Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 2H1

Gene

OR2H1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2H1
Alternative name(s):
Hs6M1-16
OLFR42A-9004.14/9026.2
Olfactory receptor 2H6
Olfactory receptor 2H8
Olfactory receptor 6-2
Short name:
OR6-2
Olfactory receptor OR6-32
Gene namesi
Name:OR2H1
Synonyms:OR2H6, OR2H8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204688.9
HGNCiHGNC:8252 OR2H1
neXtProtiNX_Q9GZK4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 234CytoplasmicSequence analysisAdd BLAST17
Transmembranei235 – 257Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 290Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini291 – 316CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26716
OpenTargetsiENSG00000204688
PharmGKBiPA32161

Polymorphism and mutation databases

BioMutaiOR2H1
DMDMi14423801

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504791 – 316Olfactory receptor 2H1Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZK4
PRIDEiQ9GZK4
ProteomicsDBi80080

Expressioni

Gene expression databases

BgeeiENSG00000204688
CleanExiHS_OR2H1
ExpressionAtlasiQ9GZK4 baseline and differential
GenevisibleiQ9GZK4 HS

Interactioni

Protein-protein interaction databases

BioGridi117800, 1 interactor
IntActiQ9GZK4, 1 interactor
STRINGi9606.ENSP00000366336

Structurei

3D structure databases

ProteinModelPortaliQ9GZK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAPF Eukaryota
ENOG41117A7 LUCA
GeneTreeiENSGT00900000140946
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ9GZK4
KOiK04257
OMAiSYNEIQL
OrthoDBiEOG09371L63
PhylomeDBiQ9GZK4
TreeFamiTF336512

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9GZK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNQSSPMGF LLLGFSEHPA LERTLFVVVF TSYLLTLVGN TLIILLSVLY
60 70 80 90 100
PRLHSPMYFF LSDLSFLDLC FTTSCVPQML VNLWGPKKTI SFLGCSVQLF
110 120 130 140 150
IFLSLGTTEC ILLTVMAFDR YVAVCQPLHY ATIIHPRLCW QLASVAWVMS
160 170 180 190 200
LVQSIVQTPS TLHLPFCPHQ QIDDFLCEVP SLIRLSCGDT SYNEIQLAVS
210 220 230 240 250
SVIFVVVPLS LILASYGATA QAVLRINSAT AWRKAFGTCS SHLTVVTLFY
260 270 280 290 300
SSVIAVYLQP KNPYAQGRGK FFGLFYAVGT PSLNPLVYTL RNKEIKRALR
310
RLLGKERDSR ESWRAA
Length:316
Mass (Da):35,339
Last modified:March 1, 2001 - v1
Checksum:i19140A7FD690CF85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158T → K in AAC00188 (Ref. 8) Curated1
Sequence conflicti184R → G in AAC00188 (Ref. 8) Curated1
Sequence conflicti215S → Y in AAC00188 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01094463D → N in allele 6M1-16*02. 1 PublicationCorresponds to variant dbSNP:rs61732185Ensembl.1
Natural variantiVAR_053143223V → M. Corresponds to variant dbSNP:rs17184086Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302604 Genomic DNA Translation: CAC20524.1
AJ302605 Genomic DNA Translation: CAC20525.1
AJ302606 Genomic DNA Translation: CAC20526.1
AJ302607 Genomic DNA Translation: CAC20527.1
AJ302608 Genomic DNA Translation: CAC20528.1
AJ302609 Genomic DNA Translation: CAC20529.1
AJ302610 Genomic DNA Translation: CAC20530.1
AJ302611 Genomic DNA Translation: CAC20531.1
AJ302612 Genomic DNA Translation: CAC20532.1
AJ302613 Genomic DNA Translation: CAC20533.1
AJ459847 mRNA Translation: CAD31039.1
AK127984 mRNA Translation: BAG54612.1
AL035542 Genomic DNA Translation: CAB44506.1
AL645927 Genomic DNA No translation available.
AL662869 Genomic DNA No translation available.
BX000531 Genomic DNA No translation available.
BX247947 Genomic DNA No translation available.
CR759956 Genomic DNA No translation available.
CR759768 Genomic DNA No translation available.
BX927133 Genomic DNA No translation available.
CR388393 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03195.1
BC048991 mRNA Translation: AAH48991.1
AF042078 Genomic DNA Translation: AAC00184.1
AF044491 Genomic DNA Translation: AAC00188.1
AF044492 Genomic DNA Translation: AAC00189.1
BK004209 Genomic DNA Translation: DAA04607.1
CCDSiCCDS4660.1
RefSeqiNP_001304943.1, NM_001318014.1
NP_001304951.1, NM_001318022.1
NP_112145.1, NM_030883.4
XP_011512772.1, XM_011514470.2
XP_011512774.1, XM_011514472.2
XP_011512775.1, XM_011514473.2
XP_011512781.1, XM_011514479.2
XP_011512785.1, XM_011514483.2
XP_011512786.1, XM_011514484.2
XP_016866226.1, XM_017010737.1
XP_016866227.1, XM_017010738.1
XP_016866228.1, XM_017010739.1
UniGeneiHs.434715
Hs.714219
Hs.740793

Genome annotation databases

EnsembliENST00000377132; ENSP00000366336; ENSG00000204688
ENST00000377133; ENSP00000366337; ENSG00000204688
ENST00000377136; ENSP00000366340; ENSG00000204688
ENST00000383550; ENSP00000373042; ENSG00000206471
ENST00000383644; ENSP00000373140; ENSG00000206516
ENST00000396792; ENSP00000380010; ENSG00000204688
ENST00000400689; ENSP00000383527; ENSG00000206471
ENST00000400693; ENSP00000383529; ENSG00000206471
ENST00000400694; ENSP00000383530; ENSG00000206471
ENST00000400712; ENSP00000383547; ENSG00000206516
ENST00000400713; ENSP00000383548; ENSG00000206516
ENST00000400714; ENSP00000383549; ENSG00000206516
ENST00000412956; ENSP00000407739; ENSG00000232984
ENST00000415581; ENSP00000396944; ENSG00000224395
ENST00000416582; ENSP00000395850; ENSG00000229125
ENST00000418376; ENSP00000395567; ENSG00000229408
ENST00000421808; ENSP00000410401; ENSG00000232984
ENST00000431658; ENSP00000394698; ENSG00000232984
ENST00000435958; ENSP00000397171; ENSG00000224395
ENST00000436167; ENSP00000388844; ENSG00000235132
ENST00000438840; ENSP00000412463; ENSG00000224395
ENST00000439879; ENSP00000409651; ENSG00000229408
ENST00000440557; ENSP00000413910; ENSG00000229125
ENST00000440672; ENSP00000396414; ENSG00000235132
ENST00000443407; ENSP00000398695; ENSG00000232984
ENST00000444920; ENSP00000410659; ENSG00000235132
ENST00000446161; ENSP00000389230; ENSG00000229408
ENST00000449826; ENSP00000411617; ENSG00000229408
ENST00000453467; ENSP00000392619; ENSG00000229125
ENST00000454071; ENSP00000395934; ENSG00000229125
ENST00000456657; ENSP00000408584; ENSG00000235132
ENST00000458051; ENSP00000405714; ENSG00000224395
GeneIDi26716
KEGGihsa:26716
UCSCiuc003nmj.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR2H1_HUMAN
AccessioniPrimary (citable) accession number: Q9GZK4
Secondary accession number(s): B0S7T4
, O43629, O43661, O43662, Q5SUN6, Q9GZK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health