UniProtKB - Q9GZM5 (YIPF3_HUMAN)

BLAST

>sp|Q9GZM5|YIPF3_HUMAN Protein YIPF3 OS=Homo sapiens OX=9606 GN=YIPF3 PE=1 SV=1
MATTAAPAGGARNGAGPEWGGFEENIQGGGSAVIDMENMDDTSGSSFEDMGELHQRLREE
EVDADAADAAAAEEEDGEFLGMKGFKGQLSRQVADQMWQAGKRQASRAFSLYANIDILRP
YFDVEPAQVRSRLLESMIPIKMVNFPQKIAGELYGPLMLVFTLVAILLHGMKTSDTIIRE
GTLMGTAIGTCFGYWLGVSSFIYFLAYLCNAQITMLQMLALLGYGLFGHCIVLFITYNIH
LHALFYLFWLLVGGLSTLRMVAVLVSRTVGPTQRLLLCGTLAALHMLFLLYLHFAYHKVV
EGILDTLEGPNIPPIQRVPRDIPAMLPAARLPTTVLNATAKAVAVTLQSH

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History
Entry version 134 (12 Sep 2018)
Sequence version 1 (01 Mar 2001)
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Protein

Protein YIPF3

Gene

YIPF3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.2 Publications

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Differentiation

Biological process

Differentiation

Protein family/group databases

TCDBⁱ	9.B.135.2.1 the membrane trafficking yip (yip) family

TCDBⁱ

9.B.135.2.1 the membrane trafficking yip (yip) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein YIPF3 Alternative name(s): Killer lineage protein 1 Natural killer cell-specific antigen KLIP1 YIP1 family member 3 Cleaved into the following chain: Protein YIPF3, 36 kDa form III
Gene namesⁱ	Name:YIPF3 Synonyms:C6orf109, KLIP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000137207.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21023 YIPF3
MIMⁱ	609775 gene
neXtProtⁱ	NX_Q9GZM5

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	2 – 148	Cytoplasmic1 PublicationAdd BLAST	147
Transmembraneⁱ	149 – 169	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	170 – 187	LumenalCuratedAdd BLAST	18
Transmembraneⁱ	188 – 208	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	209 – 214	CytoplasmicCurated	6
Transmembraneⁱ	215 – 237	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	238 – 240	LumenalCurated	3
Transmembraneⁱ	241 – 263	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	264 – 274	CytoplasmicCuratedAdd BLAST	11
Transmembraneⁱ	275 – 295	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	296 – 350	Lumenal1 PublicationAdd BLAST	55

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	25844
Open Targets More...OpenTargetsⁱ	ENSG00000137207
PharmGKBⁱ	PA134946615

Polymorphism and mutation databases

BioMutaⁱ	YIPF3
DMDMⁱ	74752534

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000244446	2 – 350	Protein YIPF3Add BLAST	349
ChainⁱPRO_0000418216	2 – ?	Protein YIPF3, 36 kDa form III

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Glycosylationⁱ	333	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	334	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	337	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	339	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	346	O-linked (GalNAc...) threonine3 Publications	1

Post-translational modificationⁱ

N-glycosylated in the ER (40 kDa form I), then O-glycosylated in the Golgi apparatus (46 kDa form II), the C-terminal lumenal region is later removed in the Golgi apparatus to produce a 36 kDa form III. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Thr-346: HexNAc (minor), HexHexNAc (major), Hex1HexNAc2 (minor), Hex2HexNAc2 (minor) and dHex1Hex2HexNAc2 (minor).4 Publications

Keywords - PTMⁱ

Acetylation, Glycoprotein

Proteomic databases

EPDⁱ	Q9GZM5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9GZM5
PaxDbⁱ	Q9GZM5
PeptideAtlas More...PeptideAtlasⁱ	Q9GZM5
PRIDEⁱ	Q9GZM5
ProteomicsDBⁱ	80087

PTM databases

CarbonylDBⁱ	Q9GZM5
GlyConnectⁱ	641
iPTMnetⁱ	Q9GZM5
PhosphoSitePlusⁱ	Q9GZM5
SwissPalmⁱ	Q9GZM5
UniCarbKBⁱ	Q9GZM5

Expressionⁱ

Tissue specificityⁱ

Expressed by nucleated hematopoietic cells (at protein level).1 Publication

Developmental stageⁱ

Expressed in fetal liver (at protein level). Expressed in embryonic hematopoiesis sites.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000137207 Expressed in 207 organ(s), highest expression level in right adrenal gland
CleanExⁱ	HS_YIPF3
ExpressionAtlasⁱ	Q9GZM5 baseline and differential
Genevisibleⁱ	Q9GZM5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA014859 HPA063699

