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Protein

Olfactory receptor 2B2

Gene

OR2B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2B2
Alternative name(s):
Hs6M1-10
Olfactory receptor 2B9
Olfactory receptor 6-1
Short name:
OR6-1
Gene namesi
Name:OR2B2
Synonyms:OR2B9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000168131.4
HGNCiHGNC:13966 OR2B2
neXtProtiNX_Q9GZK3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 357CytoplasmicSequence analysisAdd BLAST65

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32141

Polymorphism and mutation databases

BioMutaiOR2B2
DMDMi14423800

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504601 – 357Olfactory receptor 2B2Add BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZK3
PeptideAtlasiQ9GZK3
PRIDEiQ9GZK3
ProteomicsDBi80079

PTM databases

iPTMnetiQ9GZK3
PhosphoSitePlusiQ9GZK3

Expressioni

Gene expression databases

BgeeiENSG00000168131
CleanExiHS_OR2B2
ExpressionAtlasiQ9GZK3 baseline and differential
GenevisibleiQ9GZK3 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304419

Structurei

3D structure databases

ProteinModelPortaliQ9GZK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVUR Eukaryota
ENOG41117FE LUCA
GeneTreeiENSGT00740000115013
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ9GZK3
KOiK04257
OMAiPLCGHRE
OrthoDBiEOG091G0CU6
PhylomeDBiQ9GZK3
TreeFamiTF336512

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9GZK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWVNKSVPQ EFILLVFSDQ PWLEIPPFVM FLFSYILTIF GNLTIILVSH
60 70 80 90 100
VDFKLHTPMY FFLSNLSLLD LCYTTSTVPQ MLVNICNTRK VISYGGCVAQ
110 120 130 140 150
LFIFLALGST ECLLLAVMCF DRFVAICRPL HYSIIMHQRL CFQLAAASWI
160 170 180 190 200
SGFSNSVLQS TWTLKMPLCG HKEVDHFFCE VPALLKLSCV DTTANEAELF
210 220 230 240 250
FISVLFLLIP VTLILISYAF IVQAVLRIQS AEGQRKAFGT CGSHLIVVSL
260 270 280 290 300
FYGTAISMYL QPPSPSSKDR GKMVSLFCGI IAPMLNPLIY TLRNKEVKEA
310 320 330 340 350
FKRLVAKSLL NQEIRNMQMI SFAKDTVLTY LTNFSASCPI FVITIENYCN

LPQRKFP
Length:357
Mass (Da):40,412
Last modified:March 1, 2001 - v1
Checksum:i53E2F82820EC440A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057536183A → P. Corresponds to variant dbSNP:rs9368537Ensembl.1
Natural variantiVAR_010943234Q → R in allele 6M1-10*02. 1 PublicationCorresponds to variant dbSNP:rs34957169Ensembl.1
Natural variantiVAR_062014300A → S. Corresponds to variant dbSNP:rs34788973Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302584 Genomic DNA Translation: CAC20504.1
AJ302585 Genomic DNA Translation: CAC20505.1
AJ302586 Genomic DNA Translation: CAC20506.1
AJ302587 Genomic DNA Translation: CAC20507.1
AJ302588 Genomic DNA Translation: CAC20508.1
AJ302589 Genomic DNA Translation: CAC20509.1
AJ302590 Genomic DNA Translation: CAC20510.1
AJ302591 Genomic DNA Translation: CAC20511.1
AJ302592 Genomic DNA Translation: CAC20512.1
AJ302593 Genomic DNA Translation: CAC20513.1
Z98744 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03125.1
BC136881 mRNA Translation: AAI36882.1
BC136901 mRNA Translation: AAI36902.1
CCDSiCCDS4641.1
RefSeqiNP_149046.2, NM_033057.2
UniGeneiHs.307111

Genome annotation databases

EnsembliENST00000303324; ENSP00000304419; ENSG00000168131
GeneIDi81697
KEGGihsa:81697
UCSCiuc011dkw.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR2B2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZK3
Secondary accession number(s): B2RNH2, Q9GZL2, Q9Y299
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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