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Entry version 146 (10 Feb 2021)
Sequence version 2 (19 Jul 2004)
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Protein

Nuclear pore complex protein Nup88

Gene

mbo

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of nuclear pore complex (PubMed:10921908, PubMed:14638854, PubMed:17032737). Required for the anchoring of Nup214 and emb on the nuclear envelope and thereby attenuates nuclear export signal (NES)-mediated nuclear export (PubMed:14638854). Together with Nup214, required for the nuclear import of the Rel family transcription factors dorsal (dl) and Dorsal-related immunity factor (Dif) and the activation of an immune response (PubMed:10921908, PubMed:17032737).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-159227, Transport of the SLBP independent Mature mRNA
R-DME-159230, Transport of the SLBP Dependant Mature mRNA
R-DME-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DME-3108214, SUMOylation of DNA damage response and repair proteins
R-DME-3301854, Nuclear Pore Complex (NPC) Disassembly
R-DME-3371453, Regulation of HSF1-mediated heat shock response
R-DME-4551638, SUMOylation of chromatin organization proteins
R-DME-4615885, SUMOylation of DNA replication proteins
R-DME-5578749, Transcriptional regulation by small RNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex protein Nup88
Alternative name(s):
88 kDa nuclear pore complex protein
Nucleoporin Nup88
Protein members only
dNup88
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mboImported
Synonyms:Nup881 Publication
ORF Names:CG6819
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0026207, mbo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Membrane, Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002048861 – 702Nuclear pore complex protein Nup88Add BLAST702

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei191Phosphoserine1 Publication1
Modified residuei228Phosphoserine1 Publication1
Modified residuei231Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9GYU8

PRoteomics IDEntifications database

More...
PRIDEi
Q9GYU8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9GYU8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the embryo, expression is prominent in a subset of the cells of the developing CNS, dynamic stripes of epidermal cells, lymph glands and intestinal tract including the proventriculus and foregut. In the larva, expression was seen in the fusion cells of the trachea, fat body, imaginal tissues, and with abundance in the proliferating parts of the nerve cord, optic lobes of the brain and imaginal disks (PubMed:10921908). Expressed in the salivary glands (PubMed:20144761).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during embryonic development (at protein level) (PubMed:12537569). Expressed both maternally and zygotically (PubMed:10921908).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0026207, Expressed in embryo and 33 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9GYU8, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the nuclear pore complex (PubMed:14638854, PubMed:17032737).

Interacts with Nup214 and emb to attenuate emb-mediated protein export (PubMed:14638854, PubMed:17032737).

Interacts with tamo for nuclear import of target proteins including dl, msl-1, Ran and Ran-like (PubMed:12653959).

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
66656, 33 interactors

Database of interacting proteins

More...
DIPi
DIP-18195N

Protein interaction database and analysis system

More...
IntActi
Q9GYU8, 9 interactors

Molecular INTeraction database

More...
MINTi
Q9GYU8

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0082137

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9GYU8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili542 – 594Sequence analysisAdd BLAST53

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4460, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015063

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017144_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9GYU8

Identification of Orthologs from Complete Genome Data

More...
OMAi
SCSIMCL

Database of Orthologous Groups

More...
OrthoDBi
1149034at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9GYU8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019321, Nucleoporin_Nup88
IPR037700, NUP88/NUP82

