Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q9GSR1 (DPOZ_DROME)

Entry version 185 (25 May 2022)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
Add a publicationFeedback
Protein

DNA polymerase zeta catalytic subunit

Gene

PolZ1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As the catalytic subunit of the DNA polymerase zeta complex, plays a crucial role in translesion DNA synthesis (TLS) and various DNA repair mechanisms (PubMed:11267835, PubMed:16507570, PubMed:22532806, PubMed:15175013).

Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function (PubMed:15175013).

During homologous recombination (HR) repair, has a overlapping role with the error-prone translesion polymerase eta to initiate repair synthesis which is completed by end joining or another polymerase that can bind and reinitiate synthesis (PubMed:22532806).

May participate in the Rrp1-dependent base excision repair (BER) pathway responsible for repair of DNA lesions that gives rise to apurinic/apyrimidinic (AP) sites (PubMed:16507570).

Unlike mammalian orthologs, it is not an error-prone polymerase (PubMed:15175013).

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by tetracyclic diterpene antibiotic aphidicolin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi2041ZincBy similarity1
Metal bindingi2045ZincBy similarity1
Metal bindingi2054ZincBy similarity1
Metal bindingi2057ZincBy similarity1
Metal bindingi2086Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi2089Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi2098Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi2103Iron-sulfur (4Fe-4S)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA synthesis
LigandIron, Iron-sulfur, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-110312, Translesion synthesis by REV1
R-DME-5655862, Translesion synthesis by POLK
R-DME-5656121, Translesion synthesis by POLI

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase zeta catalytic subunitImported (EC:2.7.7.71 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PolZ1Imported
Synonyms:DmpolzetaImported, DNApol-zetaCurated, DNApolZ1Curated, mus2051 Publication, rev31 Publication
ORF Names:CG1925Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0002891, PolZ1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0002891

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi14 – 2130Missing in mus205; hypersensitive to alkylating agents and UV, but not sensitive to ionising radiation. In somatic cells, no effect on methyl methane sulfonate-induced mutations and homologous recombination. In germ cells, no effect on mutability by X-rays, NQO and alkylating agents. 1 PublicationAdd BLAST2117

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004487421 – 2130DNA polymerase zeta catalytic subunitAdd BLAST2130

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9GSR1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryos (at protein level) (PubMed:15175013). Expressed throughout development, with highest levels of expression in 0-8 hour embryos and adult females (PubMed:16507570).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0002891, Expressed in female gonad and 18 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9GSR1, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Catalytic subunit of the zeta DNA polymerase complex, which consists of PolZ1/DNApol-zeta and the accessory component PolZ2/Rev7 (PubMed:16507570, PubMed:15175013).

Interacts with the apurinic/apyrimidinic (AP) endonuclease Rrp1; the interaction is likely indirect and mediated via PolZ2 (PubMed:16507570).

2 Publications

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9GSR1, 1 interactor

STRING: functional protein association networks

More...STRINGi		7227.FBpp0087907

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9GSR1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9GSR1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni528 – 635DisorderedSequence analysisAdd BLAST108
Regioni734 – 891DisorderedSequence analysisAdd BLAST158
Regioni927 – 954DisorderedSequence analysisAdd BLAST28
Regioni1189 – 1243DisorderedSequence analysisAdd BLAST55

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2086 – 2103CysB motifBy similarityAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi553 – 585Polar residuesSequence analysisAdd BLAST33
Compositional biasi599 – 613Polar residuesSequence analysisAdd BLAST15
Compositional biasi621 – 635Polar residuesSequence analysisAdd BLAST15
Compositional biasi734 – 762Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi763 – 791Polar residuesSequence analysisAdd BLAST29
Compositional biasi798 – 838Polar residuesSequence analysisAdd BLAST41
Compositional biasi839 – 862Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1189 – 1204Polar residuesSequence analysisAdd BLAST16
Compositional biasi1222 – 1243Polar residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0968, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000169521

