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Entry version 173 (11 Dec 2019)
Sequence version 1 (01 Mar 2001)
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Protein

DNA polymerase zeta catalytic subunit

Gene

DNApol-zeta

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As the catalytic subunit of the DNA polymerase zeta complex, plays a crucial role in translesion DNA synthesis (TLS) and various DNA repair mechanisms (PubMed:11267835, PubMed:16507570, PubMed:22532806, PubMed:15175013). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function (PubMed:15175013). During homologous recombination (HR) repair, has a overlapping role with the error-prone translesion polymerase eta to initiate repair synthesis which is completed by end joining or another polymerase that can bind and reinitiate synthesis (PubMed:22532806). May participate in the Rrp1-dependent base excision repair (BER) pathway responsible for repair of DNA lesions that gives rise to apurinic/apyrimidinic (AP) sites (PubMed:16507570). Unlike mammalian orthologs, it is not an error-prone polymerase (PubMed:15175013).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by tetracyclic diterpene antibiotic aphidicolin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi2041ZincBy similarity1
Metal bindingi2045ZincBy similarity1
Metal bindingi2054ZincBy similarity1
Metal bindingi2057ZincBy similarity1
Metal bindingi2086Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi2089Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi2098Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi2103Iron-sulfur (4Fe-4S)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA synthesis
LigandIron, Iron-sulfur, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-110312 Translesion synthesis by REV1
R-DME-5655862 Translesion synthesis by POLK
R-DME-5656121 Translesion synthesis by POLI

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase zeta catalytic subunitImported (EC:2.7.7.71 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNApol-zetaImported
Synonyms:DmpolzetaImported, DNApolZ1Curated, mus2051 Publication, rev31 Publication
ORF Names:CG1925Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0002891 DNApol-zeta

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi14 – 2130Missing in mus205; hypersensitive to alkylating agents and UV, but not sensitive to ionising radiation. In somatic cells, no effect on methyl methane sulfonate-induced mutations and homologous recombination. In germ cells, no effect on mutability by X-rays, NQO and alkylating agents. 1 PublicationAdd BLAST2117

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004487421 – 2130DNA polymerase zeta catalytic subunitAdd BLAST2130

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9GSR1

PRoteomics IDEntifications database

More...
PRIDEi
Q9GSR2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryos (at protein level) (PubMed:15175013). Expressed throughout development, with highest levels of expression in 0-8 hour embryos and adult females (PubMed:16507570).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0002891 Expressed in 4 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Catalytic subunit of the zeta DNA polymerase complex, which consists of DNApol-zeta/DNApolZ1 and the accessory component Rev7 (PubMed:16507570, PubMed:15175013).

Interacts with the apurinic/apyrimidinic (AP) endonuclease Rrp1; the interaction is likely indirect and mediated via Rev7 (PubMed:16507570).

2 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0087907

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2086 – 2103CysB motifBy similarityAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0968 Eukaryota
COG0417 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169521

KEGG Orthology (KO)

More...
KOi
K02350

Identification of Orthologs from Complete Genome Data

More...
OMAi
HESHVPY

Database of Orthologous Groups

More...
OrthoDBi
20210at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9GSR1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.132.60, 1 hit
3.30.420.10, 1 hit
3.90.1600.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR042087 DNA_pol_B_C
IPR023211 DNA_pol_palm_dom_sf
IPR030559 PolZ_Rev3
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR025687 Znf-C4pol