The PANTHER Classification System

More...
PANTHERi
PTHR13257, PTHR13257, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10168, Nup88, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9GYU8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLTDVLELN KTELFAKIRN GLPVVQRTQN LLDCKDDLLF AWHAKDSCLL
60 70 80 90 100
VRNWRSSLAA KVNIQFQTLI PSSLVSLEVD RVLASNEGSL VALSGPRGVV
110 120 130 140 150
IMELPRRWGP DGYYKDGKPV ITCRTFGLDT QLFLKNPHLE VRQVRWHPHS
160 170 180 190 200
VSDSTLLVLL NNNTIRVYNH SKLRHVWQVG PPVLRSGANN SLCDFGELAV
210 220 230 240 250
DFDIAPAAKP RVTEPETAGN NETTLDKSNK TLVAAKSLPK QERIEWPMVV
260 270 280 290 300
LRENGNIYIL MTGVDSENTR LQGPVTITPQ AHDNYGLESC ALMIIPSLPP
310 320 330 340 350
TIVIAESNGK LHHALLMEAE ATEHSFNEVD DSVLIEPAEY VVHVLETVEL
360 370 380 390 400
ELGISAPATG KEGGNCPIYL KRDLINELRY FAYHNAGLHA VTVSFIAELQ
410 420 430 440 450
RYLESESDED RLELAVSASA EYILCTKFDS SETVNAVFGL ALLQIPAGIV
460 470 480 490 500
LLLGSGQVIS LKLVIDAQLL VTPNENKPVD SEVSQQESGP PFVDTIKSLL
510 520 530 540 550
QRSVNQPILA DKLSSPSAQE SFELLNQAIE VLREQYLKRH DLVRAAFTRH
560 570 580 590 600
INQIQLKKEQ QLQEIQDLEQ ERELISERAH KLAERFEEIS YNQELLVRKC
610 620 630 640 650
NALMQRANAS LPNSVIAERE FSQEVIRLNK VTQSLAAGLE TAKKTFNKQR
660 670 680 690 700
YHIAQSQEDL KKNAYELPEK QHRTITEILT QLTGEIDRQI TDVKRINKIV

GI
Length:702
Mass (Da):78,681
Last modified:July 19, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD40E4B81A089DAE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti79V → M in AAF98552 (PubMed:10921908).Curated1
Sequence conflicti377 – 378EL → DV in AAF98552 (PubMed:10921908).Curated2
Sequence conflicti486Q → K in AAF98552 (PubMed:10921908).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY004880 mRNA Translation: AAF98552.1
AE014297 Genomic DNA Translation: AAF54849.1
AY051827 mRNA Translation: AAK93251.1

NCBI Reference Sequences

More...
RefSeqi
NP_524330.2, NM_079606.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0082668; FBpp0082137; FBgn0026207

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41562

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6819

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY004880 mRNA Translation: AAF98552.1
AE014297 Genomic DNA Translation: AAF54849.1
AY051827 mRNA Translation: AAK93251.1
RefSeqiNP_524330.2, NM_079606.4

3D structure databases

SMRiQ9GYU8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi66656, 33 interactors
DIPiDIP-18195N
IntActiQ9GYU8, 9 interactors
MINTiQ9GYU8
STRINGi7227.FBpp0082137

PTM databases

iPTMnetiQ9GYU8

Proteomic databases

PaxDbiQ9GYU8
PRIDEiQ9GYU8

Genome annotation databases

EnsemblMetazoaiFBtr0082668; FBpp0082137; FBgn0026207
GeneIDi41562
KEGGidme:Dmel_CG6819

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
41562
FlyBaseiFBgn0026207, mbo

Phylogenomic databases

eggNOGiKOG4460, Eukaryota
GeneTreeiENSGT00390000015063
HOGENOMiCLU_017144_0_0_1
InParanoidiQ9GYU8
OMAiSCSIMCL
OrthoDBi1149034at2759
PhylomeDBiQ9GYU8

Enzyme and pathway databases

ReactomeiR-DME-159227, Transport of the SLBP independent Mature mRNA
R-DME-159230, Transport of the SLBP Dependant Mature mRNA
R-DME-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DME-3108214, SUMOylation of DNA damage response and repair proteins
R-DME-3301854, Nuclear Pore Complex (NPC) Disassembly
R-DME-3371453, Regulation of HSF1-mediated heat shock response
R-DME-4551638, SUMOylation of chromatin organization proteins
R-DME-4615885, SUMOylation of DNA replication proteins
R-DME-5578749, Transcriptional regulation by small RNAs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
41562, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
41562

Protein Ontology

More...
PROi
PR:Q9GYU8

Gene expression databases

BgeeiFBgn0026207, Expressed in embryo and 33 other tissues
GenevisibleiQ9GYU8, DM

Family and domain databases

InterProiView protein in InterPro
IPR019321, Nucleoporin_Nup88
IPR037700, NUP88/NUP82
PANTHERiPTHR13257, PTHR13257, 2 hits
PfamiView protein in Pfam
PF10168, Nup88, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUP88_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GYU8
Secondary accession number(s): Q9VG41
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 19, 2004
Last modified: February 10, 2021
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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