HPAⁱ

HPA014859
HPA063699

Interactionⁱ

Subunit structureⁱ

Interacts with YIPF4 and YIPF5.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
KRTAP10-8	P60410	3	EBI-743787,EBI-10171774
KRTAP3-2	Q9BYR7	5	EBI-743787,EBI-751260
KRTAP5-9	P26371	3	EBI-743787,EBI-3958099
KRTAP9-4	Q9BYQ2	3	EBI-743787,EBI-10185730
NOTCH2NL	Q7Z3S9	3	EBI-743787,EBI-945833
YIPF4	Q9BSR8	6	EBI-743787,EBI-751253

Protein-protein interaction databases

BioGridⁱ	117370, 113 interactors
IntActⁱ	Q9GZM5, 18 interactors
Molecular INTeraction database More...MINTⁱ	Q9GZM5
STRINGⁱ	9606.ENSP00000361499

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9GZM5
SMRⁱ	Q9GZM5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the YIP1 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IPBK Eukaryota ENOG4111EUH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000047963
HOVERGENⁱ	HBG055544
InParanoidⁱ	Q9GZM5
PhylomeDBⁱ	Q9GZM5
TreeFamⁱ	TF314073

Family and domain databases

InterProⁱ	View protein in InterPro IPR026637 YIPF3
PANTHERⁱ	PTHR15627:SF14 PTHR15627:SF14, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show all Align All

Q9GZM5-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MATTAAPAGG ARNGAGPEWG GFEENIQGGG SAVIDMENMD DTSGSSFEDM 
        60         70         80         90        100
GELHQRLREE EVDADAADAA AAEEEDGEFL GMKGFKGQLS RQVADQMWQA 
       110        120        130        140        150
GKRQASRAFS LYANIDILRP YFDVEPAQVR SRLLESMIPI KMVNFPQKIA 
       160        170        180        190        200
GELYGPLMLV FTLVAILLHG MKTSDTIIRE GTLMGTAIGT CFGYWLGVSS 
       210        220        230        240        250
FIYFLAYLCN AQITMLQMLA LLGYGLFGHC IVLFITYNIH LHALFYLFWL 
       260        270        280        290        300
LVGGLSTLRM VAVLVSRTVG PTQRLLLCGT LAALHMLFLL YLHFAYHKVV 
       310        320        330        340        350
EGILDTLEGP NIPPIQRVPR DIPAMLPAAR LPTTVLNATA KAVAVTLQSH

Length:350

Mass (Da):38,248

Last modified:March 1, 2001 - v1

Checksum:ⁱED7A566716A6B364

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E7EQR8	E7EQR8_HUMAN	Protein YIPF3 Protein YIPF3	YIPF3	356	Annotation score:
H0Y9A1	H0Y9A1_HUMAN	Protein YIPF3 Protein YIPF3	YIPF3	135	Annotation score:
D6RFI3	D6RFI3_HUMAN	Protein YIPF3 Protein YIPF3	YIPF3	262	Annotation score:
D6RGY8	D6RGY8_HUMAN	Protein YIPF3 Protein YIPF3	YIPF3	109	Annotation score:
D6RAY4	D6RAY4_HUMAN	Protein YIPF3 Protein YIPF3	YIPF3	64	Annotation score:
D6RBQ1	D6RBQ1_HUMAN	Protein YIPF3 Protein YIPF3	YIPF3	45	Annotation score:
D6RA04	D6RA04_HUMAN	Protein YIPF3 Protein YIPF3	YIPF3	63	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	103	R → G in CAG38572 (Ref. 6) Curated	1
Sequence conflictⁱ	142	M → V in BAA91439 (PubMed:14702039).Curated	1
Sequence conflictⁱ	161	F → L in AAM21161 (PubMed:12490290).Curated	1
Sequence conflictⁱ	305	D → V in CAB43375 (PubMed:11230166).Curated	1
Sequence conflictⁱ	305	D → V in CAG38572 (Ref. 6) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_026906	5	A → V. Corresponds to variant dbSNP:rs2231763Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF162672 mRNA Translation: AAM21161.1 AK000946 mRNA Translation: BAA91439.1 AK021655 mRNA Translation: BAB13866.1 AK022757 mRNA Translation: BAB14231.1 AL355802 Genomic DNA No translation available. BC019297 mRNA Translation: AAH19297.1 AL050274 mRNA Translation: CAB43375.2 CR533541 mRNA Translation: CAG38572.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4899.1
PIRⁱ	T08721
NCBI Reference Sequences More...RefSeqⁱ	NP_056203.2, NM_015388.3
UniGeneⁱ	Hs.440950

Genome annotation databases

Ensemblⁱ	ENST00000372422; ENSP00000361499; ENSG00000137207
GeneIDⁱ	25844
KEGGⁱ	hsa:25844
UCSC genome browser More...UCSCⁱ	uc003ovl.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9GZM5	YIPF3 isoform 1		PANTR		350	UniRef100_Q9GZM5
Natural killer cell-specific antigen KLIP-1 (Fragment)		PIG		157