The PANTHER Classification System

More...
PANTHERi
PTHR45812 PTHR45812, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 2 hits
PF14260 zf-C4pol, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00106 DNAPOLB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00486 POLBc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9GSR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAGEAIDG VYSVRLVIAD FYMEKPQFGM DPCYSELRGK EIKRVPVIRV
60 70 80 90 100
FGGNSRGQKT CMHVHGVFPY LYIPYDKKDF ESLERGILQM AMHLDKAINI
110 120 130 140 150
SLGQGSSNAQ HVFKIQLVKG IPFYGYHRVE HQFLKIYMFN PRFVRRAANL
160 170 180 190 200
LQSGAILSKN FSPHESHVPY ILQFMIDYNL YGMSYVHVPL EVLKFRRNHD
210 220 230 240 250
DDVIPYANVK QAQLLDITTA KKVACSALEV DVSSNFILNR FQLVAKSKSN
260 270 280 290 300
HTNPGIEAIW NDEKLRRQKL VEKHTDAGDE EKAEAVPVLE LPPTQERHQI
310 320 330 340 350
EIAESDIFYR TALESKLMTL EQSTLSEQTL SDQTILPQAT MQTTMPGTKA
360 370 380 390 400
QKRRFNLQKL LANAVYPEEC SQDQQQLLVN ASFIQNHVTC GYSSSVSLST
410 420 430 440 450
SKDESDDLDE TVVDEELILS LTQPHGAIPH DATLREEDLE LLDALQLLEE
460 470 480 490 500
QNESESHVDL DSSLAPLSQH KKFELTPELL DKETAATAAL FDEDVDSDED
510 520 530 540 550
ADQETRHDFS TVLDDVDELL LKLTQSQPAE SKELKASSKL PQIDGADDRL
560 570 580 590 600
QRTPIKSISS KSKSSPSKTP TTPIGQKSLP KSPRTPKTSA AKKYAPLALT
610 620 630 640 650
IGSSSSKKSN DEFAGRPSNP RLSLQLDQGT GTGTLRPEIS LRKKLAMSEM
660 670 680 690 700
RRKSFEDSFV LLKNDCTPVR STRRSTSNLD KTHIICSLTP RDRNPGLSDM
710 720 730 740 750
FETEDGKQLP PKKVVRKTRW STRNQDIESL PKAGCEIERP HRSEGSALDE
760 770 780 790 800
LKPRRSARHK VNSANPDECS SEIQTTGPRV TTTSLDRPQK KARLSQSPKE
810 820 830 840 850
NTKTSMNGTV ALEKATKDSS SNSESPHQQE NSVSEQIEYL ESKPKKSDET
860 870 880 890 900
ARSCDEKLQR ELIPQEPAGI SPGDSANSTE EITFSPCHDE AIESDTESDY
910 920 930 940 950
IVTKLRKTPN LKRLRWSIRS ELLNKQFTPS SGIRPPETET TPQLSPKSNE
960 970 980 990 1000
SNTPELMRSF YEHSLIVNSP SVFSDFLDSP EIHMDSPRSA PPSPDSNSFV
1010 1020 1030 1040 1050
IAPLELPPSY DEVVSGSRKM DIPEYEFQKP YYSNPSDVSK VTEVGFLVLH
1060 1070 1080 1090 1100
IPGNKLNDCD PFQSILGNDR GLASWRRRQL IAIGGLAMLQ RHRGEQKVRE
1110 1120 1130 1140 1150
YFSTQQRIAI EPAQLAPTWQ EAKIWLKAKE LLRQREEPKK SSDDIDSPIK
1160 1170 1180 1190 1200
IKRQKITMML QAEEGDGGSG DEDAGEELDC SLSLTPLSQA KDKCKATPTS
1210 1220 1230 1240 1250
SKARETGKSR LKRGTRLSFI GSQDEEPPSS QSSEQSVSSS AAQAELDRSS
1260 1270 1280 1290 1300
FLRQLEGSSQ DRQHDLSFGL SHATLDNTFG FKVNLENLQQ AKADIDCNHL
1310 1320 1330 1340 1350
TIITLEVFVS TRGDLQPDPM HDEIRCLFYA IEHSLPDEKL PSKACGYIMV
1360 1370 1380 1390 1400
NTVQDLLSEG PFHGIDRDIE VQVVTSEAEA FEALLALCER WDADIYAGYE
1410 1420 1430 1440 1450
IEMSSWGYVI DRAKHLCFNI APLLSRVPTQ KVRDFVDEDR EQFTDLDVEM
1460 1470 1480 1490 1500
KLCGRILLDV WRLMRSEIAL TSYTFENVMY HILHKRCPWH TAKSLTEWFG
1510 1520 1530 1540 1550
SPCTRWIVME YYLERVRGTL TLLDQLDLLG RTSEMAKLIG IQFYEVLSRG
1560 1570 1580 1590 1600
SQFRVESMML RIAKPKNLVP LSPSVQARAH MRAPEYLALI MEPQSRFYAD
1610 1620 1630 1640 1650
PLIVLDFQSL YPSMIIAYNY CFSTCLGRVE HLGGSSPFEF GASQLRVSRQ
1660 1670 1680 1690 1700
MLQKLLEHDL VTVSPCGVVF VKREVREGIL PRMLTEILDT RQMVKQSMKL
1710 1720 1730 1740 1750
HKDSSALQRI LHSRQLGLKL MANVTYGYTA ANFSGRMPSV EVGDSVVSKG
1760 1770 1780 1790 1800
RETLERAIKL VENNEEWKVR VVYGDTDSMF VLVPGRNRAE AFRIGEEIAK
1810 1820 1830 1840 1850
AVTEMNPQPV KLKLEKVYQP CMLQTKKRYV GYMYETADQE QPVYEAKGIE
1860 1870 1880 1890 1900
TVRRDGCPAV AKMLEKVLRI LFETQDVSKI KAYVCRQFTK LLSGRANLQD
1910 1920 1930 1940 1950
LIFAKEFRGL NGYKPTACVP ALELTRKWMQ KDPRHVPRRG ERVPFIIVNG
1960 1970 1980 1990 2000
PPGMQLIRLV RSPHDILANE GHKINAIYYI TKAIIPPLNR CLLLIGANVH
2010 2020 2030 2040 2050
DWFASLPRKL LMTPAVGTAN ELAGARGAKS TISQYFSTTS CVIDCGRQTK
2060 2070 2080 2090 2100
AGICPDCLKN ATTCVVVLSD KTARLERGYQ LTRQICQACC GRLGSLQCDS
2110 2120 2130
LDCPVLYVLE GKRRELQQIE HWNKLLEHHF
Length:2,130
Mass (Da):240,073
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i24686E9A2267FC15
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92M → V in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti339A → V in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti394S → N in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti536A → V in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti584R → H in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti677S → R in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti854C → R in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti887C → S in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti1021D → G in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti1176E → D in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti1206T → R in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti1213R → P in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti1238S → F in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti1524D → E in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti1611Y → H in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti1852V → E in AAG30223 (PubMed:11267835).Curated1
Sequence conflicti2025A → P in AAG30223 (PubMed:11267835).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF298215 mRNA Translation: AAG30223.1
AE013599 Genomic DNA Translation: AAF59191.2
AF298216 Genomic DNA Translation: AAG30224.1
AY058689 mRNA Translation: AAL13918.1

