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UniProtKB - Q9GZK6 (OR2J1_HUMAN)
Protein
Olfactory receptor 2J1
Gene
OR2J1
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.
CuratedGO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
PathwayCommonsi | Q9GZK6 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 2J1Alternative name(s): Hs6M1-4 Olfactory receptor 6-5 Short name: OR6-5 |
Gene namesi | Name:OR2J1 Synonyms:OR2J1P |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8259, OR2J1 |
neXtProti | NX_Q9GZK6 |
VEuPathDBi | HostDB:ENSG00000204702 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 26 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 27 – 50 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 51 – 58 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 59 – 80 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 81 – 101 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 102 – 121 | Helical; Name=3Sequence analysisAdd BLAST | 20 | |
Topological domaini | 122 – 140 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 141 – 159 | Helical; Name=4Sequence analysisAdd BLAST | 19 | |
Topological domaini | 160 – 196 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 197 – 220 | Helical; Name=5Sequence analysisAdd BLAST | 24 | |
Topological domaini | 221 – 237 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 238 – 260 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 261 – 273 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 274 – 293 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 294 – 312 | CytoplasmicSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Miscellaneous databases
Pharosi | Q9GZK6, Tdark |
Genetic variation databases
BioMutai | OR2J1 |
DMDMi | 147744582 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150482 | 1 – 312 | Olfactory receptor 2J1Add BLAST | 312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 6 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 98 ↔ 190 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9GZK6 |
PeptideAtlasi | Q9GZK6 |
PRIDEi | Q9GZK6 |
PTM databases
GlyGeni | Q9GZK6, 1 site |
Expressioni
Gene expression databases
Genevisiblei | Q9GZK6, HS |
Organism-specific databases
HPAi | ENSG00000204702, Not detected |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT01040000240485 |
HOGENOMi | CLU_012526_1_2_1 |
InParanoidi | Q9GZK6 |
OMAi | MGWEWGI |
OrthoDBi | 954090at2759 |
PhylomeDBi | Q9GZK6 |
TreeFami | TF336512 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9GZK6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLMKKNASFE DFFLLLGFSN WPHLEVVLFV VILIFYLITL IGNLFIIILS
60 70 80 90 100
YLDSHLHTPM YFFLSNLSFL DLCYTTSSIP QLLVNLWGPE KTISYAGCTV
110 120 130 140 150
QLYFVLALGT AECVLLVVMS YDRYAAVCRP LHYTVLMHPR FCRLLAAASW
160 170 180 190 200
VSGFTTSALH SSFTFWIPLC RHRLVDHFFC EVPALLRLSC VDTQANELTL
210 220 230 240 250
MVMSSIFVLI PLILILTSYG AIARAVLSMQ STTGLQKVLR TCGAHLMVVS
260 270 280 290 300
LFFIPVMCMY LQPPSENSQD QGKFIALFYT VVTPSLNPLI YTFRNKDVRG
310
AVKRLMGWEW GM
Polymorphismi
A stop codon in the gene coding for this protein at position Gln-194 is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019066 | 14 | L → I2 PublicationsCorresponds to variant dbSNP:rs3131087Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ302565 Genomic DNA Translation: CAC20485.1 AJ302566 Genomic DNA Translation: CAC20486.1 AJ302567 Genomic DNA Translation: CAC20487.1 AJ302568 Genomic DNA Translation: CAC20488.1 AJ302569 Genomic DNA Translation: CAC20489.1 AJ302570 Genomic DNA Translation: CAC20490.1 AL645937 Genomic DNA No translation available. CR933783 Genomic DNA No translation available. |
CCDSi | CCDS87377.1 |
RefSeqi | NP_001335223.1, NM_001348294.1 |
Genome annotation databases
Ensembli | ENST00000377171; ENSP00000366376; ENSG00000204702 ENST00000427659; ENSP00000414527; ENSG00000226931 ENST00000641659; ENSP00000493312; ENSG00000204702 |
GeneIDi | 442185 |
KEGGi | hsa:442185 |
MANE-Selecti | ENST00000641659.2; ENSP00000493312.1; NM_001348294.2; NP_001335223.1 |
UCSCi | uc063mmp.1, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ302565 Genomic DNA Translation: CAC20485.1 AJ302566 Genomic DNA Translation: CAC20486.1 AJ302567 Genomic DNA Translation: CAC20487.1 AJ302568 Genomic DNA Translation: CAC20488.1 AJ302569 Genomic DNA Translation: CAC20489.1 AJ302570 Genomic DNA Translation: CAC20490.1 AL645937 Genomic DNA No translation available. CR933783 Genomic DNA No translation available. |
CCDSi | CCDS87377.1 |
RefSeqi | NP_001335223.1, NM_001348294.1 |
3D structure databases
SMRi | Q9GZK6 |
ModBasei | Search... |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9GZK6, 1 site |
Genetic variation databases
BioMutai | OR2J1 |
DMDMi | 147744582 |
Proteomic databases
PaxDbi | Q9GZK6 |
PeptideAtlasi | Q9GZK6 |
PRIDEi | Q9GZK6 |
Protocols and materials databases
Antibodypediai | 82189, 2 antibodies from 2 providers |
DNASUi | 442185 |
Genome annotation databases
Ensembli | ENST00000377171; ENSP00000366376; ENSG00000204702 ENST00000427659; ENSP00000414527; ENSG00000226931 ENST00000641659; ENSP00000493312; ENSG00000204702 |
GeneIDi | 442185 |
KEGGi | hsa:442185 |
MANE-Selecti | ENST00000641659.2; ENSP00000493312.1; NM_001348294.2; NP_001335223.1 |
UCSCi | uc063mmp.1, human |
Organism-specific databases
CTDi | 442185 |
GeneCardsi | OR2J1 |
HGNCi | HGNC:8259, OR2J1 |
HPAi | ENSG00000204702, Not detected |
neXtProti | NX_Q9GZK6 |
VEuPathDBi | HostDB:ENSG00000204702 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT01040000240485 |
HOGENOMi | CLU_012526_1_2_1 |
InParanoidi | Q9GZK6 |
OMAi | MGWEWGI |
OrthoDBi | 954090at2759 |
PhylomeDBi | Q9GZK6 |
TreeFami | TF336512 |
Enzyme and pathway databases
PathwayCommonsi | Q9GZK6 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Miscellaneous databases
BioGRID-ORCSi | 442185, 1 hit in 36 CRISPR screens |
GenomeRNAii | 442185 |
Pharosi | Q9GZK6, Tdark |
PROi | PR:Q9GZK6 |
RNActi | Q9GZK6, protein |
Gene expression databases
Genevisiblei | Q9GZK6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OR2J1_HUMAN | |
Accessioni | Q9GZK6Primary (citable) accession number: Q9GZK6 Secondary accession number(s): A2AAS1, B0V1T2, Q9GZK1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2004 |
Last sequence update: | May 15, 2007 | |
Last modified: | February 23, 2022 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families