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Entry version 71 (02 Dec 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Extracellular matrix protein 3

Gene

ECM3

Organism
Lytechinus variegatus (Green sea urchin) (Variegated urchin)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Extracellular matrix protein that may serve as substrate for the migratory primary mesenchyme cells (PMCs), the interaction possibly providing guidance information to migrating PMCs.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Extracellular matrix protein 3
Alternative name(s):
FREM2 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ECM3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLytechinus variegatus (Green sea urchin) (Variegated urchin)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7654 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaTemnopleuroidaToxopneustidaeLytechinus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 3047ExtracellularSequence analysisAdd BLAST3028
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3048 – 3068HelicalSequence analysisAdd BLAST21
Topological domaini3069 – 3103CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001012620 – 3103Extracellular matrix protein 3Add BLAST3084

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi453N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi989N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1024N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1042N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1207N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1294N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1327N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1542N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1674N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1679N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1725N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1739N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2080N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2385N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2932N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Component of extracellular matrix fibers that interact with PMC filopodia during gastrulation (at protein level).1 Publication

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati289 – 388CSPG 1PROSITE-ProRule annotationAdd BLAST100
Repeati411 – 499CSPG 2PROSITE-ProRule annotationAdd BLAST89
Repeati520 – 630CSPG 3PROSITE-ProRule annotationAdd BLAST111
Repeati656 – 762CSPG 4PROSITE-ProRule annotationAdd BLAST107
Repeati784 – 875CSPG 5PROSITE-ProRule annotationAdd BLAST92
Repeati901 – 993CSPG 6PROSITE-ProRule annotationAdd BLAST93
Repeati1022 – 1124CSPG 7PROSITE-ProRule annotationAdd BLAST103
Repeati1145 – 1238CSPG 8PROSITE-ProRule annotationAdd BLAST94
Repeati1259 – 1357CSPG 9PROSITE-ProRule annotationAdd BLAST99
Repeati1378 – 1470CSPG 10PROSITE-ProRule annotationAdd BLAST93
Repeati1490 – 1579CSPG 11PROSITE-ProRule annotationAdd BLAST90
Repeati1613 – 1710CSPG 12PROSITE-ProRule annotationAdd BLAST98
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1717 – 1816Calx-beta 1Add BLAST100
Domaini1829 – 1942Calx-beta 2Add BLAST114
Domaini1956 – 2062Calx-beta 3Add BLAST107
Domaini2077 – 2179Calx-beta 4Add BLAST103
Domaini2197 – 2302Calx-beta 5Add BLAST106

