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Protein

Olfactory receptor 8D2

Gene

OR8D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor (Potential). May be involved in taste perception.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8D2
Alternative name(s):
Olfactory receptor OR11-303
Olfactory receptor-like protein JCG2
Gene namesi
Name:OR8D2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000197263.3
HostDB:ENSG00000279116.1
HGNCiHGNC:8482 OR8D2
neXtProtiNX_Q9GZM6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 311CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32761

Polymorphism and mutation databases

BioMutaiOR8D2
DMDMi14423803

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506601 – 311Olfactory receptor 8D2Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZM6
PeptideAtlasiQ9GZM6
PRIDEiQ9GZM6
ProteomicsDBi80088

PTM databases

iPTMnetiQ9GZM6
PhosphoSitePlusiQ9GZM6

Expressioni

Tissue specificityi

Expressed in the tongue.

Gene expression databases

BgeeiENSG00000279116
CleanExiHS_OR8D2
ExpressionAtlasiQ9GZM6 baseline and differential
GenevisibleiQ9GZM6 HS

Interactioni

Protein-protein interaction databases

BioGridi129481, 1 interactor
IntActiQ9GZM6, 2 interactors
STRINGi9606.ENSP00000350022

Structurei

3D structure databases

ProteinModelPortaliQ9GZM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8YA Eukaryota
ENOG411167D LUCA
GeneTreeiENSGT00900000140920
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ9GZM6
KOiK04257
OMAiNIVMSHR
OrthoDBiEOG091G0AZH
PhylomeDBiQ9GZM6
TreeFamiTF352753

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9GZM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSNHSSGA EFILAGLTQR PELQLPLFLL FLGIYVVTVV GNLGMIFLIA
60 70 80 90 100
LSSQLYPPVY YFLSHLSFID LCYSSVITPK MLVNFVPEEN IISFLECITQ
110 120 130 140 150
LYFFLIFVIA EGYLLTAMEY DRYVAICRPL LYNIVMSHRV CSIMMAVVYS
160 170 180 190 200
LGFLWATVHT TRMSVLSFCR SHTVSHYFCD ILPLLTLSCS STHINEILLF
210 220 230 240 250
IIGGVNTLAT TLAVLISYAF IFSSILGIHS TEGQSKAFGT CSSHLLAVGI
260 270 280 290 300
FFGSITFMYF KPPSSTTMEK EKVSSVFYIT IIPMLNPLIY SLRNKDVKNA
310
LKKMTRGRQS S
Length:311
Mass (Da):34,857
Last modified:March 1, 2001 - v1
Checksum:iECE606FBBC962A82
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024117122R → H. Corresponds to variant dbSNP:rs2512219Ensembl.1
Natural variantiVAR_053244263P → L. Corresponds to variant dbSNP:rs2466620Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162668 mRNA Translation: AAG43386.1
AF162669 Genomic DNA Translation: AAG43387.1
CH471065 Genomic DNA Translation: EAW67579.1
BC137043 mRNA Translation: AAI37044.1
BC137045 mRNA Translation: AAI37046.1
BK004202 Genomic DNA Translation: DAA04600.1
RefSeqiNP_001002918.1, NM_001002918.1
UniGeneiHs.504212

Genome annotation databases

EnsembliENST00000624618; ENSP00000485661; ENSG00000279116
GeneIDi283160
KEGGihsa:283160
UCSCiuc010sah.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR8D2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZM6
Secondary accession number(s): B9EH49, Q6IFR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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