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Entry version 75 (18 Sep 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Trypanothione synthetase

Gene

TRS

Organism
Trypanosoma cruzi (strain CL Brener)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional enzyme which catalyzes the formation of trypanothione (N1,N8-bis(glutathionyl)spermidine) from glutathione and spermidine. Converts spermidine or glutathionylspermidine into trypanothione. Can also convert aminopropylcadaverine into glutothionylaminopropylcadaverine and homotrypanothione. Also has low amidase activity, hydrolyzing trypanothione, homotrypanothione or glutathionylspermidine to form glutathione and the corresponding polyamine.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Subject to high-substrate inhibition by glutathione.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=570 µM for glutathione with spermidine as cosubstrate1 Publication
  2. KM=190 µM for glutathione with glutathionylspermidine as cosubstrate1 Publication
  3. KM=53 µM for MgATP1 Publication
  4. KM=625 µM for spermidine1 Publication
  5. KM=662 µM for aminopropylcadaverine1 Publication
  6. KM=66 µM for glutathionylspermidine1 Publication

    pH dependencei

    Optimum pH is 8.1 with spermidine as substrate. Optimum pH is 8.5 with glutathionylspermidine as substrate.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei316Transition state stabilizerBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi318Magnesium 1By similarity1
    Metal bindingi332Magnesium 1By similarity1
    Metal bindingi332Magnesium 2By similarity1
    Metal bindingi334Magnesium 2By similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei501ATPBy similarity1
    Binding sitei536ATPBy similarity1
    Binding sitei543ATP; via amide nitrogenBy similarity1
    Binding sitei571ATPBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi316 – 318ATPBy similarity3
    Nucleotide bindingi606 – 608ATPBy similarity3

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLigase, Multifunctional enzyme
    LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    6.3.1.9 6524

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    C51.A01

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Trypanothione synthetaseImported (EC:6.3.1.9)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:TRSImported
    Synonyms:TrySImported
    ORF Names:Tc00.1047053509099.50, Tc00.1047053509319.90
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrypanosoma cruzi (strain CL Brener)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri353153 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002296 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004031111 – 647Trypanothione synthetaseAdd BLAST647

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9GT49

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9GT49

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    1 Publication

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    5693.XP_810600.1

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q9GT49

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9GT49

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 166Peptidase C51PROSITE-ProRule annotationAdd BLAST141

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    In the C-terminal section; belongs to the glutathionylspermidine synthase preATP-grasp family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410J4YY Eukaryota
    COG0754 LUCA

    KEGG Orthology (KO)

    More...
    KOi
    K01833

    Database of Orthologous Groups

    More...
    OrthoDBi
    1021702at2759

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR007921 CHAP_dom
    IPR005494 GSPS_pre-ATP-grasp-like_dom
    IPR038765 Papain-like_cys_pep_sf
    IPR016185 PreATP-grasp_dom_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF05257 CHAP, 1 hit
    PF03738 GSP_synth, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52440 SSF52440, 1 hit
    SSF54001 SSF54001, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50911 CHAP, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q9GT49-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MPTLQSLAVP FGCVQGYAPG GIPAYSNKHE SYFSGERSID GNLFCGFKYQ
    60 70 80 90 100
    CVEFARRWLF ERKSLVLPDV DWAVHIFNLK EVSDARTGKP VRCVAIRNGT
    110 120 130 140 150
    AAKPVVDSLL IYPSDDYSPV GHVAAITEVG DKWVRIADQN HRFHKWDANY
    160 170 180 190 200
    AAELPLIHEK GVWTILDPLE DEVLKPLGWV TFPDTPDRNP NEPLVLHESL
    210 220 230 240 250
    HFKRGELPTL RRLTFTPTSR EKDWLDLTNE AEAYFADVCG IDVKNPKLEK
    260 270 280 290 300
    ASYYQMNREL YLDCAKYGNQ LHQMFLEATK FVLGSDELLR LFCIPEEYWP
    310 320 330 340 350
    RLRHSWETQP HAITGRFDFA FDEDTQQFKC FEYNADSAST LLECGVIQQK
    360 370 380 390 400
    WARSVGLDDG TTYSSGSLVS SRLQLAWEMA EVTGRVHFLI DNDDEEHYTA
    410 420 430 440 450
    LYVMQHASAA GLETKLCVLF DEFHFDENGV VVDSDGVAVT TVWKTWMWET
    460 470 480 490 500
    AIADHQKARV QRGNDWRPTP KDEVRLCDIL LGPNWDLRVF EPMWKIIPSN
    510 520 530 540 550
    KAILPIIYNK HPDHPALLRA SYELTVELQR TGYVRKPIVG RVGRNVTVTE
    560 570 580 590 600
    ASGDIAAKSD GDFSDRDMVY QELFRLPERD GYYAILGGWV IGDVYCGTGV
    610 620 630 640
    REDKTIITGL ESPFSALRVY QGAQRRPLTH EDLDKAEAAA VGGGLKT
    Length:647
    Mass (Da):73,458
    Last modified:March 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA8C76ACD0D90F24
    GO

