UniProtKB - Q9GZM5 (YIPF3_HUMAN)
Protein
Protein YIPF3
Gene
YIPF3
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.2 Publications
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
Keywordsi
Biological process | Differentiation |
Enzyme and pathway databases
PathwayCommonsi | Q9GZM5 |
Protein family/group databases
TCDBi | 9.B.135.2.1, the membrane trafficking yip (yip) family |
Names & Taxonomyi
Protein namesi | Recommended name: Protein YIPF3Alternative name(s): Killer lineage protein 1 Natural killer cell-specific antigen KLIP1 YIP1 family member 3 Cleaved into the following chain: |
Gene namesi | Name:YIPF3 Synonyms:C6orf109, KLIP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21023, YIPF3 |
MIMi | 609775, gene |
neXtProti | NX_Q9GZM5 |
VEuPathDBi | HostDB:ENSG00000137207.11 |
Subcellular locationi
Golgi apparatus
- cis-Golgi network membrane 1 Publication; Multi-pass membrane protein
Plasma membrane
Other locations
Note: Localization to the cytoplasm or to the cell membrane is developmentally and ontogenetically regulated.
Golgi apparatus
- Golgi apparatus Source: HPA
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: HPA
- transport vesicle Source: LIFEdb
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 148 | Cytoplasmic1 PublicationAdd BLAST | 147 | |
Transmembranei | 149 – 169 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 170 – 187 | LumenalCuratedAdd BLAST | 18 | |
Transmembranei | 188 – 208 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 209 – 214 | CytoplasmicCurated | 6 | |
Transmembranei | 215 – 237 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 238 – 240 | LumenalCurated | 3 | |
Transmembranei | 241 – 263 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 264 – 274 | CytoplasmicCuratedAdd BLAST | 11 | |
Transmembranei | 275 – 295 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 296 – 350 | Lumenal1 PublicationAdd BLAST | 55 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 25844 |
OpenTargetsi | ENSG00000137207 |
PharmGKBi | PA134946615 |
Miscellaneous databases
Pharosi | Q9GZM5, Tbio |
Genetic variation databases
BioMutai | YIPF3 |
DMDMi | 74752534 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000244446 | 2 – 350 | Protein YIPF3Add BLAST | 349 | |
ChainiPRO_0000418216 | 2 – ? | Protein YIPF3, 36 kDa form III |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Glycosylationi | 333 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 334 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 337 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 339 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 346 | O-linked (GalNAc...) threonine3 Publications | 1 |
Post-translational modificationi
N-glycosylated in the ER (40 kDa form I), then O-glycosylated in the Golgi apparatus (46 kDa form II), the C-terminal lumenal region is later removed in the Golgi apparatus to produce a 36 kDa form III. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Thr-346: HexNAc (minor), HexHexNAc (major), Hex1HexNAc2 (minor), Hex2HexNAc2 (minor) and dHex1Hex2HexNAc2 (minor).4 Publications
Keywords - PTMi
Acetylation, GlycoproteinProteomic databases
EPDi | Q9GZM5 |
jPOSTi | Q9GZM5 |
MassIVEi | Q9GZM5 |
MaxQBi | Q9GZM5 |
PaxDbi | Q9GZM5 |
PeptideAtlasi | Q9GZM5 |
PRIDEi | Q9GZM5 |
ProteomicsDBi | 80087 |
PTM databases
CarbonylDBi | Q9GZM5 |
GlyConnecti | 641, 7 N-Linked glycans (1 site), 10 O-Linked glycans (3 sites) |
GlyGeni | Q9GZM5, 6 sites, 5 O-linked glycans (2 sites) |
iPTMneti | Q9GZM5 |
MetOSitei | Q9GZM5 |
PhosphoSitePlusi | Q9GZM5 |
SwissPalmi | Q9GZM5 |
Expressioni
Tissue specificityi
Expressed by nucleated hematopoietic cells (at protein level).1 Publication
Developmental stagei
Expressed in fetal liver (at protein level). Expressed in embryonic hematopoiesis sites.1 Publication
Gene expression databases
Bgeei | ENSG00000137207, Expressed in pancreas and 221 other tissues |
ExpressionAtlasi | Q9GZM5, baseline and differential |
Genevisiblei | Q9GZM5, HS |
Organism-specific databases
HPAi | ENSG00000137207, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with YIPF4 and YIPF5.