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000203_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9GSR1

Identification of Orthologs from Complete Genome Data

More...OMAi		CYSELRG

Database of Orthologous Groups

More...OrthoDBi		20210at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9GSR1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.132.60, 1 hit
3.30.420.10, 1 hit
3.90.1600.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006172, DNA-dir_DNA_pol_B
IPR017964, DNA-dir_DNA_pol_B_CS
IPR006133, DNA-dir_DNA_pol_B_exonuc
IPR006134, DNA-dir_DNA_pol_B_multi_dom
IPR043502, DNA/RNA_pol_sf
IPR042087, DNA_pol_B_thumb
IPR023211, DNA_pol_palm_dom_sf
IPR030559, PolZ_Rev3
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR025687, Znf-C4pol

The PANTHER Classification System

More...PANTHERi		PTHR45812, PTHR45812, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00136, DNA_pol_B, 1 hit
PF03104, DNA_pol_B_exo1, 2 hits
PF14260, zf-C4pol, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00106, DNAPOLB

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00486, POLBc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00116, DNA_POLYMERASE_B, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9GSR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAGEAIDG VYSVRLVIAD FYMEKPQFGM DPCYSELRGK EIKRVPVIRV 
        60         70         80         90        100
FGGNSRGQKT CMHVHGVFPY LYIPYDKKDF ESLERGILQM AMHLDKAINI 
       110        120        130        140        150
SLGQGSSNAQ HVFKIQLVKG IPFYGYHRVE HQFLKIYMFN PRFVRRAANL 
       160        170        180        190        200
LQSGAILSKN FSPHESHVPY ILQFMIDYNL YGMSYVHVPL EVLKFRRNHD 
       210        220        230        240        250
DDVIPYANVK QAQLLDITTA KKVACSALEV DVSSNFILNR FQLVAKSKSN 
       260        270        280        290        300
HTNPGIEAIW NDEKLRRQKL VEKHTDAGDE EKAEAVPVLE LPPTQERHQI 
       310        320        330        340        350
EIAESDIFYR TALESKLMTL EQSTLSEQTL SDQTILPQAT MQTTMPGTKA 
       360        370        380        390        400
QKRRFNLQKL LANAVYPEEC SQDQQQLLVN ASFIQNHVTC GYSSSVSLST 
       410        420        430        440        450
SKDESDDLDE TVVDEELILS LTQPHGAIPH DATLREEDLE LLDALQLLEE 
       460        470        480        490        500
QNESESHVDL DSSLAPLSQH KKFELTPELL DKETAATAAL FDEDVDSDED 
       510        520        530        540        550
ADQETRHDFS TVLDDVDELL LKLTQSQPAE SKELKASSKL PQIDGADDRL 
       560        570        580        590        600
QRTPIKSISS KSKSSPSKTP TTPIGQKSLP KSPRTPKTSA AKKYAPLALT 
       610        620        630        640        650
IGSSSSKKSN DEFAGRPSNP RLSLQLDQGT GTGTLRPEIS LRKKLAMSEM 
       660        670        680        690        700
RRKSFEDSFV LLKNDCTPVR STRRSTSNLD KTHIICSLTP RDRNPGLSDM 
       710        720        730        740        750
FETEDGKQLP PKKVVRKTRW STRNQDIESL PKAGCEIERP HRSEGSALDE 
       760        770        780        790        800
LKPRRSARHK VNSANPDECS SEIQTTGPRV TTTSLDRPQK KARLSQSPKE 
       810        820        830        840        850
NTKTSMNGTV ALEKATKDSS SNSESPHQQE NSVSEQIEYL ESKPKKSDET 
       860        870        880        890        900
ARSCDEKLQR ELIPQEPAGI SPGDSANSTE EITFSPCHDE AIESDTESDY 
       910        920        930        940        950
IVTKLRKTPN LKRLRWSIRS ELLNKQFTPS SGIRPPETET TPQLSPKSNE 
       960        970        980        990       1000
SNTPELMRSF YEHSLIVNSP SVFSDFLDSP EIHMDSPRSA PPSPDSNSFV 
      1010       1020       1030       1040       1050
IAPLELPPSY DEVVSGSRKM DIPEYEFQKP YYSNPSDVSK VTEVGFLVLH 
      1060       1070       1080       1090       1100
IPGNKLNDCD PFQSILGNDR GLASWRRRQL IAIGGLAMLQ RHRGEQKVRE 
      1110       1120       1130       1140       1150
