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Protein

26S proteasome non-ATPase regulatory subunit 2

Gene

rpn-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • nematode larval development Source: WormBase
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
  • regulation of protein catabolic process Source: InterPro
  • reproduction Source: WormBase

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5668541 TNFR2 non-canonical NF-kB pathway
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-6798695 Neutrophil degranulation
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69229 Ubiquitin-dependent degradation of Cyclin D1
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 2UniRule annotation
Gene namesi
Name:rpn-1Imported
ORF Names:CELE_T22D1.9Imported, T22D1.9Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiT22D1.9 ; CE17253 ; WBGene00004458 ; rpn-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ProteasomeUniRule annotationImported

PTM / Processingi

Proteomic databases

EPDiQ9GZH5
PaxDbiQ9GZH5
PeptideAtlasiQ9GZH5

Expressioni

Gene expression databases

BgeeiWBGene00004458

Interactioni

Subunit structurei

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).UniRule annotation

Protein-protein interaction databases

IntActiQ9GZH5, 7 interactors
STRINGi6239.T22D1.9.1

Structurei

3D structure databases

ProteinModelPortaliQ9GZH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili30 – 50Sequence analysisAdd BLAST21
Coiled coili527 – 547Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the proteasome subunit S2 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2005 Eukaryota
COG5110 LUCA
GeneTreeiENSGT00550000074983
HOGENOMiHOG000176022
InParanoidiQ9GZH5
KOiK03028
OMAiMVDICAY
OrthoDBiEOG091G04TC
PhylomeDBiQ9GZH5

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR016643 26S_Psome_Rpn1
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002015 Proteasome/cyclosome_rpt
PANTHERiPTHR10943:SF1 PTHR10943:SF1, 1 hit
PfamiView protein in Pfam
PF01851 PC_rep, 1 hit
PIRSFiPIRSF015965 26S_Psome_Rpn1, 1 hit
SUPFAMiSSF48371 SSF48371, 6 hits

Sequencei

Sequence statusi: Complete.

Q9GZH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVATTQQTPK EADKKKADDK KVPEKAEPKK EEMSEEDQKL EEDLNLLVQR
60 70 80 90 100
LSEPDTTLYK PSLETMRTLI RASTTSMTSV PKPLKFMRPH YNKMKEIFTS
110 120 130 140 150
IVAPDVKKLC ADIISVLAMT SDERTDTINY RILGSHEPIG DWGHEYVRHL
160 170 180 190 200
AMEMSEEWKK EGTSDARKAE LLKLTQDIVS HHMKHNAEVE ACDLLIEIER
210 220 230 240 250
IDLLISYVQE VDHQRVCLYL LSCAPLTPDP DNIILIRTAL QLYLKFNRYL
260 270 280 290 300
EAVRCAIMVN DIPQVHQIFA KASDPLLRKQ MAILLGRHQI FLDYEGSADS
310 320 330 340 350
DALAELNSNA HLYEYFHSLA RELDIMEPKT PEGIYKSHLE HSRPFGNSAQ
360 370 380 390 400
PDSTRMNLAA ALVNGFVNCG FGVDKMMAET EEASRWFYKN KEYGMLTAAA
410 420 430 440 450
SQGLIWRWDI DTGLAQCDRF LYINDDYIKA GTLLAIGIIS SGIQDACDPA
460 470 480 490 500
SALLLDHVQS DRSIMRVGSI LGLGLAYANS KRETVTKNEE RGVIFELKKV
510 520 530 540 550
LSDQKPSAIP EVKGLAGLSL GLILVGTADA EAAMEMLQAL MDKSETELTD
560 570 580 590 600
PNMRFLALGI ALIFLQTQDK SDVFVESLRS LPDPFGAMVS TLVEVCAYAG
610 620 630 640 650
TGNVLKIQKL LHLCSEHYET PAAEKKTAAS RGPRGPAPAA ATPARPAAQP
660 670 680 690 700
GNVNVAGTPA PTGTPAVAPA APRRDLPGAA SAATPGAPET AAADATPAPP
710 720 730 740 750
AKPDLSSQQA VAVLGIGLIA MGDDIGSQMA LRMFGHLIRY GEPVIRRAVP
760 770 780 790 800
LALSLLSVSN PQLNILETLS KFSHDSDADT AHNAIFAMGL VGAGTNNARL
810 820 830 840 850
VAMLRNLASY HYKDQVSLML VRIAQGLTHL GKGTMTLNPW HSDRQLLSPS
860 870 880 890 900
ALASLLSICF SFLDANNTIL NNRQHYLLYT LVLAMQPRML TTLVEDEMKP
910 920 930 940 950
GSLKQLNVSV RVGQAVDVVA QAGKPKTITG FQTHTTPVLL AHGERAELAN
960 970 980
DEYLSVTPHL EGLVILKKNP DYQPVVVSTK K
Length:981
Mass (Da):107,381
Last modified:March 1, 2001 - v1
Checksum:i802D6D30E7EB3546
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCD62025.1
PIRiT32707
RefSeqiNP_501064.1, NM_068663.4
UniGeneiCel.5136

Genome annotation databases

EnsemblMetazoaiT22D1.9; T22D1.9; WBGene00004458
GeneIDi177455
KEGGicel:CELE_T22D1.9
UCSCiT22D1.9.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiQ9GZH5_CAEEL
AccessioniPrimary (citable) accession number: Q9GZH5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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