NCBI Reference Sequences

More...
RefSeqi
NP_524881.2, NM_080142.3

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0088831; FBpp0087907; FBgn0002891

Database of genes from NCBI RefSeq genomes

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GeneIDi
47186

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG1925

UCSC genome browser

More...
UCSCi
CG1925-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298215 mRNA Translation: AAG30223.1
AE013599 Genomic DNA Translation: AAF59191.2
AF298216 Genomic DNA Translation: AAG30224.1
AY058689 mRNA Translation: AAL13918.1
RefSeqiNP_524881.2, NM_080142.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0087907

Proteomic databases

PaxDbiQ9GSR1
PRIDEiQ9GSR2

Genome annotation databases

EnsemblMetazoaiFBtr0088831; FBpp0087907; FBgn0002891
GeneIDi47186
KEGGidme:Dmel_CG1925
UCSCiCG1925-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
47186
FlyBaseiFBgn0002891 DNApol-zeta

Phylogenomic databases

eggNOGiKOG0968 Eukaryota
COG0417 LUCA
GeneTreeiENSGT00940000169521
KOiK02350
OMAiHESHVPY
OrthoDBi20210at2759
PhylomeDBiQ9GSR1

Enzyme and pathway databases

ReactomeiR-DME-110312 Translesion synthesis by REV1
R-DME-5655862 Translesion synthesis by POLK
R-DME-5656121 Translesion synthesis by POLI

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
47186

Gene expression databases

BgeeiFBgn0002891 Expressed in 4 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di1.10.132.60, 1 hit
3.30.420.10, 1 hit
3.90.1600.10, 1 hit
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR042087 DNA_pol_B_C
IPR023211 DNA_pol_palm_dom_sf
IPR030559 PolZ_Rev3
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR025687 Znf-C4pol
PANTHERiPTHR45812 PTHR45812, 1 hit
PfamiView protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 2 hits
PF14260 zf-C4pol, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPOZ_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GSR1
Secondary accession number(s): Q95TM2, Q9GSR2, Q9V319
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 11, 2019
Last sequence update: March 1, 2001
Last modified: December 11, 2019
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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