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Protein
Submitted name:

DNA polymerase zeta catalytic subunit

Gene

mus205

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: InterPro
  • DNA-directed DNA polymerase activity Source: FlyBase
  • nucleotide binding Source: InterPro

GO - Biological processi

  • double-strand break repair via homologous recombination Source: FlyBase
  • error-prone translesion synthesis Source: GO_Central
  • nucleic acid phosphodiester bond hydrolysis Source: GOC
  • translesion synthesis Source: FlyBase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-110312 Translesion synthesis by REV1
R-DME-5655862 Translesion synthesis by POLK
R-DME-5656121 Translesion synthesis by POLI

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DNA polymerase zeta catalytic subunitImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mus205Imported
ORF Names:CG1925Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0002891 mus205

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9GSR2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0002891 Expressed in 4 organ(s), highest expression level in material anatomical entity

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9GSR2 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9GSR2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 189DNA_pol_B_exo1InterPro annotationAdd BLAST135
Domaini1363 – 1478DNA_pol_B_exo1InterPro annotationAdd BLAST116
Domaini1543 – 1992DNA_pol_BInterPro annotationAdd BLAST450
Domaini2043 – 2107zf-C4polInterPro annotationAdd BLAST65

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0968 Eukaryota
COG0417 LUCA

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01N0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit
3.90.1600.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR023211 DNA_pol_palm_dom_sf
IPR030559 PolZ_Rev3
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR025687 Znf-C4pol

