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UniProtKB - Q9GZM5 (YIPF3_HUMAN)

Entry version 148 (10 Feb 2021)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
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Protein

Protein YIPF3

Gene

YIPF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9GZM5

Protein family/group databases

Transport Classification Database

More...TCDBi		9.B.135.2.1, the membrane trafficking yip (yip) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein YIPF3
Alternative name(s):
Killer lineage protein 1
Natural killer cell-specific antigen KLIP1
YIP1 family member 3
Cleaved into the following chain:
Protein YIPF3, 36 kDa form III
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YIPF3
Synonyms:C6orf109, KLIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21023, YIPF3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609775, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9GZM5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000137207.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 148Cytoplasmic1 PublicationAdd BLAST147
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 187LumenalCuratedAdd BLAST18
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 214CytoplasmicCurated6
Transmembranei215 – 237HelicalSequence analysisAdd BLAST23
Topological domaini238 – 240LumenalCurated3
Transmembranei241 – 263HelicalSequence analysisAdd BLAST23
Topological domaini264 – 274CytoplasmicCuratedAdd BLAST11
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296 – 350Lumenal1 PublicationAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		25844

Open Targets

More...OpenTargetsi		ENSG00000137207

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134946615

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9GZM5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		YIPF3

Domain mapping of disease mutations (DMDM)

More...DMDMi		74752534

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002444462 – 350Protein YIPF3Add BLAST349
ChainiPRO_00004182162 – ?Protein YIPF3, 36 kDa form III

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi333O-linked (GalNAc...) threonine1 Publication1
Glycosylationi334O-linked (GalNAc...) threonine1 Publication1
Glycosylationi337N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi339O-linked (GalNAc...) threonine1 Publication1
Glycosylationi346O-linked (GalNAc...) threonine3 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated in the ER (40 kDa form I), then O-glycosylated in the Golgi apparatus (46 kDa form II), the C-terminal lumenal region is later removed in the Golgi apparatus to produce a 36 kDa form III. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Thr-346: HexNAc (minor), HexHexNAc (major), Hex1HexNAc2 (minor), Hex2HexNAc2 (minor) and dHex1Hex2HexNAc2 (minor).4 Publications

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9GZM5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9GZM5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9GZM5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9GZM5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9GZM5

PeptideAtlas

More...PeptideAtlasi		Q9GZM5

PRoteomics IDEntifications database

More...PRIDEi		Q9GZM5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80087

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q9GZM5

GlyConnect protein glycosylation platform

More...GlyConnecti		641, 7 N-Linked glycans (1 site), 10 O-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9GZM5, 6 sites, 5 O-linked glycans (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9GZM5

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9GZM5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9GZM5

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9GZM5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by nucleated hematopoietic cells (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal liver (at protein level). Expressed in embryonic hematopoiesis sites.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000137207, Expressed in pancreas and 221 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9GZM5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9GZM5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000137207, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with YIPF4 and YIPF5.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117370, 133 interactors

Protein interaction database and analysis system

More...IntActi		Q9GZM5, 112 interactors

Molecular INTeraction database

More...MINTi		Q9GZM5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361499

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9GZM5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9GZM5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the YIP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3114, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153766

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9GZM5

Database of Orthologous Groups

More...OrthoDBi		1332379at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9GZM5

TreeFam database of animal gene trees

More...TreeFami		TF314073

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026637, YIPF3

The PANTHER Classification System

More...PANTHERi		PTHR15627:SF14, PTHR15627:SF14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9GZM5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATTAAPAGG ARNGAGPEWG GFEENIQGGG SAVIDMENMD DTSGSSFEDM 
        60         70         80         90        100
GELHQRLREE EVDADAADAA AAEEEDGEFL GMKGFKGQLS RQVADQMWQA 
       110        120        130        140        150
GKRQASRAFS LYANIDILRP YFDVEPAQVR SRLLESMIPI KMVNFPQKIA 
       160        170        180        190        200
GELYGPLMLV FTLVAILLHG MKTSDTIIRE GTLMGTAIGT CFGYWLGVSS 
       210        220        230        240        250
FIYFLAYLCN AQITMLQMLA LLGYGLFGHC IVLFITYNIH LHALFYLFWL 
       260        270        280        290        300
LVGGLSTLRM VAVLVSRTVG PTQRLLLCGT LAALHMLFLL YLHFAYHKVV 
       310        320        330        340        350
EGILDTLEGP NIPPIQRVPR DIPAMLPAAR LPTTVLNATA KAVAVTLQSH
Length:350
Mass (Da):38,248
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED7A566716A6B364
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EQR8E7EQR8_HUMAN
Protein YIPF3
YIPF3
356Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGY8D6RGY8_HUMAN
Protein YIPF3
YIPF3
109Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFI3D6RFI3_HUMAN
Protein YIPF3
YIPF3
262Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9A1H0Y9A1_HUMAN
Protein YIPF3
YIPF3
135Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAY4D6RAY4_HUMAN
Protein YIPF3
YIPF3
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RA04D6RA04_HUMAN
Protein YIPF3
YIPF3
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBQ1D6RBQ1_HUMAN
Protein YIPF3
YIPF3
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti103R → G in CAG38572 (Ref. 6) Curated1
Sequence conflicti142M → V in BAA91439 (PubMed:14702039).Curated1
Sequence conflicti161F → L in AAM21161 (PubMed:12490290).Curated1
Sequence conflicti305D → V in CAB43375 (PubMed:11230166).Curated1
Sequence conflicti305D → V in CAG38572 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0269065A → V. Corresponds to variant dbSNP:rs2231763Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF162672 mRNA Translation: AAM21161.1
AK000946 mRNA Translation: BAA91439.1
AK021655 mRNA Translation: BAB13866.1
AK022757 mRNA Translation: BAB14231.1
AL355802 Genomic DNA No translation available.
BC019297 mRNA Translation: AAH19297.1
AL050274 mRNA Translation: CAB43375.2
CR533541 mRNA Translation: CAG38572.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4899.1