2 PublicationsBinary interactionsi
Hide detailsQ9GZM5
Protein-protein interaction databases
BioGRIDi | 117370, 133 interactors |
IntActi | Q9GZM5, 112 interactors |
MINTi | Q9GZM5 |
STRINGi | 9606.ENSP00000361499 |
Miscellaneous databases
RNActi | Q9GZM5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the YIP1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3114, Eukaryota |
GeneTreei | ENSGT00940000153766 |
InParanoidi | Q9GZM5 |
OrthoDBi | 1332379at2759 |
PhylomeDBi | Q9GZM5 |
TreeFami | TF314073 |
Family and domain databases
InterProi | View protein in InterPro IPR026637, YIPF3 |
PANTHERi | PTHR15627:SF14, PTHR15627:SF14, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q9GZM5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATTAAPAGG ARNGAGPEWG GFEENIQGGG SAVIDMENMD DTSGSSFEDM
60 70 80 90 100
GELHQRLREE EVDADAADAA AAEEEDGEFL GMKGFKGQLS RQVADQMWQA
110 120 130 140 150
GKRQASRAFS LYANIDILRP YFDVEPAQVR SRLLESMIPI KMVNFPQKIA
160 170 180 190 200
GELYGPLMLV FTLVAILLHG MKTSDTIIRE GTLMGTAIGT CFGYWLGVSS
210 220 230 240 250
FIYFLAYLCN AQITMLQMLA LLGYGLFGHC IVLFITYNIH LHALFYLFWL
260 270 280 290 300
LVGGLSTLRM VAVLVSRTVG PTQRLLLCGT LAALHMLFLL YLHFAYHKVV
310 320 330 340 350
EGILDTLEGP NIPPIQRVPR DIPAMLPAAR LPTTVLNATA KAVAVTLQSH
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EQR8 | E7EQR8_HUMAN | Protein YIPF3 | YIPF3 | 356 | Annotation score: | ||
D6RGY8 | D6RGY8_HUMAN | Protein YIPF3 | YIPF3 | 109 | Annotation score: | ||
D6RFI3 | D6RFI3_HUMAN | Protein YIPF3 | YIPF3 | 262 | Annotation score: | ||
H0Y9A1 | H0Y9A1_HUMAN | Protein YIPF3 | YIPF3 | 135 | Annotation score: | ||
D6RAY4 | D6RAY4_HUMAN | Protein YIPF3 | YIPF3 | 64 | Annotation score: | ||
D6RA04 | D6RA04_HUMAN | Protein YIPF3 | YIPF3 | 63 | Annotation score: | ||
D6RBQ1 | D6RBQ1_HUMAN | Protein YIPF3 | YIPF3 | 45 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 103 | R → G in CAG38572 (Ref. 6) Curated | 1 | |
Sequence conflicti | 142 | M → V in BAA91439 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 161 | F → L in AAM21161 (PubMed:12490290).Curated | 1 | |
Sequence conflicti | 305 | D → V in CAB43375 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 305 | D → V in CAG38572 (Ref. 6) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026906 | 5 | A → V. Corresponds to variant dbSNP:rs2231763Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF162672 mRNA Translation: AAM21161.1 AK000946 mRNA Translation: BAA91439.1 AK021655 mRNA Translation: BAB13866.1 AK022757 mRNA Translation: BAB14231.1 AL355802 Genomic DNA No translation available. BC019297 mRNA Translation: AAH19297.1 AL050274 mRNA Translation: CAB43375.2 CR533541 mRNA Translation: CAG38572.1 |
CCDSi | CCDS4899.1 |
PIRi | T08721 |
RefSeqi | NP_056203.2, NM_015388.3 |
Genome annotation databases
Ensembli | ENST00000372422; ENSP00000361499; ENSG00000137207 |