Protein	Similar proteins		Species	Score	Length	Source
Q9GZM5	Protein YIPF3		RAT		347	UniRef90_Q9GZM5
Protein YIPF3		MOUSE		347
YIPF3 isoform 1		PANTR		350
Natural killer cell-specific antigen KLIP-1 (Fragment)		PIG		157
YIPF3 isoform 3		PONAB		356
+100

Protein	Similar proteins		Species	Score	Length	Source
Q9GZM5	Protein YIPF3		RAT		347	UniRef50_Q9GZM5
Protein YIPF3		MOUSE		347
Protein YIPF3		CHICK		336
YIPF3 isoform 1		PANTR		350
Natural killer cell-specific antigen KLIP-1 (Fragment)		PIG		157
+216

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF162672 mRNA Translation: AAM21161.1 AK000946 mRNA Translation: BAA91439.1 AK021655 mRNA Translation: BAB13866.1 AK022757 mRNA Translation: BAB14231.1 AL355802 Genomic DNA No translation available. BC019297 mRNA Translation: AAH19297.1 AL050274 mRNA Translation: CAB43375.2 CR533541 mRNA Translation: CAG38572.1
CCDSⁱ	CCDS4899.1
PIRⁱ	T08721
RefSeqⁱ	NP_056203.2, NM_015388.3
UniGeneⁱ	Hs.440950

3D structure databases

ProteinModelPortalⁱ	Q9GZM5
SMRⁱ	Q9GZM5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117370, 113 interactors
IntActⁱ	Q9GZM5, 18 interactors
MINTⁱ	Q9GZM5
STRINGⁱ	9606.ENSP00000361499

Protein family/group databases

TCDBⁱ	9.B.135.2.1 the membrane trafficking yip (yip) family

TCDBⁱ

9.B.135.2.1 the membrane trafficking yip (yip) family

PTM databases

CarbonylDBⁱ	Q9GZM5
GlyConnectⁱ	641
iPTMnetⁱ	Q9GZM5
PhosphoSitePlusⁱ	Q9GZM5
SwissPalmⁱ	Q9GZM5
UniCarbKBⁱ	Q9GZM5

Polymorphism and mutation databases

BioMutaⁱ	YIPF3
DMDMⁱ	74752534

Proteomic databases

EPDⁱ	Q9GZM5
MaxQBⁱ	Q9GZM5
PaxDbⁱ	Q9GZM5
PeptideAtlasⁱ	Q9GZM5
PRIDEⁱ	Q9GZM5
ProteomicsDBⁱ	80087

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	25844
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000372422; ENSP00000361499; ENSG00000137207
GeneIDⁱ	25844
KEGGⁱ	hsa:25844
UCSCⁱ	uc003ovl.2 human

Organism-specific databases

CTDⁱ	25844
DisGeNETⁱ	25844
EuPathDBⁱ	HostDB:ENSG00000137207.11
GeneCardsⁱ	YIPF3
HGNCⁱ	HGNC:21023 YIPF3
HPAⁱ	HPA014859 HPA063699
MIMⁱ	609775 gene
neXtProtⁱ	NX_Q9GZM5
OpenTargetsⁱ	ENSG00000137207
PharmGKBⁱ	PA134946615
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IPBK Eukaryota ENOG4111EUH LUCA
GeneTreeⁱ	ENSGT00510000047963
HOVERGENⁱ	HBG055544
InParanoidⁱ	Q9GZM5
PhylomeDBⁱ	Q9GZM5
TreeFamⁱ	TF314073

Miscellaneous databases

ChiTaRSⁱ	YIPF3 human
GeneWikiⁱ	YIPF3
GenomeRNAiⁱ	25844
Protein Ontology More...PROⁱ	PR:Q9GZM5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000137207 Expressed in 207 organ(s), highest expression level in right adrenal gland
CleanExⁱ	HS_YIPF3
ExpressionAtlasⁱ	Q9GZM5 baseline and differential
Genevisibleⁱ	Q9GZM5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026637 YIPF3
PANTHERⁱ	PTHR15627:SF14 PTHR15627:SF14, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	YIPF3_HUMAN
Accessionⁱ	Q9GZM5Primary (citable) accession number: Q9GZM5 Secondary accession number(s): Q5JTD2 , Q6FI85, Q8NI57, Q9NWE3, Q9Y3U9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
	Last sequence update:	March 1, 2001
	Last modified:	September 12, 2018
	This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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UniParc

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UniRef

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Supporting data

UniProtKB - Q9GZM5 (YIPF3_HUMAN)

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Protein YIPF3

YIPF3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Golgi apparatus

Other locations

Golgi apparatus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