YFSTQQRIAI EPAQLAPTWQ EAKIWLKAKE LLRQREEPKK SSDDIDSPIK 
      1160       1170       1180       1190       1200
IKRQKITMML QAEEGDGGSG DEDAGEELDC SLSLTPLSQA KDKCKATPTS 
      1210       1220       1230       1240       1250
SKARETGKSR LKRGTRLSFI GSQDEEPPSS QSSEQSVSSS AAQAELDRSS 
      1260       1270       1280       1290       1300
FLRQLEGSSQ DRQHDLSFGL SHATLDNTFG FKVNLENLQQ AKADIDCNHL 
      1310       1320       1330       1340       1350
TIITLEVFVS TRGDLQPDPM HDEIRCLFYA IEHSLPDEKL PSKACGYIMV 
      1360       1370       1380       1390       1400
NTVQDLLSEG PFHGIDRDIE VQVVTSEAEA FEALLALCER WDADIYAGYE 
      1410       1420       1430       1440       1450
IEMSSWGYVI DRAKHLCFNI APLLSRVPTQ KVRDFVDEDR EQFTDLDVEM 
      1460       1470       1480       1490       1500
KLCGRILLDV WRLMRSEIAL TSYTFENVMY HILHKRCPWH TAKSLTEWFG 
      1510       1520       1530       1540       1550
SPCTRWIVME YYLERVRGTL TLLDQLDLLG RTSEMAKLIG IQFYEVLSRG 
      1560       1570       1580       1590       1600
SQFRVESMML RIAKPKNLVP LSPSVQARAH MRAPEYLALI MEPQSRFYAD 
      1610       1620       1630       1640       1650
PLIVLDFQSL YPSMIIAYNY CFSTCLGRVE HLGGSSPFEF GASQLRVSRQ 
      1660       1670       1680       1690       1700
MLQKLLEHDL VTVSPCGVVF VKREVREGIL PRMLTEILDT RQMVKQSMKL 
      1710       1720       1730       1740       1750
HKDSSALQRI LHSRQLGLKL MANVTYGYTA ANFSGRMPSV EVGDSVVSKG 
      1760       1770       1780       1790       1800
RETLERAIKL VENNEEWKVR VVYGDTDSMF VLVPGRNRAE AFRIGEEIAK 
      1810       1820       1830       1840       1850
AVTEMNPQPV KLKLEKVYQP CMLQTKKRYV GYMYETADQE QPVYEAKGIE 
      1860       1870       1880       1890       1900
TVRRDGCPAV AKMLEKVLRI LFETQDVSKI KAYVCRQFTK LLSGRANLQD 
      1910       1920       1930       1940       1950
LIFAKEFRGL NGYKPTACVP ALELTRKWMQ KDPRHVPRRG ERVPFIIVNG 
      1960       1970       1980       1990       2000
PPGMQLIRLV RSPHDILANE GHKINAIYYI TKAIIPPLNR CLLLIGANVH 
      2010       2020       2030       2040       2050
DWFASLPRKL LMTPAVGTAN ELAGARGAKS TISQYFSTTS CVIDCGRQTK 
      2060       2070       2080       2090       2100
AGICPDCLKN ATTCVVVLSD KTARLERGYQ LTRQICQACC GRLGSLQCDS 
      2110       2120       2130
LDCPVLYVLE GKRRELQQIE HWNKLLEHHF
Length:2,130
Mass (Da):240,073
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i24686E9A2267FC15
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92M → V in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti339A → V in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti394S → N in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti536A → V in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti584R → H in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti677S → R in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti854C → R in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti887C → S in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti1021D → G in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti1176E → D in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti1206T → R in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti1213R → P in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti1238S → F in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti1524D → E in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti1611Y → H in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti1852V → E in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti2025A → P in AAG30223 (PubMed:11267835).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF298215 mRNA Translation: AAG30223.1
AE013599 Genomic DNA Translation: AAF59191.2
AF298216 Genomic DNA Translation: AAG30224.1
AY058689 mRNA Translation: AAL13918.1