GeneIDi | 25844 |
KEGGi | hsa:25844 |
UCSCi | uc003ovl.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF162672 mRNA Translation: AAM21161.1 AK000946 mRNA Translation: BAA91439.1 AK021655 mRNA Translation: BAB13866.1 AK022757 mRNA Translation: BAB14231.1 AL355802 Genomic DNA No translation available. BC019297 mRNA Translation: AAH19297.1 AL050274 mRNA Translation: CAB43375.2 CR533541 mRNA Translation: CAG38572.1 |
CCDSi | CCDS4899.1 |
PIRi | T08721 |
RefSeqi | NP_056203.2, NM_015388.3 |
3D structure databases
SMRi | Q9GZM5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117370, 133 interactors |
IntActi | Q9GZM5, 112 interactors |
MINTi | Q9GZM5 |
STRINGi | 9606.ENSP00000361499 |
Protein family/group databases
TCDBi | 9.B.135.2.1, the membrane trafficking yip (yip) family |
PTM databases
CarbonylDBi | Q9GZM5 |
GlyConnecti | 641, 7 N-Linked glycans (1 site), 10 O-Linked glycans (3 sites) |
GlyGeni | Q9GZM5, 6 sites, 5 O-linked glycans (2 sites) |
iPTMneti | Q9GZM5 |
MetOSitei | Q9GZM5 |
PhosphoSitePlusi | Q9GZM5 |
SwissPalmi | Q9GZM5 |
Genetic variation databases
BioMutai | YIPF3 |
DMDMi | 74752534 |
Proteomic databases
EPDi | Q9GZM5 |
jPOSTi | Q9GZM5 |
MassIVEi | Q9GZM5 |
MaxQBi | Q9GZM5 |
PaxDbi | Q9GZM5 |
PeptideAtlasi | Q9GZM5 |
PRIDEi | Q9GZM5 |
ProteomicsDBi | 80087 |
Protocols and materials databases
Antibodypediai | 3101, 110 antibodies |
DNASUi | 25844 |
Genome annotation databases
Ensembli | ENST00000372422; ENSP00000361499; ENSG00000137207 |
GeneIDi | 25844 |
KEGGi | hsa:25844 |
UCSCi | uc003ovl.2, human |
Organism-specific databases
CTDi | 25844 |
DisGeNETi | 25844 |
GeneCardsi | YIPF3 |
HGNCi | HGNC:21023, YIPF3 |
HPAi | ENSG00000137207, Low tissue specificity |
MIMi | 609775, gene |
neXtProti | NX_Q9GZM5 |
OpenTargetsi | ENSG00000137207 |
PharmGKBi | PA134946615 |
VEuPathDBi | HostDB:ENSG00000137207.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3114, Eukaryota |
GeneTreei | ENSGT00940000153766 |
InParanoidi | Q9GZM5 |
OrthoDBi | 1332379at2759 |
PhylomeDBi | Q9GZM5 |
TreeFami | TF314073 |
Enzyme and pathway databases
PathwayCommonsi | Q9GZM5 |
Miscellaneous databases
BioGRID-ORCSi | 25844, 46 hits in 874 CRISPR screens |
ChiTaRSi | YIPF3, human |
GeneWikii | YIPF3 |
GenomeRNAii | 25844 |
Pharosi | Q9GZM5, Tbio |
PROi | PR:Q9GZM5 |
RNActi | Q9GZM5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137207, Expressed in pancreas and 221 other tissues |
ExpressionAtlasi | Q9GZM5, baseline and differential |
Genevisiblei | Q9GZM5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026637, YIPF3 |
PANTHERi | PTHR15627:SF14, PTHR15627:SF14, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YIPF3_HUMAN | |
Accessioni | Q9GZM5Primary (citable) accession number: Q9GZM5 Secondary accession number(s): Q5JTD2 Q9Y3U9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families