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Entry version 94 (25 May 2022)
Sequence version 1 (01 Mar 2001)
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Protein

Crt homolog 1

Gene

crtp1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate endogenous transporter.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.7.20.2, the drug/metabolite transporter (dmt) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Crt homolog 1
Alternative name(s):
Chloroquine resistance transporter paralog 1
Short name:
DdCRTp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:crtp1
Synonyms:ssa662
ORF Names:DDB_G0276943
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0276943, crtp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 80LumenalSequence analysis10
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 121CytoplasmicSequence analysisAdd BLAST20
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 146LumenalSequence analysis4
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 175CytoplasmicSequence analysis8
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 207LumenalSequence analysisAdd BLAST11
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 248CytoplasmicSequence analysisAdd BLAST20
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 322LumenalSequence analysisAdd BLAST53
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 352CytoplasmicSequence analysis9
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374LumenalSequence analysis1
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 473CytoplasmicSequence analysisAdd BLAST78

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003853631 – 473Crt homolog 1Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9GSB0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0185065

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q9GSB0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9GSB0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CRT-like transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR5M, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_571661_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9GSB0

Identification of Orthologs from Complete Genome Data

More...
OMAi
IWPALMI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9GSB0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013936, CRT-like
IPR017258, Transprt_Chloroquine

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08627, CRT-like, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037671, Transprt_Chloroquine_res, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9GSB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNNDKEKQP LLSSINNEDD NGATINIVEP VPWYSNIPQK IKNSMSKETI
60 70 80 90 100
TILIYVVLYV TSGVINSVLL KKVMNKFTNY AFFLSQLTNF GYVPIFGAVT
110 120 130 140 150
AYKIFFTKDI PQETRDFPTR KFAIMGALDA ITGFFVVIGG VSTSGPLQQL
160 170 180 190 200
LNQAIIPFTM IASFIFLKER YSLIQLGGAL VIIGGVVTSL IPSLLGGSSG
210 220 230 240 250
GNKPFWNFFY LLSVIPGALS NVYKDIGFQA VADMDVWYLQ YWDSLYQSIF
260 270 280 290 300
GLFLFPVNNW LPPPATVKFE QILPFMKEGA ECLAGINSII PSYINGTSSF
310 320 330 340 350
TATSCTYAPD ATITCDDCHN AWIVIILYMT INIIYNIFIL LVLKHAGATV
360 370 380 390 400
YSIANTLRLP LTNIVFSIHF IMGSAVSPFS GLSVAGLVII LVGLGGYRVG
410 420 430 440 450
SMIKQKKAAA AGGAIKVIPS YGPAGMDNII PVQKEYIEPK SQAHLRNQFF
460 470
GKLGINVPEA RYRAANNNNY GDA
Length:473
Mass (Da):51,809
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7075EE2AD148FFB6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF317500 mRNA Translation: AAG31811.1
AAFI02000019 Genomic DNA Translation: EAL68973.1

NCBI Reference Sequences

More...
RefSeqi
XP_642959.1, XM_637867.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL68973; EAL68973; DDB_G0276943

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8620828

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0276943

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317500 mRNA Translation: AAG31811.1
AAFI02000019 Genomic DNA Translation: EAL68973.1
RefSeqiXP_642959.1, XM_637867.1

3D structure databases

AlphaFoldDBiQ9GSB0
SMRiQ9GSB0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0185065

Protein family/group databases

TCDBi2.A.7.20.2, the drug/metabolite transporter (dmt) superfamily

Proteomic databases

PaxDbiQ9GSB0

Genome annotation databases

EnsemblProtistsiEAL68973; EAL68973; DDB_G0276943
GeneIDi8620828
KEGGiddi:DDB_G0276943

Organism-specific databases

dictyBaseiDDB_G0276943, crtp1

Phylogenomic databases

eggNOGiENOG502QR5M, Eukaryota
HOGENOMiCLU_571661_0_0_1
InParanoidiQ9GSB0
OMAiIWPALMI
PhylomeDBiQ9GSB0

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9GSB0

Family and domain databases

InterProiView protein in InterPro
IPR013936, CRT-like
IPR017258, Transprt_Chloroquine
PfamiView protein in Pfam
PF08627, CRT-like, 1 hit
PIRSFiPIRSF037671, Transprt_Chloroquine_res, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRTP1_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GSB0
Secondary accession number(s): Q550H3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 1, 2001
Last modified: May 25, 2022
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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