The PANTHER Classification System

More...
PANTHERi
PTHR10322:SF26 PTHR10322:SF26, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 2 hits
PF14260 zf-C4pol, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00106 DNAPOLB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00486 POLBc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9GSR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAGEAIDG VYSVRLVIAD FYMEKPQFGM DPCYSELRGK EIKRVPVIRV
60 70 80 90 100
FGGNSRGQKT CMHVHGVFPY LYIPYDKKDF ESLERGILQM AVHLDKAINI
110 120 130 140 150
SLGQGSSNAQ HVFKIQLVKG IPFYGYHRVE HQFLKIYMFN PRFVRRAANL
160 170 180 190 200
LQSGAILSKN FSPHESHVPY ILQFMIDYNL YGMSYVHVPL EVLKFRRNHD
210 220 230 240 250
DDVIPYANVK QAQLLDITTA KKVACSALEV DVSSNFILNR FQLVAKSKSN
260 270 280 290 300
HTNPGIEAIW NDEKLRRQKL VEKHTDAGDE EKAEAVPVLE LPPTQERHQI
310 320 330 340 350
EIAESDIFYR TALESKLMTL EQSTLSEQTL SDQTILPQVT MQTTMPGTKA
360 370 380 390 400
QKRRFNLQKL LANAVYPEEC SQDQQQLLVN ASFIQNHVTC GYSNSVSLST
410 420 430 440 450
SKDESDDLDE TVVDEELILS LTQPHGAIPH DATLREEDLE LLDALQLLEE
460 470 480 490 500
QNESESHVDL DSSLAPLSQH KKFELTPELL DKETAATAAL FDEDVDSDED
510 520 530 540 550
ADQETRHDFS TVLDDVDELL LKLTQSQPAE SKELKVSSKL PQIDGADDRL
560 570 580 590 600
QRTPIKSISS KSKSSPSKTP TTPIGQKSLP KSPHTPKTSA AKKYAPLALT
610 620 630 640 650
IGSSSSKKSN DEFAGRPSNP RLSLQLDQGT GTGTLRPEIS LRKKLAMSEM
660 670 680 690 700
RRKSFEDSFV LLKNDCTPVR STRRSTRNLD KTHIICSLTP RDRNPGLSDM
710 720 730 740 750
FETEDGKQLP PKKVVRKTRW STRNQDIESL PKAGCEIERP HRSEGSALDE
760 770 780 790 800
LKPRRSARHK VNSANPDECS SEIQTTGPRV TTTSLDRPQK KARLSQSPKE
810 820 830 840 850
NTKTSMNGTV ALEKATKDSS SNSESPHQQE NSVSEQIEYL ESKPKKSDET
860 870 880 890 900
ARSRDEKLQR ELIPQEPAGI SPGDSANSTE EITFSPSHDE AIESDTESDY
910 920 930 940 950
IVTKLRKTPN LKRLRWSIRS ELLNKQFTPS SGIRPPETET TPQLSPKSNE
960 970 980 990 1000
SNTPELMRSF YEHSLIVNSP SVFSDFLDSP EIHMDSPRSA PPSPDSNSFV
1010 1020 1030 1040 1050
IAPLELPPSY DEVVSGSRKM GIPEYEFQKP YYSNPSDVSK VTEVGFLVLH
1060 1070 1080 1090 1100
IPGNKLNDCD PFQSILGNDR GLASWRRRQL IAIGGLAMLQ RHRGEQKVRE
1110 1120 1130 1140 1150
YFSTQQRIAI EPAQLAPTWQ EAKIWLKAKE LLRQREEPKK SSDDIDSPIK
1160 1170 1180 1190 1200
IKRQKITMML QAEEGDGGSG DEDAGDELDC SLSLTPLSQA KDKCKATPTS
1210 1220 1230 1240 1250
SKARERGKSR LKPGTRLSFI GSQDEEPPSS QSSEQSVFSS AAQAELDRSS
1260 1270 1280 1290 1300
FLRQLEGSSQ DRQHDLSFGL SHATLDNTFG FKVNLENLQQ AKADIDCNHL
1310 1320 1330 1340 1350
TIITLEVFVS TRGDLQPDPM HDEIRCLFYA IEHSLPDEKL PSKACGYIMV
1360 1370 1380 1390 1400
NTVQDLLSEG PFHGIDRDIE VQVVTSEAEA FEALLALCER WDADIYAGYE
1410 1420 1430 1440 1450
IEMSSWGYVI DRAKHLCFNI APLLSRVPTQ KVRDFVDEDR EQFTDLDVEM
1460 1470 1480 1490 1500
KLCGRILLDV WRLMRSEIAL TSYTFENVMY HILHKRCPWH TAKSLTEWFG
1510 1520 1530 1540 1550
SPCTRWIVME YYLERVRGTL TLLEQLDLLG RTSEMAKLIG IQFYEVLSRG
1560 1570 1580 1590 1600
SQFRVESMML RIAKPKNLVP LSPSVQARAH MRAPEYLALI MEPQSRFYAD
1610 1620 1630 1640 1650
PLIVLDFQSL HPSMIIAYNY CFSTCLGRVE HLGGSSPFEF GASQLRVSRQ
1660 1670 1680 1690 1700
MLQKLLEHDL VTVSPCGVVF VKREVREGIL PRMLTEILDT RQMVKQSMKL
1710 1720 1730 1740 1750
HKDSSALQRI LHSRQLGLKL MANVTYGYTA ANFSGRMPSV EVGDSVVSKG
1760 1770 1780 1790 1800
RETLERAIKL VENNEEWKVR VVYGDTDSMF VLVPGRNRAE AFRIGEEIAK
1810 1820 1830 1840 1850
AVTEMNPQPV KLKLEKVYQP CMLQTKKRYV GYMYETADQE QPVYEAKGIE
1860 1870 1880 1890 1900
TERRDGCPAV AKMLEKVLRI LFETQDVSKI KAYVCRQFTK LLSGRANLQD
1910 1920 1930 1940 1950
LIFAKEFRGL NGYKPTACVP ALELTRKWMQ KDPRHVPRRG ERVPFIIVNG
1960 1970 1980 1990 2000
PPGMQLIRLV RSPHDILANE GHKINAIYYI TKAIIPPLNR CLLLIGANVH
2010 2020 2030 2040 2050
DWFASLPRKL LMTPAVGTAN ELAGPRGAKS TISQYFSTTS CVIDCGRQTK
2060 2070 2080 2090 2100
AGICPDCLKN ATTCVVVLSD KTARLERGYQ LTRQICQACC GRLGSLQCDS
2110 2120 2130
LDCPVLYVLE GKRRELQQIE HWNKLLEHHF
Length:2,130
Mass (Da):240,239
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i170111031B83B794
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF298215 mRNA Translation: AAG30223.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298215 mRNA Translation: AAG30223.1

3D structure databases

ProteinModelPortaliQ9GSR2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9GSR2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0002891 mus205

Phylogenomic databases

eggNOGiKOG0968 Eukaryota
COG0417 LUCA
OrthoDBiEOG091G01N0

Enzyme and pathway databases

ReactomeiR-DME-110312 Translesion synthesis by REV1
R-DME-5655862 Translesion synthesis by POLK
R-DME-5656121 Translesion synthesis by POLI

Gene expression databases

BgeeiFBgn0002891 Expressed in 4 organ(s), highest expression level in material anatomical entity
ExpressionAtlasiQ9GSR2 baseline and differential

Family and domain databases

Gene3Di3.30.420.10, 1 hit
3.90.1600.10, 1 hit
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR023211 DNA_pol_palm_dom_sf
IPR030559 PolZ_Rev3
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR025687 Znf-C4pol
PANTHERiPTHR10322:SF26 PTHR10322:SF26, 2 hits
PfamiView protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 2 hits
PF14260 zf-C4pol, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9GSR2_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GSR2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: December 5, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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