NCBI Reference Sequences

More...RefSeqi		NP_524881.2, NM_080142.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0088831; FBpp0087907; FBgn0002891

Database of genes from NCBI RefSeq genomes

More...GeneIDi		47186

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG1925

UCSC genome browser

More...UCSCi		CG1925-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298215 mRNA Translation: AAG30223.1
AE013599 Genomic DNA Translation: AAF59191.2
AF298216 Genomic DNA Translation: AAG30224.1
AY058689 mRNA Translation: AAL13918.1
RefSeqiNP_524881.2, NM_080142.3

3D structure databases

AlphaFoldDBiQ9GSR1
SMRiQ9GSR1
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9GSR1, 1 interactor
STRINGi7227.FBpp0087907

Proteomic databases

PaxDbiQ9GSR1

Genome annotation databases

EnsemblMetazoaiFBtr0088831; FBpp0087907; FBgn0002891
GeneIDi47186
KEGGidme:Dmel_CG1925
UCSCiCG1925-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		47186
FlyBaseiFBgn0002891, PolZ1
VEuPathDBiVectorBase:FBgn0002891

Phylogenomic databases

eggNOGiKOG0968, Eukaryota
GeneTreeiENSGT00940000169521
HOGENOMiCLU_000203_3_1_1
InParanoidiQ9GSR1
OMAiCYSELRG
OrthoDBi20210at2759
PhylomeDBiQ9GSR1

Enzyme and pathway databases

ReactomeiR-DME-110312, Translesion synthesis by REV1
R-DME-5655862, Translesion synthesis by POLK
R-DME-5656121, Translesion synthesis by POLI

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		47186, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		47186

Protein Ontology

More...PROi		PR:Q9GSR1

Gene expression databases

BgeeiFBgn0002891, Expressed in female gonad and 18 other tissues
ExpressionAtlasiQ9GSR1, baseline and differential

Family and domain databases

Gene3Di1.10.132.60, 1 hit
3.30.420.10, 1 hit
3.90.1600.10, 1 hit
InterProiView protein in InterPro
IPR006172, DNA-dir_DNA_pol_B
IPR017964, DNA-dir_DNA_pol_B_CS
IPR006133, DNA-dir_DNA_pol_B_exonuc
IPR006134, DNA-dir_DNA_pol_B_multi_dom
IPR043502, DNA/RNA_pol_sf
IPR042087, DNA_pol_B_thumb
IPR023211, DNA_pol_palm_dom_sf
IPR030559, PolZ_Rev3
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR025687, Znf-C4pol
PANTHERiPTHR45812, PTHR45812, 1 hit
PfamiView protein in Pfam
PF00136, DNA_pol_B, 1 hit
PF03104, DNA_pol_B_exo1, 2 hits
PF14260, zf-C4pol, 1 hit
PRINTSiPR00106, DNAPOLB
SMARTiView protein in SMART
SM00486, POLBc, 1 hit
SUPFAMiSSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS00116, DNA_POLYMERASE_B, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPOZ_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GSR1
Secondary accession number(s): Q95TM2, Q9GSR2, Q9V319
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 11, 2019
Last sequence update: March 1, 2001
Last modified: May 25, 2022
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again