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FRAS1 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.2030, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126, Cadherin-like_dom
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR039005, CSPG_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03160, Calx-beta, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00237, Calx_beta, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF141072, SSF141072, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51854, CSPG, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GV77-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASALLCFLA AILPGMIAAQ NTWVLGTSDV RTVEPVNPVG GGVSLGGIDI
60 70 80 90 100
DSTENRIIVQ NTGIAVPFGR EKAIDPNSEL VINVQAGDSC SIKVLPRQSD
110 120 130 140 150
PLSQIPGRLV PPSFPCDFSP GEVKYVHFGS RKPQTDKVKL QLRYDTATDV
160 170 180 190 200
YIIPFTIDVR VESKQLEIVT RNVPLVVQDL MGTSDALDAD KLEFEFDSNT
210 220 230 240 250
EVCKVTVLSS TSGLPRYGEV MNHDEQGQMI DCNDFLELGI QYRHTAATSS
260 270 280 290 300
PREDYIPLVV ELQNQQGQVI KQEYFQSMVR IIDGDDNTPP SLVLSSDMMM
310 320 330 340 350
EVDQFVMTAI TPSILAAEDV ETPADMLIFN ITSQTLGPDD GMIVSTDDRN
360 370 380 390 400
QPITSFTQKD LRDLKIAYKP PPRDTDVQTI YQIELEIVDS ELATSETHSL
410 420 430 440 450
LIVVKPKNTL APVVTTNTGL VLFEGQSRPL LGGQNLGISD EDNLQDVIIA
460 470 480 490 500
PINGSRYGEL RIGNQRIKQF TIADLIEGAV TYHHYGTDTY SDNIIFRMTD
510 520 530 540 550
GQHEVEFLFP ITIAPIDDEA PIVDVNTGVT VNENEVVAIT NFVLSATDID
560 570 580 590 600
SDDSEIRFVL EQPLSDMGNL FLRQVNIPED PQNWISQDNF YEREVTEFTL
610 620 630 640 650
EDIQNGHLFY QHGGSHNADP VFDRILFRVV DSADPQPNES PVQELLVKVM
660 670 680 690 700
PQDLQPPEMF GGTTLQLSVD EFQITPILKK NLRFTDMDSN DRELKYTIVS
710 720 730 740 750
PLTDSDSNNN LPVGDIVLTD EPNTPINMFT QAQINHMKVS YKPPSTELGI
760 770 780 790 800
APRAITFQFV VQDTQGNMGS PHNFIILLRP VDNQPPTITN TGVQVFERGT
810 820 830 840 850
VIIDQTMLDA TDPDTDRNSI RVVLVQPPVF GTMNLNDIAL EKGDEFTLGD
860 870 880 890 900
IENSRVKYVS GDAEEQSDEI HLEITDGVHV VPIVIHINVA PIDDEAPTLD
910 920 930 940 950
LPPGTIGSFL EVQENSFSLI TSNILSASDP DTEDLLLTFI VDRQPNEGRI
960 970 980 990 1000
ESNGVVADVF TQQDIVNGLV RYVHTGGEIG PSKRDDSFNL TLSDMSPDWI
1010 1020 1030 1040 1050
LGGNEITQVE VYVTVLPVDN LAPNVTMGVQ FYVDEAGKGN INMTHLQAPD
1060 1070 1080 1090 1100
VDTEDDDILC TIVVAPSVGY LENISPAPGS EKSRGGMPIS AFSIKDLRLN
1110 1120 1130 1140 1150
HINYVQSIHQ GMEPEEDQFT FRCTDGVNES PNFLFPINII PVNDEEPQVY
1160 1170 1180 1190 1200
AREIIVDEGG QRIIDEPLLR AEDGDVPADE LHFFIVTPPQ HGTITYTRLE
1210 1220 1230 1240 1250
GDIPILNFTM DQIANGNDIK YIHDDSETTE DSFTVLLTDG KYEITKEITI
1260 1270 1280 1290 1300
TILEVDDETP RLTINDGIDI EIGESRIISN RILKATDLDS ADSNLTYTVR
1310 1320 1330 1340 1350
YAPEKGLLQR LSKFDGSVVE NITLGMNFTQ WEVDNQRIRY VHTDGDGGRD
1360 1370 1380 1390 1400
LIKFDITDGT NPLIDRYFYV TVDHIDNVHP SIINAGVTMQ EGSRVTLTTS
1410 1420 1430 1440 1450
IISTSDLNSP DEDLLFTITT APTKGHLEST DNPGMPINSF TQLDLAGSKI
1460 1470 1480 1490 1500
YYVHTADDEV KMDSFQFQVT DGFNTVVRTF RISFTDVDNK EPVVRYDTIR
1510 1520 1530 1540 1550
LQEGDNKLIT PFELGIDDRD TPANELRFTI TQLPIHGNIL RNNTALVTEF
1560 1570 1580 1590 1600
TMHDINENLI SYQHDGSEQT ADSFSFIVTD GTHNEFYVLP DITTLTRQPQ
1610 1620 1630 1640 1650
QVPIEIVPVD NGAPQIVVNR GAPTLDLLGT GELGFMITNK YLMSEDRDSV
1660 1670 1680 1690 1700
DNSLLYVITT QPQHGYIMNI ALGNISITNF TQSDVNNMYI QYIVYPNVDA
1710 1720 1730 1740 1750
TSDTFFVEVR DAGGNTLPNQ PFRLNWSWIS LEKEYYEVNE TERYLNIKLV
1760 1770 1780 1790 1800
RRGYLGETSF VGIQTADGTA IADEDFRGKS ARQVQFNPGQ TEGFWRVRIL
1810 1820 1830 1840 1850
NDRLYEQAEV FEIILHDPVM GALEYPDRAV VTIFDAEDES GVFIDLPDNY
1860 1870 1880 1890 1900
VIEEDIGEFL VPIRRTGDLS QELMASCSTM PGSATGSDPS PVLSFSDYIS
1910 1920 1930 1940 1950
RMEEDPDNMV AFDKGEDLAY CRILIIDDSL YEEDETFQVK LSNPMGGRIG
1960 1970 1980 1990 2000
NPSAINVIIA GDTDDVPSFY FGEPEYKVDE NAPFVEVTVF RTGTDVSKMA
2010 2020 2030 2040 2050
SVTVRSRASN PVSAVAGEDY AGISRNLDFA PGVNQQTVKV YIIDDRGQPR
2060 2070 2080 2090 2100
LEGPETFELV LNMPMNGVLG APSKTVITIN DTISDLPKVE FRHPTYEVNE
2110 2120 2130 2140 2150
NDIRITAEVV RSGDLSIESS VRCYTRQGSA QVMMDYDERP NTEASIITFL
2160 2170 2180 2190 2200
PGERSKTCTV LLMDDNVFEP DEAFRLVLGS PRTASGVPAV VGEQNVTVVT
2210 2220 2230 2240 2250
VHDVGDAPII KFPETKFSID EPTDLDSVVT VSIPVIRMGD NTQTSIVRVF
2260 2270 2280 2290 2300
TKDGSARSGI DYNPLSQVLE FGFNVTERVV EIEILPDEDR NEMREAFTLH
2310 2320 2330 2340 2350
ITNDQMMIAD VQMNHAIIYI EQEGQASGVT FPSQPVVVSL LDYDDIPNAR
2360 2370 2380 2390 2400
TNPPRGYPLI CVSPCNPKYP DFATTGPICD SEGLNDTVTQ FRWMVSAPTS
2410 2420 2430 2440 2450
ESGVTSPLRQ TDSDTFFSST KSITLDSVYF GPGSRVQCVA RAVGSEGDAG
2460 2470 2480 2490 2500
REHPSNSIVI STTDGMCMPR VANAIGAEPF TARMRYTGPA DPDYPNKVRL
2510 2520 2530 2540 2550
TVTMPHVDGM LPVISTRQLS NFELALSKDG YRVGTHRCSN LLDYNEIPTD
2560 2570 2580 2590 2600
FGFITEETKN PNVVGDTYAY QYSPELRGEE TLRFYRNLNL EACLWEFNAY
2610 2620 2630 2640 2650
YDMSELLDEC GGLVGTDGQV LDLVQSYVSM RIPLFVSFVF HSPVATGGWK
2660 2670 2680 2690 2700
HFDQQSTLQL TFVYDTSILW QNGIGSQVTT GTQSLQGNLY PTSMRIDEDG
2710 2720 2730 2740 2750
RLVVNFRTEA LFNGLFVQSH QSTDVVSTVN SIDHPGITYS LSLLRTEPTY
2760 2770 2780 2790 2800
AQPEQLWQFV SDLSVSDYSG TYTIQLVPCT TLPNTVYSQP PVCNPEDIIT
2810 2820 2830 2840 2850
FELPIRFQQV SDPVPEEYSL NTEFVLVGKE SIYLSDGSMG FGEGSDVAYN
2860 2870 2880 2890 2900
PGDTIFGRIH VDPVQNLGAG FNLDIQKVFL CTGRDGYIPK YNPAANEYGC
2910 2920 2930 2940 2950
VADTPNLLYA FKILDRGAPD TIVREFNGLP FNATLAIDNA ADLELVQQPG
2960 2970 2980 2990 3000
ADGFRLASDA LFEVDYGRTW YLHSIYSMRS SESSGIGKRE TEHHAISSRQ
3010 3020 3030 3040 3050
RRQANSEALV DPAQGQGTNM KRVALQGPQD VDNNLGGTYE LAPKGTNVVM
3060 3070 3080 3090 3100
IAVVIGVILI ILLVALVIGV VVRRRQAKQQ PVVVVNGSAK VVSNVHFDDN