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti2P → T in strain: Silvio X10/7. 1 Publication1
    Natural varianti5Q → K in strain: Silvio X10/7. 1 Publication1
    Natural varianti71D → E in allele TRS-2. 1 Publication1
    Natural varianti89K → Q in allele TRS-2 and strain Silvio X10/7. 2 Publications1
    Natural varianti90P → N in allele TRS-2. 1 Publication1
    Natural varianti106V → A in allele TRS-2. 1 Publication1
    Natural varianti132K → N in allele TRS-2. 1 Publication1
    Natural varianti175K → R in allele TRS-2. 1 Publication1
    Natural varianti184D → E in allele TRS-2 and strain Silvio X10/7. 2 Publications1
    Natural varianti207L → V in allele TRS-2 and strain Silvio X10/7. 2 Publications1
    Natural varianti218T → N in allele TRS-2 and strain Silvio X10/7. 2 Publications1
    Natural varianti237D → G in strain: Silvio X10/7. 1 Publication1
    Natural varianti237D → S in allele TRS-2. 1 Publication1
    Natural varianti248L → V in allele TRS-2 and strain Silvio X10/7. 2 Publications1
    Natural varianti265A → T in allele TRS-2. 1 Publication1
    Natural varianti265A → V in strain: Silvio X10/7. 1 Publication1
    Natural varianti283L → I in allele TRS-2 and strain Silvio X10/7. 2 Publications1
    Natural varianti288L → Q in allele TRS-2 and strain Silvio X10/7. 2 Publications1
    Natural varianti291L → V in allele TRS-2. 1 Publication1
    Natural varianti293C → H in allele TRS-2 and strain Silvio X10/7. 2 Publications1
    Natural varianti304 – 305HS → YL in strain: Silvio X10/7. 1 Publication2
    Natural varianti365S → C in allele TRS-2. 1 Publication1
    Natural varianti369V → I in allele TRS-2 and strain Silvio X10/7. 2 Publications1
    Natural varianti381E → G in strain: Silvio X10/7. 1 Publication1
    Natural varianti392N → K in allele TRS-2 and strain Silvio X10/7. 2 Publications1
    Natural varianti397H → Y in allele TRS-2 and strain Silvio X10/7. 2 Publications1
    Natural varianti487L → M in strain: Silvio X10/7. 1 Publication1
    Natural varianti498P → S in strain: Silvio X10/7. 1 Publication1
    Natural varianti526V → I in strain: Silvio X10/7. 1 Publication1
    Natural varianti535R → K in allele TRS-2 and strain Silvio X10/7. 2 Publications1
    Natural varianti562D → N in allele TRS-2 and strain Silvio X10/7. 2 Publications1
    Natural varianti564S → L in strain: Silvio X10/7. 1 Publication1
    Natural varianti604K → T in strain: Silvio X10/7. 1 Publication1
    Natural varianti615S → I in allele TRS-2. 1 Publication1
    Natural varianti615S → R in strain: Silvio X10/7. 1 Publication1
    Natural varianti624Q → P in allele TRS-2. 1 Publication1
    Natural varianti635K → N in strain: Silvio X10/7. 1 Publication1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF311782 Genomic DNA Translation: AAL26803.1
    AF283000 Genomic DNA Translation: AAG15408.1
    AF283001 Genomic DNA Translation: AAG15409.1
    AY155571 Genomic DNA Translation: AAO00722.1
    AAHK01000291 Genomic DNA Translation: EAN94225.1
    AAHK01000838 Genomic DNA Translation: EAN88749.1

    NCBI Reference Sequences

    More...
    RefSeqi
    XP_810600.1, XM_805507.1
    XP_816076.1, XM_810983.1

    Genome annotation databases

    Ensembl protists genome annotation project

    More...
    EnsemblProtistsi
    EAN88749; EAN88749; Tc00.1047053509319.90
    EAN94225; EAN94225; Tc00.1047053509099.50

    GeneDB pathogen genome database from Sanger Institute

    More...
    GeneDBi
    TcCLB.509099.50:pep
    TcCLB.509319.90:pep

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    3541408
    3547898

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    tcr:509099.50
    tcr:509319.90

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF311782 Genomic DNA Translation: AAL26803.1
    AF283000 Genomic DNA Translation: AAG15408.1
    AF283001 Genomic DNA Translation: AAG15409.1
    AY155571 Genomic DNA Translation: AAO00722.1
    AAHK01000291 Genomic DNA Translation: EAN94225.1
    AAHK01000838 Genomic DNA Translation: EAN88749.1
    RefSeqiXP_810600.1, XM_805507.1
    XP_816076.1, XM_810983.1

    3D structure databases

    SMRiQ9GT49
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi5693.XP_810600.1

    Chemistry databases

    BindingDBiQ9GT49

    Protein family/group databases

    MEROPSiC51.A01

    Proteomic databases

    PaxDbiQ9GT49
    PRIDEiQ9GT49

    Genome annotation databases

    EnsemblProtistsiEAN88749; EAN88749; Tc00.1047053509319.90
    EAN94225; EAN94225; Tc00.1047053509099.50
    GeneDBiTcCLB.509099.50:pep
    TcCLB.509319.90:pep
    GeneIDi3541408
    3547898
    KEGGitcr:509099.50
    tcr:509319.90

    Phylogenomic databases

    eggNOGiENOG410J4YY Eukaryota
    COG0754 LUCA
    KOiK01833
    OrthoDBi1021702at2759

    Enzyme and pathway databases

    BRENDAi6.3.1.9 6524

    Family and domain databases

    InterProiView protein in InterPro
    IPR007921 CHAP_dom
    IPR005494 GSPS_pre-ATP-grasp-like_dom
    IPR038765 Papain-like_cys_pep_sf
    IPR016185 PreATP-grasp_dom_sf
    PfamiView protein in Pfam
    PF05257 CHAP, 1 hit
    PF03738 GSP_synth, 1 hit
    SUPFAMiSSF52440 SSF52440, 1 hit
    SSF54001 SSF54001, 1 hit
    PROSITEiView protein in PROSITE
    PS50911 CHAP, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRYS_TRYCC
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GT49
    Secondary accession number(s): Q95WL5, Q9GT48
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
    Last sequence update: March 1, 2001
    Last modified: September 18, 2019
    This is version 75 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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