF04880 NUDE_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDEL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZM8
Secondary accession number(s): B3KP93
, D3DTS0, J3QT32, Q86T80, Q8TAR7, Q9UH50
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2001
Last modified: February 13, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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