Protein sequence database of the Protein Information Resource

More...PIRi		T08721

NCBI Reference Sequences

More...RefSeqi		NP_056203.2, NM_015388.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000372422; ENSP00000361499; ENSG00000137207

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25844

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:25844

UCSC genome browser

More...UCSCi		uc003ovl.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162672 mRNA Translation: AAM21161.1
AK000946 mRNA Translation: BAA91439.1
AK021655 mRNA Translation: BAB13866.1
AK022757 mRNA Translation: BAB14231.1
AL355802 Genomic DNA No translation available.
BC019297 mRNA Translation: AAH19297.1
AL050274 mRNA Translation: CAB43375.2
CR533541 mRNA Translation: CAG38572.1
CCDSiCCDS4899.1
PIRiT08721
RefSeqiNP_056203.2, NM_015388.3

3D structure databases

SMRiQ9GZM5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117370, 133 interactors
IntActiQ9GZM5, 112 interactors
MINTiQ9GZM5
STRINGi9606.ENSP00000361499

Protein family/group databases

TCDBi9.B.135.2.1, the membrane trafficking yip (yip) family

PTM databases

CarbonylDBiQ9GZM5
GlyConnecti641, 7 N-Linked glycans (1 site), 10 O-Linked glycans (3 sites)
GlyGeniQ9GZM5, 6 sites, 5 O-linked glycans (2 sites)
iPTMnetiQ9GZM5
MetOSiteiQ9GZM5
PhosphoSitePlusiQ9GZM5
SwissPalmiQ9GZM5

Genetic variation databases

BioMutaiYIPF3
DMDMi74752534

Proteomic databases

EPDiQ9GZM5
jPOSTiQ9GZM5
MassIVEiQ9GZM5
MaxQBiQ9GZM5
PaxDbiQ9GZM5
PeptideAtlasiQ9GZM5
PRIDEiQ9GZM5
ProteomicsDBi80087

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3101, 110 antibodies

The DNASU plasmid repository

More...DNASUi		25844

Genome annotation databases

EnsembliENST00000372422; ENSP00000361499; ENSG00000137207
GeneIDi25844
KEGGihsa:25844
UCSCiuc003ovl.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25844
DisGeNETi25844

GeneCards: human genes, protein and diseases

More...GeneCardsi		YIPF3
HGNCiHGNC:21023, YIPF3
HPAiENSG00000137207, Low tissue specificity
MIMi609775, gene
neXtProtiNX_Q9GZM5
OpenTargetsiENSG00000137207
PharmGKBiPA134946615
VEuPathDBiHostDB:ENSG00000137207.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3114, Eukaryota
GeneTreeiENSGT00940000153766
InParanoidiQ9GZM5
OrthoDBi1332379at2759
PhylomeDBiQ9GZM5
TreeFamiTF314073

Enzyme and pathway databases

PathwayCommonsiQ9GZM5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		25844, 46 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		YIPF3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		YIPF3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		25844
PharosiQ9GZM5, Tbio

Protein Ontology

More...PROi		PR:Q9GZM5
RNActiQ9GZM5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000137207, Expressed in pancreas and 221 other tissues
ExpressionAtlasiQ9GZM5, baseline and differential
GenevisibleiQ9GZM5, HS

Family and domain databases

InterProiView protein in InterPro
IPR026637, YIPF3
PANTHERiPTHR15627:SF14, PTHR15627:SF14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYIPF3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZM5
Secondary accession number(s): Q5JTD2
, Q6FI85, Q8NI57, Q9NWE3, Q9Y3U9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2001
Last modified: February 10, 2021
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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