TEV
Length:3,103
Mass (Da):343,775
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79D7EBEDE1C54393
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti489 – 500TYSDN…FRMTD → KCKYVYEKGIPF in AAA77050 (Ref. 2) CuratedAdd BLAST12
Sequence conflicti554S → P in AAA77050 (Ref. 2) Curated1
Sequence conflicti778L → V in AAA77050 (Ref. 2) Curated1
Sequence conflicti1046L → H in AAA77050 (Ref. 2) Curated1
Sequence conflicti1112M → I in AAA77050 (Ref. 2) Curated1
Sequence conflicti1118 – 1125QFTFRCTD → HSLSVVLM in AAA77050 (Ref. 2) Curated8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF287478 mRNA Translation: AAG00570.1
U34202 mRNA Translation: AAA77050.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287478 mRNA Translation: AAG00570.1
U34202 mRNA Translation: AAA77050.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di2.60.40.2030, 5 hits
InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR039005, CSPG_rpt
PfamiView protein in Pfam
PF03160, Calx-beta, 5 hits
SMARTiView protein in SMART
SM00237, Calx_beta, 5 hits
SUPFAMiSSF141072, SSF141072, 5 hits
PROSITEiView protein in PROSITE
PS51854, CSPG, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFREM2_LYTVA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GV77
Secondary accession number(s): Q25429
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2001
Last modified: December 2, 2020
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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